Guanylate kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guanylate kinase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7XAW4_LEIDO

TriTrypDb:

LdBPK_362390.1 , LdCL_360029600 , LDHU3_36.3180

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAW4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0044237	cellular metabolic process	2	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0004385	guanylate kinase activity	6	2
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	2
GO:0019205	nucleobase-containing compound kinase activity	5	2
GO:0050145	nucleoside monophosphate kinase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.388
CLV_NRD_NRD_1	268	270	PF00675	0.333
CLV_NRD_NRD_1	39	41	PF00675	0.375
CLV_NRD_NRD_1	60	62	PF00675	0.476
CLV_NRD_NRD_1	82	84	PF00675	0.279
CLV_PCSK_KEX2_1	164	166	PF00082	0.329
CLV_PCSK_KEX2_1	39	41	PF00082	0.497
CLV_PCSK_KEX2_1	60	62	PF00082	0.367
CLV_PCSK_KEX2_1	82	84	PF00082	0.360
CLV_PCSK_SKI1_1	138	142	PF00082	0.449
CLV_PCSK_SKI1_1	149	153	PF00082	0.282
CLV_PCSK_SKI1_1	175	179	PF00082	0.371
CLV_Separin_Metazoa	316	320	PF03568	0.324
DEG_APCC_KENBOX_2	291	295	PF00400	0.262
DEG_SPOP_SBC_1	117	121	PF00917	0.400
DOC_MAPK_gen_1	245	254	PF00069	0.328
DOC_MAPK_gen_1	39	47	PF00069	0.435
DOC_MAPK_HePTP_8	242	254	PF00069	0.262
DOC_MAPK_HePTP_8	36	48	PF00069	0.456
DOC_MAPK_MEF2A_6	245	254	PF00069	0.298
DOC_MAPK_MEF2A_6	39	48	PF00069	0.396
DOC_PP2B_LxvP_1	114	117	PF13499	0.349
DOC_PP2B_LxvP_1	203	206	PF13499	0.468
DOC_PP4_FxxP_1	253	256	PF00568	0.388
DOC_PP4_FxxP_1	47	50	PF00568	0.294
DOC_USP7_MATH_1	11	15	PF00917	0.692
DOC_USP7_MATH_1	117	121	PF00917	0.420
DOC_USP7_MATH_1	16	20	PF00917	0.630
DOC_USP7_MATH_1	182	186	PF00917	0.415
DOC_USP7_MATH_1	209	213	PF00917	0.742
DOC_USP7_MATH_1	224	228	PF00917	0.744
DOC_USP7_MATH_1	50	54	PF00917	0.299
DOC_WW_Pin1_4	120	125	PF00397	0.478
DOC_WW_Pin1_4	232	237	PF00397	0.641
LIG_14-3-3_CanoR_1	175	180	PF00244	0.437
LIG_14-3-3_CanoR_1	207	212	PF00244	0.554
LIG_14-3-3_CanoR_1	269	277	PF00244	0.380
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BIR_III_2	192	196	PF00653	0.237
LIG_BRCT_BRCA1_1	233	237	PF00533	0.502
LIG_deltaCOP1_diTrp_1	65	72	PF00928	0.388
LIG_FHA_1	121	127	PF00498	0.340
LIG_FHA_1	153	159	PF00498	0.336
LIG_FHA_1	172	178	PF00498	0.498
LIG_FHA_1	242	248	PF00498	0.330
LIG_FHA_1	33	39	PF00498	0.618
LIG_FHA_2	269	275	PF00498	0.468
LIG_FHA_2	66	72	PF00498	0.324
LIG_FHA_2	93	99	PF00498	0.374
LIG_LIR_Apic_2	235	241	PF02991	0.538
LIG_LIR_Gen_1	110	117	PF02991	0.223
LIG_LIR_Gen_1	308	318	PF02991	0.449
LIG_LIR_Gen_1	97	105	PF02991	0.385
LIG_LIR_Nem_3	110	114	PF02991	0.234
LIG_LIR_Nem_3	296	301	PF02991	0.336
