Cyclin-e binding protein 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclin-e binding protein 1-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7XAY5_LEIDO

TriTrypDb:

LdBPK_362730.1 , LdCL_360033700 , LDHU3_36.3760

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAY5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.684
CLV_C14_Caspase3-7	19	23	PF00656	0.642
CLV_C14_Caspase3-7	224	228	PF00656	0.690
CLV_C14_Caspase3-7	408	412	PF00656	0.725
CLV_NRD_NRD_1	162	164	PF00675	0.608
CLV_PCSK_KEX2_1	162	164	PF00082	0.506
CLV_PCSK_SKI1_1	214	218	PF00082	0.588
CLV_PCSK_SKI1_1	241	245	PF00082	0.468
CLV_PCSK_SKI1_1	278	282	PF00082	0.551
CLV_PCSK_SKI1_1	287	291	PF00082	0.493
CLV_PCSK_SKI1_1	32	36	PF00082	0.665
CLV_PCSK_SKI1_1	489	493	PF00082	0.626
DEG_Nend_Nbox_1	1	3	PF02207	0.661
DEG_SCF_TRCP1_1	411	417	PF00400	0.676
DEG_SPOP_SBC_1	204	208	PF00917	0.580
DEG_SPOP_SBC_1	220	224	PF00917	0.595
DEG_SPOP_SBC_1	669	673	PF00917	0.680
DOC_CYCLIN_RxL_1	287	296	PF00134	0.475
DOC_MAPK_gen_1	194	202	PF00069	0.711
DOC_MAPK_MEF2A_6	194	202	PF00069	0.711
DOC_MAPK_MEF2A_6	66	74	PF00069	0.580
DOC_PP1_RVXF_1	288	294	PF00149	0.473
DOC_PP2B_LxvP_1	158	161	PF13499	0.515
DOC_PP2B_LxvP_1	376	379	PF13499	0.644
DOC_PP2B_LxvP_1	390	393	PF13499	0.372
DOC_PP2B_LxvP_1	524	527	PF13499	0.724
DOC_PP2B_LxvP_1	554	557	PF13499	0.714
DOC_PP4_FxxP_1	606	609	PF00568	0.606
DOC_USP7_MATH_1	103	107	PF00917	0.497
DOC_USP7_MATH_1	140	144	PF00917	0.551
DOC_USP7_MATH_1	16	20	PF00917	0.511
DOC_USP7_MATH_1	189	193	PF00917	0.672
DOC_USP7_MATH_1	204	208	PF00917	0.635
DOC_USP7_MATH_1	219	223	PF00917	0.576
DOC_USP7_MATH_1	37	41	PF00917	0.611
DOC_USP7_MATH_1	379	383	PF00917	0.633
DOC_USP7_MATH_1	431	435	PF00917	0.641
DOC_USP7_MATH_1	540	544	PF00917	0.756
DOC_USP7_MATH_1	635	639	PF00917	0.658
DOC_USP7_MATH_1	649	653	PF00917	0.572
DOC_USP7_MATH_1	669	673	PF00917	0.602
DOC_USP7_MATH_1	692	696	PF00917	0.765
DOC_USP7_MATH_1	711	715	PF00917	0.481
DOC_USP7_MATH_1	82	86	PF00917	0.621
DOC_WW_Pin1_4	185	190	PF00397	0.731
DOC_WW_Pin1_4	35	40	PF00397	0.685
DOC_WW_Pin1_4	562	567	PF00397	0.696
DOC_WW_Pin1_4	576	581	PF00397	0.646
DOC_WW_Pin1_4	590	595	PF00397	0.574
DOC_WW_Pin1_4	656	661	PF00397	0.685
DOC_WW_Pin1_4	677	682	PF00397	0.699
LIG_14-3-3_CanoR_1	337	342	PF00244	0.534
LIG_14-3-3_CanoR_1	597	606	PF00244	0.720
LIG_14-3-3_CanoR_1	619	625	PF00244	0.687
LIG_APCC_ABBA_1	31	36	PF00400	0.661
LIG_Clathr_ClatBox_1	292	296	PF01394	0.511
LIG_eIF4E_1	628	634	PF01652	0.625
LIG_FHA_1	211	217	PF00498	0.604
LIG_FHA_1	251	257	PF00498	0.355
LIG_FHA_1	330	336	PF00498	0.545
LIG_FHA_1	338	344	PF00498	0.543
LIG_FHA_1	40	46	PF00498	0.611
LIG_FHA_1	415	421	PF00498	0.579
LIG_FHA_1	464	470	PF00498	0.700
LIG_FHA_1	519	525	PF00498	0.704
LIG_FHA_1	577	583	PF00498	0.744
