Serine/threonine-protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAZ4_LEIDO

TriTrypDb:

LdBPK_362170.1 , LdCL_360027400 , LDHU3_36.2820

Length:

914

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1

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Expansion

Sequence features

A0A3S7XAZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAZ4

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.523
CLV_C14_Caspase3-7	23	27	PF00656	0.739
CLV_C14_Caspase3-7	688	692	PF00656	0.730
CLV_C14_Caspase3-7	782	786	PF00656	0.695
CLV_NRD_NRD_1	185	187	PF00675	0.451
CLV_NRD_NRD_1	499	501	PF00675	0.347
CLV_NRD_NRD_1	664	666	PF00675	0.775
CLV_NRD_NRD_1	8	10	PF00675	0.716
CLV_NRD_NRD_1	88	90	PF00675	0.673
CLV_PCSK_KEX2_1	403	405	PF00082	0.338

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N5	Leptomonas seymouri	48%	95%
A4HP73	Leishmania braziliensis	65%	97%
A4IDH8	Leishmania infantum	100%	100%
E9ASY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1L7	Leishmania major	88%	98%

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