Nodulin-like/Major Facilitator Superfamily, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nodulin-like, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XB11_LEIDO

TriTrypDb:

LdBPK_362900.1 , LdCL_360035400 , LDHU3_36.4030

Length:

607

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 125
NetGPI	no	yes: 0, no: 125

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	118
GO:0110165	cellular anatomical entity	1	118
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

A0A3S7XB11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB11

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	54
GO:0022857	transmembrane transporter activity	2	54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	248	250	PF00675	0.290
CLV_NRD_NRD_1	354	356	PF00675	0.475
CLV_NRD_NRD_1	458	460	PF00675	0.364
CLV_NRD_NRD_1	599	601	PF00675	0.330
CLV_PCSK_KEX2_1	248	250	PF00082	0.301
CLV_PCSK_KEX2_1	30	32	PF00082	0.287
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.324
CLV_PCSK_SKI1_1	166	170	PF00082	0.360
CLV_PCSK_SKI1_1	181	185	PF00082	0.467
CLV_PCSK_SKI1_1	459	463	PF00082	0.301
CLV_PCSK_SKI1_1	539	543	PF00082	0.321
CLV_PCSK_SKI1_1	594	598	PF00082	0.354
CLV_PCSK_SKI1_1	600	604	PF00082	0.361
DEG_APCC_DBOX_1	458	466	PF00400	0.551
DEG_Nend_Nbox_1	1	3	PF02207	0.703
DEG_SPOP_SBC_1	342	346	PF00917	0.586
DOC_ANK_TNKS_1	157	164	PF00023	0.550
DOC_CDC14_PxL_1	93	101	PF14671	0.482
DOC_CKS1_1	567	572	PF01111	0.382
DOC_CYCLIN_RxL_1	536	545	PF00134	0.332
DOC_CYCLIN_yCln2_LP_2	489	495	PF00134	0.246
DOC_MAPK_gen_1	120	128	PF00069	0.180
DOC_MAPK_gen_1	156	164	PF00069	0.514
DOC_MAPK_gen_1	30	40	PF00069	0.454
DOC_MAPK_gen_1	355	362	PF00069	0.509
DOC_MAPK_gen_1	457	467	PF00069	0.512
DOC_MAPK_MEF2A_6	122	130	PF00069	0.309
DOC_MAPK_MEF2A_6	156	164	PF00069	0.471
DOC_MAPK_MEF2A_6	31	40	PF00069	0.488
DOC_MAPK_MEF2A_6	385	392	PF00069	0.516
DOC_MAPK_MEF2A_6	457	465	PF00069	0.529
DOC_PP1_RVXF_1	505	512	PF00149	0.396
DOC_PP1_RVXF_1	589	596	PF00149	0.474
DOC_PP2B_LxvP_1	300	303	PF13499	0.264
DOC_PP2B_LxvP_1	482	485	PF13499	0.413
DOC_PP2B_LxvP_1	489	492	PF13499	0.265
DOC_PP2B_PxIxI_1	491	497	PF00149	0.355
DOC_PP2B_PxIxI_1	569	575	PF00149	0.386
DOC_PP4_FxxP_1	82	85	PF00568	0.314
DOC_USP7_MATH_1	232	236	PF00917	0.544
DOC_USP7_MATH_2	311	317	PF00917	0.744
DOC_USP7_UBL2_3	548	552	PF12436	0.410
DOC_USP7_UBL2_3	597	601	PF12436	0.571
DOC_WW_Pin1_4	343	348	PF00397	0.746
DOC_WW_Pin1_4	566	571	PF00397	0.407
LIG_14-3-3_CanoR_1	223	230	PF00244	0.550
LIG_14-3-3_CanoR_1	355	360	PF00244	0.652
