Transmembrane_emp24_domain-containing_protein/Gen eDB:LmjF.36.2150

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane emp24 domain-containing protein

Species:

Leishmania donovani

UniProt:

A0A3S7XAW3_LEIDO

TriTrypDb:

LdBPK_362280.1 , LdCL_360028500 , LDHU3_36.2970

Length:

268

Annotations

LeishMANIAdb annotations

Conserved eukaryotic protein. Probable receptor for ER-Golgi trafficking of GPI-anchored proteins. Related to metazoan Tmed10.. Localization: ER (by homology) / Golgi (by homology)

Annotations by Jardim et al.

Intracellular protein trafficking, COP-coated vesicle membrane erv25

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 0
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0005794	Golgi apparatus	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A0A3S7XAW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAW3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.470
CLV_NRD_NRD_1	15	17	PF00675	0.696
CLV_NRD_NRD_1	166	168	PF00675	0.620
CLV_NRD_NRD_1	262	264	PF00675	0.519
CLV_PCSK_KEX2_1	15	17	PF00082	0.730
CLV_PCSK_KEX2_1	165	167	PF00082	0.561
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.561
CLV_PCSK_SKI1_1	137	141	PF00082	0.562
CLV_PCSK_SKI1_1	185	189	PF00082	0.561
CLV_PCSK_SKI1_1	256	260	PF00082	0.365
DEG_APCC_DBOX_1	190	198	PF00400	0.422
DEG_MDM2_SWIB_1	233	241	PF02201	0.422
DOC_MAPK_DCC_7	15	23	PF00069	0.604
DOC_MAPK_gen_1	137	145	PF00069	0.362
DOC_MAPK_gen_1	15	23	PF00069	0.544
DOC_MAPK_gen_1	165	174	PF00069	0.384
DOC_MAPK_MEF2A_6	137	145	PF00069	0.472
DOC_MAPK_MEF2A_6	15	23	PF00069	0.624
DOC_PP1_RVXF_1	47	54	PF00149	0.433
DOC_WW_Pin1_4	33	38	PF00397	0.559
DOC_WW_Pin1_4	74	79	PF00397	0.457
LIG_Actin_WH2_2	243	261	PF00022	0.389
LIG_BRCT_BRCA1_1	127	131	PF00533	0.433
LIG_CORNRBOX	243	251	PF00104	0.514
LIG_FHA_1	60	66	PF00498	0.417
LIG_FHA_1	90	96	PF00498	0.404
LIG_FHA_2	174	180	PF00498	0.343
LIG_LIR_Gen_1	230	241	PF02991	0.353
LIG_LIR_Gen_1	42	51	PF02991	0.450
LIG_LIR_Nem_3	230	236	PF02991	0.363
LIG_LIR_Nem_3	42	46	PF02991	0.450
LIG_NRBOX	20	26	PF00104	0.573
LIG_Pex14_2	233	237	PF04695	0.404
LIG_SH2_SRC	177	180	PF00017	0.466
LIG_SH2_STAP1	97	101	PF00017	0.433
LIG_SH2_STAT3	175	178	PF00017	0.433
LIG_SH2_STAT5	175	178	PF00017	0.454
LIG_SH2_STAT5	193	196	PF00017	0.250
LIG_TRAF2_1	133	136	PF00917	0.326
LIG_TRAF2_1	176	179	PF00917	0.433
LIG_TYR_ITIM	41	46	PF00017	0.386
MOD_CK1_1	229	235	PF00069	0.355
MOD_CK1_1	63	69	PF00069	0.433
MOD_CK1_1	74	80	PF00069	0.282
MOD_CK2_1	173	179	PF00069	0.422
MOD_CK2_1	199	205	PF00069	0.380
MOD_GlcNHglycan	117	120	PF01048	0.591
MOD_GlcNHglycan	200	204	PF01048	0.654
MOD_GlcNHglycan	247	250	PF01048	0.498
MOD_GlcNHglycan	73	76	PF01048	0.631
MOD_GlcNHglycan	86	89	PF01048	0.555
MOD_GSK3_1	210	217	PF00069	0.441
MOD_GSK3_1	225	232	PF00069	0.358
MOD_GSK3_1	59	66	PF00069	0.353
MOD_NEK2_1	1	6	PF00069	0.697
MOD_NEK2_1	125	130	PF00069	0.433
MOD_NEK2_1	215	220	PF00069	0.409
MOD_NEK2_1	257	262	PF00069	0.546
MOD_NEK2_1	45	50	PF00069	0.366
MOD_NEK2_1	84	89	PF00069	0.422
MOD_PIKK_1	60	66	PF00454	0.477
MOD_PIKK_1	77	83	PF00454	0.433
MOD_PKA_2	220	226	PF00069	0.354
MOD_PKA_2	84	90	PF00069	0.416
MOD_PKB_1	224	232	PF00069	0.361
MOD_Plk_1	104	110	PF00069	0.422
MOD_Plk_1	199	205	PF00069	0.326
MOD_Plk_1	229	235	PF00069	0.377
MOD_Plk_2-3	173	179	PF00069	0.343
MOD_Plk_4	215	221	PF00069	0.360
MOD_ProDKin_1	33	39	PF00069	0.562
MOD_ProDKin_1	74	80	PF00069	0.457
MOD_SUMO_for_1	149	152	PF00179	0.437
MOD_SUMO_rev_2	129	139	PF00179	0.362
MOD_SUMO_rev_2	179	187	PF00179	0.422
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.386
TRG_ENDOCYTIC_2	43	46	PF00928	0.386
TRG_ER_diArg_1	82	85	PF00400	0.326
TRG_ER_diLys_1	264	268	PF00400	0.666
TRG_NLS_MonoCore_2	262	267	PF00514	0.725
TRG_NLS_MonoExtC_3	164	170	PF00514	0.386
TRG_NLS_MonoExtN_4	263	268	PF00514	0.739
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A9	Leptomonas seymouri	57%	100%
A0A1X0P7Z0	Trypanosomatidae	32%	100%
A4HP84	Leishmania braziliensis	81%	100%
A4IDI9	Leishmania infantum	100%	100%
D0A380	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ASZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q1K6	Leishmania major	93%	100%
Q5A302	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	100%
V5BBT5	Trypanosoma cruzi	35%	100%