DUF4456 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAV9_LEIDO

TriTrypDb:

LdBPK_362320.1 , LdCL_360028900 , LDHU3_36.3100

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.639
CLV_NRD_NRD_1	106	108	PF00675	0.604
CLV_NRD_NRD_1	125	127	PF00675	0.608
CLV_NRD_NRD_1	204	206	PF00675	0.627
CLV_NRD_NRD_1	303	305	PF00675	0.698
CLV_NRD_NRD_1	350	352	PF00675	0.616
CLV_NRD_NRD_1	457	459	PF00675	0.567
CLV_NRD_NRD_1	470	472	PF00675	0.588
CLV_NRD_NRD_1	491	493	PF00675	0.556
CLV_NRD_NRD_1	555	557	PF00675	0.572
CLV_PCSK_FUR_1	420	424	PF00082	0.647
CLV_PCSK_KEX2_1	106	108	PF00082	0.604
CLV_PCSK_KEX2_1	125	127	PF00082	0.570
CLV_PCSK_KEX2_1	196	198	PF00082	0.552
CLV_PCSK_KEX2_1	204	206	PF00082	0.554
CLV_PCSK_KEX2_1	422	424	PF00082	0.711
CLV_PCSK_KEX2_1	457	459	PF00082	0.567
CLV_PCSK_KEX2_1	470	472	PF00082	0.588
CLV_PCSK_KEX2_1	510	512	PF00082	0.643
CLV_PCSK_KEX2_1	534	536	PF00082	0.661
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.573
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.682
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.611
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.661
CLV_PCSK_SKI1_1	166	170	PF00082	0.524
CLV_PCSK_SKI1_1	191	195	PF00082	0.518
CLV_PCSK_SKI1_1	204	208	PF00082	0.494
CLV_PCSK_SKI1_1	305	309	PF00082	0.609
CLV_PCSK_SKI1_1	32	36	PF00082	0.622
CLV_PCSK_SKI1_1	449	453	PF00082	0.627
CLV_PCSK_SKI1_1	497	501	PF00082	0.604
CLV_PCSK_SKI1_1	561	565	PF00082	0.592
DEG_APCC_DBOX_1	555	563	PF00400	0.556
DEG_Kelch_Keap1_1	94	99	PF01344	0.665
DOC_CKS1_1	228	233	PF01111	0.586
DOC_CYCLIN_yClb3_PxF_3	578	584	PF00134	0.616
DOC_MAPK_FxFP_2	575	578	PF00069	0.627
DOC_PP2B_LxvP_1	570	573	PF13499	0.551
DOC_PP4_FxxP_1	575	578	PF00568	0.644
DOC_USP7_MATH_1	128	132	PF00917	0.589
DOC_USP7_MATH_1	137	141	PF00917	0.617
DOC_USP7_MATH_1	245	249	PF00917	0.609
DOC_USP7_MATH_1	279	283	PF00917	0.634
DOC_USP7_MATH_1	404	408	PF00917	0.596
DOC_USP7_MATH_1	466	470	PF00917	0.684
DOC_USP7_UBL2_3	308	312	PF12436	0.624
DOC_USP7_UBL2_3	493	497	PF12436	0.506
DOC_USP7_UBL2_3	510	514	PF12436	0.490
DOC_USP7_UBL2_3	549	553	PF12436	0.609
DOC_USP7_UBL2_3	557	561	PF12436	0.512
DOC_WW_Pin1_4	209	214	PF00397	0.648
DOC_WW_Pin1_4	227	232	PF00397	0.495
DOC_WW_Pin1_4	356	361	PF00397	0.741
LIG_14-3-3_CanoR_1	106	110	PF00244	0.704
LIG_14-3-3_CanoR_1	175	179	PF00244	0.491
LIG_14-3-3_CanoR_1	204	213	PF00244	0.596
LIG_14-3-3_CanoR_1	238	242	PF00244	0.597
LIG_14-3-3_CanoR_1	351	360	PF00244	0.696
LIG_14-3-3_CanoR_1	492	496	PF00244	0.549
LIG_BIR_II_1	1	5	PF00653	0.674
LIG_BIR_III_4	433	437	PF00653	0.653
LIG_EVH1_1	570	574	PF00568	0.652
LIG_EVH1_1	577	581	PF00568	0.591
LIG_FHA_1	23	29	PF00498	0.660
LIG_FHA_1	261	267	PF00498	0.715
LIG_FHA_1	498	504	PF00498	0.545
LIG_FHA_1	516	522	PF00498	0.465
LIG_FHA_2	361	367	PF00498	0.669
LIG_FHA_2	69	75	PF00498	0.811
LIG_FHA_2	84	90	PF00498	0.526
LIG_FHA_2	95	101	PF00498	0.597
LIG_LIR_Gen_1	120	129	PF02991	0.657
LIG_LIR_Gen_1	494	503	PF02991	0.555
LIG_LIR_Nem_3	120	124	PF02991	0.657
LIG_LIR_Nem_3	494	498	PF02991	0.549
LIG_NRBOX	219	225	PF00104	0.785
LIG_Pex14_1	491	495	PF04695	0.552
