Cullin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cullin-like protein

Gene product:

cullin-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7XB28_LEIDO

TriTrypDb:

LdBPK_363210.1 , LdCL_360038700 , LDHU3_36.4420

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XB28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB28

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901575	organic substance catabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0019899	enzyme binding	3	11
GO:0031625	ubiquitin protein ligase binding	5	11
GO:0044389	ubiquitin-like protein ligase binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	95	99	PF00656	0.501
CLV_NRD_NRD_1	513	515	PF00675	0.255
CLV_NRD_NRD_1	517	519	PF00675	0.245
CLV_NRD_NRD_1	630	632	PF00675	0.584
CLV_NRD_NRD_1	7	9	PF00675	0.520
CLV_PCSK_KEX2_1	286	288	PF00082	0.311
CLV_PCSK_KEX2_1	504	506	PF00082	0.329
CLV_PCSK_KEX2_1	512	514	PF00082	0.291
CLV_PCSK_KEX2_1	9	11	PF00082	0.513
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.262
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.231
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.513
CLV_PCSK_SKI1_1	202	206	PF00082	0.370
CLV_PCSK_SKI1_1	289	293	PF00082	0.322
CLV_PCSK_SKI1_1	353	357	PF00082	0.293
CLV_PCSK_SKI1_1	452	456	PF00082	0.263
CLV_PCSK_SKI1_1	504	508	PF00082	0.320
CLV_PCSK_SKI1_1	519	523	PF00082	0.218
CLV_PCSK_SKI1_1	648	652	PF00082	0.311
DEG_MDM2_SWIB_1	17	24	PF02201	0.391
DEG_SCF_FBW7_2	393	400	PF00400	0.446
DEG_SPOP_SBC_1	204	208	PF00917	0.431
DOC_CKS1_1	182	187	PF01111	0.462
DOC_CKS1_1	394	399	PF01111	0.446
DOC_CYCLIN_RxL_1	319	328	PF00134	0.472
DOC_MAPK_FxFP_2	315	318	PF00069	0.462
DOC_MAPK_gen_1	466	476	PF00069	0.478
DOC_MAPK_gen_1	518	526	PF00069	0.511
DOC_MAPK_MEF2A_6	407	414	PF00069	0.462
DOC_MAPK_MEF2A_6	468	476	PF00069	0.508
DOC_MAPK_MEF2A_6	677	684	PF00069	0.487
DOC_PP1_RVXF_1	516	523	PF00149	0.416
DOC_PP2B_LxvP_1	494	497	PF13499	0.511
DOC_PP4_FxxP_1	315	318	PF00568	0.462
DOC_USP7_MATH_1	139	143	PF00917	0.534
DOC_USP7_MATH_1	157	161	PF00917	0.475
DOC_USP7_MATH_1	172	176	PF00917	0.362
DOC_USP7_MATH_1	405	409	PF00917	0.497
DOC_USP7_MATH_1	554	558	PF00917	0.521
DOC_USP7_MATH_1	664	668	PF00917	0.530
DOC_USP7_MATH_1	70	74	PF00917	0.462
DOC_USP7_UBL2_3	34	38	PF12436	0.497
DOC_USP7_UBL2_3	607	611	PF12436	0.505
DOC_WW_Pin1_4	181	186	PF00397	0.462
DOC_WW_Pin1_4	341	346	PF00397	0.430
DOC_WW_Pin1_4	393	398	PF00397	0.446
DOC_WW_Pin1_4	468	473	PF00397	0.524
DOC_WW_Pin1_4	671	676	PF00397	0.449
LIG_14-3-3_CanoR_1	129	139	PF00244	0.487
LIG_14-3-3_CanoR_1	43	49	PF00244	0.541
