Protein-tyrosine phosphatase 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein-tyrosine phosphatase 1-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7XAX7_LEIDO

TriTrypDb:

LdBPK_362310.1 , LdCL_360028800 , LDHU3_36.3080

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAX7

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004725	protein tyrosine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	397	401	PF00656	0.277
CLV_C14_Caspase3-7	71	75	PF00656	0.477
CLV_NRD_NRD_1	201	203	PF00675	0.590
CLV_NRD_NRD_1	323	325	PF00675	0.329
CLV_NRD_NRD_1	454	456	PF00675	0.270
CLV_NRD_NRD_1	460	462	PF00675	0.271
CLV_NRD_NRD_1	489	491	PF00675	0.527
CLV_PCSK_KEX2_1	201	203	PF00082	0.596
CLV_PCSK_KEX2_1	323	325	PF00082	0.314
CLV_PCSK_KEX2_1	454	456	PF00082	0.314
CLV_PCSK_KEX2_1	83	85	PF00082	0.548
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.391
CLV_PCSK_SKI1_1	180	184	PF00082	0.470
CLV_PCSK_SKI1_1	455	459	PF00082	0.308
CLV_PCSK_SKI1_1	513	517	PF00082	0.447
CLV_PCSK_SKI1_1	519	523	PF00082	0.426
CLV_Separin_Metazoa	320	324	PF03568	0.314
DOC_CYCLIN_yCln2_LP_2	415	421	PF00134	0.314
DOC_MAPK_MEF2A_6	414	421	PF00069	0.270
DOC_MAPK_MEF2A_6	470	479	PF00069	0.266
DOC_MAPK_RevD_3	475	491	PF00069	0.362
DOC_PP2B_LxvP_1	415	418	PF13499	0.314
DOC_USP7_MATH_1	178	182	PF00917	0.518
DOC_USP7_MATH_1	26	30	PF00917	0.600
DOC_USP7_MATH_1	288	292	PF00917	0.270
DOC_USP7_MATH_1	388	392	PF00917	0.295
DOC_USP7_MATH_1	394	398	PF00917	0.244
DOC_USP7_MATH_1	79	83	PF00917	0.506
DOC_WW_Pin1_4	165	170	PF00397	0.608
DOC_WW_Pin1_4	174	179	PF00397	0.496
DOC_WW_Pin1_4	37	42	PF00397	0.747
DOC_WW_Pin1_4	413	418	PF00397	0.314
LIG_14-3-3_CanoR_1	150	155	PF00244	0.505
LIG_14-3-3_CanoR_1	20	25	PF00244	0.592
LIG_14-3-3_CanoR_1	490	498	PF00244	0.423
LIG_AP_GAE_1	105	111	PF02883	0.404
LIG_APCC_ABBA_1	303	308	PF00400	0.266
LIG_BIR_II_1	1	5	PF00653	0.594
LIG_CtBP_PxDLS_1	169	173	PF00389	0.604
LIG_FHA_1	216	222	PF00498	0.726
LIG_FHA_1	265	271	PF00498	0.438
LIG_FHA_1	316	322	PF00498	0.268
LIG_FHA_1	414	420	PF00498	0.367
LIG_FHA_1	428	434	PF00498	0.199
LIG_FHA_1	68	74	PF00498	0.563
LIG_FHA_2	235	241	PF00498	0.277
LIG_FHA_2	271	277	PF00498	0.266
LIG_FHA_2	404	410	PF00498	0.268
LIG_LIR_Gen_1	255	262	PF02991	0.314
LIG_LIR_Gen_1	358	368	PF02991	0.266
LIG_LIR_Gen_1	370	377	PF02991	0.266
LIG_LIR_Gen_1	472	482	PF02991	0.283
LIG_LIR_Gen_1	98	109	PF02991	0.348
