ADP-ribosylation factor GTPase activating protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor GTPase activating protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XB38_LEIDO

TriTrypDb:

LdBPK_363300.1 , LdCL_360039700 , LDHU3_36.4540

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XB38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB38

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.465
CLV_NRD_NRD_1	15	17	PF00675	0.321
CLV_NRD_NRD_1	5	7	PF00675	0.521
CLV_PCSK_KEX2_1	117	119	PF00082	0.465
CLV_PCSK_SKI1_1	111	115	PF00082	0.416
CLV_PCSK_SKI1_1	117	121	PF00082	0.346
CLV_PCSK_SKI1_1	12	16	PF00082	0.513
CLV_PCSK_SKI1_1	62	66	PF00082	0.513
CLV_PCSK_SKI1_1	84	88	PF00082	0.298
CLV_Separin_Metazoa	13	17	PF03568	0.436
DEG_APCC_DBOX_1	32	40	PF00400	0.402
DEG_Nend_UBRbox_3	1	3	PF02207	0.597
DEG_SPOP_SBC_1	193	197	PF00917	0.665
DOC_CKS1_1	304	309	PF01111	0.586
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.623
DOC_MAPK_MEF2A_6	107	114	PF00069	0.394
DOC_PP1_RVXF_1	109	115	PF00149	0.338
DOC_PP2B_LxvP_1	215	218	PF13499	0.627
DOC_PP2B_LxvP_1	422	425	PF13499	0.491
DOC_PP4_FxxP_1	330	333	PF00568	0.622
DOC_SPAK_OSR1_1	76	80	PF12202	0.513
DOC_USP7_MATH_1	151	155	PF00917	0.679
DOC_USP7_MATH_1	184	188	PF00917	0.664
DOC_USP7_MATH_1	280	284	PF00917	0.730
DOC_USP7_MATH_1	331	335	PF00917	0.618
DOC_USP7_MATH_1	401	405	PF00917	0.755
DOC_USP7_MATH_1	417	421	PF00917	0.546
DOC_WW_Pin1_4	195	200	PF00397	0.815
DOC_WW_Pin1_4	303	308	PF00397	0.591
DOC_WW_Pin1_4	413	418	PF00397	0.694
LIG_14-3-3_CanoR_1	4	14	PF00244	0.556
LIG_14-3-3_CanoR_1	76	80	PF00244	0.436
LIG_BRCT_BRCA1_1	388	392	PF00533	0.689
LIG_FHA_1	228	234	PF00498	0.809
LIG_FHA_2	63	69	PF00498	0.433
LIG_IBAR_NPY_1	339	341	PF08397	0.635
LIG_LIR_Apic_2	327	333	PF02991	0.623
LIG_LIR_Apic_2	352	356	PF02991	0.708
LIG_LIR_Gen_1	182	193	PF02991	0.824
LIG_LIR_Nem_3	182	188	PF02991	0.721
LIG_LIR_Nem_3	235	240	PF02991	0.793
LIG_LIR_Nem_3	40	45	PF02991	0.513
LIG_Pex14_1	89	93	PF04695	0.411
LIG_Pex14_2	185	189	PF04695	0.719
LIG_PTAP_UEV_1	332	337	PF05743	0.576
LIG_SH2_CRK	251	255	PF00017	0.816
LIG_SH2_CRK	381	385	PF00017	0.756
LIG_SH2_NCK_1	381	385	PF00017	0.756
LIG_SH2_SRC	413	416	PF00017	0.695
LIG_SH2_STAT3	297	300	PF00017	0.733
LIG_SH2_STAT3	341	344	PF00017	0.704
LIG_SH2_STAT5	37	40	PF00017	0.411
LIG_SH3_1	381	387	PF00018	0.577
LIG_SH3_2	173	178	PF14604	0.755
LIG_SH3_3	145	151	PF00018	0.756
LIG_SH3_3	157	163	PF00018	0.513
LIG_SH3_3	167	173	PF00018	0.642
LIG_SH3_3	205	211	PF00018	0.680
LIG_SH3_3	215	221	PF00018	0.657
LIG_SH3_3	237	243	PF00018	0.647
LIG_SH3_3	312	318	PF00018	0.604
LIG_SH3_3	330	336	PF00018	0.606
LIG_SH3_3	381	387	PF00018	0.601
