Glycerophosphocholine phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

related to multifunctional cyclin-dependent kinase pho85-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7XAZ7_LEIDO

TriTrypDb:

LdBPK_362710.1 , LdCL_360033500 , LDHU3_36.3740

Length:

991

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7XAZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAZ7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009395	phospholipid catabolic process	5	7
GO:0009987	cellular process	1	7
GO:0016042	lipid catabolic process	4	7
GO:0019637	organophosphate metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044242	cellular lipid catabolic process	4	7
GO:0044248	cellular catabolic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0046434	organophosphate catabolic process	4	7
GO:0046475	glycerophospholipid catabolic process	6	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046503	glycerolipid catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901575	organic substance catabolic process	3	7
GO:0016310	phosphorylation	5	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008081	phosphoric diester hydrolase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0047389	glycerophosphocholine phosphodiesterase activity	6	7
GO:0016301	kinase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.705
CLV_C14_Caspase3-7	269	273	PF00656	0.586
CLV_C14_Caspase3-7	333	337	PF00656	0.655
CLV_C14_Caspase3-7	817	821	PF00656	0.340
CLV_NRD_NRD_1	193	195	PF00675	0.574
CLV_NRD_NRD_1	329	331	PF00675	0.590
CLV_NRD_NRD_1	427	429	PF00675	0.648
CLV_NRD_NRD_1	629	631	PF00675	0.388
CLV_NRD_NRD_1	822	824	PF00675	0.340
CLV_NRD_NRD_1	950	952	PF00675	0.295
CLV_PCSK_FUR_1	378	382	PF00082	0.555
CLV_PCSK_KEX2_1	193	195	PF00082	0.574
CLV_PCSK_KEX2_1	328	330	PF00082	0.595
CLV_PCSK_KEX2_1	380	382	PF00082	0.581
CLV_PCSK_KEX2_1	427	429	PF00082	0.648
CLV_PCSK_KEX2_1	661	663	PF00082	0.312
CLV_PCSK_KEX2_1	950	952	PF00082	0.295
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.529
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.312
CLV_PCSK_SKI1_1	455	459	PF00082	0.567
CLV_PCSK_SKI1_1	707	711	PF00082	0.331
CLV_PCSK_SKI1_1	767	771	PF00082	0.312
CLV_PCSK_SKI1_1	813	817	PF00082	0.325
CLV_PCSK_SKI1_1	823	827	PF00082	0.350
CLV_PCSK_SKI1_1	857	861	PF00082	0.350
CLV_PCSK_SKI1_1	950	954	PF00082	0.312
CLV_Separin_Metazoa	325	329	PF03568	0.639
CLV_Separin_Metazoa	574	578	PF03568	0.445
DEG_SCF_FBW7_1	136	142	PF00400	0.532
DEG_SPOP_SBC_1	338	342	PF00917	0.555
DEG_SPOP_SBC_1	401	405	PF00917	0.654
DEG_SPOP_SBC_1	986	990	PF00917	0.564
DOC_ANK_TNKS_1	331	338	PF00023	0.600
DOC_CDC14_PxL_1	232	240	PF14671	0.671
DOC_CKS1_1	136	141	PF01111	0.593