LIG_LIR_Nem_3	105	111	PF02991	0.353
LIG_LIR_Nem_3	255	260	PF02991	0.480
LIG_LIR_Nem_3	358	364	PF02991	0.266
LIG_LIR_Nem_3	370	374	PF02991	0.266
LIG_LIR_Nem_3	472	477	PF02991	0.283
LIG_LIR_Nem_3	89	93	PF02991	0.411
LIG_LIR_Nem_3	98	104	PF02991	0.314
LIG_NRP_CendR_1	522	523	PF00754	0.492
LIG_PCNA_PIPBox_1	251	260	PF02747	0.314
LIG_PTB_Apo_2	84	91	PF02174	0.386
LIG_SH2_CRK	344	348	PF00017	0.314
LIG_SH2_CRK	371	375	PF00017	0.214
LIG_SH2_CRK	437	441	PF00017	0.323
LIG_SH2_CRK	474	478	PF00017	0.266
LIG_SH2_CRK	93	97	PF00017	0.395
LIG_SH2_GRB2like	135	138	PF00017	0.392
LIG_SH2_GRB2like	229	232	PF00017	0.266
LIG_SH2_NCK_1	371	375	PF00017	0.214
LIG_SH2_PTP2	135	138	PF00017	0.392
LIG_SH2_PTP2	327	330	PF00017	0.314
LIG_SH2_SRC	135	138	PF00017	0.413
LIG_SH2_SRC	229	232	PF00017	0.314
LIG_SH2_SRC	344	347	PF00017	0.314
LIG_SH2_STAP1	262	266	PF00017	0.413
LIG_SH2_STAP1	313	317	PF00017	0.266
LIG_SH2_STAT5	135	138	PF00017	0.396
LIG_SH2_STAT5	229	232	PF00017	0.325
LIG_SH2_STAT5	313	316	PF00017	0.266
LIG_SH2_STAT5	327	330	PF00017	0.266
LIG_SH2_STAT5	346	349	PF00017	0.165
LIG_SH2_STAT5	437	440	PF00017	0.266
LIG_SH2_STAT5	59	62	PF00017	0.527
LIG_SH3_3	319	325	PF00018	0.323
LIG_SH3_3	344	350	PF00018	0.314
LIG_SH3_3	379	385	PF00018	0.277
LIG_SH3_3	5	11	PF00018	0.554
LIG_SUMO_SIM_anti_2	255	263	PF11976	0.314
LIG_SUMO_SIM_anti_2	265	270	PF11976	0.236
LIG_SUMO_SIM_par_1	267	274	PF11976	0.270
LIG_TRAF2_1	140	143	PF00917	0.354
LIG_TRAF2_1	249	252	PF00917	0.314
LIG_TRAF2_1	360	363	PF00917	0.266
LIG_TRAF2_1	96	99	PF00917	0.468
LIG_TYR_ITIM	342	347	PF00017	0.314
MOD_CDC14_SPxK_1	177	180	PF00782	0.507
MOD_CDK_SPxK_1	174	180	PF00069	0.544
MOD_CK1_1	15	21	PF00069	0.592
MOD_CK1_1	161	167	PF00069	0.580
MOD_CK1_1	168	174	PF00069	0.533
MOD_CK1_1	181	187	PF00069	0.350
MOD_CK1_1	29	35	PF00069	0.524
MOD_CK1_1	299	305	PF00069	0.277
MOD_CK1_1	331	337	PF00069	0.314
MOD_CK1_1	357	363	PF00069	0.267
MOD_CK1_1	392	398	PF00069	0.276
MOD_CK1_1	6	12	PF00069	0.535
MOD_CK1_1	69	75	PF00069	0.567
MOD_CK2_1	18	24	PF00069	0.608
MOD_CK2_1	234	240	PF00069	0.277
MOD_CK2_1	270	276	PF00069	0.266
MOD_CK2_1	357	363	PF00069	0.297
MOD_CK2_1	79	85	PF00069	0.464
MOD_GlcNHglycan	152	155	PF01048	0.515
MOD_GlcNHglycan	289	293	PF01048	0.277
MOD_GlcNHglycan	31	34	PF01048	0.646
MOD_GlcNHglycan	330	333	PF01048	0.295
MOD_GlcNHglycan	386	389	PF01048	0.300
MOD_GlcNHglycan	396	399	PF01048	0.216
MOD_GlcNHglycan	423	426	PF01048	0.246
MOD_GlcNHglycan	48	51	PF01048	0.683
MOD_GlcNHglycan	492	495	PF01048	0.420
MOD_GlcNHglycan	55	58	PF01048	0.622
MOD_GSK3_1	12	19	PF00069	0.600
MOD_GSK3_1	146	153	PF00069	0.554
MOD_GSK3_1	155	162	PF00069	0.547
MOD_GSK3_1	174	181	PF00069	0.551
MOD_GSK3_1	260	267	PF00069	0.307
MOD_GSK3_1	29	36	PF00069	0.487
MOD_GSK3_1	311	318	PF00069	0.268
MOD_GSK3_1	37	44	PF00069	0.660
MOD_GSK3_1	384	391	PF00069	0.422
MOD_GSK3_1	399	406	PF00069	0.224
MOD_GSK3_1	486	493	PF00069	0.308
MOD_GSK3_1	53	60	PF00069	0.509
MOD_N-GLC_1	15	20	PF02516	0.608
MOD_N-GLC_1	403	408	PF02516	0.250
MOD_N-GLC_1	449	454	PF02516	0.318
MOD_NEK2_1	123	128	PF00069	0.380
MOD_NEK2_1	163	168	PF00069	0.647
MOD_NEK2_1	197	202	PF00069	0.470
MOD_NEK2_1	243	248	PF00069	0.261
MOD_NEK2_1	448	453	PF00069	0.317
MOD_NEK2_1	66	71	PF00069	0.532
MOD_PIKK_1	243	249	PF00454	0.266
MOD_PIKK_1	331	337	PF00454	0.295
MOD_PIKK_1	43	49	PF00454	0.605
MOD_PKA_1	490	496	PF00069	0.505
MOD_PKA_2	149	155	PF00069	0.472
MOD_PKA_2	19	25	PF00069	0.522
MOD_PKA_2	328	334	PF00069	0.282
MOD_PKA_2	9	15	PF00069	0.556
MOD_Plk_1	111	117	PF00069	0.382
MOD_Plk_1	141	147	PF00069	0.350
MOD_Plk_1	235	241	PF00069	0.473
MOD_Plk_1	26	32	PF00069	0.581
MOD_Plk_1	264	270	PF00069	0.314
MOD_Plk_1	3	9	PF00069	0.591
MOD_Plk_1	449	455	PF00069	0.333
MOD_Plk_2-3	311	317	PF00069	0.241
MOD_Plk_4	141	147	PF00069	0.397
MOD_Plk_4	26	32	PF00069	0.503
MOD_Plk_4	264	270	PF00069	0.299
MOD_Plk_4	429	435	PF00069	0.266
MOD_Plk_4	9	15	PF00069	0.550
MOD_ProDKin_1	165	171	PF00069	0.606
MOD_ProDKin_1	174	180	PF00069	0.488
MOD_ProDKin_1	37	43	PF00069	0.748
MOD_ProDKin_1	413	419	PF00069	0.314
TRG_DiLeu_BaEn_1	99	104	PF01217	0.341
TRG_DiLeu_BaEn_2	275	281	PF01217	0.314
TRG_DiLeu_BaEn_2	471	477	PF01217	0.266
TRG_DiLeu_BaEn_3	362	368	PF01217	0.266
TRG_ENDOCYTIC_2	135	138	PF00928	0.398
TRG_ENDOCYTIC_2	344	347	PF00928	0.314
TRG_ENDOCYTIC_2	371	374	PF00928	0.214
TRG_ENDOCYTIC_2	437	440	PF00928	0.323
TRG_ENDOCYTIC_2	474	477	PF00928	0.266
TRG_ENDOCYTIC_2	478	481	PF00928	0.266
TRG_ER_diArg_1	322	324	PF00400	0.314
TRG_ER_diArg_1	453	455	PF00400	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN6	Leptomonas seymouri	49%	100%
A4HP87	Leishmania braziliensis	73%	99%
A4IDJ2	Leishmania infantum	100%	100%
E9ASZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
P34138	Dictyostelium discoideum	25%	100%
Q4Q1K3	Leishmania major	90%	100%