Serine/threonine protein kinase, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAX0_LEIDO

TriTrypDb:

LdBPK_362420.1 , LdCL_360029900 , LDHU3_36.3220

Length:

476

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005952	cAMP-dependent protein kinase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1

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Expansion

Sequence features

A0A3S7XAX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAX0

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	23
GO:0006793	phosphorus metabolic process	3	23
GO:0006796	phosphate-containing compound metabolic process	4	23
GO:0006807	nitrogen compound metabolic process	2	23
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	23
GO:0009987	cellular process	1	23
GO:0016310	phosphorylation	5	23
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	23
GO:0003824	catalytic activity	1	23
GO:0004672	protein kinase activity	3	23
GO:0004674	protein serine/threonine kinase activity	4	22
GO:0004690	cyclic nucleotide-dependent protein kinase activity	5	1
GO:0004691	cAMP-dependent protein kinase activity	6	1
GO:0005488	binding	1	23
GO:0005524	ATP binding	5	23
GO:0016301	kinase activity	4	23
GO:0016740	transferase activity	2	23

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.434
CLV_NRD_NRD_1	210	212	PF00675	0.383
CLV_NRD_NRD_1	215	217	PF00675	0.352
CLV_NRD_NRD_1	392	394	PF00675	0.396
CLV_NRD_NRD_1	418	420	PF00675	0.561
CLV_PCSK_FUR_1	122	126	PF00082	0.428
CLV_PCSK_KEX2_1	124	126	PF00082	0.434
CLV_PCSK_KEX2_1	210	212	PF00082	0.316
CLV_PCSK_KEX2_1	214	216	PF00082	0.277
CLV_PCSK_KEX2_1	392	394	PF00082	0.419

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9A0	Leptomonas seymouri	27%	73%
A0A0S4JI45	Bodo saltans	25%	73%
A0A1X0NIX2	Trypanosomatidae	37%	100%
A0A1X0NUB2	Trypanosomatidae	30%	82%
A0A3Q8IAQ1	Leishmania donovani	41%	100%
A0A3Q8IB30	Leishmania donovani	33%	100%
A0A3Q8IC87	Leishmania donovani	29%	100%
A0A3Q8IFK8	Leishmania donovani	39%	100%
A0A3S7X9R4	Leishmania donovani	26%	100%
A0A3S7X9S2	Leishmania donovani	26%	100%

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