LIG_FHA_1	628	634	PF00498	0.603
LIG_FHA_1	649	655	PF00498	0.668
LIG_FHA_1	695	701	PF00498	0.811
LIG_FHA_2	342	348	PF00498	0.565
LIG_FHA_2	403	409	PF00498	0.746
LIG_FHA_2	446	452	PF00498	0.511
LIG_LIR_Apic_2	676	681	PF02991	0.612
LIG_LIR_Gen_1	307	316	PF02991	0.411
LIG_LIR_Gen_1	446	455	PF02991	0.526
LIG_LIR_Gen_1	714	719	PF02991	0.661
LIG_LIR_Nem_3	123	129	PF02991	0.411
LIG_LIR_Nem_3	231	235	PF02991	0.811
LIG_LIR_Nem_3	284	289	PF02991	0.479
LIG_LIR_Nem_3	307	311	PF02991	0.411
LIG_LIR_Nem_3	384	390	PF02991	0.558
LIG_LIR_Nem_3	434	439	PF02991	0.577
LIG_LIR_Nem_3	446	450	PF02991	0.497
LIG_LIR_Nem_3	714	718	PF02991	0.658
LIG_PDZ_Class_2	714	719	PF00595	0.572
LIG_SH2_CRK	110	114	PF00017	0.492
LIG_SH2_CRK	126	130	PF00017	0.331
LIG_SH2_CRK	373	377	PF00017	0.737
LIG_SH2_CRK	442	446	PF00017	0.633
LIG_SH2_CRK	61	65	PF00017	0.473
LIG_SH2_GRB2like	122	125	PF00017	0.411
LIG_SH2_PTP2	715	718	PF00017	0.761
LIG_SH2_STAP1	122	126	PF00017	0.411
LIG_SH2_STAP1	349	353	PF00017	0.611
LIG_SH2_STAP1	61	65	PF00017	0.473
LIG_SH2_STAT3	499	502	PF00017	0.769
LIG_SH2_STAT5	110	113	PF00017	0.411
LIG_SH2_STAT5	442	445	PF00017	0.628
LIG_SH2_STAT5	49	52	PF00017	0.485
LIG_SH2_STAT5	499	502	PF00017	0.675
LIG_SH2_STAT5	715	718	PF00017	0.761
LIG_SH3_3	232	238	PF00018	0.702
LIG_SH3_3	332	338	PF00018	0.455
LIG_SH3_3	497	503	PF00018	0.737
LIG_SUMO_SIM_anti_2	67	75	PF11976	0.495
LIG_SUMO_SIM_par_1	252	257	PF11976	0.411
LIG_SUMO_SIM_par_1	277	285	PF11976	0.514
LIG_SUMO_SIM_par_1	661	666	PF11976	0.680
LIG_SUMO_SIM_par_1	67	75	PF11976	0.483
LIG_TYR_ITIM	108	113	PF00017	0.436
LIG_UBA3_1	45	53	PF00899	0.545
MOD_CDK_SPxxK_3	590	597	PF00069	0.614
MOD_CK1_1	133	139	PF00069	0.547
MOD_CK1_1	207	213	PF00069	0.599
MOD_CK1_1	222	228	PF00069	0.639
MOD_CK1_1	336	342	PF00069	0.472
MOD_CK1_1	382	388	PF00069	0.566
MOD_CK1_1	432	438	PF00069	0.593
MOD_CK1_1	576	582	PF00069	0.705
MOD_CK1_1	596	602	PF00069	0.717
MOD_CK1_1	694	700	PF00069	0.713
MOD_CK2_1	341	347	PF00069	0.656
MOD_CK2_1	445	451	PF00069	0.524
MOD_CK2_1	670	676	PF00069	0.607
MOD_CK2_1	86	92	PF00069	0.632
MOD_GlcNHglycan	113	116	PF01048	0.411
MOD_GlcNHglycan	158	161	PF01048	0.542
MOD_GlcNHglycan	22	25	PF01048	0.669
MOD_GlcNHglycan	227	230	PF01048	0.791
MOD_GlcNHglycan	258	261	PF01048	0.513
MOD_GlcNHglycan	39	42	PF01048	0.605
MOD_GlcNHglycan	411	414	PF01048	0.770
MOD_GlcNHglycan	538	541	PF01048	0.724
MOD_GlcNHglycan	569	572	PF01048	0.669
MOD_GlcNHglycan	61	64	PF01048	0.464
MOD_GlcNHglycan	625	628	PF01048	0.711
MOD_GlcNHglycan	637	640	PF01048	0.558
MOD_GlcNHglycan	656	659	PF01048	0.686
MOD_GlcNHglycan	693	697	PF01048	0.714
MOD_GlcNHglycan	84	87	PF01048	0.629
MOD_GlcNHglycan	92	95	PF01048	0.505
MOD_GSK3_1	130	137	PF00069	0.489
MOD_GSK3_1	16	23	PF00069	0.609
MOD_GSK3_1	179	186	PF00069	0.790