DOC_CYCLIN_yCln2_LP_2	364	370	PF00134	0.564
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.486
DOC_MAPK_DCC_7	241	250	PF00069	0.652
DOC_MAPK_gen_1	630	637	PF00069	0.412
DOC_MAPK_gen_1	643	650	PF00069	0.255
DOC_MAPK_gen_1	841	850	PF00069	0.312
DOC_MAPK_MEF2A_6	241	250	PF00069	0.684
DOC_MAPK_MEF2A_6	643	650	PF00069	0.379
DOC_PP1_RVXF_1	631	638	PF00149	0.255
DOC_PP1_RVXF_1	811	817	PF00149	0.312
DOC_PP1_RVXF_1	821	828	PF00149	0.312
DOC_PP2B_LxvP_1	119	122	PF13499	0.491
DOC_PP2B_LxvP_1	364	367	PF13499	0.533
DOC_PP2B_LxvP_1	585	588	PF13499	0.405
DOC_PP2B_LxvP_1	72	75	PF13499	0.486
DOC_PP4_FxxP_1	133	136	PF00568	0.642
DOC_USP7_MATH_1	139	143	PF00917	0.578
DOC_USP7_MATH_1	216	220	PF00917	0.626
DOC_USP7_MATH_1	263	267	PF00917	0.634
DOC_USP7_MATH_1	270	274	PF00917	0.653
DOC_USP7_MATH_1	314	318	PF00917	0.614
DOC_USP7_MATH_1	33	37	PF00917	0.661
DOC_USP7_MATH_1	385	389	PF00917	0.590
DOC_USP7_MATH_1	400	404	PF00917	0.584
DOC_USP7_MATH_1	46	50	PF00917	0.502
DOC_USP7_MATH_1	604	608	PF00917	0.340
DOC_USP7_MATH_1	880	884	PF00917	0.332
DOC_WW_Pin1_4	135	140	PF00397	0.586
DOC_WW_Pin1_4	143	148	PF00397	0.519
DOC_WW_Pin1_4	164	169	PF00397	0.547
DOC_WW_Pin1_4	240	245	PF00397	0.649
DOC_WW_Pin1_4	331	336	PF00397	0.606
DOC_WW_Pin1_4	396	401	PF00397	0.632
DOC_WW_Pin1_4	600	605	PF00397	0.383
DOC_WW_Pin1_4	672	677	PF00397	0.332
DOC_WW_Pin1_4	75	80	PF00397	0.538
DOC_WW_Pin1_4	770	775	PF00397	0.352
DOC_WW_Pin1_4	888	893	PF00397	0.412
LIG_14-3-3_CanoR_1	100	109	PF00244	0.558
LIG_14-3-3_CanoR_1	110	119	PF00244	0.509
LIG_14-3-3_CanoR_1	157	161	PF00244	0.623
LIG_14-3-3_CanoR_1	24	32	PF00244	0.506
LIG_14-3-3_CanoR_1	396	400	PF00244	0.746
LIG_14-3-3_CanoR_1	431	437	PF00244	0.628
LIG_14-3-3_CanoR_1	524	533	PF00244	0.464
LIG_14-3-3_CanoR_1	577	585	PF00244	0.391
LIG_14-3-3_CanoR_1	730	740	PF00244	0.462
LIG_14-3-3_CanoR_1	823	828	PF00244	0.340
LIG_14-3-3_CanoR_1	912	920	PF00244	0.340
LIG_APCC_ABBA_1	274	279	PF00400	0.661
LIG_BRCT_BRCA1_1	218	222	PF00533	0.605
LIG_BRCT_BRCA1_1	297	301	PF00533	0.472
LIG_BRCT_BRCA1_1	437	441	PF00533	0.614
LIG_BRCT_BRCA1_1	578	582	PF00533	0.400
LIG_BRCT_BRCA1_1	775	779	PF00533	0.312
LIG_BRCT_BRCA1_1	792	796	PF00533	0.312
LIG_BRCT_BRCA1_1	798	802	PF00533	0.312
LIG_Clathr_ClatBox_1	125	129	PF01394	0.530
LIG_Clathr_ClatBox_1	753	757	PF01394	0.340
LIG_eIF4E_1	555	561	PF01652	0.343
LIG_eIF4E_1	785	791	PF01652	0.388
LIG_FHA_1	215	221	PF00498	0.601
LIG_FHA_1	241	247	PF00498	0.573
LIG_FHA_1	403	409	PF00498	0.683
LIG_FHA_1	459	465	PF00498	0.570
LIG_FHA_1	475	481	PF00498	0.410
LIG_FHA_1	496	502	PF00498	0.397
LIG_FHA_1	528	534	PF00498	0.542
LIG_FHA_1	704	710	PF00498	0.388
LIG_FHA_1	914	920	PF00498	0.340
