Methyltransferase domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XB23_LEIDO

TriTrypDb:

LdBPK_362780.1 , LdCL_360034200 , LDHU3_36.3860

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XB23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB23

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	12
GO:0002098	tRNA wobble uridine modification	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	12
GO:0006400	tRNA modification	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008173	RNA methyltransferase activity	4	12
GO:0008175	tRNA methyltransferase activity	5	12
GO:0016300	tRNA (uracil) methyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0000049	tRNA binding	5	1
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.508
CLV_NRD_NRD_1	171	173	PF00675	0.425
CLV_NRD_NRD_1	232	234	PF00675	0.282
CLV_PCSK_FUR_1	169	173	PF00082	0.404
CLV_PCSK_FUR_1	229	233	PF00082	0.320
CLV_PCSK_KEX2_1	15	17	PF00082	0.478
CLV_PCSK_KEX2_1	169	171	PF00082	0.410
CLV_PCSK_KEX2_1	176	178	PF00082	0.357
CLV_PCSK_KEX2_1	231	233	PF00082	0.294
CLV_PCSK_KEX2_1	264	266	PF00082	0.462
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.478
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.382
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.443
CLV_PCSK_PC7_1	172	178	PF00082	0.272
CLV_PCSK_PC7_1	260	266	PF00082	0.495
CLV_PCSK_SKI1_1	176	180	PF00082	0.459
CLV_PCSK_SKI1_1	237	241	PF00082	0.223
CLV_PCSK_SKI1_1	99	103	PF00082	0.587
CLV_Separin_Metazoa	150	154	PF03568	0.388
CLV_Separin_Metazoa	193	197	PF03568	0.272
CLV_Separin_Metazoa	238	242	PF03568	0.223
DEG_APCC_DBOX_1	236	244	PF00400	0.191
DEG_APCC_KENBOX_2	329	333	PF00400	0.286
DEG_SPOP_SBC_1	108	112	PF00917	0.555
DOC_MAPK_gen_1	229	236	PF00069	0.354
DOC_PP4_FxxP_1	33	36	PF00568	0.452
DOC_USP7_MATH_1	131	135	PF00917	0.547
DOC_USP7_MATH_1	208	212	PF00917	0.316
DOC_WW_Pin1_4	8	13	PF00397	0.693
LIG_14-3-3_CanoR_1	153	160	PF00244	0.433
LIG_14-3-3_CanoR_1	99	109	PF00244	0.627
LIG_Actin_WH2_2	138	155	PF00022	0.279
LIG_BIR_II_1	1	5	PF00653	0.702
LIG_BRCT_BRCA1_1	210	214	PF00533	0.304
LIG_EVH1_1	33	37	PF00568	0.416
LIG_FHA_1	195	201	PF00498	0.279
LIG_FHA_1	261	267	PF00498	0.487
LIG_FHA_1	314	320	PF00498	0.516
LIG_FHA_2	23	29	PF00498	0.633
LIG_LIR_Gen_1	331	337	PF02991	0.267
LIG_PDZ_Class_3	335	340	PF00595	0.361
LIG_RPA_C_Fungi	166	178	PF08784	0.248
LIG_SH2_CRK	52	56	PF00017	0.346
LIG_SH2_STAP1	147	151	PF00017	0.338
LIG_SH2_STAT5	141	144	PF00017	0.279
LIG_SH2_STAT5	253	256	PF00017	0.348
LIG_SH2_STAT5	93	96	PF00017	0.374
LIG_SH3_3	125	131	PF00018	0.538
LIG_SH3_3	182	188	PF00018	0.320
LIG_SH3_3	28	34	PF00018	0.559
LIG_SUMO_SIM_anti_2	219	224	PF11976	0.244
LIG_SUMO_SIM_par_1	318	324	PF11976	0.282
LIG_TRAF2_1	190	193	PF00917	0.272
LIG_TRFH_1	33	37	PF08558	0.416
LIG_WRC_WIRS_1	132	137	PF05994	0.451
MOD_CDK_SPxxK_3	8	15	PF00069	0.528
MOD_CK1_1	112	118	PF00069	0.656
MOD_CK1_1	8	14	PF00069	0.572
MOD_CK2_1	187	193	PF00069	0.248
MOD_CK2_1	296	302	PF00069	0.454
MOD_Cter_Amidation	174	177	PF01082	0.272
MOD_GlcNHglycan	1	4	PF01048	0.646
MOD_GlcNHglycan	111	114	PF01048	0.628
MOD_GlcNHglycan	173	176	PF01048	0.447
MOD_GlcNHglycan	189	192	PF01048	0.115
MOD_GlcNHglycan	210	213	PF01048	0.281
MOD_GlcNHglycan	7	10	PF01048	0.611
MOD_GlcNHglycan	94	97	PF01048	0.522
MOD_GSK3_1	103	110	PF00069	0.650
MOD_GSK3_1	309	316	PF00069	0.418
MOD_N-GLC_2	332	334	PF02516	0.261
MOD_NEK2_1	100	105	PF00069	0.554
MOD_NEK2_1	109	114	PF00069	0.608
MOD_NEK2_1	151	156	PF00069	0.275
MOD_NEK2_1	59	64	PF00069	0.368
MOD_PIKK_1	152	158	PF00454	0.388
MOD_PKA_1	171	177	PF00069	0.420
MOD_PKA_2	152	158	PF00069	0.433
MOD_PKA_2	171	177	PF00069	0.304
MOD_PKB_1	169	177	PF00069	0.420
MOD_Plk_2-3	22	28	PF00069	0.722
MOD_Plk_2-3	309	315	PF00069	0.418
MOD_Plk_4	323	329	PF00069	0.318
MOD_ProDKin_1	8	14	PF00069	0.692
MOD_SUMO_for_1	178	181	PF00179	0.272
MOD_SUMO_rev_2	112	120	PF00179	0.554
MOD_SUMO_rev_2	8	17	PF00179	0.519
TRG_DiLeu_BaEn_1	238	243	PF01217	0.249
TRG_ENDOCYTIC_2	294	297	PF00928	0.296
TRG_ENDOCYTIC_2	52	55	PF00928	0.336
TRG_ER_diArg_1	16	19	PF00400	0.482
TRG_ER_diArg_1	169	172	PF00400	0.320
TRG_ER_diArg_1	231	233	PF00400	0.279
TRG_NLS_MonoExtC_3	14	20	PF00514	0.677
TRG_NLS_MonoExtC_3	175	181	PF00514	0.370
TRG_NLS_MonoExtN_4	12	19	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I4	Leptomonas seymouri	63%	100%
A0A0S4J705	Bodo saltans	39%	100%
A0A1X0NKG3	Trypanosomatidae	45%	100%
A0A422ND22	Trypanosoma rangeli	40%	100%
A4HPD1	Leishmania braziliensis	80%	100%
A4ICH1	Leishmania infantum	99%	100%
C4V9L5	Nosema ceranae (strain BRL01)	30%	100%
D0A3J1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AT42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q1F6	Leishmania major	94%	100%
V5DGL8	Trypanosoma cruzi	44%	100%