LIG_14-3-3_CanoR_1	419	428	PF00244	0.372
LIG_14-3-3_CanoR_1	441	445	PF00244	0.304
LIG_14-3-3_CanoR_1	61	69	PF00244	0.338
LIG_Actin_WH2_2	232	250	PF00022	0.605
LIG_Actin_WH2_2	576	593	PF00022	0.376
LIG_APCC_ABBA_1	494	499	PF00400	0.343
LIG_APCC_ABBA_1	51	56	PF00400	0.361
LIG_BRCT_BRCA1_1	138	142	PF00533	0.390
LIG_BRCT_BRCA1_1	315	319	PF00533	0.719
LIG_BRCT_BRCA1_1	45	49	PF00533	0.341
LIG_BRCT_BRCA1_1	54	58	PF00533	0.267
LIG_Clathr_ClatBox_1	359	363	PF01394	0.706
LIG_Clathr_ClatBox_1	495	499	PF01394	0.378
LIG_deltaCOP1_diTrp_1	387	395	PF00928	0.498
LIG_FHA_1	10	16	PF00498	0.567
LIG_FHA_1	123	129	PF00498	0.305
LIG_FHA_1	197	203	PF00498	0.361
LIG_FHA_1	265	271	PF00498	0.337
LIG_FHA_1	286	292	PF00498	0.373
LIG_FHA_1	343	349	PF00498	0.762
LIG_FHA_1	409	415	PF00498	0.323
LIG_FHA_1	420	426	PF00498	0.336
LIG_FHA_1	428	434	PF00498	0.337
LIG_FHA_1	462	468	PF00498	0.463
LIG_FHA_1	527	533	PF00498	0.289
LIG_FHA_1	567	573	PF00498	0.310
LIG_FHA_1	72	78	PF00498	0.335
LIG_FHA_2	147	153	PF00498	0.358
LIG_FHA_2	316	322	PF00498	0.634
LIG_FHA_2	329	335	PF00498	0.777
LIG_FHA_2	376	382	PF00498	0.563
LIG_GBD_Chelix_1	200	208	PF00786	0.433
LIG_GBD_Chelix_1	283	291	PF00786	0.316
LIG_GBD_Chelix_1	476	484	PF00786	0.222
LIG_LIR_Gen_1	189	198	PF02991	0.286
LIG_LIR_Gen_1	378	388	PF02991	0.506
LIG_LIR_Gen_1	427	435	PF02991	0.309
LIG_LIR_Gen_1	526	535	PF02991	0.314
LIG_LIR_Gen_1	577	588	PF02991	0.334
LIG_LIR_Nem_3	129	134	PF02991	0.298
LIG_LIR_Nem_3	189	194	PF02991	0.259
LIG_LIR_Nem_3	378	383	PF02991	0.524
LIG_LIR_Nem_3	387	392	PF02991	0.460
LIG_LIR_Nem_3	427	432	PF02991	0.334
LIG_LIR_Nem_3	500	506	PF02991	0.382
LIG_LIR_Nem_3	526	531	PF02991	0.293
LIG_LIR_Nem_3	577	583	PF02991	0.341
LIG_MAD2	460	468	PF02301	0.556
LIG_Pex14_2	216	220	PF04695	0.424
LIG_Pex14_2	5	9	PF04695	0.641
LIG_Pex14_2	511	515	PF04695	0.534
LIG_Pex14_2	54	58	PF04695	0.303
LIG_PTB_Apo_2	521	528	PF02174	0.527
LIG_SH2_CRK	252	256	PF00017	0.374
LIG_SH2_CRK	273	277	PF00017	0.374
LIG_SH2_CRK	429	433	PF00017	0.358
LIG_SH2_CRK	86	90	PF00017	0.311
LIG_SH2_NCK_1	273	277	PF00017	0.371
LIG_SH2_NCK_1	90	94	PF00017	0.370
LIG_SH2_PTP2	254	257	PF00017	0.302
LIG_SH2_PTP2	493	496	PF00017	0.328
LIG_SH2_SRC	254	257	PF00017	0.324
LIG_SH2_SRC	90	93	PF00017	0.529
LIG_SH2_STAP1	240	244	PF00017	0.618
LIG_SH2_STAP1	429	433	PF00017	0.355
LIG_SH2_STAT5	14	17	PF00017	0.567
LIG_SH2_STAT5	193	196	PF00017	0.313
LIG_SH2_STAT5	215	218	PF00017	0.451
LIG_SH2_STAT5	254	257	PF00017	0.330
LIG_SH2_STAT5	273	276	PF00017	0.347
LIG_SH2_STAT5	413	416	PF00017	0.302