LIG_FHA_2	100	106	PF00498	0.580
LIG_FHA_2	165	171	PF00498	0.593
LIG_FHA_2	419	425	PF00498	0.719
LIG_FHA_2	954	960	PF00498	0.509
LIG_Integrin_isoDGR_2	821	823	PF01839	0.340
LIG_LIR_Apic_2	130	136	PF02991	0.617
LIG_LIR_Apic_2	155	161	PF02991	0.623
LIG_LIR_Gen_1	227	237	PF02991	0.563
LIG_LIR_Gen_1	548	559	PF02991	0.408
LIG_LIR_Gen_1	579	590	PF02991	0.390
LIG_LIR_Gen_1	636	641	PF02991	0.388
LIG_LIR_Gen_1	826	834	PF02991	0.300
LIG_LIR_Gen_1	843	850	PF02991	0.231
LIG_LIR_Gen_1	962	971	PF02991	0.388
LIG_LIR_Nem_3	227	232	PF02991	0.530
LIG_LIR_Nem_3	38	44	PF02991	0.540
LIG_LIR_Nem_3	548	554	PF02991	0.438
LIG_LIR_Nem_3	579	585	PF02991	0.399
LIG_LIR_Nem_3	673	677	PF02991	0.496
LIG_LIR_Nem_3	826	830	PF02991	0.300
LIG_LIR_Nem_3	843	848	PF02991	0.231
LIG_LIR_Nem_3	861	865	PF02991	0.312
LIG_LIR_Nem_3	934	939	PF02991	0.347
LIG_LIR_Nem_3	962	968	PF02991	0.312
LIG_MYND_1	236	240	PF01753	0.653
LIG_MYND_1	75	79	PF01753	0.559
LIG_Pex14_1	551	555	PF04695	0.425
LIG_REV1ctd_RIR_1	130	135	PF16727	0.590
LIG_REV1ctd_RIR_1	17	26	PF16727	0.608
LIG_RPA_C_Fungi	17	29	PF08784	0.484
LIG_SH2_CRK	158	162	PF00017	0.608
LIG_SH2_CRK	233	237	PF00017	0.678
LIG_SH2_CRK	674	678	PF00017	0.388
LIG_SH2_CRK	686	690	PF00017	0.265
LIG_SH2_CRK	845	849	PF00017	0.340
LIG_SH2_GRB2like	302	305	PF00017	0.446
LIG_SH2_NCK_1	158	162	PF00017	0.608
LIG_SH2_NCK_1	233	237	PF00017	0.678
LIG_SH2_NCK_1	968	972	PF00017	0.315
LIG_SH2_SRC	463	466	PF00017	0.389
LIG_SH2_SRC	866	869	PF00017	0.388
LIG_SH2_STAP1	845	849	PF00017	0.312
LIG_SH2_STAP1	968	972	PF00017	0.291
LIG_SH2_STAT3	785	788	PF00017	0.312
LIG_SH2_STAT3	95	98	PF00017	0.492
LIG_SH2_STAT5	463	466	PF00017	0.389
LIG_SH2_STAT5	503	506	PF00017	0.469
LIG_SH2_STAT5	536	539	PF00017	0.513
LIG_SH2_STAT5	555	558	PF00017	0.245
LIG_SH2_STAT5	674	677	PF00017	0.388
LIG_SH2_STAT5	686	689	PF00017	0.265
LIG_SH2_STAT5	76	79	PF00017	0.636
LIG_SH2_STAT5	866	869	PF00017	0.388
LIG_SH2_STAT5	95	98	PF00017	0.568
LIG_SH2_STAT5	963	966	PF00017	0.388
LIG_SH3_1	233	239	PF00018	0.681
LIG_SH3_1	241	247	PF00018	0.615
LIG_SH3_2	236	241	PF14604	0.697
LIG_SH3_3	133	139	PF00018	0.593
LIG_SH3_3	233	239	PF00018	0.625
LIG_SH3_3	241	247	PF00018	0.649
LIG_SH3_3	287	293	PF00018	0.677
LIG_SH3_3	303	309	PF00018	0.497
LIG_SH3_3	453	459	PF00018	0.471
LIG_SH3_3	496	502	PF00018	0.527
LIG_SH3_3	528	534	PF00018	0.447
LIG_SH3_3	780	786	PF00018	0.312
LIG_SH3_3	896	902	PF00018	0.322
LIG_SH3_3	927	933	PF00018	0.490
LIG_SUMO_SIM_par_1	124	130	PF11976	0.529
LIG_SUMO_SIM_par_1	246	252	PF11976	0.653
LIG_SUMO_SIM_par_1	295	300	PF11976	0.407
LIG_SUMO_SIM_par_1	57	62	PF11976	0.509
LIG_SUMO_SIM_par_1	646	652	PF11976	0.402
LIG_TRAF2_1	102	105	PF00917	0.517
LIG_TRAF2_2	306	311	PF00917	0.584
