LeishMANIAdb
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Peptidyl-prolyl cis-trans isomerase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Peptidyl-prolyl cis-trans isomerase
Gene product:
cyclophilin-like protein
Species:
Leishmania donovani
UniProt:
A0A3S7XB52_LEIDO
TriTrypDb:
LdBPK_363280.1 * , LdCL_360039500 , LDHU3_36.4520
Length:
266

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7XB52
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB52

PDB structure(s): 7aih_BI , 7am2_Bl , 7ane_BI

Function

Biological processes
Term Name Level Count
GO:0000413 protein peptidyl-prolyl isomerization 7 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0018193 peptidyl-amino acid modification 5 11
GO:0018208 peptidyl-proline modification 6 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0006457 protein folding 2 1
GO:0009987 cellular process 1 1
Molecular functions
Term Name Level Count
GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3 11
GO:0003824 catalytic activity 1 11
GO:0016853 isomerase activity 2 11
GO:0016859 cis-trans isomerase activity 3 11
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0005488 binding 1 1
GO:0016018 cyclosporin A binding 4 1
GO:0033218 amide binding 2 1
GO:0042277 peptide binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 126 130 PF00656 0.372
CLV_C14_Caspase3-7 44 48 PF00656 0.432
CLV_PCSK_SKI1_1 17 21 PF00082 0.577
CLV_PCSK_SKI1_1 54 58 PF00082 0.333
DOC_CKS1_1 35 40 PF01111 0.488
DOC_MAPK_gen_1 188 197 PF00069 0.405
DOC_PP1_RVXF_1 93 99 PF00149 0.327
DOC_PP4_FxxP_1 181 184 PF00568 0.290
DOC_PP4_FxxP_1 32 35 PF00568 0.444
DOC_USP7_MATH_1 106 110 PF00917 0.407
DOC_USP7_MATH_1 123 127 PF00917 0.205
DOC_USP7_MATH_1 28 32 PF00917 0.513
DOC_USP7_MATH_1 55 59 PF00917 0.432
DOC_USP7_MATH_1 87 91 PF00917 0.339
DOC_WW_Pin1_4 24 29 PF00397 0.554
DOC_WW_Pin1_4 34 39 PF00397 0.446
LIG_14-3-3_CanoR_1 147 152 PF00244 0.361
LIG_14-3-3_CanoR_1 54 60 PF00244 0.576
LIG_14-3-3_CanoR_1 95 99 PF00244 0.420
LIG_AP2alpha_1 136 140 PF02296 0.299
LIG_APCC_ABBA_1 174 179 PF00400 0.298
LIG_BRCT_BRCA1_1 108 112 PF00533 0.405
LIG_BRCT_BRCA1_1 209 213 PF00533 0.278
LIG_BRCT_BRCA1_2 108 114 PF00533 0.405
LIG_deltaCOP1_diTrp_1 62 68 PF00928 0.481
LIG_EVH1_1 34 38 PF00568 0.379
LIG_EVH1_2 12 16 PF00568 0.496
LIG_FHA_1 169 175 PF00498 0.298
LIG_FHA_1 253 259 PF00498 0.222
LIG_FHA_1 44 50 PF00498 0.435
LIG_FHA_1 55 61 PF00498 0.597
LIG_FHA_1 95 101 PF00498 0.353
LIG_FHA_2 42 48 PF00498 0.445
LIG_GSK3_LRP6_1 24 29 PF00069 0.442
LIG_LIR_Apic_2 179 184 PF02991 0.279
LIG_LIR_Apic_2 29 35 PF02991 0.447
LIG_LIR_Gen_1 109 119 PF02991 0.301
LIG_LIR_Gen_1 190 198 PF02991 0.450
LIG_LIR_Gen_1 235 245 PF02991 0.409
LIG_LIR_Gen_1 97 106 PF02991 0.334
LIG_LIR_Nem_3 109 115 PF02991 0.301
LIG_LIR_Nem_3 15 19 PF02991 0.523
LIG_LIR_Nem_3 175 180 PF02991 0.306
LIG_LIR_Nem_3 210 215 PF02991 0.278
LIG_LIR_Nem_3 235 240 PF02991 0.404
LIG_LIR_Nem_3 97 101 PF02991 0.334
LIG_MLH1_MIPbox_1 209 213 PF16413 0.278
LIG_Pex14_2 136 140 PF04695 0.323
LIG_Pex14_2 16 20 PF04695 0.530
LIG_SH2_STAT3 158 161 PF00017 0.296
LIG_SH2_STAT5 158 161 PF00017 0.310
LIG_SH2_STAT5 40 43 PF00017 0.486
LIG_SH2_STAT5 52 55 PF00017 0.336
LIG_SH3_3 19 25 PF00018 0.556
LIG_SH3_3 199 205 PF00018 0.312
LIG_SH3_3 2 8 PF00018 0.502
LIG_SH3_3 32 38 PF00018 0.428
LIG_SUMO_SIM_anti_2 255 262 PF11976 0.401
LIG_SUMO_SIM_par_1 255 262 PF11976 0.400
