LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7XB03_LEIDO
TriTrypDb:
LdBPK_362270.1 , LdCL_360028400 , LDHU3_36.2960
Length:
356

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XB03
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB03

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0016787 hydrolase activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 157 161 PF00656 0.302
CLV_C14_Caspase3-7 311 315 PF00656 0.407
CLV_NRD_NRD_1 218 220 PF00675 0.481
CLV_NRD_NRD_1 73 75 PF00675 0.485
CLV_PCSK_KEX2_1 218 220 PF00082 0.481
CLV_PCSK_KEX2_1 269 271 PF00082 0.523
CLV_PCSK_PC1ET2_1 269 271 PF00082 0.430
CLV_PCSK_SKI1_1 156 160 PF00082 0.430
CLV_PCSK_SKI1_1 165 169 PF00082 0.457
CLV_PCSK_SKI1_1 334 338 PF00082 0.449
DEG_SPOP_SBC_1 136 140 PF00917 0.413
DEG_SPOP_SBC_1 239 243 PF00917 0.503
DOC_MAPK_gen_1 170 178 PF00069 0.523
DOC_MAPK_JIP1_4 172 178 PF00069 0.511
DOC_MAPK_MEF2A_6 114 123 PF00069 0.500
DOC_MAPK_MEF2A_6 170 178 PF00069 0.523
DOC_PP4_FxxP_1 168 171 PF00568 0.502
DOC_USP7_MATH_1 150 154 PF00917 0.445
DOC_USP7_MATH_1 250 254 PF00917 0.670
DOC_USP7_MATH_1 324 328 PF00917 0.400
DOC_WW_Pin1_4 10 15 PF00397 0.481
DOC_WW_Pin1_4 19 24 PF00397 0.483
DOC_WW_Pin1_4 4 9 PF00397 0.499
LIG_14-3-3_CanoR_1 137 145 PF00244 0.582
LIG_14-3-3_CanoR_1 206 210 PF00244 0.418
LIG_14-3-3_CterR_2 352 356 PF00244 0.566
LIG_Actin_WH2_2 326 342 PF00022 0.452
LIG_BIR_III_4 129 133 PF00653 0.461
LIG_BIR_III_4 160 164 PF00653 0.370
LIG_Clathr_ClatBox_1 285 289 PF01394 0.462
LIG_Clathr_ClatBox_1 31 35 PF01394 0.297
LIG_deltaCOP1_diTrp_1 195 199 PF00928 0.461
LIG_FHA_2 137 143 PF00498 0.443
LIG_FHA_2 206 212 PF00498 0.410
LIG_FHA_2 35 41 PF00498 0.410
LIG_HCF-1_HBM_1 142 145 PF13415 0.460
LIG_LIR_Gen_1 106 115 PF02991 0.381
LIG_LIR_Gen_1 27 34 PF02991 0.480
LIG_LIR_Gen_1 276 286 PF02991 0.465
LIG_LIR_Gen_1 97 102 PF02991 0.453
LIG_LIR_Nem_3 106 110 PF02991 0.366
LIG_LIR_Nem_3 195 199 PF02991 0.525
LIG_LIR_Nem_3 222 228 PF02991 0.377
LIG_LIR_Nem_3 27 32 PF02991 0.482
LIG_LIR_Nem_3 276 281 PF02991 0.465
LIG_LIR_Nem_3 83 88 PF02991 0.365
LIG_LIR_Nem_3 97 101 PF02991 0.374
LIG_PCNA_yPIPBox_3 109 120 PF02747 0.454
LIG_PTB_Apo_2 33 40 PF02174 0.284
LIG_PTB_Phospho_1 33 39 PF10480 0.278
LIG_SH2_CRK 107 111 PF00017 0.472
LIG_SH2_CRK 112 116 PF00017 0.457
LIG_SH2_CRK 85 89 PF00017 0.405
LIG_SH2_NCK_1 221 225 PF00017 0.396
