Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XB48_LEIDO

TriTrypDb:

LdBPK_363200.1 , LdCL_360038600 , LDHU3_36.4410

Length:

142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7XB48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB48

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0007031	peroxisome organization	5	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	109	111	PF00082	0.541
CLV_PCSK_KEX2_1	58	60	PF00082	0.473
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.536
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.473
CLV_PCSK_SKI1_1	59	63	PF00082	0.428
CLV_PCSK_SKI1_1	75	79	PF00082	0.405
CLV_Separin_Metazoa	35	39	PF03568	0.351
DEG_APCC_DBOX_1	58	66	PF00400	0.331
DOC_CYCLIN_RxL_1	72	82	PF00134	0.476
DOC_MAPK_gen_1	109	117	PF00069	0.495
DOC_MAPK_gen_1	58	64	PF00069	0.458
DOC_MAPK_MEF2A_6	90	98	PF00069	0.365
DOC_PP1_RVXF_1	73	79	PF00149	0.418
DOC_USP7_MATH_1	41	45	PF00917	0.479
LIG_14-3-3_CanoR_1	110	116	PF00244	0.507
LIG_DCNL_PONY_1	1	4	PF03556	0.457
LIG_FHA_1	112	118	PF00498	0.510
LIG_FHA_1	87	93	PF00498	0.520
LIG_LIR_Gen_1	82	92	PF02991	0.482
LIG_LIR_Nem_3	82	88	PF02991	0.476
LIG_Pex14_1	18	22	PF04695	0.361
LIG_SH2_STAT5	47	50	PF00017	0.347
LIG_SUMO_SIM_anti_2	114	119	PF11976	0.430
LIG_UBA3_1	1	7	PF00899	0.577
LIG_UBA3_1	61	66	PF00899	0.526
MOD_Cter_Amidation	10	13	PF01082	0.492
MOD_GSK3_1	92	99	PF00069	0.419
MOD_NEK2_1	96	101	PF00069	0.481
MOD_Plk_4	111	117	PF00069	0.224
MOD_Plk_4	92	98	PF00069	0.386
TRG_ENDOCYTIC_2	85	88	PF00928	0.379
TRG_ER_diArg_1	73	76	PF00400	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N3	Leptomonas seymouri	73%	68%
A0A0S4JN26	Bodo saltans	28%	73%
A0A1X0NKF5	Trypanosomatidae	48%	72%
A0A422NM43	Trypanosoma rangeli	43%	71%
A4HPH1	Leishmania braziliensis	92%	100%
A4ID93	Leishmania infantum	100%	100%
D0A3I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	72%
E9AT83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q1B4	Leishmania major	96%	100%
V5BKE1	Trypanosoma cruzi	43%	71%