Serine/threonine-protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAZ4_LEIDO

TriTrypDb:

LdBPK_362170.1 , LdCL_360027400 , LDHU3_36.2820

Length:

914

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAZ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.523
CLV_C14_Caspase3-7	23	27	PF00656	0.739
CLV_C14_Caspase3-7	688	692	PF00656	0.730
CLV_C14_Caspase3-7	782	786	PF00656	0.695
CLV_NRD_NRD_1	185	187	PF00675	0.451
CLV_NRD_NRD_1	499	501	PF00675	0.347
CLV_NRD_NRD_1	664	666	PF00675	0.775
CLV_NRD_NRD_1	8	10	PF00675	0.716
CLV_NRD_NRD_1	88	90	PF00675	0.673
CLV_PCSK_KEX2_1	403	405	PF00082	0.338
CLV_PCSK_KEX2_1	499	501	PF00082	0.347
CLV_PCSK_KEX2_1	664	666	PF00082	0.775
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.338
CLV_PCSK_SKI1_1	166	170	PF00082	0.553
CLV_PCSK_SKI1_1	186	190	PF00082	0.275
CLV_PCSK_SKI1_1	315	319	PF00082	0.382
CLV_PCSK_SKI1_1	365	369	PF00082	0.411
CLV_PCSK_SKI1_1	657	661	PF00082	0.739
CLV_PCSK_SKI1_1	857	861	PF00082	0.446
CLV_Separin_Metazoa	339	343	PF03568	0.609
DEG_APCC_DBOX_1	185	193	PF00400	0.478
DEG_APCC_DBOX_1	364	372	PF00400	0.411
DEG_SCF_TRCP1_1	547	552	PF00400	0.690
DEG_SPOP_SBC_1	106	110	PF00917	0.642
DOC_ANK_TNKS_1	270	277	PF00023	0.713
DOC_CKS1_1	137	142	PF01111	0.689
DOC_CKS1_1	67	72	PF01111	0.717
DOC_CYCLIN_RxL_1	312	322	PF00134	0.385
DOC_CYCLIN_yClb1_LxF_4	833	839	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.500
DOC_MAPK_gen_1	230	237	PF00069	0.457
DOC_MAPK_gen_1	301	310	PF00069	0.618
DOC_MAPK_gen_1	403	409	PF00069	0.222
DOC_MAPK_gen_1	437	447	PF00069	0.299
DOC_MAPK_gen_1	722	732	PF00069	0.573
DOC_MAPK_gen_1	871	879	PF00069	0.472
DOC_MAPK_MEF2A_6	119	127	PF00069	0.714
DOC_MAPK_MEF2A_6	230	237	PF00069	0.457
DOC_MAPK_MEF2A_6	301	310	PF00069	0.618
DOC_MAPK_MEF2A_6	342	349	PF00069	0.483
DOC_MAPK_NFAT4_5	230	238	PF00069	0.561
DOC_PP2B_LxvP_1	102	105	PF13499	0.837
DOC_PP2B_LxvP_1	711	714	PF13499	0.748
DOC_PP4_FxxP_1	672	675	PF00568	0.659
DOC_PP4_FxxP_1	676	679	PF00568	0.658
DOC_PP4_FxxP_1	720	723	PF00568	0.684
DOC_PP4_FxxP_1	862	865	PF00568	0.446
DOC_USP7_MATH_1	106	110	PF00917	0.673
DOC_USP7_MATH_1	28	32	PF00917	0.728
DOC_USP7_MATH_1	377	381	PF00917	0.482
DOC_USP7_MATH_1	393	397	PF00917	0.280
DOC_USP7_MATH_1	528	532	PF00917	0.723
DOC_USP7_MATH_1	538	542	PF00917	0.684
DOC_USP7_MATH_1	59	63	PF00917	0.807