LIG_TYR_ITIM	556	561	PF00017	0.335
LIG_TYR_ITIM	684	689	PF00017	0.388
LIG_UBA3_1	654	661	PF00899	0.363
LIG_WRC_WIRS_1	621	626	PF05994	0.388
LIG_WRC_WIRS_1	827	832	PF05994	0.312
LIG_WRC_WIRS_1	862	867	PF05994	0.312
LIG_WW_3	238	242	PF00397	0.640
MOD_CDK_SPxK_1	672	678	PF00069	0.340
MOD_CK1_1	159	165	PF00069	0.509
MOD_CK1_1	266	272	PF00069	0.636
MOD_CK1_1	317	323	PF00069	0.615
MOD_CK1_1	34	40	PF00069	0.616
MOD_CK1_1	403	409	PF00069	0.656
MOD_CK1_1	413	419	PF00069	0.581
MOD_CK1_1	426	432	PF00069	0.593
MOD_CK1_1	525	531	PF00069	0.457
MOD_CK1_1	578	584	PF00069	0.436
MOD_CK1_1	617	623	PF00069	0.389
MOD_CK1_1	716	722	PF00069	0.346
MOD_CK1_1	732	738	PF00069	0.490
MOD_CK1_1	745	751	PF00069	0.279
MOD_CK2_1	111	117	PF00069	0.558
MOD_CK2_1	164	170	PF00069	0.592
MOD_CK2_1	221	227	PF00069	0.601
MOD_CK2_1	418	424	PF00069	0.650
MOD_CK2_1	762	768	PF00069	0.436
MOD_CK2_1	87	93	PF00069	0.616
MOD_CK2_1	99	105	PF00069	0.444
MOD_Cter_Amidation	821	824	PF01082	0.340
MOD_DYRK1A_RPxSP_1	396	400	PF00069	0.585
MOD_GlcNHglycan	113	116	PF01048	0.507
MOD_GlcNHglycan	178	182	PF01048	0.613
MOD_GlcNHglycan	209	212	PF01048	0.700
MOD_GlcNHglycan	251	254	PF01048	0.639
MOD_GlcNHglycan	26	29	PF01048	0.677
MOD_GlcNHglycan	268	271	PF01048	0.644
MOD_GlcNHglycan	33	36	PF01048	0.573
MOD_GlcNHglycan	382	385	PF01048	0.607
MOD_GlcNHglycan	415	418	PF01048	0.685
MOD_GlcNHglycan	428	431	PF01048	0.607
MOD_GlcNHglycan	437	440	PF01048	0.611
MOD_GlcNHglycan	519	522	PF01048	0.447
MOD_GlcNHglycan	527	530	PF01048	0.418
MOD_GlcNHglycan	604	607	PF01048	0.316
MOD_GlcNHglycan	744	747	PF01048	0.308
MOD_GlcNHglycan	874	877	PF01048	0.344
MOD_GlcNHglycan	908	911	PF01048	0.485
MOD_GSK3_1	135	142	PF00069	0.530
MOD_GSK3_1	156	163	PF00069	0.723
MOD_GSK3_1	266	273	PF00069	0.695
MOD_GSK3_1	314	321	PF00069	0.604
MOD_GSK3_1	391	398	PF00069	0.625
MOD_GSK3_1	400	407	PF00069	0.686
MOD_GSK3_1	418	425	PF00069	0.549
MOD_GSK3_1	513	520	PF00069	0.423
MOD_GSK3_1	523	530	PF00069	0.462
MOD_GSK3_1	596	603	PF00069	0.320
MOD_GSK3_1	729	736	PF00069	0.431
MOD_GSK3_1	741	748	PF00069	0.278
MOD_GSK3_1	928	935	PF00069	0.349
MOD_N-GLC_1	411	416	PF02516	0.662
MOD_N-GLC_1	684	689	PF02516	0.388
MOD_N-GLC_2	5	7	PF02516	0.537
MOD_N-GLC_2	833	835	PF02516	0.312
MOD_NEK2_1	207	212	PF00069	0.702
MOD_NEK2_1	297	302	PF00069	0.402
MOD_NEK2_1	31	36	PF00069	0.558
MOD_NEK2_1	339	344	PF00069	0.560
MOD_NEK2_1	379	384	PF00069	0.608
MOD_NEK2_1	402	407	PF00069	0.638
MOD_NEK2_1	411	416	PF00069	0.586
MOD_NEK2_1	522	527	PF00069	0.507
MOD_NEK2_1	596	601	PF00069	0.369
MOD_NEK2_1	684	689	PF00069	0.312
MOD_NEK2_1	729	734	PF00069	0.388
MOD_NEK2_1	790	795	PF00069	0.388
MOD_NEK2_1	840	845	PF00069	0.312
MOD_NEK2_2	450	455	PF00069	0.503