LIG_SH2_STAT5	429	432	PF00017	0.265
LIG_SH2_STAT5	450	453	PF00017	0.548
LIG_SH2_STAT5	493	496	PF00017	0.306
LIG_SH2_STAT5	497	500	PF00017	0.305
LIG_SH2_STAT5	592	595	PF00017	0.469
LIG_SH2_STAT5	81	84	PF00017	0.306
LIG_SH3_3	305	311	PF00018	0.593
LIG_SH3_3	367	373	PF00018	0.578
LIG_SH3_3	465	471	PF00018	0.282
LIG_SH3_3	564	570	PF00018	0.311
LIG_Sin3_3	258	265	PF02671	0.436
LIG_SUMO_SIM_anti_2	146	152	PF11976	0.358
LIG_SUMO_SIM_anti_2	569	575	PF11976	0.369
LIG_SUMO_SIM_par_1	124	129	PF11976	0.320
LIG_SUMO_SIM_par_1	146	152	PF11976	0.239
LIG_SUMO_SIM_par_1	193	199	PF11976	0.358
LIG_SUMO_SIM_par_1	569	575	PF11976	0.319
LIG_TYR_ITIM	250	255	PF00017	0.352
LIG_TYR_ITIM	271	276	PF00017	0.329
LIG_TYR_ITIM	491	496	PF00017	0.384
LIG_TYR_ITIM	84	89	PF00017	0.319
LIG_UBA3_1	541	548	PF00899	0.454
LIG_WRC_WIRS_1	2	7	PF05994	0.677
MOD_CK1_1	146	152	PF00069	0.350
MOD_CK1_1	174	180	PF00069	0.362
MOD_CK1_1	346	352	PF00069	0.733
MOD_CK1_1	427	433	PF00069	0.347
MOD_CK1_1	526	532	PF00069	0.343
MOD_CK1_1	70	76	PF00069	0.325
MOD_CK2_1	13	19	PF00069	0.554
MOD_CK2_1	146	152	PF00069	0.402
MOD_CK2_1	328	334	PF00069	0.787
MOD_CK2_1	375	381	PF00069	0.537
MOD_GlcNHglycan	138	141	PF01048	0.344
MOD_GlcNHglycan	188	191	PF01048	0.454
MOD_GlcNHglycan	436	439	PF01048	0.300
MOD_GSK3_1	1	8	PF00069	0.600
MOD_GSK3_1	122	129	PF00069	0.306
MOD_GSK3_1	166	173	PF00069	0.342
MOD_GSK3_1	182	189	PF00069	0.230
MOD_GSK3_1	315	322	PF00069	0.694
MOD_GSK3_1	342	349	PF00069	0.746
MOD_GSK3_1	375	382	PF00069	0.584
MOD_GSK3_1	39	46	PF00069	0.331
MOD_GSK3_1	403	410	PF00069	0.417
MOD_GSK3_1	67	74	PF00069	0.271
MOD_GSK3_1	9	16	PF00069	0.518
MOD_N-GLC_1	186	191	PF02516	0.443
MOD_N-GLC_1	223	228	PF02516	0.245
MOD_N-GLC_1	407	412	PF02516	0.545
MOD_N-GLC_1	523	528	PF02516	0.441
MOD_N-GLC_2	136	138	PF02516	0.359
MOD_NEK2_1	1	6	PF00069	0.608
MOD_NEK2_1	134	139	PF00069	0.339
MOD_NEK2_1	171	176	PF00069	0.381
MOD_NEK2_1	196	201	PF00069	0.286
MOD_NEK2_1	264	269	PF00069	0.335
MOD_NEK2_1	271	276	PF00069	0.326
MOD_NEK2_1	291	296	PF00069	0.335
MOD_NEK2_1	336	341	PF00069	0.771
MOD_NEK2_1	39	44	PF00069	0.302
MOD_NEK2_1	9	14	PF00069	0.575
MOD_NEK2_2	232	237	PF00069	0.562
MOD_NEK2_2	523	528	PF00069	0.471
MOD_PIKK_1	7	13	PF00454	0.593
MOD_PKA_1	355	361	PF00069	0.720
MOD_PKA_2	440	446	PF00069	0.342
MOD_PKB_1	221	229	PF00069	0.558
MOD_Plk_1	523	529	PF00069	0.438
MOD_Plk_1	67	73	PF00069	0.261
MOD_Plk_2-3	52	58	PF00069	0.171
MOD_Plk_4	143	149	PF00069	0.328
MOD_Plk_4	171	177	PF00069	0.368
MOD_Plk_4	196	202	PF00069	0.251