LIG_14-3-3_CanoR_1	452	461	PF00244	0.472
LIG_14-3-3_CanoR_1	601	610	PF00244	0.538
LIG_14-3-3_CanoR_1	638	643	PF00244	0.497
LIG_APCC_ABBA_1	366	371	PF00400	0.511
LIG_BIR_II_1	1	5	PF00653	0.566
LIG_BRCT_BRCA1_1	174	178	PF00533	0.462
LIG_BRCT_BRCA1_1	527	531	PF00533	0.511
LIG_EH1_1	546	554	PF00400	0.511
LIG_EVH1_2	472	476	PF00568	0.462
LIG_FHA_1	182	188	PF00498	0.570
LIG_FHA_1	236	242	PF00498	0.449
LIG_FHA_1	259	265	PF00498	0.451
LIG_FHA_1	290	296	PF00498	0.509
LIG_FHA_1	363	369	PF00498	0.538
LIG_FHA_1	394	400	PF00498	0.490
LIG_FHA_1	465	471	PF00498	0.499
LIG_FHA_1	480	486	PF00498	0.378
LIG_FHA_1	544	550	PF00498	0.419
LIG_FHA_1	637	643	PF00498	0.384
LIG_FHA_2	14	20	PF00498	0.436
LIG_FHA_2	159	165	PF00498	0.473
LIG_FHA_2	674	680	PF00498	0.511
LIG_FHA_2	692	698	PF00498	0.511
LIG_Integrin_isoDGR_2	516	518	PF01839	0.229
LIG_LIR_Apic_2	312	318	PF02991	0.461
LIG_LIR_Gen_1	13	19	PF02991	0.428
LIG_LIR_Gen_1	228	237	PF02991	0.511
LIG_LIR_Gen_1	239	250	PF02991	0.511
LIG_LIR_Gen_1	276	285	PF02991	0.479
LIG_LIR_Gen_1	346	356	PF02991	0.462
LIG_LIR_Gen_1	40	49	PF02991	0.429
LIG_LIR_Gen_1	475	481	PF02991	0.447
LIG_LIR_Gen_1	579	589	PF02991	0.462
LIG_LIR_Gen_1	655	665	PF02991	0.519
LIG_LIR_Gen_1	66	76	PF02991	0.530
LIG_LIR_Nem_3	13	17	PF02991	0.432
LIG_LIR_Nem_3	18	24	PF02991	0.247
LIG_LIR_Nem_3	227	233	PF02991	0.511
LIG_LIR_Nem_3	239	245	PF02991	0.511
LIG_LIR_Nem_3	276	281	PF02991	0.500
LIG_LIR_Nem_3	314	320	PF02991	0.412
LIG_LIR_Nem_3	346	351	PF02991	0.462
LIG_LIR_Nem_3	40	44	PF02991	0.429
LIG_LIR_Nem_3	430	436	PF02991	0.530
LIG_LIR_Nem_3	475	479	PF02991	0.435
LIG_LIR_Nem_3	483	489	PF02991	0.420
LIG_LIR_Nem_3	579	584	PF02991	0.462
LIG_LIR_Nem_3	655	661	PF02991	0.478
LIG_LIR_Nem_3	66	72	PF02991	0.530
LIG_LIR_Nem_3	92	96	PF02991	0.419
LIG_MLH1_MIPbox_1	174	178	PF16413	0.462
LIG_Pex14_2	17	21	PF04695	0.400
LIG_Pex14_2	278	282	PF04695	0.497
LIG_Pex14_2	402	406	PF04695	0.416
LIG_Pex14_2	599	603	PF04695	0.350
LIG_Pex14_2	89	93	PF04695	0.521
LIG_PTB_Apo_2	108	115	PF02174	0.447
LIG_PTB_Phospho_1	108	114	PF10480	0.447
LIG_SH2_CRK	242	246	PF00017	0.511
LIG_SH2_CRK	416	420	PF00017	0.462
LIG_SH2_CRK	489	493	PF00017	0.472
LIG_SH2_CRK	56	60	PF00017	0.538
LIG_SH2_CRK	658	662	PF00017	0.519
LIG_SH2_GRB2like	109	112	PF00017	0.445
LIG_SH2_GRB2like	370	373	PF00017	0.462
LIG_SH2_GRB2like	489	492	PF00017	0.472
LIG_SH2_NCK_1	489	493	PF00017	0.472
LIG_SH2_PTP2	231	234	PF00017	0.511
LIG_SH2_SRC	370	373	PF00017	0.462
LIG_SH2_STAP1	225	229	PF00017	0.566
LIG_SH2_STAP1	242	246	PF00017	0.400
LIG_SH2_STAT3	194	197	PF00017	0.562