MOD_GSK3_1	203	210	PF00069	0.702
MOD_GSK3_1	221	228	PF00069	0.612
MOD_GSK3_1	250	257	PF00069	0.360
MOD_GSK3_1	329	336	PF00069	0.518
MOD_GSK3_1	337	344	PF00069	0.525
MOD_GSK3_1	35	42	PF00069	0.451
MOD_GSK3_1	379	386	PF00069	0.579
MOD_GSK3_1	445	452	PF00069	0.510
MOD_GSK3_1	536	543	PF00069	0.705
MOD_GSK3_1	572	579	PF00069	0.695
MOD_GSK3_1	593	600	PF00069	0.744
MOD_GSK3_1	623	630	PF00069	0.679
MOD_GSK3_1	688	695	PF00069	0.721
MOD_GSK3_1	82	89	PF00069	0.616
MOD_LATS_1	331	337	PF00433	0.525
MOD_N-GLC_1	432	437	PF02516	0.622
MOD_N-GLC_1	702	707	PF02516	0.715
MOD_N-GLC_2	322	324	PF02516	0.411
MOD_NEK2_1	156	161	PF00069	0.490
MOD_NEK2_1	20	25	PF00069	0.601
MOD_NEK2_1	205	210	PF00069	0.564
MOD_NEK2_1	254	259	PF00069	0.411
MOD_NEK2_1	274	279	PF00069	0.307
MOD_NEK2_1	281	286	PF00069	0.426
MOD_NEK2_1	329	334	PF00069	0.528
MOD_NEK2_1	429	434	PF00069	0.686
MOD_NEK2_1	449	454	PF00069	0.388
MOD_NEK2_1	654	659	PF00069	0.660
MOD_NEK2_1	72	77	PF00069	0.503
MOD_NEK2_2	189	194	PF00069	0.713
MOD_NEK2_2	372	377	PF00069	0.650
MOD_NEK2_2	47	52	PF00069	0.400
MOD_NEK2_2	506	511	PF00069	0.628
MOD_PKA_2	336	342	PF00069	0.489
MOD_PKA_2	409	415	PF00069	0.717
MOD_PKA_2	596	602	PF00069	0.822
MOD_PKA_2	604	610	PF00069	0.698
MOD_PKA_2	618	624	PF00069	0.570
MOD_Plk_1	122	128	PF00069	0.402
MOD_Plk_1	349	355	PF00069	0.615
MOD_Plk_1	383	389	PF00069	0.570
MOD_Plk_1	432	438	PF00069	0.605
MOD_Plk_1	669	675	PF00069	0.616
MOD_Plk_2-3	670	676	PF00069	0.593
MOD_Plk_4	130	136	PF00069	0.490
MOD_Plk_4	250	256	PF00069	0.411
MOD_Plk_4	304	310	PF00069	0.513
MOD_Plk_4	383	389	PF00069	0.591
MOD_Plk_4	41	47	PF00069	0.660
MOD_Plk_4	415	421	PF00069	0.540
MOD_Plk_4	506	512	PF00069	0.625
MOD_Plk_4	526	532	PF00069	0.632
MOD_Plk_4	620	626	PF00069	0.764
MOD_Plk_4	628	634	PF00069	0.594
MOD_Plk_4	649	655	PF00069	0.700
MOD_Plk_4	695	701	PF00069	0.716
MOD_Plk_4	711	717	PF00069	0.659
MOD_Plk_4	86	92	PF00069	0.544
MOD_ProDKin_1	185	191	PF00069	0.729
MOD_ProDKin_1	35	41	PF00069	0.691
MOD_ProDKin_1	562	568	PF00069	0.697
MOD_ProDKin_1	576	582	PF00069	0.647
MOD_ProDKin_1	590	596	PF00069	0.572
MOD_ProDKin_1	656	662	PF00069	0.683
MOD_ProDKin_1	677	683	PF00069	0.699
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.661
TRG_ENDOCYTIC_2	110	113	PF00928	0.492
TRG_ENDOCYTIC_2	126	129	PF00928	0.331
TRG_ENDOCYTIC_2	373	376	PF00928	0.650
TRG_ENDOCYTIC_2	387	390	PF00928	0.353
TRG_ENDOCYTIC_2	442	445	PF00928	0.576
TRG_ENDOCYTIC_2	61	64	PF00928	0.474
TRG_ENDOCYTIC_2	715	718	PF00928	0.660
TRG_ER_diArg_1	161	163	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB4	Leptomonas seymouri	43%	100%
A4HPC6	Leishmania braziliensis	71%	100%
A4ICG6	Leishmania infantum	99%	100%
E9AT37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1G1	Leishmania major	92%	100%