LIG_SH2_SRC 39 42 PF00017 0.447
LIG_SH2_STAP1 201 205 PF00017 0.353
LIG_SH2_STAP1 221 225 PF00017 0.396
LIG_SH2_STAP1 301 305 PF00017 0.286
LIG_SH2_STAP1 321 325 PF00017 0.443
LIG_SH2_STAP1 98 102 PF00017 0.454
LIG_SH2_STAT3 201 204 PF00017 0.320
LIG_SH2_STAT5 146 149 PF00017 0.315
LIG_SH2_STAT5 87 90 PF00017 0.518
LIG_SH3_3 171 177 PF00018 0.669
LIG_SUMO_SIM_par_1 30 35 PF11976 0.347
LIG_TRAF2_1 262 265 PF00917 0.414
MOD_CK2_1 205 211 PF00069 0.394
MOD_CK2_1 259 265 PF00069 0.474
MOD_CK2_1 34 40 PF00069 0.349
MOD_GlcNHglycan 248 251 PF01048 0.646
MOD_GlcNHglycan 254 257 PF01048 0.642
MOD_GlcNHglycan 259 262 PF01048 0.591
MOD_GlcNHglycan 296 299 PF01048 0.320
MOD_GlcNHglycan 316 319 PF01048 0.302
MOD_GlcNHglycan 326 329 PF01048 0.340
MOD_GSK3_1 150 157 PF00069 0.361
MOD_GSK3_1 240 247 PF00069 0.535
MOD_GSK3_1 348 355 PF00069 0.587
MOD_N-GLC_1 150 155 PF02516 0.390
MOD_N-GLC_1 314 319 PF02516 0.541
MOD_NEK2_1 119 124 PF00069 0.496
MOD_NEK2_1 238 243 PF00069 0.500
MOD_NEK2_1 251 256 PF00069 0.669
MOD_NEK2_1 257 262 PF00069 0.376
MOD_NEK2_1 294 299 PF00069 0.371
MOD_NEK2_2 80 85 PF00069 0.417
MOD_PK_1 137 143 PF00069 0.398
MOD_PKA_2 136 142 PF00069 0.465
MOD_PKA_2 205 211 PF00069 0.483
MOD_PKA_2 257 263 PF00069 0.672
MOD_PKA_2 70 76 PF00069 0.286
MOD_Plk_1 281 287 PF00069 0.443
MOD_Plk_1 34 40 PF00069 0.285
MOD_Plk_4 24 30 PF00069 0.433
MOD_Plk_4 281 287 PF00069 0.456
MOD_Plk_4 34 40 PF00069 0.313
MOD_Plk_4 80 86 PF00069 0.363
MOD_ProDKin_1 19 25 PF00069 0.471
MOD_ProDKin_1 4 10 PF00069 0.500
TRG_DiLeu_BaEn_1 234 239 PF01217 0.514
TRG_DiLeu_BaEn_2 96 102 PF01217 0.393
TRG_DiLeu_BaLyEn_6 112 117 PF01217 0.352
TRG_ENDOCYTIC_2 107 110 PF00928 0.409
TRG_ENDOCYTIC_2 221 224 PF00928 0.336
TRG_ENDOCYTIC_2 225 228 PF00928 0.348
TRG_ENDOCYTIC_2 85 88 PF00928 0.392
TRG_ENDOCYTIC_2 98 101 PF00928 0.498
TRG_ER_diArg_1 170 173 PF00400 0.600
TRG_ER_diArg_1 217 219 PF00400 0.473
TRG_Pf-PMV_PEXEL_1 334 338 PF00026 0.412

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I684 Leptomonas seymouri 67% 100%
A0A1X0P7P0 Trypanosomatidae 29% 100%
A0A422N520 Trypanosoma rangeli 27% 100%
A4HP83 Leishmania braziliensis 80% 100%
A4IDI8 Leishmania infantum 99% 100%
E9ASZ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q1K7 Leishmania major 93% 100%
V5BKX8 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS