TP6A_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAZ9_LEIDO

TriTrypDb:

LdBPK_362920.1 , LdCL_360035600 , LDHU3_36.4070

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005694	chromosome	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0000228	nuclear chromosome	6	1

Expansion

Sequence features

A0A3S7XAZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAZ9

Function

Biological processes
Term	Name	Level	Count
GO:0000706	meiotic DNA double-strand break processing	3	1
GO:0000729	DNA double-strand break processing	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0007131	reciprocal meiotic recombination	3	1
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0035825	homologous recombination	6	1
GO:0042138	meiotic DNA double-strand break formation	4	1
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0061982	meiosis I cell cycle process	3	1
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0003916	DNA topoisomerase activity	3	11
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	3	11
GO:0005488	binding	1	11
GO:0008094	ATP-dependent activity, acting on DNA	2	11
GO:0016853	isomerase activity	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000166	nucleotide binding	3	5
GO:0005524	ATP binding	5	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	426	430	PF00656	0.596
CLV_NRD_NRD_1	290	292	PF00675	0.451
CLV_NRD_NRD_1	71	73	PF00675	0.736
CLV_PCSK_KEX2_1	119	121	PF00082	0.557
CLV_PCSK_KEX2_1	290	292	PF00082	0.451
CLV_PCSK_KEX2_1	411	413	PF00082	0.456
CLV_PCSK_KEX2_1	71	73	PF00082	0.736
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.512
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.528
CLV_PCSK_PC7_1	286	292	PF00082	0.493
CLV_PCSK_SKI1_1	151	155	PF00082	0.648
CLV_PCSK_SKI1_1	183	187	PF00082	0.396
CLV_PCSK_SKI1_1	244	248	PF00082	0.521
CLV_PCSK_SKI1_1	296	300	PF00082	0.409
CLV_PCSK_SKI1_1	360	364	PF00082	0.560
CLV_PCSK_SKI1_1	448	452	PF00082	0.525
DEG_APCC_DBOX_1	285	293	PF00400	0.379
DEG_APCC_DBOX_1	442	450	PF00400	0.407
DEG_SCF_FBW7_1	167	172	PF00400	0.421
DOC_CKS1_1	74	79	PF01111	0.732
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.589
DOC_MAPK_DCC_7	358	367	PF00069	0.553
DOC_MAPK_gen_1	119	127	PF00069	0.501
DOC_MAPK_gen_1	358	367	PF00069	0.553
DOC_MAPK_gen_1	458	467	PF00069	0.547
DOC_MAPK_JIP1_4	241	247	PF00069	0.528
DOC_MAPK_MEF2A_6	296	305	PF00069	0.311
DOC_MAPK_MEF2A_6	358	367	PF00069	0.553
DOC_MAPK_NFAT4_5	360	368	PF00069	0.534
DOC_PP2B_LxvP_1	105	108	PF13499	0.592
DOC_PP4_FxxP_1	147	150	PF00568	0.565
DOC_USP7_MATH_1	181	185	PF00917	0.503
DOC_USP7_MATH_1	205	209	PF00917	0.600
DOC_USP7_MATH_1	330	334	PF00917	0.760
DOC_USP7_MATH_1	420	424	PF00917	0.577
DOC_USP7_MATH_1	425	429	PF00917	0.677
DOC_WW_Pin1_4	146	151	PF00397	0.604
DOC_WW_Pin1_4	165	170	PF00397	0.661
DOC_WW_Pin1_4	263	268	PF00397	0.632
DOC_WW_Pin1_4	326	331	PF00397	0.710
DOC_WW_Pin1_4	341	346	PF00397	0.761
DOC_WW_Pin1_4	347	352	PF00397	0.658
DOC_WW_Pin1_4	37	42	PF00397	0.681
DOC_WW_Pin1_4	73	78	PF00397	0.766
LIG_14-3-3_CanoR_1	112	118	PF00244	0.445
LIG_14-3-3_CanoR_1	443	447	PF00244	0.421
LIG_14-3-3_CanoR_1	47	54	PF00244	0.505
LIG_14-3-3_CanoR_1	65	70	PF00244	0.407
LIG_Actin_WH2_2	397	413	PF00022	0.496
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BRCT_BRCA1_1	376	380	PF00533	0.592
LIG_BRCT_BRCA1_1	386	390	PF00533	0.691
LIG_BRCT_BRCA1_1	489	493	PF00533	0.436
LIG_CaM_IQ_9	404	420	PF13499	0.552
LIG_CAP-Gly_1	486	493	PF01302	0.412
LIG_Clathr_ClatBox_1	245	249	PF01394	0.413
LIG_EH1_1	57	65	PF00400	0.539
LIG_eIF4E_1	100	106	PF01652	0.438
LIG_FHA_1	189	195	PF00498	0.454
LIG_FHA_1	212	218	PF00498	0.463
LIG_FHA_1	354	360	PF00498	0.537
LIG_FHA_1	437	443	PF00498	0.543
LIG_FHA_1	55	61	PF00498	0.425
LIG_FHA_1	85	91	PF00498	0.672
LIG_FHA_2	4	10	PF00498	0.715
LIG_FHA_2	401	407	PF00498	0.417
LIG_FHA_2	474	480	PF00498	0.473
LIG_FHA_2	92	98	PF00498	0.425
LIG_GBD_Chelix_1	186	194	PF00786	0.493
LIG_LIR_Apic_2	144	150	PF02991	0.599
LIG_LIR_Apic_2	324	330	PF02991	0.648
LIG_LIR_Apic_2	97	103	PF02991	0.523
LIG_LIR_Gen_1	269	275	PF02991	0.529
LIG_LIR_Gen_1	75	85	PF02991	0.673
LIG_LIR_Nem_3	240	246	PF02991	0.579
LIG_LIR_Nem_3	269	273	PF02991	0.555
LIG_LIR_Nem_3	277	283	PF02991	0.491
LIG_LIR_Nem_3	341	346	PF02991	0.782
LIG_LIR_Nem_3	57	61	PF02991	0.477
LIG_LIR_Nem_3	75	81	PF02991	0.562
LIG_LYPXL_yS_3	280	283	PF13949	0.494
LIG_PDZ_Class_3	488	493	PF00595	0.607
LIG_Pex14_1	376	380	PF04695	0.543
LIG_Pex14_2	30	34	PF04695	0.571
LIG_SH2_CRK	100	104	PF00017	0.496
LIG_SH2_CRK	243	247	PF00017	0.521
LIG_SH2_CRK	270	274	PF00017	0.380
LIG_SH2_CRK	78	82	PF00017	0.716
LIG_SH2_NCK_1	215	219	PF00017	0.503
LIG_SH2_PTP2	302	305	PF00017	0.504
LIG_SH2_STAP1	270	274	PF00017	0.477
LIG_SH2_STAT3	15	18	PF00017	0.592
LIG_SH2_STAT3	59	62	PF00017	0.516
LIG_SH2_STAT5	171	174	PF00017	0.411
LIG_SH2_STAT5	302	305	PF00017	0.475
LIG_SH2_STAT5	59	62	PF00017	0.432
LIG_SH3_3	468	474	PF00018	0.448
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.557
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.543
LIG_SUMO_SIM_par_1	190	196	PF11976	0.544
LIG_SUMO_SIM_par_1	199	204	PF11976	0.383
LIG_SUMO_SIM_par_1	244	249	PF11976	0.381
LIG_WRC_WIRS_1	340	345	PF05994	0.696
MOD_CDC14_SPxK_1	40	43	PF00782	0.706
MOD_CDK_SPK_2	146	151	PF00069	0.604
MOD_CDK_SPxK_1	37	43	PF00069	0.685
MOD_CK1_1	216	222	PF00069	0.487
MOD_CK1_1	341	347	PF00069	0.747
MOD_CK1_1	353	359	PF00069	0.602
MOD_CK1_1	430	436	PF00069	0.655
MOD_CK2_1	18	24	PF00069	0.507
MOD_CK2_1	420	426	PF00069	0.485
MOD_CK2_1	473	479	PF00069	0.467
MOD_GlcNHglycan	202	206	PF01048	0.516
MOD_GlcNHglycan	207	210	PF01048	0.439
MOD_GlcNHglycan	263	266	PF01048	0.597
MOD_GlcNHglycan	346	349	PF01048	0.717
MOD_GlcNHglycan	352	355	PF01048	0.617
MOD_GlcNHglycan	386	389	PF01048	0.675
MOD_GlcNHglycan	422	425	PF01048	0.615
MOD_GlcNHglycan	429	432	PF01048	0.669
MOD_GSK3_1	142	149	PF00069	0.584
MOD_GSK3_1	165	172	PF00069	0.619
MOD_GSK3_1	201	208	PF00069	0.514
MOD_GSK3_1	209	216	PF00069	0.472
MOD_GSK3_1	257	264	PF00069	0.495
MOD_GSK3_1	326	333	PF00069	0.749
MOD_GSK3_1	370	377	PF00069	0.507
MOD_GSK3_1	425	432	PF00069	0.661
MOD_GSK3_1	76	83	PF00069	0.767
MOD_NEK2_1	1	6	PF00069	0.604
MOD_NEK2_1	176	181	PF00069	0.540
MOD_NEK2_1	213	218	PF00069	0.420
MOD_NEK2_1	261	266	PF00069	0.645
MOD_NEK2_1	274	279	PF00069	0.383
MOD_NEK2_1	321	326	PF00069	0.599
MOD_NEK2_1	374	379	PF00069	0.565
MOD_NEK2_1	394	399	PF00069	0.633
MOD_OFUCOSY	371	378	PF10250	0.518
MOD_PIKK_1	331	337	PF00454	0.761
MOD_PIKK_1	394	400	PF00454	0.596
MOD_PK_1	412	418	PF00069	0.470
MOD_PKA_2	111	117	PF00069	0.490
MOD_PKA_2	172	178	PF00069	0.476
MOD_PKA_2	205	211	PF00069	0.476
MOD_PKA_2	442	448	PF00069	0.394
MOD_PKA_2	46	52	PF00069	0.533
MOD_PKA_2	64	70	PF00069	0.446
MOD_Plk_2-3	91	97	PF00069	0.522
MOD_Plk_4	142	148	PF00069	0.583
MOD_Plk_4	181	187	PF00069	0.419
MOD_Plk_4	314	320	PF00069	0.395
MOD_Plk_4	370	376	PF00069	0.509
MOD_Plk_4	412	418	PF00069	0.498
MOD_Plk_4	473	479	PF00069	0.545
MOD_Plk_4	54	60	PF00069	0.450
MOD_Plk_4	76	82	PF00069	0.679
MOD_ProDKin_1	146	152	PF00069	0.609
MOD_ProDKin_1	165	171	PF00069	0.643
MOD_ProDKin_1	263	269	PF00069	0.633
MOD_ProDKin_1	326	332	PF00069	0.711
MOD_ProDKin_1	341	347	PF00069	0.758
MOD_ProDKin_1	37	43	PF00069	0.685
MOD_ProDKin_1	73	79	PF00069	0.768
MOD_SUMO_for_1	461	464	PF00179	0.496
TRG_DiLeu_BaEn_1	24	29	PF01217	0.494
TRG_ENDOCYTIC_2	243	246	PF00928	0.527
TRG_ENDOCYTIC_2	270	273	PF00928	0.559
TRG_ENDOCYTIC_2	280	283	PF00928	0.458
TRG_ENDOCYTIC_2	302	305	PF00928	0.504
TRG_ENDOCYTIC_2	78	81	PF00928	0.744
TRG_ER_diArg_1	289	291	PF00400	0.464
TRG_ER_diArg_1	458	461	PF00400	0.555
TRG_ER_diArg_1	70	72	PF00400	0.713
TRG_NES_CRM1_1	17	33	PF08389	0.557
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7M4	Leptomonas seymouri	41%	100%
A0A1X0NL58	Trypanosomatidae	31%	100%
A0A3R7LIJ3	Trypanosoma rangeli	31%	100%
A4HPE4	Leishmania braziliensis	79%	100%
A4ICI5	Leishmania infantum	100%	100%
D0A3F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AT55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1E2	Leishmania major	91%	100%
V5BPV6	Trypanosoma cruzi	32%	100%