DOC_USP7_MATH_1	598	602	PF00917	0.547
DOC_USP7_MATH_1	683	687	PF00917	0.670
DOC_USP7_MATH_1	696	700	PF00917	0.723
DOC_USP7_MATH_1	702	706	PF00917	0.837
DOC_USP7_MATH_1	714	718	PF00917	0.720
DOC_USP7_MATH_1	72	76	PF00917	0.551
DOC_USP7_MATH_1	772	776	PF00917	0.671
DOC_USP7_MATH_1	781	785	PF00917	0.662
DOC_USP7_MATH_1	788	792	PF00917	0.686
DOC_USP7_UBL2_3	10	14	PF12436	0.737
DOC_USP7_UBL2_3	415	419	PF12436	0.408
DOC_USP7_UBL2_3	657	661	PF12436	0.720
DOC_USP7_UBL2_3	898	902	PF12436	0.598
DOC_WW_Pin1_4	107	112	PF00397	0.746
DOC_WW_Pin1_4	136	141	PF00397	0.709
DOC_WW_Pin1_4	26	31	PF00397	0.768
DOC_WW_Pin1_4	285	290	PF00397	0.650
DOC_WW_Pin1_4	385	390	PF00397	0.487
DOC_WW_Pin1_4	468	473	PF00397	0.411
DOC_WW_Pin1_4	534	539	PF00397	0.732
DOC_WW_Pin1_4	575	580	PF00397	0.787
DOC_WW_Pin1_4	60	65	PF00397	0.738
DOC_WW_Pin1_4	66	71	PF00397	0.704
DOC_WW_Pin1_4	675	680	PF00397	0.668
DOC_WW_Pin1_4	706	711	PF00397	0.739
DOC_WW_Pin1_4	737	742	PF00397	0.472
DOC_WW_Pin1_4	79	84	PF00397	0.631
LIG_14-3-3_CanoR_1	119	127	PF00244	0.753
LIG_14-3-3_CanoR_1	453	459	PF00244	0.513
LIG_14-3-3_CanoR_1	787	793	PF00244	0.564
LIG_14-3-3_CanoR_1	857	862	PF00244	0.548
LIG_14-3-3_CanoR_1	89	95	PF00244	0.675
LIG_14-3-3_CterR_2	911	914	PF00244	0.753
LIG_Actin_WH2_2	256	273	PF00022	0.650
LIG_APCC_ABBA_1	739	744	PF00400	0.504
LIG_APCC_ABBAyCdc20_2	315	321	PF00400	0.395
LIG_BIR_III_4	57	61	PF00653	0.737
LIG_BIR_III_4	73	77	PF00653	0.728
LIG_BRCT_BRCA1_1	685	689	PF00533	0.597
LIG_BRCT_BRCA1_1	716	720	PF00533	0.702
LIG_BRCT_BRCA1_2	716	722	PF00533	0.669
LIG_Clathr_ClatBox_1	340	344	PF01394	0.479
LIG_EVH1_1	102	106	PF00568	0.744
LIG_EVH1_2	909	913	PF00568	0.723
LIG_FHA_1	210	216	PF00498	0.595
LIG_FHA_1	27	33	PF00498	0.800
LIG_FHA_1	297	303	PF00498	0.566
LIG_FHA_1	464	470	PF00498	0.411
LIG_FHA_1	472	478	PF00498	0.411
LIG_FHA_1	816	822	PF00498	0.512
LIG_FHA_1	831	837	PF00498	0.424
LIG_FHA_2	129	135	PF00498	0.727
LIG_FHA_2	165	171	PF00498	0.589
LIG_FHA_2	19	25	PF00498	0.735
LIG_FHA_2	196	202	PF00498	0.463
LIG_FHA_2	31	37	PF00498	0.746
LIG_FHA_2	52	58	PF00498	0.728
LIG_FHA_2	561	567	PF00498	0.644
LIG_FHA_2	686	692	PF00498	0.729
LIG_FHA_2	702	708	PF00498	0.514
LIG_FHA_2	766	772	PF00498	0.472
LIG_FHA_2	780	786	PF00498	0.711
LIG_FHA_2	889	895	PF00498	0.539
LIG_LIR_Apic_2	671	675	PF02991	0.663
