Protein NipSnap

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein NipSnap

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XB37_LEIDO

TriTrypDb:

LdBPK_363060.1 , LdCL_360037000 , LDHU3_36.4230

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XB37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB37

PDB structure(s): 7aih_Al , 7am2_Al , 7ane_Al

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	146	152	PF00089	0.371
CLV_NRD_NRD_1	305	307	PF00675	0.510
CLV_NRD_NRD_1	311	313	PF00675	0.569
CLV_NRD_NRD_1	46	48	PF00675	0.551
CLV_PCSK_KEX2_1	148	150	PF00082	0.339
CLV_PCSK_KEX2_1	305	307	PF00082	0.426
CLV_PCSK_KEX2_1	58	60	PF00082	0.540
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.379
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.547
CLV_PCSK_PC7_1	301	307	PF00082	0.459
CLV_PCSK_PC7_1	54	60	PF00082	0.551
CLV_PCSK_SKI1_1	145	149	PF00082	0.378
CLV_PCSK_SKI1_1	30	34	PF00082	0.586
CLV_PCSK_SKI1_1	321	325	PF00082	0.519
CLV_Separin_Metazoa	230	234	PF03568	0.404
DEG_Nend_Nbox_1	1	3	PF02207	0.718
DEG_SPOP_SBC_1	41	45	PF00917	0.487
DOC_CKS1_1	135	140	PF01111	0.413
DOC_CYCLIN_RxL_1	27	36	PF00134	0.580
DOC_MAPK_gen_1	226	234	PF00069	0.537
DOC_PP2B_PxIxI_1	178	184	PF00149	0.279
DOC_PP4_FxxP_1	10	13	PF00568	0.542
DOC_USP7_MATH_1	314	318	PF00917	0.677
DOC_USP7_MATH_2	256	262	PF00917	0.415
DOC_USP7_UBL2_3	90	94	PF12436	0.408
DOC_WW_Pin1_4	134	139	PF00397	0.399
DOC_WW_Pin1_4	175	180	PF00397	0.322
DOC_WW_Pin1_4	252	257	PF00397	0.370
LIG_14-3-3_CanoR_1	134	138	PF00244	0.392
LIG_14-3-3_CanoR_1	149	157	PF00244	0.280
LIG_14-3-3_CanoR_1	233	240	PF00244	0.507
LIG_14-3-3_CanoR_1	259	266	PF00244	0.430
LIG_14-3-3_CanoR_1	278	287	PF00244	0.582
LIG_14-3-3_CanoR_1	59	63	PF00244	0.548
LIG_14-3-3_CterR_2	342	346	PF00244	0.600
LIG_BRCT_BRCA1_1	6	10	PF00533	0.554
LIG_Clathr_ClatBox_1	32	36	PF01394	0.525
LIG_deltaCOP1_diTrp_1	81	89	PF00928	0.412
LIG_FHA_1	12	18	PF00498	0.631
LIG_FHA_1	122	128	PF00498	0.334
LIG_FHA_1	176	182	PF00498	0.347
LIG_FHA_1	187	193	PF00498	0.501
LIG_FHA_1	27	33	PF00498	0.474
LIG_FHA_1	279	285	PF00498	0.436
LIG_FHA_2	200	206	PF00498	0.416
LIG_FHA_2	253	259	PF00498	0.383
LIG_FHA_2	41	47	PF00498	0.640
LIG_LIR_Apic_2	151	157	PF02991	0.316
LIG_LIR_Apic_2	7	13	PF02991	0.486
LIG_LIR_Gen_1	177	186	PF02991	0.305
LIG_LIR_Gen_1	81	89	PF02991	0.434
LIG_LIR_Nem_3	126	131	PF02991	0.302
LIG_LIR_Nem_3	177	183	PF02991	0.326
LIG_LIR_Nem_3	286	290	PF02991	0.491
LIG_LIR_Nem_3	81	86	PF02991	0.477
LIG_LIR_Nem_3	87	92	PF02991	0.405
LIG_LRP6_Inhibitor_1	113	119	PF00058	0.391
LIG_Pex14_2	71	75	PF04695	0.385
LIG_SH2_CRK	110	114	PF00017	0.294
LIG_SH2_CRK	69	73	PF00017	0.390
LIG_SH2_PTP2	244	247	PF00017	0.356
LIG_SH2_SRC	154	157	PF00017	0.432
LIG_SH2_SRC	166	169	PF00017	0.438
LIG_SH2_STAP1	110	114	PF00017	0.349