LIG_SH3_3	456	462	PF00018	0.703
LIG_SUMO_SIM_par_1	144	149	PF11976	0.641
LIG_SUMO_SIM_par_1	445	450	PF11976	0.761
LIG_SxIP_EBH_1	433	445	PF03271	0.588
LIG_TRAF2_1	179	182	PF00917	0.783
LIG_TRAF2_1	424	427	PF00917	0.761
LIG_WRC_WIRS_1	90	95	PF05994	0.513
MOD_CK1_1	155	161	PF00069	0.704
MOD_CK1_1	171	177	PF00069	0.736
MOD_CK1_1	187	193	PF00069	0.631
MOD_CK1_1	195	201	PF00069	0.608
MOD_CK1_1	266	272	PF00069	0.606
MOD_CK1_1	374	380	PF00069	0.651
MOD_CK1_1	432	438	PF00069	0.622
MOD_CK1_1	48	54	PF00069	0.513
MOD_CK1_1	67	73	PF00069	0.513
MOD_CK2_1	155	161	PF00069	0.704
MOD_CK2_1	62	68	PF00069	0.397
MOD_GlcNHglycan	124	128	PF01048	0.587
MOD_GlcNHglycan	170	173	PF01048	0.730
MOD_GlcNHglycan	189	192	PF01048	0.751
MOD_GlcNHglycan	251	254	PF01048	0.803
MOD_GlcNHglycan	310	313	PF01048	0.603
MOD_GlcNHglycan	333	336	PF01048	0.608
MOD_GlcNHglycan	374	377	PF01048	0.735
MOD_GlcNHglycan	393	396	PF01048	0.493
MOD_GlcNHglycan	403	406	PF01048	0.727
MOD_GlcNHglycan	47	50	PF01048	0.515
MOD_GlcNHglycan	99	102	PF01048	0.389
MOD_GSK3_1	151	158	PF00069	0.755
MOD_GSK3_1	189	196	PF00069	0.692
MOD_GSK3_1	285	292	PF00069	0.751
MOD_GSK3_1	319	326	PF00069	0.563
MOD_GSK3_1	397	404	PF00069	0.646
MOD_GSK3_1	413	420	PF00069	0.685
MOD_GSK3_1	431	438	PF00069	0.520
MOD_N-GLC_1	23	28	PF02516	0.377
MOD_N-GLC_1	274	279	PF02516	0.811
MOD_N-GLC_1	435	440	PF02516	0.591
MOD_NEK2_1	146	151	PF00069	0.814
MOD_NEK2_1	189	194	PF00069	0.611
MOD_NEK2_1	290	295	PF00069	0.823
MOD_NEK2_1	371	376	PF00069	0.688
MOD_NEK2_1	449	454	PF00069	0.775
MOD_NEK2_1	45	50	PF00069	0.408
MOD_NEK2_2	184	189	PF00069	0.531
MOD_NEK2_2	211	216	PF00069	0.611
MOD_NEK2_2	23	28	PF00069	0.377
MOD_NEK2_2	89	94	PF00069	0.474
MOD_PIKK_1	137	143	PF00454	0.759
MOD_PIKK_1	16	22	PF00454	0.513
MOD_PIKK_1	274	280	PF00454	0.758
MOD_PIKK_1	285	291	PF00454	0.611
MOD_PIKK_1	319	325	PF00454	0.600
MOD_PKA_1	16	22	PF00069	0.411
MOD_PKA_2	5	11	PF00069	0.605
MOD_PKA_2	75	81	PF00069	0.436
MOD_Plk_1	123	129	PF00069	0.621
MOD_Plk_1	152	158	PF00069	0.639
MOD_Plk_1	23	29	PF00069	0.377
MOD_Plk_1	435	441	PF00069	0.584
MOD_Plk_4	184	190	PF00069	0.610
MOD_Plk_4	228	234	PF00069	0.744
MOD_Plk_4	280	286	PF00069	0.666
MOD_ProDKin_1	195	201	PF00069	0.814
MOD_ProDKin_1	303	309	PF00069	0.589
MOD_ProDKin_1	413	419	PF00069	0.694
TRG_DiLeu_BaEn_2	114	120	PF01217	0.299
TRG_DiLeu_BaEn_4	115	121	PF01217	0.299
TRG_ER_diArg_1	117	119	PF00400	0.436
TRG_ER_diArg_1	3	6	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P3S6	Trypanosomatidae	38%	100%
A4HPI1	Leishmania braziliensis	70%	100%
A4IDA3	Leishmania infantum	99%	100%
E9AT93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q1A4	Leishmania major	76%	89%