MOD_Plk_4	291	297	PF00069	0.367
MOD_Plk_4	355	361	PF00069	0.722
MOD_Plk_4	375	381	PF00069	0.548
MOD_Plk_4	400	406	PF00069	0.333
MOD_Plk_4	408	414	PF00069	0.315
MOD_Plk_4	424	430	PF00069	0.268
MOD_Plk_4	43	49	PF00069	0.314
MOD_Plk_4	523	529	PF00069	0.319
MOD_Plk_4	583	589	PF00069	0.266
MOD_ProDKin_1	343	349	PF00069	0.740
MOD_ProDKin_1	566	572	PF00069	0.384
MOD_SUMO_rev_2	27	32	PF00179	0.512
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.523
TRG_ENDOCYTIC_2	132	135	PF00928	0.281
TRG_ENDOCYTIC_2	193	196	PF00928	0.313
TRG_ENDOCYTIC_2	252	255	PF00928	0.352
TRG_ENDOCYTIC_2	273	276	PF00928	0.328
TRG_ENDOCYTIC_2	429	432	PF00928	0.294
TRG_ENDOCYTIC_2	493	496	PF00928	0.333
TRG_ENDOCYTIC_2	592	595	PF00928	0.513
TRG_ENDOCYTIC_2	81	84	PF00928	0.312
TRG_ENDOCYTIC_2	86	89	PF00928	0.321
TRG_ENDOCYTIC_2	90	93	PF00928	0.483
TRG_ER_diArg_1	155	158	PF00400	0.527
TRG_ER_diArg_1	220	223	PF00400	0.560
TRG_ER_diArg_1	247	249	PF00400	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	28%	95%
A0A0N1HT40	Leptomonas seymouri	31%	100%
A0A0N1HZC2	Leptomonas seymouri	72%	97%
A0A0N1IKC5	Leptomonas seymouri	31%	100%
A0A0N1PAX2	Leptomonas seymouri	40%	100%
A0A0N1PB63	Leptomonas seymouri	48%	92%
A0A0N1PD04	Leptomonas seymouri	24%	95%
A0A0N1PFR4	Leptomonas seymouri	29%	92%
A0A0S4JR45	Bodo saltans	26%	100%
A0A1X0NKK0	Trypanosomatidae	55%	100%
A0A1X0NL32	Trypanosomatidae	30%	97%
A0A1X0NM09	Trypanosomatidae	54%	99%
A0A1X0NRW5	Trypanosomatidae	25%	87%
A0A1X0NV13	Trypanosomatidae	30%	93%
A0A1X0NV19	Trypanosomatidae	31%	100%
A0A1X0NV27	Trypanosomatidae	31%	100%
A0A1X0NVH8	Trypanosomatidae	31%	92%
A0A1X0NVM7	Trypanosomatidae	31%	94%
A0A1X0NWQ1	Trypanosomatidae	31%	95%
A0A1X0NZE6	Trypanosomatidae	31%	100%
A0A1X0NZU2	Trypanosomatidae	27%	94%
A0A1X0NZU5	Trypanosomatidae	31%	100%
A0A1X0NZW1	Trypanosomatidae	29%	100%
A0A1X0P0M7	Trypanosomatidae	31%	100%
A0A381MMW5	Leishmania infantum	30%	100%
A0A3Q8I7Y9	Leishmania donovani	29%	92%
A0A3Q8IEC4	Leishmania donovani	30%	100%
A0A3Q8IF95	Leishmania donovani	44%	100%
A0A3Q8IIT5	Leishmania donovani	28%	100%
A0A3Q8ISY9	Leishmania donovani	27%	100%
A0A3R7JPZ0	Trypanosoma rangeli	47%	100%
A0A3R7JSQ9	Trypanosoma rangeli	27%	100%
A0A3R7KKN8	Trypanosoma rangeli	30%	100%
A0A3R7MAQ7	Trypanosoma rangeli	26%	86%
A0A3R7N3S6	Trypanosoma rangeli	24%	94%
A0A3R7N415	Trypanosoma rangeli	29%	100%
A0A3R7N921	Trypanosoma rangeli	30%	100%
A0A3R7R443	Trypanosoma rangeli	28%	100%
A0A3R7R6N6	Trypanosoma rangeli	44%	100%
A0A3S7WRJ4	Leishmania donovani	31%	100%