LIG_TRAF2_1 183 186 PF00917 0.312
LIG_TRFH_1 32 36 PF08558 0.459
MOD_GlcNHglycan 166 169 PF01048 0.359
MOD_GlcNHglycan 202 205 PF01048 0.298
MOD_GSK3_1 142 149 PF00069 0.295
MOD_GSK3_1 164 171 PF00069 0.298
MOD_GSK3_1 24 31 PF00069 0.518
MOD_GSK3_1 62 69 PF00069 0.597
MOD_N-GLC_1 147 152 PF02516 0.356
MOD_N-GLC_1 207 212 PF02516 0.298
MOD_N-GLC_1 223 228 PF02516 0.298
MOD_NEK2_1 197 202 PF00069 0.278
MOD_NEK2_1 207 212 PF00069 0.278
MOD_NEK2_1 223 228 PF00069 0.405
MOD_NEK2_1 41 46 PF00069 0.489
MOD_NEK2_1 68 73 PF00069 0.565
MOD_NEK2_2 172 177 PF00069 0.402
MOD_NEK2_2 28 33 PF00069 0.515
MOD_PIKK_1 207 213 PF00454 0.281
MOD_PIKK_1 87 93 PF00454 0.339
MOD_PKA_2 146 152 PF00069 0.358
MOD_PKA_2 69 75 PF00069 0.521
MOD_PKA_2 94 100 PF00069 0.420
MOD_Plk_1 147 153 PF00069 0.324
MOD_Plk_4 172 178 PF00069 0.278
MOD_Plk_4 55 61 PF00069 0.440
MOD_ProDKin_1 24 30 PF00069 0.555
MOD_ProDKin_1 34 40 PF00069 0.445
MOD_SUMO_rev_2 182 190 PF00179 0.353
TRG_ENDOCYTIC_2 177 180 PF00928 0.289
TRG_ER_FFAT_1 175 186 PF00635 0.289
TRG_Pf-PMV_PEXEL_1 17 21 PF00026 0.530

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P364 Leptomonas seymouri 31% 100%
A0A0N0P523 Leptomonas seymouri 38% 96%
A0A0N0P839 Leptomonas seymouri 36% 100%
A0A0N1I0P5 Leptomonas seymouri 38% 100%
A0A0N1I6E6 Leptomonas seymouri 37% 100%
A0A0N1I8P9 Leptomonas seymouri 39% 90%
A0A0N1IAQ4 Leptomonas seymouri 40% 75%
A0A0N1IL84 Leptomonas seymouri 35% 83%
A0A0N1PC19 Leptomonas seymouri 78% 100%
A0A0N1PDY0 Leptomonas seymouri 28% 100%
A0A0S4IKA5 Bodo saltans 31% 88%
A0A0S4J378 Bodo saltans 36% 100%
A0A0S4J8W7 Bodo saltans 36% 100%
A0A0S4J9U9 Bodo saltans 57% 100%
A0A0S4JAB5 Bodo saltans 35% 75%
A0A0S4JID7 Bodo saltans 29% 100%
A0A0S4KGS8 Bodo saltans 35% 100%
A0A0S4KLH0 Bodo saltans 36% 100%
A0A1X0NJS0 Trypanosomatidae 35% 100%
A0A1X0NTQ9 Trypanosomatidae 39% 100%
A0A1X0NTS4 Trypanosomatidae 33% 100%
A0A1X0NXG7 Trypanosomatidae 39% 100%
A0A1X0P184 Trypanosomatidae 38% 100%
A0A1X0P2K2 Trypanosomatidae 30% 100%
A0A1X0P4X3 Trypanosomatidae 72% 100%
A0A1X0P563 Trypanosomatidae 36% 75%
A0A3Q8ICB3 Leishmania donovani 33% 100%
A0A3Q8IIG9 Leishmania donovani 40% 75%
A0A3R7M7E5 Trypanosoma rangeli 33% 86%
A0A3R7MP70 Trypanosoma rangeli 72% 100%
A0A3R7RC31 Trypanosoma rangeli 37% 100%
A0A3R7RE54 Trypanosoma rangeli 39% 100%
A0A3R7RI88 Trypanosoma rangeli 35% 100%
A0A3S5H5N2 Leishmania donovani 39% 100%
A0A3S5H7U6 Leishmania donovani 37% 100%
A0A3S5IQL2 Trypanosoma rangeli 30% 100%
A0A3S7WXF4 Leishmania donovani 40% 90%
A0A3S7WYY5 Leishmania donovani 41% 96%
A0A3S7X325 Leishmania donovani 28% 100%
A0A3S7X410 Leishmania donovani 35% 100%
A0A422N1Z9 Trypanosoma rangeli 38% 100%
A0A422N490 Trypanosoma rangeli 33% 100%
A0A422P185 Trypanosoma rangeli 37% 75%
A0A451EJ79 Leishmania donovani 34% 80%
A4FV72 Bos taurus 35% 88%
A4H346 Leishmania braziliensis 33% 79%
A4H4H8 Leishmania braziliensis 35% 100%
A4H8P7 Leishmania braziliensis 34% 76%
A4HCI8 Leishmania braziliensis 32% 100%
A4HCL8 Leishmania braziliensis 39% 90%
A4HE26 Leishmania braziliensis 39% 96%
A4HHU7 Leishmania braziliensis 27% 100%
A4HIW9 Leishmania braziliensis 36% 100%
A4HLM4 Leishmania braziliensis 37% 100%
A4HNE1 Leishmania braziliensis 40% 75%
A4HPH9 Leishmania braziliensis 90% 100%
A4HRE3 Leishmania infantum 34% 80%
A4HSQ3 Leishmania infantum 39% 100%
A4I004 Leishmania infantum 33% 100%
A4I042 Leishmania infantum 40% 90%