LIG_LIR_Apic_2	717	723	PF02991	0.695
LIG_LIR_Apic_2	766	772	PF02991	0.472
LIG_LIR_Apic_2	860	865	PF02991	0.445
LIG_LIR_Gen_1	159	169	PF02991	0.521
LIG_LIR_Gen_1	332	341	PF02991	0.495
LIG_LIR_Gen_1	796	804	PF02991	0.458
LIG_LIR_Nem_3	159	165	PF02991	0.523
LIG_LIR_Nem_3	257	263	PF02991	0.703
LIG_LIR_Nem_3	3	7	PF02991	0.742
LIG_LIR_Nem_3	332	337	PF02991	0.483
LIG_LIR_Nem_3	487	493	PF02991	0.389
LIG_LIR_Nem_3	744	750	PF02991	0.587
LIG_LIR_Nem_3	796	801	PF02991	0.444
LIG_LIR_Nem_3	891	895	PF02991	0.440
LIG_LYPXL_yS_3	501	504	PF13949	0.411
LIG_MYND_1	268	272	PF01753	0.752
LIG_MYND_1	83	87	PF01753	0.756
LIG_NRBOX	218	224	PF00104	0.496
LIG_Pex14_2	209	213	PF04695	0.521
LIG_Pex14_2	290	294	PF04695	0.707
LIG_Pex14_2	672	676	PF04695	0.679
LIG_PTB_Apo_2	666	673	PF02174	0.684
LIG_Rb_LxCxE_1	247	261	PF01857	0.544
LIG_SH2_CRK	314	318	PF00017	0.570
LIG_SH2_NCK_1	609	613	PF00017	0.557
LIG_SH2_SRC	323	326	PF00017	0.529
LIG_SH2_SRC	609	612	PF00017	0.546
LIG_SH2_STAP1	94	98	PF00017	0.677
LIG_SH2_STAT5	323	326	PF00017	0.508
LIG_SH2_STAT5	444	447	PF00017	0.411
LIG_SH2_STAT5	450	453	PF00017	0.411
LIG_SH2_STAT5	837	840	PF00017	0.535
LIG_SH2_STAT5	867	870	PF00017	0.503
LIG_SH2_STAT5	890	893	PF00017	0.433
LIG_SH3_2	84	89	PF14604	0.667
LIG_SH3_3	100	106	PF00018	0.630
LIG_SH3_3	134	140	PF00018	0.723
LIG_SH3_3	150	156	PF00018	0.468
LIG_SH3_3	347	353	PF00018	0.573
LIG_SH3_3	406	412	PF00018	0.222
LIG_SH3_3	435	441	PF00018	0.513
LIG_SH3_3	707	713	PF00018	0.748
LIG_SH3_3	80	86	PF00018	0.844
LIG_SH3_3	904	910	PF00018	0.724
LIG_SH3_4	898	905	PF00018	0.600
LIG_SUMO_SIM_par_1	856	863	PF11976	0.455
LIG_SUMO_SIM_par_1	875	880	PF11976	0.440
LIG_TRAF2_1	326	329	PF00917	0.471
LIG_TRAF2_1	518	521	PF00917	0.675
LIG_TRAF2_1	98	101	PF00917	0.772
LIG_WRC_WIRS_1	1	6	PF05994	0.715
LIG_WRC_WIRS_1	165	170	PF05994	0.584
LIG_WW_1	441	444	PF00397	0.436
LIG_WW_2	83	86	PF00397	0.658
LIG_WW_3	908	912	PF00397	0.750
MOD_CDK_SPK_2	385	390	PF00069	0.474
MOD_CDK_SPxxK_3	112	119	PF00069	0.730
MOD_CK1_1	110	116	PF00069	0.660
MOD_CK1_1	151	157	PF00069	0.643
MOD_CK1_1	200	206	PF00069	0.473
MOD_CK1_1	38	44	PF00069	0.752
MOD_CK1_1	388	394	PF00069	0.438
MOD_CK1_1	414	420	PF00069	0.436
MOD_CK1_1	436	442	PF00069	0.398
MOD_CK1_1	471	477	PF00069	0.391
MOD_CK1_1	52	58	PF00069	0.835
MOD_CK1_1	533	539	PF00069	0.699