LIG_SH2_STAT5	109	112	PF00017	0.444
LIG_SH2_STAT5	170	173	PF00017	0.491
LIG_SH2_STAT5	177	180	PF00017	0.486
LIG_SH2_STAT5	194	197	PF00017	0.491
LIG_SH2_STAT5	210	213	PF00017	0.372
LIG_SH2_STAT5	231	234	PF00017	0.511
LIG_SH2_STAT5	489	492	PF00017	0.439
LIG_SH2_STAT5	702	705	PF00017	0.321
LIG_SH2_STAT5	85	88	PF00017	0.567
LIG_SH3_3	669	675	PF00018	0.511
LIG_SH3_4	607	614	PF00018	0.484
LIG_SUMO_SIM_anti_2	477	483	PF11976	0.450
LIG_SUMO_SIM_anti_2	562	567	PF11976	0.462
LIG_SUMO_SIM_par_1	477	483	PF11976	0.472
LIG_TRAF2_1	338	341	PF00917	0.508
LIG_TRAF2_1	456	459	PF00917	0.462
LIG_UBA3_1	145	150	PF00899	0.462
LIG_UBA3_1	323	331	PF00899	0.447
LIG_UBA3_1	461	469	PF00899	0.497
LIG_WRC_WIRS_1	14	19	PF05994	0.444
LIG_WRC_WIRS_1	275	280	PF05994	0.497
MOD_CDC14_SPxK_1	674	677	PF00782	0.462
MOD_CDK_SPxK_1	671	677	PF00069	0.462
MOD_CDK_SPxxK_3	343	350	PF00069	0.511
MOD_CK1_1	101	107	PF00069	0.495
MOD_CK1_1	15	21	PF00069	0.469
MOD_CK1_1	248	254	PF00069	0.554
MOD_CK1_1	274	280	PF00069	0.493
MOD_CK1_1	3	9	PF00069	0.597
MOD_CK1_1	37	43	PF00069	0.429
MOD_CK1_1	525	531	PF00069	0.439
MOD_CK1_1	543	549	PF00069	0.511
MOD_CK1_1	627	633	PF00069	0.526
MOD_CK2_1	118	124	PF00069	0.511
MOD_CK2_1	19	25	PF00069	0.336
MOD_CK2_1	249	255	PF00069	0.431
MOD_CK2_1	570	576	PF00069	0.543
MOD_CK2_1	691	697	PF00069	0.557
MOD_Cter_Amidation	516	519	PF01082	0.246
MOD_GlcNHglycan	140	144	PF01048	0.240
MOD_GlcNHglycan	207	210	PF01048	0.362
MOD_GlcNHglycan	238	241	PF01048	0.347
MOD_GlcNHglycan	452	455	PF01048	0.311
MOD_GlcNHglycan	482	485	PF01048	0.278
MOD_GlcNHglycan	542	545	PF01048	0.311
MOD_GlcNHglycan	612	615	PF01048	0.458
MOD_GlcNHglycan	618	621	PF01048	0.513
MOD_GlcNHglycan	666	669	PF01048	0.257
MOD_GlcNHglycan	697	700	PF01048	0.465
MOD_GSK3_1	15	22	PF00069	0.432
MOD_GSK3_1	168	175	PF00069	0.554
MOD_GSK3_1	236	243	PF00069	0.522
MOD_GSK3_1	245	252	PF00069	0.455
MOD_GSK3_1	289	296	PF00069	0.358
MOD_GSK3_1	464	471	PF00069	0.472
MOD_GSK3_1	492	499	PF00069	0.491
MOD_GSK3_1	576	583	PF00069	0.533
MOD_GSK3_1	638	645	PF00069	0.446
MOD_GSK3_1	691	698	PF00069	0.509
MOD_N-GLC_1	357	362	PF02516	0.284
MOD_N-GLC_1	559	564	PF02516	0.269
MOD_N-GLC_1	592	597	PF02516	0.440
MOD_N-GLC_1	96	101	PF02516	0.324
MOD_NEK2_1	131	136	PF00069	0.482
MOD_NEK2_1	145	150	PF00069	0.467
MOD_NEK2_1	205	210	PF00069	0.491
MOD_NEK2_1	241	246	PF00069	0.478
MOD_NEK2_1	362	367	PF00069	0.446
MOD_NEK2_1	4	9	PF00069	0.569
MOD_NEK2_1	479	484	PF00069	0.456
MOD_NEK2_1	522	527	PF00069	0.521
MOD_NEK2_1	548	553	PF00069	0.416
MOD_NEK2_1	603	608	PF00069	0.507
MOD_NEK2_1	642	647	PF00069	0.466