LIG_LIR_Nem_3	308	314	PF02991	0.314
LIG_LIR_Nem_3	65	69	PF02991	0.388
LIG_LIR_Nem_3	97	102	PF02991	0.364
LIG_PDZ_Class_1	324	329	PF00595	0.538
LIG_Pex14_1	66	70	PF04695	0.294
LIG_SH2_CRK	111	115	PF00017	0.294
LIG_SH2_CRK	238	242	PF00017	0.503
LIG_SH2_CRK	311	315	PF00017	0.425
LIG_SH2_STAT5	166	169	PF00017	0.294
LIG_SH2_STAT5	301	304	PF00017	0.380
LIG_SH2_STAT5	92	95	PF00017	0.324
LIG_SH3_3	2	8	PF00018	0.556
LIG_SH3_3	230	236	PF00018	0.603
LIG_SUMO_SIM_par_1	173	180	PF11976	0.344
LIG_SUMO_SIM_par_1	199	204	PF11976	0.668
LIG_SUMO_SIM_par_1	321	328	PF11976	0.547
LIG_TRAF2_1	95	98	PF00917	0.388
LIG_TYR_ITIM	109	114	PF00017	0.294
LIG_TYR_ITIM	309	314	PF00017	0.366
MOD_CK1_1	120	126	PF00069	0.375
MOD_CK1_1	227	233	PF00069	0.749
MOD_CK1_1	53	59	PF00069	0.303
MOD_CK1_1	75	81	PF00069	0.302
MOD_CK2_1	268	274	PF00069	0.373
MOD_CK2_1	65	71	PF00069	0.324
MOD_CK2_1	92	98	PF00069	0.388
MOD_CMANNOS	287	290	PF00535	0.273
MOD_GlcNHglycan	18	21	PF01048	0.588
MOD_GlcNHglycan	50	53	PF01048	0.298
MOD_GSK3_1	116	123	PF00069	0.376
MOD_GSK3_1	171	178	PF00069	0.373
MOD_GSK3_1	220	227	PF00069	0.790
MOD_GSK3_1	50	57	PF00069	0.262
MOD_GSK3_1	70	77	PF00069	0.347
MOD_N-GLC_1	293	298	PF02516	0.436
MOD_NEK2_1	133	138	PF00069	0.371
MOD_NEK2_1	201	206	PF00069	0.656
MOD_NEK2_1	32	37	PF00069	0.605
MOD_NEK2_1	324	329	PF00069	0.629
MOD_NEK2_1	70	75	PF00069	0.309
MOD_PIKK_1	177	183	PF00454	0.237
MOD_PK_1	207	213	PF00069	0.557
MOD_PKA_2	268	274	PF00069	0.323
MOD_Plk_1	109	115	PF00069	0.392
MOD_Plk_1	273	279	PF00069	0.326
MOD_Plk_1	293	299	PF00069	0.436
MOD_Plk_1	70	76	PF00069	0.374
MOD_Plk_2-3	268	274	PF00069	0.329
MOD_Plk_2-3	293	299	PF00069	0.374
MOD_Plk_2-3	65	71	PF00069	0.324
MOD_Plk_4	140	146	PF00069	0.449
MOD_Plk_4	196	202	PF00069	0.532
MOD_Plk_4	227	233	PF00069	0.629
MOD_Plk_4	293	299	PF00069	0.374
MOD_Plk_4	54	60	PF00069	0.294
MOD_Plk_4	65	71	PF00069	0.294
MOD_ProDKin_1	120	126	PF00069	0.478
MOD_ProDKin_1	232	238	PF00069	0.639
MOD_SUMO_rev_2	263	271	PF00179	0.388
TRG_DiLeu_BaEn_1	98	103	PF01217	0.388
TRG_ENDOCYTIC_2	111	114	PF00928	0.294
TRG_ENDOCYTIC_2	311	314	PF00928	0.372
TRG_ENDOCYTIC_2	91	94	PF00928	0.351
TRG_ER_diArg_1	147	150	PF00400	0.468
TRG_ER_diArg_1	163	165	PF00400	0.317
TRG_ER_diArg_1	38	40	PF00400	0.443
TRG_ER_diArg_1	59	61	PF00400	0.324
TRG_ER_diArg_1	81	83	PF00400	0.359
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I117	Leptomonas seymouri	51%	100%
A0A1X0P7T4	Trypanosomatidae	31%	100%
A0A3R7LXR6	Trypanosoma rangeli	30%	100%
A4HP95	Leishmania braziliensis	74%	100%
A4IDK0	Leishmania infantum	99%	100%
E9AT03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4Q1J5	Leishmania major	88%	100%