MOD_CK1_1	66	72	PF00069	0.819
MOD_CK1_1	687	693	PF00069	0.697
MOD_CK1_1	698	704	PF00069	0.712
MOD_CK1_1	709	715	PF00069	0.705
MOD_CK1_1	770	776	PF00069	0.480
MOD_CK2_1	170	176	PF00069	0.528
MOD_CK2_1	18	24	PF00069	0.693
MOD_CK2_1	290	296	PF00069	0.696
MOD_CK2_1	30	36	PF00069	0.697
MOD_CK2_1	323	329	PF00069	0.466
MOD_CK2_1	514	520	PF00069	0.675
MOD_CK2_1	539	545	PF00069	0.635
MOD_CK2_1	555	561	PF00069	0.698
MOD_CK2_1	668	674	PF00069	0.801
MOD_CK2_1	701	707	PF00069	0.750
MOD_CK2_1	888	894	PF00069	0.489
MOD_CK2_1	90	96	PF00069	0.749
MOD_Cter_Amidation	7	10	PF01082	0.832
MOD_GlcNHglycan	120	123	PF01048	0.725
MOD_GlcNHglycan	260	263	PF01048	0.593
MOD_GlcNHglycan	325	328	PF01048	0.529
MOD_GlcNHglycan	416	419	PF01048	0.434
MOD_GlcNHglycan	427	430	PF01048	0.305
MOD_GlcNHglycan	43	46	PF01048	0.842
MOD_GlcNHglycan	516	519	PF01048	0.689
MOD_GlcNHglycan	530	533	PF01048	0.713
MOD_GlcNHglycan	547	550	PF01048	0.557
MOD_GlcNHglycan	704	707	PF01048	0.704
MOD_GlcNHglycan	714	717	PF01048	0.789
MOD_GlcNHglycan	73	77	PF01048	0.832
MOD_GlcNHglycan	774	777	PF01048	0.627
MOD_GlcNHglycan	862	865	PF01048	0.446
MOD_GlcNHglycan	96	99	PF01048	0.829
MOD_GSK3_1	106	113	PF00069	0.611
MOD_GSK3_1	123	130	PF00069	0.672
MOD_GSK3_1	135	142	PF00069	0.589
MOD_GSK3_1	254	261	PF00069	0.615
MOD_GSK3_1	26	33	PF00069	0.813
MOD_GSK3_1	393	400	PF00069	0.409
MOD_GSK3_1	410	417	PF00069	0.385
MOD_GSK3_1	512	519	PF00069	0.674
MOD_GSK3_1	528	535	PF00069	0.762
MOD_GSK3_1	545	552	PF00069	0.707
MOD_GSK3_1	556	563	PF00069	0.681
MOD_GSK3_1	59	66	PF00069	0.787
MOD_GSK3_1	659	666	PF00069	0.734
MOD_GSK3_1	683	690	PF00069	0.656
MOD_GSK3_1	694	701	PF00069	0.738
MOD_GSK3_1	702	709	PF00069	0.748
MOD_GSK3_1	712	719	PF00069	0.812
MOD_GSK3_1	72	79	PF00069	0.836
MOD_GSK3_1	767	774	PF00069	0.487
MOD_GSK3_1	779	786	PF00069	0.710
MOD_GSK3_1	793	800	PF00069	0.594
MOD_GSK3_1	90	97	PF00069	0.588
MOD_LATS_1	48	54	PF00433	0.811
MOD_N-GLC_1	170	175	PF02516	0.527
MOD_N-GLC_1	296	301	PF02516	0.603
MOD_N-GLC_1	38	43	PF02516	0.842
MOD_N-GLC_1	528	533	PF02516	0.786
MOD_N-GLC_1	556	561	PF02516	0.726
MOD_N-GLC_1	668	673	PF02516	0.800
MOD_N-GLC_1	788	793	PF02516	0.691
MOD_N-GLC_2	866	868	PF02516	0.486
MOD_NEK2_1	118	123	PF00069	0.770
MOD_NEK2_1	127	132	PF00069	0.690
MOD_NEK2_1	290	295	PF00069	0.755
MOD_NEK2_1	463	468	PF00069	0.411