LIG_Pex14_2	250	254	PF04695	0.617
LIG_RPA_C_Fungi	466	478	PF08784	0.584
LIG_RPA_C_Plants	299	310	PF08784	0.622
LIG_SH2_CRK	495	499	PF00017	0.548
LIG_SH2_STAP1	337	341	PF00017	0.595
LIG_SH2_STAP1	495	499	PF00017	0.548
LIG_SH3_2	10	15	PF14604	0.671
LIG_SH3_2	228	233	PF14604	0.628
LIG_SH3_3	210	216	PF00018	0.645
LIG_SH3_3	225	231	PF00018	0.533
LIG_SH3_3	46	52	PF00018	0.642
LIG_SH3_3	568	574	PF00018	0.645
LIG_SH3_3	575	581	PF00018	0.597
LIG_SH3_3	7	13	PF00018	0.671
LIG_TRAF2_1	364	367	PF00917	0.591
LIG_TRAF2_1	527	530	PF00917	0.645
LIG_TRAF2_1	73	76	PF00917	0.636
LIG_TRAF2_1	97	100	PF00917	0.666
MOD_CDC14_SPxK_1	359	362	PF00782	0.594
MOD_CDK_SPxK_1	227	233	PF00069	0.584
MOD_CDK_SPxK_1	356	362	PF00069	0.590
MOD_CK1_1	174	180	PF00069	0.490
MOD_CK1_1	358	364	PF00069	0.649
MOD_CK2_1	360	366	PF00069	0.670
MOD_CK2_1	466	472	PF00069	0.741
MOD_CK2_1	513	519	PF00069	0.638
MOD_CK2_1	70	76	PF00069	0.701
MOD_CK2_1	83	89	PF00069	0.538
MOD_CK2_1	94	100	PF00069	0.609
MOD_Cter_Amidation	104	107	PF01082	0.610
MOD_Cter_Amidation	508	511	PF01082	0.605
MOD_GlcNHglycan	188	191	PF01048	0.557
MOD_GlcNHglycan	21	25	PF01048	0.691
MOD_GlcNHglycan	247	250	PF01048	0.786
MOD_GlcNHglycan	292	295	PF01048	0.657
MOD_GlcNHglycan	415	418	PF01048	0.638
MOD_GlcNHglycan	464	467	PF01048	0.738
MOD_GSK3_1	105	112	PF00069	0.763
MOD_GSK3_1	204	211	PF00069	0.594
MOD_GSK3_1	237	244	PF00069	0.686
MOD_GSK3_1	351	358	PF00069	0.665
MOD_GSK3_1	411	418	PF00069	0.681
MOD_GSK3_1	423	430	PF00069	0.599
MOD_GSK3_1	462	469	PF00069	0.649
MOD_GSK3_1	497	504	PF00069	0.499
MOD_LATS_1	537	543	PF00433	0.569
MOD_N-GLC_1	171	176	PF02516	0.587
MOD_N-GLC_2	371	373	PF02516	0.596
MOD_NEK2_1	445	450	PF00069	0.562
MOD_NEK2_1	484	489	PF00069	0.524
MOD_NEK2_2	54	59	PF00069	0.606
MOD_PIKK_1	204	210	PF00454	0.591
MOD_PIKK_1	260	266	PF00454	0.648
MOD_PK_1	277	283	PF00069	0.630
MOD_PKA_1	204	210	PF00069	0.591
MOD_PKA_1	351	357	PF00069	0.636
MOD_PKA_1	396	402	PF00069	0.618
MOD_PKA_2	105	111	PF00069	0.731
MOD_PKA_2	174	180	PF00069	0.490
MOD_PKA_2	204	210	PF00069	0.591
MOD_PKA_2	237	243	PF00069	0.592
MOD_PKA_2	355	361	PF00069	0.628
MOD_PKA_2	427	433	PF00069	0.601
MOD_PKA_2	491	497	PF00069	0.551
MOD_PKA_2	67	73	PF00069	0.815
MOD_PKA_2	83	89	PF00069	0.685
MOD_Plk_1	484	490	PF00069	0.521
MOD_Plk_4	396	402	PF00069	0.618
MOD_ProDKin_1	209	215	PF00069	0.646
MOD_ProDKin_1	227	233	PF00069	0.499
MOD_ProDKin_1	356	362	PF00069	0.741
MOD_SUMO_rev_2	270	279	PF00179	0.597
MOD_SUMO_rev_2	389	399	PF00179	0.575
MOD_SUMO_rev_2	442	451	PF00179	0.636
TRG_DiLeu_BaEn_1	315	320	PF01217	0.588
TRG_DiLeu_BaEn_3	149	155	PF01217	0.633
TRG_ENDOCYTIC_2	337	340	PF00928	0.597
TRG_ENDOCYTIC_2	495	498	PF00928	0.550
TRG_ER_diArg_1	124	126	PF00400	0.639
TRG_ER_diArg_1	296	299	PF00400	0.672
TRG_ER_diArg_1	457	459	PF00400	0.533
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.650
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HP88	Leishmania braziliensis	64%	100%
A4IDJ3	Leishmania infantum	100%	100%
E9ASZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q1K2	Leishmania major	89%	100%