MOD_NEK2_2	158	163	PF00069	0.530
MOD_NEK2_2	225	230	PF00069	0.511
MOD_PIKK_1	576	582	PF00454	0.515
MOD_PIKK_1	98	104	PF00454	0.468
MOD_PKA_2	309	315	PF00069	0.446
MOD_Plk_1	12	18	PF00069	0.455
MOD_Plk_1	158	164	PF00069	0.512
MOD_Plk_1	24	30	PF00069	0.461
MOD_Plk_1	310	316	PF00069	0.547
MOD_Plk_1	357	363	PF00069	0.497
MOD_Plk_1	559	565	PF00069	0.562
MOD_Plk_1	642	648	PF00069	0.489
MOD_Plk_1	96	102	PF00069	0.452
MOD_Plk_2-3	13	19	PF00069	0.520
MOD_Plk_2-3	249	255	PF00069	0.462
MOD_Plk_2-3	652	658	PF00069	0.446
MOD_Plk_4	225	231	PF00069	0.452
MOD_Plk_4	241	247	PF00069	0.480
MOD_Plk_4	274	280	PF00069	0.461
MOD_Plk_4	364	370	PF00069	0.483
MOD_Plk_4	388	394	PF00069	0.462
MOD_Plk_4	436	442	PF00069	0.443
MOD_Plk_4	44	50	PF00069	0.422
MOD_Plk_4	548	554	PF00069	0.418
MOD_Plk_4	55	61	PF00069	0.404
MOD_Plk_4	642	648	PF00069	0.511
MOD_Plk_4	70	76	PF00069	0.467
MOD_Plk_4	81	87	PF00069	0.456
MOD_ProDKin_1	181	187	PF00069	0.462
MOD_ProDKin_1	341	347	PF00069	0.430
MOD_ProDKin_1	393	399	PF00069	0.446
MOD_ProDKin_1	468	474	PF00069	0.524
MOD_ProDKin_1	671	677	PF00069	0.449
MOD_SUMO_for_1	285	288	PF00179	0.462
MOD_SUMO_for_1	32	35	PF00179	0.462
MOD_SUMO_rev_2	459	467	PF00179	0.554
MOD_SUMO_rev_2	674	682	PF00179	0.467
TRG_DiLeu_BaEn_1	475	480	PF01217	0.511
TRG_DiLeu_BaLyEn_6	410	415	PF01217	0.501
TRG_ENDOCYTIC_2	14	17	PF00928	0.541
TRG_ENDOCYTIC_2	231	234	PF00928	0.511
TRG_ENDOCYTIC_2	242	245	PF00928	0.511
TRG_ENDOCYTIC_2	489	492	PF00928	0.439
TRG_ENDOCYTIC_2	56	59	PF00928	0.538
TRG_ENDOCYTIC_2	658	661	PF00928	0.519
TRG_ER_diArg_1	511	514	PF00400	0.511
TRG_ER_diArg_1	8	11	PF00400	0.518
TRG_NES_CRM1_1	235	249	PF08389	0.511
TRG_NLS_MonoExtC_3	7	13	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.272
TRG_Pf-PMV_PEXEL_1	518	523	PF00026	0.326
TRG_Pf-PMV_PEXEL_1	648	652	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9C6	Leptomonas seymouri	67%	100%
A0A1X0NKJ9	Trypanosomatidae	27%	100%
A0A3R7LZU1	Trypanosoma rangeli	28%	99%
A2A432	Mus musculus	21%	73%
A4HPH2	Leishmania braziliensis	89%	100%
A4ID94	Leishmania infantum	99%	100%
D0A3I2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AT84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O14122	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	20%	96%
Q13620	Homo sapiens	21%	77%
Q17391	Caenorhabditis elegans	20%	91%
Q23639	Caenorhabditis elegans	21%	92%
Q3TCH7	Mus musculus	20%	93%
Q4Q1B3	Leishmania major	96%	100%
Q8LGH4	Arabidopsis thaliana	21%	89%
Q9C9L0	Arabidopsis thaliana	21%	96%
Q9ZVH4	Arabidopsis thaliana	21%	96%
V5B0B0	Trypanosoma cruzi	28%	100%