MOD_NEK2_1	689	694	PF00069	0.594
MOD_NEK2_1	830	835	PF00069	0.475
MOD_PIKK_1	398	404	PF00454	0.468
MOD_PIKK_1	788	794	PF00454	0.640
MOD_PK_1	178	184	PF00069	0.612
MOD_PK_1	403	409	PF00069	0.338
MOD_PK_1	797	803	PF00069	0.433
MOD_PKA_1	403	409	PF00069	0.338
MOD_PKA_1	651	657	PF00069	0.713
MOD_PKA_1	660	666	PF00069	0.714
MOD_PKA_2	118	124	PF00069	0.796
MOD_PKA_2	403	409	PF00069	0.424
MOD_PKA_2	436	442	PF00069	0.490
MOD_PKA_2	663	669	PF00069	0.783
MOD_PKA_2	694	700	PF00069	0.728
MOD_PKA_2	815	821	PF00069	0.495
MOD_Plk_1	151	157	PF00069	0.556
MOD_Plk_1	195	201	PF00069	0.550
MOD_Plk_1	556	562	PF00069	0.735
MOD_Plk_1	668	674	PF00069	0.762
MOD_Plk_1	743	749	PF00069	0.588
MOD_Plk_1	765	771	PF00069	0.471
MOD_Plk_1	824	830	PF00069	0.465
MOD_Plk_2-3	520	526	PF00069	0.606
MOD_Plk_4	313	319	PF00069	0.499
MOD_Plk_4	471	477	PF00069	0.391
MOD_Plk_4	857	863	PF00069	0.446
MOD_ProDKin_1	107	113	PF00069	0.745
MOD_ProDKin_1	136	142	PF00069	0.697
MOD_ProDKin_1	26	32	PF00069	0.769
MOD_ProDKin_1	285	291	PF00069	0.651
MOD_ProDKin_1	385	391	PF00069	0.487
MOD_ProDKin_1	468	474	PF00069	0.411
MOD_ProDKin_1	534	540	PF00069	0.732
MOD_ProDKin_1	575	581	PF00069	0.786
MOD_ProDKin_1	60	66	PF00069	0.738
MOD_ProDKin_1	675	681	PF00069	0.670
MOD_ProDKin_1	706	712	PF00069	0.739
MOD_ProDKin_1	737	743	PF00069	0.471
MOD_ProDKin_1	79	85	PF00069	0.793
MOD_SUMO_for_1	177	180	PF00179	0.451
MOD_SUMO_for_1	300	303	PF00179	0.638
MOD_SUMO_rev_2	36	44	PF00179	0.669
MOD_SUMO_rev_2	894	899	PF00179	0.696
TRG_DiLeu_BaLyEn_6	854	859	PF01217	0.474
TRG_ENDOCYTIC_2	314	317	PF00928	0.464
TRG_ENDOCYTIC_2	444	447	PF00928	0.411
TRG_ENDOCYTIC_2	491	494	PF00928	0.411
TRG_ENDOCYTIC_2	501	504	PF00928	0.411
TRG_ENDOCYTIC_2	609	612	PF00928	0.546
TRG_ENDOCYTIC_2	837	840	PF00928	0.493
TRG_ENDOCYTIC_2	867	870	PF00928	0.503
TRG_ENDOCYTIC_2	892	895	PF00928	0.487
TRG_ER_diArg_1	229	232	PF00400	0.467
TRG_ER_diArg_1	499	501	PF00400	0.352
TRG_NES_CRM1_1	332	344	PF08389	0.466
TRG_NLS_MonoExtC_3	13	18	PF00514	0.734
TRG_NLS_MonoExtN_4	11	18	PF00514	0.731
TRG_NLS_MonoExtN_4	722	728	PF00514	0.700
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N5	Leptomonas seymouri	48%	95%
A4HP73	Leishmania braziliensis	65%	97%
A4IDH8	Leishmania infantum	100%	100%
E9ASY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1L7	Leishmania major	88%	98%