Cyclin-e binding protein 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclin-e binding protein 1-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7XAY5_LEIDO

TriTrypDb:

LdBPK_362730.1 , LdCL_360033700 , LDHU3_36.3760

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7XAY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAY5

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.684
CLV_C14_Caspase3-7	19	23	PF00656	0.642
CLV_C14_Caspase3-7	224	228	PF00656	0.690
CLV_C14_Caspase3-7	408	412	PF00656	0.725
CLV_NRD_NRD_1	162	164	PF00675	0.608
CLV_PCSK_KEX2_1	162	164	PF00082	0.506
CLV_PCSK_SKI1_1	214	218	PF00082	0.588
CLV_PCSK_SKI1_1	241	245	PF00082	0.468
CLV_PCSK_SKI1_1	278	282	PF00082	0.551
CLV_PCSK_SKI1_1	287	291	PF00082	0.493

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB4	Leptomonas seymouri	43%	100%
A4HPC6	Leishmania braziliensis	71%	100%
A4ICG6	Leishmania infantum	99%	100%
E9AT37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1G1	Leishmania major	92%	100%

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