Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAX1_LEIDO

TriTrypDb:

LdBPK_362620.1 , LdCL_360032200 , LDHU3_36.3580

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	483	487	PF00656	0.580
CLV_NRD_NRD_1	391	393	PF00675	0.465
CLV_PCSK_KEX2_1	143	145	PF00082	0.672
CLV_PCSK_KEX2_1	391	393	PF00082	0.465
CLV_PCSK_KEX2_1	405	407	PF00082	0.384
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.672
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.514
CLV_PCSK_SKI1_1	261	265	PF00082	0.507
DEG_SCF_FBW7_1	62	68	PF00400	0.696
DEG_SPOP_SBC_1	151	155	PF00917	0.680
DEG_SPOP_SBC_1	315	319	PF00917	0.617
DOC_CKS1_1	28	33	PF01111	0.674
DOC_CKS1_1	439	444	PF01111	0.429
DOC_CKS1_1	59	64	PF01111	0.699
DOC_CYCLIN_RxL_1	258	266	PF00134	0.412
DOC_CYCLIN_yClb5_NLxxxL_5	264	273	PF00134	0.453
DOC_MAPK_MEF2A_6	433	440	PF00069	0.570
DOC_MAPK_NFAT4_5	433	441	PF00069	0.481
DOC_PP1_RVXF_1	51	58	PF00149	0.644
DOC_PP2B_LxvP_1	205	208	PF13499	0.597
DOC_PP2B_LxvP_1	485	488	PF13499	0.634
DOC_SPAK_OSR1_1	386	390	PF12202	0.475
DOC_USP7_MATH_1	142	146	PF00917	0.738
DOC_USP7_MATH_1	151	155	PF00917	0.643
DOC_USP7_MATH_1	308	312	PF00917	0.603
DOC_USP7_MATH_1	467	471	PF00917	0.620
DOC_USP7_MATH_1	480	484	PF00917	0.554
DOC_USP7_MATH_1	488	492	PF00917	0.623
DOC_USP7_MATH_1	78	82	PF00917	0.652
DOC_WW_Pin1_4	174	179	PF00397	0.613
DOC_WW_Pin1_4	24	29	PF00397	0.664
DOC_WW_Pin1_4	438	443	PF00397	0.444
DOC_WW_Pin1_4	446	451	PF00397	0.521
DOC_WW_Pin1_4	55	60	PF00397	0.692
DOC_WW_Pin1_4	61	66	PF00397	0.642
LIG_14-3-3_CanoR_1	134	139	PF00244	0.699
LIG_14-3-3_CanoR_1	245	253	PF00244	0.473
LIG_14-3-3_CanoR_1	386	390	PF00244	0.540
LIG_14-3-3_CanoR_1	391	397	PF00244	0.484
LIG_BIR_III_4	160	164	PF00653	0.641
LIG_BRCT_BRCA1_1	209	213	PF00533	0.592
LIG_BRCT_BRCA1_1	383	387	PF00533	0.455
LIG_CaM_IQ_9	378	394	PF13499	0.461
LIG_FHA_1	175	181	PF00498	0.716
LIG_FHA_1	222	228	PF00498	0.463
LIG_FHA_1	291	297	PF00498	0.438
LIG_FHA_1	409	415	PF00498	0.458
LIG_FHA_1	439	445	PF00498	0.502
LIG_FHA_1	62	68	PF00498	0.645
LIG_FHA_2	215	221	PF00498	0.547
LIG_FHA_2	453	459	PF00498	0.528
LIG_FHA_2	83	89	PF00498	0.666
LIG_IRF3_LxIS_1	348	353	PF10401	0.431
LIG_LIR_Gen_1	232	241	PF02991	0.459
LIG_LIR_Gen_1	281	291	PF02991	0.401
LIG_LIR_Gen_1	30	41	PF02991	0.640
LIG_LIR_Gen_1	424	431	PF02991	0.460
LIG_LIR_LC3C_4	458	462	PF02991	0.488
LIG_LIR_Nem_3	110	116	PF02991	0.707
LIG_LIR_Nem_3	232	237	PF02991	0.455
LIG_LIR_Nem_3	257	263	PF02991	0.453
LIG_LIR_Nem_3	279	285	PF02991	0.459
LIG_LIR_Nem_3	30	36	PF02991	0.641
LIG_LIR_Nem_3	399	404	PF02991	0.506
LIG_LIR_Nem_3	424	429	PF02991	0.459
LIG_PTB_Apo_2	324	331	PF02174	0.610
LIG_PTB_Phospho_1	324	330	PF10480	0.614
LIG_SH2_STAP1	283	287	PF00017	0.406
LIG_SH2_STAP1	300	304	PF00017	0.348
LIG_SH2_STAT3	300	303	PF00017	0.466
LIG_SH2_STAT5	234	237	PF00017	0.610
LIG_SH2_STAT5	300	303	PF00017	0.466
LIG_SH2_STAT5	330	333	PF00017	0.675
LIG_SH3_2	139	144	PF14604	0.655
LIG_SH3_3	106	112	PF00018	0.792
LIG_SH3_3	136	142	PF00018	0.654
LIG_SH3_3	209	215	PF00018	0.615
LIG_SH3_3	25	31	PF00018	0.665
LIG_SH3_3	256	262	PF00018	0.456
LIG_SH3_3	414	420	PF00018	0.482
LIG_SH3_3	436	442	PF00018	0.450
LIG_SH3_3	459	465	PF00018	0.479
LIG_SH3_3	56	62	PF00018	0.715
LIG_SUMO_SIM_anti_2	226	233	PF11976	0.478
LIG_SUMO_SIM_anti_2	236	242	PF11976	0.360
LIG_SUMO_SIM_anti_2	458	463	PF11976	0.481
LIG_SUMO_SIM_par_1	226	233	PF11976	0.419
LIG_SUMO_SIM_par_1	261	266	PF11976	0.463
LIG_SUMO_SIM_par_1	410	416	PF11976	0.460
LIG_SUMO_SIM_par_1	458	463	PF11976	0.481
LIG_SUMO_SIM_par_1	63	71	PF11976	0.600
MOD_CK1_1	103	109	PF00069	0.780
MOD_CK1_1	145	151	PF00069	0.694
MOD_CK1_1	153	159	PF00069	0.624
MOD_CK1_1	176	182	PF00069	0.701
MOD_CK1_1	226	232	PF00069	0.473
MOD_CK1_1	27	33	PF00069	0.672
MOD_CK1_1	311	317	PF00069	0.611
MOD_CK1_1	353	359	PF00069	0.538
MOD_CK1_1	449	455	PF00069	0.523
MOD_CK1_1	470	476	PF00069	0.656
MOD_CK1_1	58	64	PF00069	0.753
MOD_CK2_1	329	335	PF00069	0.635
MOD_CK2_1	65	71	PF00069	0.726
MOD_CK2_1	78	84	PF00069	0.597
MOD_GlcNHglycan	102	106	PF01048	0.669
MOD_GlcNHglycan	182	185	PF01048	0.619
MOD_GlcNHglycan	209	212	PF01048	0.616
MOD_GlcNHglycan	248	251	PF01048	0.451
MOD_GlcNHglycan	308	311	PF01048	0.730
MOD_GlcNHglycan	318	321	PF01048	0.667
MOD_GlcNHglycan	322	325	PF01048	0.612
MOD_GlcNHglycan	352	355	PF01048	0.458
MOD_GlcNHglycan	398	401	PF01048	0.474
MOD_GlcNHglycan	477	480	PF01048	0.593
MOD_GSK3_1	101	108	PF00069	0.753
MOD_GSK3_1	142	149	PF00069	0.767
MOD_GSK3_1	172	179	PF00069	0.746
MOD_GSK3_1	226	233	PF00069	0.463
MOD_GSK3_1	311	318	PF00069	0.741
MOD_GSK3_1	353	360	PF00069	0.545
MOD_GSK3_1	381	388	PF00069	0.581
MOD_GSK3_1	392	399	PF00069	0.357
MOD_GSK3_1	40	47	PF00069	0.640
MOD_GSK3_1	467	474	PF00069	0.644
MOD_GSK3_1	61	68	PF00069	0.695
MOD_GSK3_1	78	85	PF00069	0.538
MOD_LATS_1	390	396	PF00433	0.452
MOD_N-GLC_1	246	251	PF02516	0.446
MOD_N-GLC_1	374	379	PF02516	0.610
MOD_N-GLC_1	47	52	PF02516	0.571
MOD_N-GLC_1	481	486	PF02516	0.678
MOD_NEK2_1	165	170	PF00069	0.632
MOD_NEK2_1	180	185	PF00069	0.616
MOD_NEK2_1	230	235	PF00069	0.462
MOD_NEK2_1	263	268	PF00069	0.527
MOD_NEK2_1	350	355	PF00069	0.454
MOD_NEK2_1	357	362	PF00069	0.575
MOD_NEK2_1	369	374	PF00069	0.406
MOD_NEK2_1	381	386	PF00069	0.401
MOD_NEK2_1	396	401	PF00069	0.306
MOD_NEK2_1	460	465	PF00069	0.470
MOD_NEK2_1	471	476	PF00069	0.562
MOD_NEK2_1	72	77	PF00069	0.678
MOD_NEK2_2	385	390	PF00069	0.467
MOD_NEK2_2	400	405	PF00069	0.366
MOD_PIKK_1	13	19	PF00454	0.659
MOD_PIKK_1	449	455	PF00454	0.523
MOD_PKA_2	133	139	PF00069	0.656
MOD_PKA_2	311	317	PF00069	0.654
MOD_PKA_2	385	391	PF00069	0.535
MOD_PKA_2	44	50	PF00069	0.625
MOD_PKA_2	72	78	PF00069	0.655
MOD_Plk_1	334	340	PF00069	0.616
MOD_Plk_1	374	380	PF00069	0.482
MOD_Plk_1	481	487	PF00069	0.633
MOD_Plk_1	78	84	PF00069	0.578
MOD_Plk_2-3	334	340	PF00069	0.616
MOD_Plk_4	223	229	PF00069	0.494
MOD_Plk_4	236	242	PF00069	0.344
MOD_Plk_4	467	473	PF00069	0.571
MOD_ProDKin_1	174	180	PF00069	0.616
MOD_ProDKin_1	24	30	PF00069	0.665
MOD_ProDKin_1	438	444	PF00069	0.454
MOD_ProDKin_1	446	452	PF00069	0.509
MOD_ProDKin_1	55	61	PF00069	0.692
MOD_SUMO_rev_2	22	28	PF00179	0.659
MOD_SUMO_rev_2	37	43	PF00179	0.545
TRG_DiLeu_BaEn_1	456	461	PF01217	0.520
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.439
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.369
TRG_ENDOCYTIC_2	234	237	PF00928	0.468
TRG_ENDOCYTIC_2	282	285	PF00928	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HPB5	Leishmania braziliensis	74%	100%
A4ICF5	Leishmania infantum	100%	100%
E9AT26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1H2	Leishmania major	92%	100%