LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7XB21_LEIDO
TriTrypDb:
LdBPK_363000.1 , LdCL_360036400 , LDHU3_36.4160
Length:
260

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 9
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7XB21
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB21

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 19 21 PF00675 0.700
CLV_NRD_NRD_1 206 208 PF00675 0.321
CLV_PCSK_KEX2_1 155 157 PF00082 0.395
CLV_PCSK_PC1ET2_1 155 157 PF00082 0.358
CLV_PCSK_SKI1_1 40 44 PF00082 0.471
CLV_PCSK_SKI1_1 85 89 PF00082 0.508
DEG_Nend_Nbox_1 1 3 PF02207 0.620
DOC_CDC14_PxL_1 146 154 PF14671 0.459
DOC_CKS1_1 33 38 PF01111 0.475
DOC_MAPK_gen_1 155 163 PF00069 0.415
DOC_MAPK_gen_1 207 214 PF00069 0.482
DOC_PP1_RVXF_1 38 45 PF00149 0.477
DOC_PP1_RVXF_1 96 102 PF00149 0.381
DOC_PP2B_LxvP_1 181 184 PF13499 0.380
DOC_PP4_FxxP_1 2 5 PF00568 0.567
DOC_PP4_FxxP_1 249 252 PF00568 0.399
DOC_USP7_MATH_1 10 14 PF00917 0.760
DOC_USP7_MATH_1 123 127 PF00917 0.558
DOC_USP7_MATH_1 138 142 PF00917 0.655
DOC_USP7_MATH_1 19 23 PF00917 0.714
DOC_USP7_MATH_1 237 241 PF00917 0.530
DOC_WW_Pin1_4 26 31 PF00397 0.582
DOC_WW_Pin1_4 32 37 PF00397 0.440
LIG_14-3-3_CanoR_1 91 99 PF00244 0.399
LIG_APCC_ABBA_1 201 206 PF00400 0.406
LIG_BRCT_BRCA1_1 165 169 PF00533 0.404
LIG_BRCT_BRCA1_1 40 44 PF00533 0.395
LIG_FHA_1 101 107 PF00498 0.419
LIG_FHA_1 163 169 PF00498 0.333
LIG_LIR_Gen_1 158 168 PF02991 0.456
LIG_LIR_Nem_3 154 160 PF02991 0.476
LIG_LIR_Nem_3 177 182 PF02991 0.478
LIG_LIR_Nem_3 224 229 PF02991 0.391
LIG_LIR_Nem_3 67 73 PF02991 0.447
LIG_LYPXL_S_1 225 229 PF13949 0.335
LIG_LYPXL_SIV_4 69 77 PF13949 0.426
LIG_LYPXL_yS_3 226 229 PF13949 0.335
LIG_Pex14_2 178 182 PF04695 0.394
LIG_PTB_Apo_2 112 119 PF02174 0.418
LIG_REV1ctd_RIR_1 85 95 PF16727 0.376
LIG_SH2_CRK 70 74 PF00017 0.382
LIG_SH2_SRC 31 34 PF00017 0.530
LIG_SH2_STAT5 107 110 PF00017 0.539
LIG_SH2_STAT5 209 212 PF00017 0.405
LIG_SH2_STAT5 31 34 PF00017 0.548
LIG_SH2_STAT5 53 56 PF00017 0.399
LIG_SH2_STAT5 86 89 PF00017 0.360
LIG_SH3_2 150 155 PF14604 0.550
LIG_SH3_3 134 140 PF00018 0.659
LIG_SH3_3 147 153 PF00018 0.525
LIG_SH3_3 27 33 PF00018 0.549
LIG_SH3_3 4 10 PF00018 0.594
LIG_SH3_3 66 72 PF00018 0.495
LIG_TYR_ITIM 68 73 PF00017 0.485
LIG_TYR_ITSM 222 229 PF00017 0.349
LIG_UBA3_1 1 9 PF00899 0.614
LIG_WRC_WIRS_1 189 194 PF05994 0.411
MOD_CK1_1 126 132 PF00069 0.527
MOD_CK1_1 240 246 PF00069 0.514
MOD_CK1_1 38 44 PF00069 0.450
MOD_GlcNHglycan 185 188 PF01048 0.407
MOD_GlcNHglycan 215 220 PF01048 0.561
MOD_GlcNHglycan 231 234 PF01048 0.342
MOD_GlcNHglycan 242 245 PF01048 0.447
MOD_GSK3_1 10 17 PF00069 0.704
MOD_GSK3_1 40 47 PF00069 0.519
MOD_N-GLC_1 237 242 PF02516 0.513
MOD_NEK2_1 101 106 PF00069 0.440
MOD_NEK2_1 163 168 PF00069 0.467
MOD_NEK2_1 44 49 PF00069 0.389
MOD_NEK2_2 51 56 PF00069 0.432
MOD_PIKK_1 44 50 PF00454 0.279
MOD_PK_1 56 62 PF00069 0.465
MOD_PKA_2 14 20 PF00069 0.681
MOD_Plk_1 237 243 PF00069 0.578
MOD_Plk_1 94 100 PF00069 0.425
MOD_Plk_4 128 134 PF00069 0.699
MOD_Plk_4 138 144 PF00069 0.543
MOD_Plk_4 174 180 PF00069 0.505
MOD_Plk_4 188 194 PF00069 0.427
MOD_Plk_4 221 227 PF00069 0.374
MOD_Plk_4 56 62 PF00069 0.465
MOD_ProDKin_1 26 32 PF00069 0.573
TRG_ENDOCYTIC_2 160 163 PF00928 0.443
TRG_ENDOCYTIC_2 209 212 PF00928 0.355
TRG_ENDOCYTIC_2 226 229 PF00928 0.326
TRG_ENDOCYTIC_2 70 73 PF00928 0.387

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCH2 Leptomonas seymouri 67% 100%
A0A0S4IV73 Bodo saltans 36% 100%
A0A1X0NKA4 Trypanosomatidae 44% 100%
A0A3R7L2T5 Trypanosoma rangeli 37% 100%
A4HPF2 Leishmania braziliensis 79% 100%
A4ICJ3 Leishmania infantum 100% 100%
D0A3G4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9AT63 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q1D4 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS