Serine/threonine protein kinase, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAX0_LEIDO

TriTrypDb:

LdBPK_362420.1 , LdCL_360029900 , LDHU3_36.3220

Length:

476

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005952	cAMP-dependent protein kinase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3S7XAX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAX0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	23
GO:0006793	phosphorus metabolic process	3	23
GO:0006796	phosphate-containing compound metabolic process	4	23
GO:0006807	nitrogen compound metabolic process	2	23
GO:0008152	metabolic process	1	23
GO:0009987	cellular process	1	23
GO:0016310	phosphorylation	5	23
GO:0019538	protein metabolic process	3	23
GO:0036211	protein modification process	4	23
GO:0043170	macromolecule metabolic process	3	23
GO:0043412	macromolecule modification	4	23
GO:0044237	cellular metabolic process	2	23
GO:0044238	primary metabolic process	2	23
GO:0071704	organic substance metabolic process	2	23
GO:1901564	organonitrogen compound metabolic process	3	23
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	23
GO:0003824	catalytic activity	1	23
GO:0004672	protein kinase activity	3	23
GO:0004674	protein serine/threonine kinase activity	4	22
GO:0005488	binding	1	23
GO:0005524	ATP binding	5	23
GO:0016301	kinase activity	4	23
GO:0016740	transferase activity	2	23
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	23
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	23
GO:0017076	purine nucleotide binding	4	23
GO:0030554	adenyl nucleotide binding	5	23
GO:0032553	ribonucleotide binding	3	23
GO:0032555	purine ribonucleotide binding	4	23
GO:0032559	adenyl ribonucleotide binding	5	23
GO:0035639	purine ribonucleoside triphosphate binding	4	23
GO:0036094	small molecule binding	2	23
GO:0043167	ion binding	2	23
GO:0043168	anion binding	3	23
GO:0097159	organic cyclic compound binding	2	23
GO:0097367	carbohydrate derivative binding	2	23
GO:0140096	catalytic activity, acting on a protein	2	23
GO:1901265	nucleoside phosphate binding	3	23
GO:1901363	heterocyclic compound binding	2	23
GO:0004690	cyclic nucleotide-dependent protein kinase activity	5	1
GO:0004691	cAMP-dependent protein kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.434
CLV_NRD_NRD_1	210	212	PF00675	0.383
CLV_NRD_NRD_1	215	217	PF00675	0.352
CLV_NRD_NRD_1	392	394	PF00675	0.396
CLV_NRD_NRD_1	418	420	PF00675	0.561
CLV_PCSK_FUR_1	122	126	PF00082	0.428
CLV_PCSK_KEX2_1	124	126	PF00082	0.434
CLV_PCSK_KEX2_1	210	212	PF00082	0.316
CLV_PCSK_KEX2_1	214	216	PF00082	0.277
CLV_PCSK_KEX2_1	392	394	PF00082	0.419
CLV_PCSK_KEX2_1	418	420	PF00082	0.556
CLV_PCSK_PC7_1	120	126	PF00082	0.438
CLV_PCSK_PC7_1	210	216	PF00082	0.295
CLV_PCSK_SKI1_1	375	379	PF00082	0.292
DEG_APCC_DBOX_1	100	108	PF00400	0.276
DEG_APCC_DBOX_1	384	392	PF00400	0.470
DEG_Nend_UBRbox_1	1	4	PF02207	0.451
DOC_CYCLIN_yClb3_PxF_3	162	168	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.289
DOC_PP4_FxxP_1	7	10	PF00568	0.360
DOC_USP7_MATH_1	21	25	PF00917	0.634
DOC_USP7_MATH_1	34	38	PF00917	0.589
DOC_USP7_MATH_1	428	432	PF00917	0.505
DOC_WW_Pin1_4	144	149	PF00397	0.510
DOC_WW_Pin1_4	177	182	PF00397	0.211
DOC_WW_Pin1_4	218	223	PF00397	0.281
DOC_WW_Pin1_4	288	293	PF00397	0.323
DOC_WW_Pin1_4	464	469	PF00397	0.591
LIG_14-3-3_CanoR_1	283	292	PF00244	0.268
LIG_14-3-3_CanoR_1	304	308	PF00244	0.281
LIG_14-3-3_CanoR_1	392	401	PF00244	0.413
LIG_14-3-3_CanoR_1	471	476	PF00244	0.469
LIG_Clathr_ClatBox_1	198	202	PF01394	0.361
LIG_Clathr_ClatBox_1	363	367	PF01394	0.343
LIG_CtBP_PxDLS_1	463	467	PF00389	0.476
LIG_eIF4E_1	90	96	PF01652	0.418
LIG_FHA_1	224	230	PF00498	0.211
LIG_FHA_1	260	266	PF00498	0.291
LIG_FHA_1	372	378	PF00498	0.283
LIG_FHA_1	470	476	PF00498	0.573
LIG_FHA_2	222	228	PF00498	0.291
LIG_FHA_2	31	37	PF00498	0.616
LIG_FHA_2	330	336	PF00498	0.225
LIG_Integrin_RGD_1	301	303	PF01839	0.211
LIG_IRF3_LxIS_1	66	71	PF10401	0.433
LIG_LIR_Apic_2	291	297	PF02991	0.311
LIG_LIR_Apic_2	5	10	PF02991	0.363
LIG_LIR_Gen_1	227	238	PF02991	0.301
LIG_LIR_Gen_1	342	352	PF02991	0.209
LIG_LIR_Gen_1	358	368	PF02991	0.291
LIG_LIR_Gen_1	408	417	PF02991	0.404
LIG_LIR_Nem_3	110	114	PF02991	0.360
LIG_LIR_Nem_3	143	149	PF02991	0.456
LIG_LIR_Nem_3	227	233	PF02991	0.303
LIG_LIR_Nem_3	342	348	PF02991	0.275
LIG_LIR_Nem_3	358	364	PF02991	0.239
LIG_LIR_Nem_3	408	413	PF02991	0.470
LIG_MYND_1	162	166	PF01753	0.398
LIG_MYND_1	51	55	PF01753	0.505
LIG_NRBOX	317	323	PF00104	0.239
LIG_PDZ_Class_1	471	476	PF00595	0.469
LIG_Pex14_2	432	436	PF04695	0.488
LIG_SH2_CRK	111	115	PF00017	0.380
LIG_SH2_CRK	345	349	PF00017	0.211
LIG_SH2_CRK	361	365	PF00017	0.211
LIG_SH2_CRK	90	94	PF00017	0.331
LIG_SH2_GRB2like	352	355	PF00017	0.211
LIG_SH2_NCK_1	111	115	PF00017	0.380
LIG_SH2_SRC	111	114	PF00017	0.362
LIG_SH2_STAP1	319	323	PF00017	0.371
LIG_SH2_STAP1	352	356	PF00017	0.343
LIG_SH2_STAT5	203	206	PF00017	0.460
LIG_SH2_STAT5	294	297	PF00017	0.305
LIG_SH2_STAT5	383	386	PF00017	0.398
LIG_SH2_STAT5	94	97	PF00017	0.309
LIG_SH3_3	156	162	PF00018	0.501
LIG_SH3_3	457	463	PF00018	0.536
LIG_SH3_3	49	55	PF00018	0.624
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.248
LIG_SUMO_SIM_par_1	320	325	PF11976	0.211
LIG_SUMO_SIM_par_1	362	367	PF11976	0.354
LIG_TRAF2_1	402	405	PF00917	0.321
LIG_TRFH_1	293	297	PF08558	0.284
LIG_TYR_ITIM	317	322	PF00017	0.367
LIG_TYR_ITIM	359	364	PF00017	0.211
MOD_CDK_SPxxK_3	464	471	PF00069	0.496
MOD_CK1_1	134	140	PF00069	0.493
MOD_CK1_1	306	312	PF00069	0.315
MOD_CK1_1	395	401	PF00069	0.409
MOD_CK1_1	5	11	PF00069	0.384
MOD_CK1_1	69	75	PF00069	0.541
MOD_CK2_1	221	227	PF00069	0.291
MOD_CK2_1	30	36	PF00069	0.523
MOD_CK2_1	329	335	PF00069	0.222
MOD_CK2_1	399	405	PF00069	0.425
MOD_GlcNHglycan	136	139	PF01048	0.551
MOD_GlcNHglycan	413	416	PF01048	0.299
MOD_GlcNHglycan	422	425	PF01048	0.528
MOD_GlcNHglycan	448	451	PF01048	0.754
MOD_GSK3_1	26	33	PF00069	0.577
MOD_GSK3_1	284	291	PF00069	0.301
MOD_GSK3_1	395	402	PF00069	0.420
MOD_GSK3_1	405	412	PF00069	0.357
MOD_GSK3_1	42	49	PF00069	0.547
MOD_GSK3_1	436	443	PF00069	0.653
MOD_GSK3_1	5	12	PF00069	0.513
MOD_GSK3_1	66	73	PF00069	0.534
MOD_N-GLC_1	399	404	PF02516	0.344
MOD_NEK2_1	258	263	PF00069	0.302
MOD_NEK2_1	322	327	PF00069	0.266
MOD_NEK2_1	409	414	PF00069	0.499
MOD_NEK2_1	68	73	PF00069	0.490
MOD_NEK2_2	436	441	PF00069	0.616
MOD_PIKK_1	278	284	PF00454	0.319
MOD_PK_1	2	8	PF00069	0.388
MOD_PKA_1	392	398	PF00069	0.315
MOD_PKA_2	303	309	PF00069	0.264
MOD_PKA_2	370	376	PF00069	0.257
MOD_PKA_2	392	398	PF00069	0.400
MOD_Plk_1	395	401	PF00069	0.324
MOD_Plk_1	66	72	PF00069	0.584
MOD_Plk_4	2	8	PF00069	0.388
MOD_Plk_4	405	411	PF00069	0.319
MOD_Plk_4	9	15	PF00069	0.399
MOD_ProDKin_1	144	150	PF00069	0.510
MOD_ProDKin_1	177	183	PF00069	0.211
MOD_ProDKin_1	218	224	PF00069	0.281
MOD_ProDKin_1	288	294	PF00069	0.323
MOD_ProDKin_1	464	470	PF00069	0.590
MOD_SUMO_for_1	252	255	PF00179	0.289
MOD_SUMO_for_1	307	310	PF00179	0.211
MOD_SUMO_rev_2	398	408	PF00179	0.347
TRG_DiLeu_BaEn_1	196	201	PF01217	0.264
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.435
TRG_ENDOCYTIC_2	111	114	PF00928	0.390
TRG_ENDOCYTIC_2	319	322	PF00928	0.371
TRG_ENDOCYTIC_2	345	348	PF00928	0.238
TRG_ENDOCYTIC_2	361	364	PF00928	0.211
TRG_ENDOCYTIC_2	90	93	PF00928	0.342
TRG_ER_diArg_1	122	125	PF00400	0.429
TRG_ER_diArg_1	209	211	PF00400	0.316
TRG_ER_diArg_1	213	216	PF00400	0.277
TRG_ER_diArg_1	391	393	PF00400	0.403
TRG_ER_diArg_1	417	419	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9A0	Leptomonas seymouri	27%	73%
A0A0S4JI45	Bodo saltans	25%	73%
A0A1X0NIX2	Trypanosomatidae	37%	100%
A0A1X0NUB2	Trypanosomatidae	30%	82%
A0A3Q8IAQ1	Leishmania donovani	41%	100%
A0A3Q8IB30	Leishmania donovani	33%	100%
A0A3Q8IC87	Leishmania donovani	29%	100%
A0A3Q8IFK8	Leishmania donovani	39%	100%
A0A3S7X9R4	Leishmania donovani	26%	100%
A0A3S7X9S2	Leishmania donovani	26%	100%
A0A422P4V9	Trypanosoma rangeli	25%	100%
A4H7V0	Leishmania braziliensis	24%	67%
A4H9L8	Leishmania braziliensis	33%	100%
A4HCD7	Leishmania braziliensis	28%	100%
A4HCE6	Leishmania braziliensis	37%	100%
A4HJT5	Leishmania braziliensis	39%	100%
A4HXY2	Leishmania infantum	33%	100%
A4HZV1	Leishmania infantum	29%	100%
A4HZW8	Leishmania infantum	41%	100%
A4I7A1	Leishmania infantum	39%	100%
A4IBT4	Leishmania infantum	26%	100%
A4IBT9	Leishmania infantum	26%	100%
A4IDK3	Leishmania infantum	99%	100%
A5GFW1	Sus scrofa	26%	100%
C6K3W8	Leptomonas seymouri	26%	90%
C9ZTU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	87%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A7M4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	69%
D0AA64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	83%
E9AFM1	Leishmania major	27%	100%
E9APX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	67%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AT06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O14965	Homo sapiens	26%	100%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P51817	Homo sapiens	27%	100%
P92958	Arabidopsis thaliana	28%	93%
Q27687	Leishmania major	33%	100%
Q2TA06	Bos taurus	26%	100%
Q38868	Arabidopsis thaliana	29%	88%
Q4Q1J2	Leishmania major	93%	100%
Q4Q5W2	Leishmania major	40%	100%
Q4QBQ2	Leishmania major	40%	100%
Q4QFK4	Leishmania major	25%	76%
Q6FV07	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	26%	100%
Q6GPN6	Xenopus laevis	26%	100%
Q869W6	Dictyostelium discoideum	28%	100%
Q91819	Xenopus laevis	26%	100%
Q91820	Xenopus laevis	26%	100%
Q9SLI2	Arabidopsis thaliana	27%	78%
Q9SN43	Arabidopsis thaliana	27%	97%
V5AS81	Trypanosoma cruzi	24%	67%
V5B9Y9	Trypanosoma cruzi	24%	100%
V5DC40	Trypanosoma cruzi	23%	87%