LIG_SH2_STAP1	123	127	PF00017	0.368
LIG_SH2_STAT3	130	133	PF00017	0.321
LIG_SH2_STAT5	123	126	PF00017	0.423
LIG_SH2_STAT5	128	131	PF00017	0.304
LIG_SH2_STAT5	154	157	PF00017	0.364
LIG_SH2_STAT5	166	169	PF00017	0.239
LIG_SH2_STAT5	244	247	PF00017	0.322
LIG_SH3_1	191	197	PF00018	0.392
LIG_SH3_3	103	109	PF00018	0.406
LIG_SH3_3	191	197	PF00018	0.373
LIG_SH3_3	222	228	PF00018	0.375
LIG_SH3_4	94	101	PF00018	0.369
LIG_TRAF2_1	255	258	PF00917	0.466
MOD_CDK_SPxxK_3	252	259	PF00069	0.367
MOD_CK1_1	20	26	PF00069	0.655
MOD_CK1_1	326	332	PF00069	0.491
MOD_CK1_1	4	10	PF00069	0.702
MOD_CK2_1	199	205	PF00069	0.430
MOD_CK2_1	252	258	PF00069	0.386
MOD_Cter_Amidation	56	59	PF01082	0.550
MOD_GlcNHglycan	19	22	PF01048	0.624
MOD_GlcNHglycan	215	218	PF01048	0.474
MOD_GlcNHglycan	3	6	PF01048	0.648
MOD_GlcNHglycan	316	319	PF01048	0.509
MOD_GlcNHglycan	326	329	PF01048	0.427
MOD_GSK3_1	129	136	PF00069	0.491
MOD_GSK3_1	156	163	PF00069	0.292
MOD_GSK3_1	16	23	PF00069	0.653
MOD_GSK3_1	319	326	PF00069	0.486
MOD_N-GLC_1	278	283	PF02516	0.542
MOD_N-GLC_1	314	319	PF02516	0.540
MOD_N-GLC_1	324	329	PF02516	0.624
MOD_N-GLC_1	338	343	PF02516	0.561
MOD_NEK2_1	1	6	PF00069	0.669
MOD_NEK2_1	160	165	PF00069	0.325
MOD_NEK2_1	17	22	PF00069	0.600
MOD_NEK2_1	186	191	PF00069	0.504
MOD_NEK2_1	323	328	PF00069	0.453
MOD_NEK2_1	338	343	PF00069	0.511
MOD_NEK2_2	123	128	PF00069	0.448
MOD_NEK2_2	199	204	PF00069	0.460
MOD_PIKK_1	129	135	PF00454	0.420
MOD_PIKK_1	148	154	PF00454	0.275
MOD_PIKK_1	278	284	PF00454	0.578
MOD_PKA_1	148	154	PF00069	0.372
MOD_PKA_1	47	53	PF00069	0.591
MOD_PKA_1	58	64	PF00069	0.482
MOD_PKA_2	11	17	PF00069	0.697
MOD_PKA_2	133	139	PF00069	0.394
MOD_PKA_2	148	154	PF00069	0.292
MOD_PKA_2	258	264	PF00069	0.423
MOD_PKA_2	58	64	PF00069	0.495
MOD_Plk_4	123	129	PF00069	0.354
MOD_Plk_4	319	325	PF00069	0.515
MOD_ProDKin_1	134	140	PF00069	0.392
MOD_ProDKin_1	175	181	PF00069	0.316
MOD_ProDKin_1	252	258	PF00069	0.371
MOD_SUMO_rev_2	40	50	PF00179	0.659
TRG_DiLeu_BaEn_1	168	173	PF01217	0.317
TRG_DiLeu_BaEn_1	230	235	PF01217	0.398
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.615
TRG_DiLeu_LyEn_5	230	235	PF01217	0.398
TRG_ENDOCYTIC_2	110	113	PF00928	0.302
TRG_ENDOCYTIC_2	244	247	PF00928	0.322
TRG_ENDOCYTIC_2	69	72	PF00928	0.390
TRG_ER_diArg_1	277	280	PF00400	0.437
TRG_ER_diArg_1	304	306	PF00400	0.461
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED1	Leptomonas seymouri	83%	100%
A0A0S4J0P0	Bodo saltans	59%	100%
A0A1X0NM32	Trypanosomatidae	70%	100%
A0A3R7MQ73	Trypanosoma rangeli	68%	100%
A4HPF7	Leishmania braziliensis	92%	100%
A4ID79	Leishmania infantum	100%	100%
D0A3H0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	99%
E9AT69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q1C8	Leishmania major	97%	100%
V5BPU3	Trypanosoma cruzi	68%	100%