A0A3S7WRJ5	Leishmania donovani	31%	100%
A0A3S7WRL4	Leishmania donovani	29%	100%
A0A3S7WRS3	Leishmania donovani	26%	100%
A0A3S7WSR4	Leishmania donovani	31%	100%
A0A3S7WWU1	Leishmania donovani	48%	100%
A0A3S7X2G0	Leishmania donovani	30%	100%
A0A3S7X2K5	Leishmania donovani	29%	100%
A0A422MSE4	Trypanosoma rangeli	31%	100%
A0A422MSP6	Trypanosoma rangeli	29%	100%
A0A422MST9	Trypanosoma rangeli	29%	100%
A0A422MU68	Trypanosoma rangeli	49%	100%
A4H6J0	Leishmania braziliensis	31%	100%
A4H6J1	Leishmania braziliensis	32%	100%
A4H6J3	Leishmania braziliensis	30%	100%
A4H6Q5	Leishmania braziliensis	25%	100%
A4HC19	Leishmania braziliensis	47%	100%
A4HHG2	Leishmania braziliensis	27%	100%
A4HHG3	Leishmania braziliensis	28%	100%
A4HHG4	Leishmania braziliensis	30%	100%
A4HJW3	Leishmania braziliensis	28%	100%
A4HPE2	Leishmania braziliensis	87%	100%
A4HUX5	Leishmania infantum	32%	100%
A4HUX6	Leishmania infantum	30%	100%
A4HUX7	Leishmania infantum	28%	100%
A4HUX8	Leishmania infantum	28%	100%
A4HV40	Leishmania infantum	26%	100%
A4HZF5	Leishmania infantum	44%	100%
A4HZJ4	Leishmania infantum	48%	100%
A4I4L2	Leishmania infantum	28%	100%
A4I7C5	Leishmania infantum	27%	100%
A4ICI3	Leishmania infantum	100%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A7B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	94%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	89%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AE01	Leishmania major	30%	100%
E9AE09	Leishmania major	29%	100%
E9AE10	Leishmania major	29%	100%
E9AE11	Leishmania major	30%	100%
E9AGK5	Leishmania infantum	31%	100%
E9AHJ0	Leishmania infantum	30%	100%
E9AHJ1	Leishmania infantum	30%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ALS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ANL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	98%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q1E4	Leishmania major	97%	100%
Q4Q5T8	Leishmania major	28%	100%
Q4QC27	Leishmania major	47%	100%
Q4QC28	Leishmania major	44%	99%
Q4QFY5	Leishmania major	31%	100%
Q4QGU8	Leishmania major	26%	100%
Q4QH10	Leishmania major	28%	100%
Q4QH11	Leishmania major	28%	98%
Q4QH12	Leishmania major	28%	98%
Q4QH13	Leishmania major	29%	98%
Q4QH14	Leishmania major	30%	100%
Q4QH15	Leishmania major	31%	100%
V5B647	Trypanosoma cruzi	33%	96%
V5B983	Trypanosoma cruzi	30%	100%
V5BBB1	Trypanosoma cruzi	30%	100%
V5BFV8	Trypanosoma cruzi	29%	91%
V5BQY6	Trypanosoma cruzi	26%	86%
V5BVP0	Trypanosoma cruzi	29%	100%
V5DT25	Trypanosoma cruzi	30%	98%