A4I1D2 Leishmania infantum 41% 96%
A4I4Z7 Leishmania infantum 27% 100%
A4I698 Leishmania infantum 35% 100%
A4I935 Leishmania infantum 37% 100%
A4IC14 Leishmania infantum 40% 75%
A4IDA1 Leishmania infantum 99% 100%
A8X8D0 Caenorhabditis briggsae 36% 85%
B3A0R0 Lottia gigantea 36% 100%
C9ZIV0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
C9ZQE6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZRQ0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
C9ZSQ5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
C9ZT99 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
C9ZUX8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 88%
C9ZVY5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 94%
C9ZYI8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 75%
D0A8E1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
D4AY02 Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) 36% 100%
E9AC11 Leishmania major 34% 79%
E9AFV2 Leishmania major 40% 75%
E9AJA8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 80%
E9AKP0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9AT91 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9AVX7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AW05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 92%
E9AXG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 96%
E9B0C7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B1F3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B400 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B705 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 75%
O02614 Leishmania major 41% 96%
O49605 Arabidopsis thaliana 36% 100%
O93826 Arthroderma benhamiae 36% 100%
O94273 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 37% 100%
P0C1H9 Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) 38% 100%
P0C1I0 Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) 34% 100%
P0C1I1 Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) 40% 73%
P0C1I2 Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) 37% 84%
P0C1I3 Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) 39% 100%
P0C1I9 Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) 38% 79%
P0CP78 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 34% 100%
P0CP79 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 34% 100%
P0CP80 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 39% 71%
P0CP81 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 39% 71%
P0CP82 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 42% 100%
P0CP83 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 42% 100%
P15425 Drosophila melanogaster 35% 100%
P23284 Homo sapiens 36% 100%
P23285 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 100%
P24367 Gallus gallus 34% 100%
P24368 Rattus norvegicus 37% 100%
P24369 Mus musculus 35% 100%
P25007 Drosophila melanogaster 34% 100%
P25334 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 84%
P25719 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 36% 100%
P26882 Bos taurus 38% 72%
P28517 Calliphora vicina 35% 100%
P29117 Rattus norvegicus 36% 100%
P30404 Bos taurus 36% 100%
P30405 Homo sapiens 35% 100%
P30412 Mus musculus 35% 100%
P34791 Arabidopsis thaliana 32% 100%
P35176 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 100%
P45877 Homo sapiens 36% 100%
P47103 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 35% 68%