MOD_OFUCOSY	84	91	PF10250	0.498
MOD_PIKK_1	10	16	PF00454	0.629
MOD_PIKK_1	100	106	PF00454	0.580
MOD_PIKK_1	156	162	PF00454	0.612
MOD_PIKK_1	304	310	PF00454	0.602
MOD_PIKK_1	432	438	PF00454	0.590
MOD_PIKK_1	474	480	PF00454	0.429
MOD_PIKK_1	733	739	PF00454	0.385
MOD_PKA_1	380	386	PF00069	0.568
MOD_PKA_1	823	829	PF00069	0.340
MOD_PKA_2	156	162	PF00069	0.612
MOD_PKA_2	380	386	PF00069	0.562
MOD_PKA_2	391	397	PF00069	0.592
MOD_PKA_2	426	432	PF00069	0.719
MOD_PKA_2	523	529	PF00069	0.464
MOD_PKA_2	576	582	PF00069	0.432
MOD_PKA_2	729	735	PF00069	0.340
MOD_PKA_2	99	105	PF00069	0.554
MOD_PKB_1	22	30	PF00069	0.503
MOD_Plk_1	139	145	PF00069	0.564
MOD_Plk_1	196	202	PF00069	0.628
MOD_Plk_1	263	269	PF00069	0.641
MOD_Plk_1	495	501	PF00069	0.389
MOD_Plk_1	508	514	PF00069	0.472
MOD_Plk_1	617	623	PF00069	0.312
MOD_Plk_1	684	690	PF00069	0.359
MOD_Plk_1	749	755	PF00069	0.441
MOD_Plk_4	146	152	PF00069	0.561
MOD_Plk_4	297	303	PF00069	0.406
MOD_Plk_4	513	519	PF00069	0.410
MOD_Plk_4	527	533	PF00069	0.418
MOD_Plk_4	546	552	PF00069	0.318
MOD_Plk_4	586	592	PF00069	0.370
MOD_Plk_4	713	719	PF00069	0.388
MOD_Plk_4	749	755	PF00069	0.388
MOD_Plk_4	885	891	PF00069	0.312
MOD_Plk_4	959	965	PF00069	0.388
MOD_ProDKin_1	135	141	PF00069	0.584
MOD_ProDKin_1	143	149	PF00069	0.515
MOD_ProDKin_1	164	170	PF00069	0.557
MOD_ProDKin_1	240	246	PF00069	0.649
MOD_ProDKin_1	331	337	PF00069	0.601
MOD_ProDKin_1	396	402	PF00069	0.632
MOD_ProDKin_1	600	606	PF00069	0.383
MOD_ProDKin_1	672	678	PF00069	0.332
MOD_ProDKin_1	75	81	PF00069	0.541
MOD_ProDKin_1	770	776	PF00069	0.352
MOD_ProDKin_1	888	894	PF00069	0.412
MOD_SUMO_for_1	660	663	PF00179	0.388
MOD_SUMO_rev_2	776	786	PF00179	0.312
MOD_SUMO_rev_2	846	856	PF00179	0.312
TRG_DiLeu_BaEn_1	227	232	PF01217	0.497
TRG_DiLeu_BaEn_2	802	808	PF01217	0.312
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.442
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.388
TRG_DiLeu_BaLyEn_6	786	791	PF01217	0.315
TRG_ENDOCYTIC_2	558	561	PF00928	0.330
TRG_ENDOCYTIC_2	674	677	PF00928	0.412
TRG_ENDOCYTIC_2	686	689	PF00928	0.361
TRG_ENDOCYTIC_2	845	848	PF00928	0.312
TRG_ENDOCYTIC_2	862	865	PF00928	0.183
TRG_ENDOCYTIC_2	963	966	PF00928	0.388
TRG_ER_diArg_1	192	194	PF00400	0.492
TRG_ER_diArg_1	327	330	PF00400	0.578
TRG_ER_diArg_1	950	952	PF00400	0.340
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	690	695	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	857	861	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL19	Leptomonas seymouri	55%	96%
A4HPC4	Leishmania braziliensis	80%	100%
A4ICG4	Leishmania infantum	100%	100%
E9AT35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q1G3	Leishmania major	94%	100%