P52009 Caenorhabditis elegans 38% 100%
P52013 Caenorhabditis elegans 33% 100%
P52014 Caenorhabditis elegans 34% 100%
P52018 Caenorhabditis elegans 37% 100%
P53691 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 37% 72%
P80311 Bos taurus 34% 100%
P84343 Neospora caninum 33% 100%
Q01490 Orpinomyces sp. (strain PC-2) 35% 100%
Q08752 Homo sapiens 38% 72%
Q08E11 Bos taurus 36% 100%
Q09637 Caenorhabditis elegans 36% 86%
Q11004 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 75%
Q1RMP7 Bos taurus 34% 87%
Q26516 Schistosoma japonicum 39% 100%
Q26548 Schistosoma mansoni 39% 97%
Q26551 Schistosoma mansoni 33% 100%
Q27774 Schistosoma japonicum 35% 100%
Q2TZ33 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 40% 100%
Q2U0E0 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 40% 72%
Q2UGK2 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 36% 100%
Q4G338 Haemonchus contortus 35% 82%
Q4HXF6 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 38% 72%
Q4I5R9 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 36% 100%
Q4IPH4 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 37% 100%
Q4P0V4 Ustilago maydis (strain 521 / FGSC 9021) 38% 67%
Q4Q1A6 Leishmania major 94% 100%
Q4Q424 Leishmania major 37% 100%
Q4Q6Q9 Leishmania major 34% 100%
Q4Q7V7 Leishmania major 26% 100%
Q4QBH1 Leishmania major 38% 90%
Q4QBK2 Leishmania major 33% 100%
Q4QJ67 Leishmania major 38% 100%
Q4WCM6 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 40% 100%
Q4WIF3 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 43% 71%
Q4WP12 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 39% 100%
Q54SM3 Dictyostelium discoideum 39% 100%
Q5ACI8 Candida albicans (strain SC5314 / ATCC MYA-2876) 35% 72%
Q5AQL0 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 40% 100%
Q5B4E7 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 43% 72%
Q5B4R3 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 33% 100%
Q5R723 Pongo abelii 36% 88%
Q5U8Z7 Amanita muscaria 43% 72%
Q6BXZ7 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 38% 72%
Q6C4W6 Yarrowia lipolytica (strain CLIB 122 / E 150) 33% 100%
Q6CBP4 Yarrowia lipolytica (strain CLIB 122 / E 150) 38% 72%
Q6CL78 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 38% 72%
Q6DGG0 Rattus norvegicus 38% 72%
Q6FNU6 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 38% 72%
Q75A33 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 40% 72%
Q7S7Z6 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 35% 93%
Q7SG06 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 38% 100%
Q8IXY8 Homo sapiens 34% 86%
Q8L8W5 Arabidopsis thaliana 36% 100%
Q8LDP4 Arabidopsis thaliana 37% 100%
Q8X166 Aspergillus niger 39% 100%
Q99KR7 Mus musculus 36% 100%
Q9ASS6 Arabidopsis thaliana 35% 100%
Q9C566 Arabidopsis thaliana 39% 74%
Q9CR16 Mus musculus 38% 72%
Q9LIK6 Arabidopsis thaliana 28% 100%
Q9P3X9 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 40% 71%
Q9QZH3 Mus musculus 35% 88%
Q9SP02 Arabidopsis thaliana 37% 100%
Q9TW32 Dictyostelium discoideum 36% 100%
Q9UNP9 Homo sapiens 36% 88%
Q9V3G3 Drosophila melanogaster 33% 89%
Q9ZVJ4 Arabidopsis thaliana 37% 100%
V5B2A0 Trypanosoma cruzi 38% 100%
V5B9Y6 Trypanosoma cruzi 35% 86%
V5BGX2 Trypanosoma cruzi 29% 100%
V5BHF5 Trypanosoma cruzi 36% 100%
V5D532 Trypanosoma cruzi 35% 100%
V5D7H4 Trypanosoma cruzi 38% 75%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS