LeishMANIAdb
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Choline transporter-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Choline transporter-like protein
Gene product:
Plasma-membrane choline transporter, putative
Species:
Leishmania donovani
UniProt:
A0A3S7XAV8_LEIDO
TriTrypDb:
LdBPK_362340.1 , LdCL_360029100 , LDHU3_36.3120
Length:
511

Annotations

LeishMANIAdb annotations

Highly homologous to other eukaryotic choline transporters. The protein family expanded in parazitic kinetoplastids.

Annotations by Jardim et al.

Transporters, Plasma-membrane choline transporter

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 23
NetGPI no yes: 0, no: 23
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 24
GO:0016020 membrane 2 24
GO:0110165 cellular anatomical entity 1 24
GO:0005737 cytoplasm 2 1
GO:0020016 ciliary pocket 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7XAV8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAV8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0009987 cellular process 1 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 24
GO:0022857 transmembrane transporter activity 2 24

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 30 34 PF00656 0.621
CLV_PCSK_KEX2_1 322 324 PF00082 0.431
CLV_PCSK_KEX2_1 399 401 PF00082 0.260
CLV_PCSK_PC1ET2_1 322 324 PF00082 0.436
CLV_PCSK_PC1ET2_1 399 401 PF00082 0.280
CLV_PCSK_SKI1_1 322 326 PF00082 0.448
CLV_PCSK_SKI1_1 381 385 PF00082 0.342
DEG_MDM2_SWIB_1 100 107 PF02201 0.383
DEG_MDM2_SWIB_1 201 209 PF02201 0.410
DEG_MDM2_SWIB_1 280 288 PF02201 0.361
DEG_MDM2_SWIB_1 85 93 PF02201 0.581
DEG_SPOP_SBC_1 324 328 PF00917 0.350
DOC_ANK_TNKS_1 442 449 PF00023 0.211
DOC_CKS1_1 287 292 PF01111 0.432
DOC_MAPK_MEF2A_6 186 195 PF00069 0.333
DOC_MAPK_MEF2A_6 231 240 PF00069 0.526
DOC_MAPK_MEF2A_6 381 389 PF00069 0.558
DOC_PP4_FxxP_1 462 465 PF00568 0.466
DOC_SPAK_OSR1_1 79 83 PF12202 0.570
DOC_USP7_MATH_1 143 147 PF00917 0.347
DOC_USP7_MATH_1 26 30 PF00917 0.712
DOC_USP7_MATH_1 465 469 PF00917 0.366
DOC_WW_Pin1_4 119 124 PF00397 0.479
DOC_WW_Pin1_4 286 291 PF00397 0.432
DOC_WW_Pin1_4 417 422 PF00397 0.268
LIG_14-3-3_CanoR_1 221 227 PF00244 0.518
LIG_14-3-3_CanoR_1 323 332 PF00244 0.272
LIG_Actin_WH2_2 206 223 PF00022 0.321
LIG_Actin_WH2_2 357 372 PF00022 0.397
LIG_APCC_ABBA_1 61 66 PF00400 0.603
LIG_BIR_II_1 1 5 PF00653 0.698
LIG_BIR_III_4 33 37 PF00653 0.625
LIG_BIR_III_4 499 503 PF00653 0.633
LIG_BRCT_BRCA1_1 1 5 PF00533 0.620
LIG_BRCT_BRCA1_1 330 334 PF00533 0.273
LIG_BRCT_BRCA1_1 430 434 PF00533 0.424
LIG_BRCT_BRCA1_1 459 463 PF00533 0.463
LIG_deltaCOP1_diTrp_1 87 94 PF00928 0.475
LIG_EH1_1 187 195 PF00400 0.296
LIG_EH1_1 272 280 PF00400 0.445
LIG_EH1_1 451 459 PF00400 0.362
LIG_eIF4E_1 413 419 PF01652 0.484
LIG_FHA_1 170 176 PF00498 0.293
LIG_FHA_1 227 233 PF00498 0.511
LIG_FHA_1 287 293 PF00498 0.464
LIG_FHA_1 295 301 PF00498 0.284
LIG_FHA_1 399 405 PF00498 0.475
LIG_FHA_1 425 431 PF00498 0.323
LIG_FHA_1 470 476 PF00498 0.488
LIG_GBD_Chelix_1 453 461 PF00786 0.280
LIG_LIR_Apic_2 460 465 PF02991 0.489
LIG_LIR_Gen_1 101 112 PF02991 0.404
LIG_LIR_Gen_1 244 255 PF02991 0.371
LIG_LIR_Gen_1 431 441 PF02991 0.464
LIG_LIR_Gen_1 471 481 PF02991 0.516
LIG_LIR_Gen_1 87 97 PF02991 0.472
LIG_LIR_LC3C_4 336 339 PF02991 0.307
LIG_LIR_Nem_3 101 107 PF02991 0.316
LIG_LIR_Nem_3 242 248 PF02991 0.367
LIG_LIR_Nem_3 326 332 PF02991 0.328
LIG_LIR_Nem_3 377 382 PF02991 0.424
LIG_LIR_Nem_3 431 437 PF02991 0.402
LIG_LIR_Nem_3 460 466 PF02991 0.375
LIG_LIR_Nem_3 47 53 PF02991 0.718
LIG_LIR_Nem_3 471 477 PF02991 0.430
LIG_LIR_Nem_3 87 92 PF02991 0.469
LIG_MLH1_MIPbox_1 459 463 PF16413 0.307
LIG_Pex14_2 100 104 PF04695 0.347
LIG_Pex14_2 201 205 PF04695 0.371
LIG_Pex14_2 280 284 PF04695 0.341
LIG_Pex14_2 410 414 PF04695 0.489
LIG_Pex14_2 85 89 PF04695 0.600
LIG_Rb_LxCxE_1 366 377 PF01857 0.452
LIG_SH2_CRK 382 386 PF00017 0.484
LIG_SH2_CRK 492 496 PF00017 0.537
LIG_SH2_CRK 50 54 PF00017 0.700
LIG_SH2_GRB2like 356 359 PF00017 0.459
LIG_SH2_GRB2like 378 381 PF00017 0.478
LIG_SH2_GRB2like 413 416 PF00017 0.484
LIG_SH2_PTP2 134 137 PF00017 0.355
LIG_SH2_PTP2 247 250 PF00017 0.445
LIG_SH2_PTP2 271 274 PF00017 0.219
LIG_SH2_SRC 356 359 PF00017 0.459
LIG_SH2_SRC 394 397 PF00017 0.498
LIG_SH2_STAT3 263 266 PF00017 0.232
LIG_SH2_STAT5 134 137 PF00017 0.293
LIG_SH2_STAT5 166 169 PF00017 0.407
LIG_SH2_STAT5 247 250 PF00017 0.354
LIG_SH2_STAT5 271 274 PF00017 0.365
LIG_SH2_STAT5 305 308 PF00017 0.325
LIG_SH2_STAT5 378 381 PF00017 0.467
LIG_SH2_STAT5 394 397 PF00017 0.467
LIG_SH2_STAT5 413 416 PF00017 0.484
LIG_SH3_3 252 258 PF00018 0.412
LIG_SH3_3 310 316 PF00018 0.267
LIG_SH3_3 50 56 PF00018 0.687
LIG_SH3_3 59 65 PF00018 0.555
LIG_SUMO_SIM_par_1 426 431 PF11976 0.395
LIG_TYR_ITIM 132 137 PF00017 0.305
LIG_TYR_ITIM 48 53 PF00017 0.713
LIG_WRC_WIRS_1 318 323 PF05994 0.254
MOD_CK1_1 122 128 PF00069 0.494
MOD_CK1_1 146 152 PF00069 0.387
MOD_CK1_1 286 292 PF00069 0.487
MOD_CK1_1 328 334 PF00069 0.330
MOD_CK1_1 351 357 PF00069 0.543
MOD_CK1_1 468 474 PF00069 0.483
MOD_CK2_1 351 357 PF00069 0.459
MOD_CK2_1 390 396 PF00069 0.547
MOD_GlcNHglycan 124 127 PF01048 0.678
MOD_GlcNHglycan 141 144 PF01048 0.212
MOD_GlcNHglycan 178 181 PF01048 0.367
MOD_GlcNHglycan 222 225 PF01048 0.267
MOD_GlcNHglycan 29 32 PF01048 0.535
MOD_GlcNHglycan 297 300 PF01048 0.343
MOD_GlcNHglycan 350 354 PF01048 0.297
MOD_GlcNHglycan 467 470 PF01048 0.255
MOD_GlcNHglycan 50 53 PF01048 0.516
MOD_GSK3_1 113 120 PF00069 0.398
MOD_GSK3_1 139 146 PF00069 0.438
MOD_GSK3_1 226 233 PF00069 0.510
MOD_GSK3_1 324 331 PF00069 0.318
MOD_GSK3_1 424 431 PF00069 0.303
MOD_GSK3_1 465 472 PF00069 0.316
MOD_GSK3_1 98 105 PF00069 0.358
MOD_N-GLC_1 10 15 PF02516 0.552
MOD_N-GLC_1 500 505 PF02516 0.351
MOD_N-GLC_2 415 417 PF02516 0.358
MOD_NEK2_1 176 181 PF00069 0.325
MOD_NEK2_1 219 224 PF00069 0.493
MOD_NEK2_1 226 231 PF00069 0.481
MOD_NEK2_1 239 244 PF00069 0.384
MOD_NEK2_1 278 283 PF00069 0.290
MOD_NEK2_1 293 298 PF00069 0.246
MOD_NEK2_1 300 305 PF00069 0.396
MOD_NEK2_1 348 353 PF00069 0.516
MOD_NEK2_1 428 433 PF00069 0.314
MOD_NEK2_1 441 446 PF00069 0.263
MOD_NEK2_1 48 53 PF00069 0.744
MOD_NEK2_1 491 496 PF00069 0.524
MOD_NEK2_2 469 474 PF00069 0.486
MOD_PIKK_1 117 123 PF00454 0.445
MOD_PIKK_1 283 289 PF00454 0.300
MOD_PIKK_1 38 44 PF00454 0.736
MOD_PKA_1 322 328 PF00069 0.245
MOD_PKA_2 220 226 PF00069 0.538
MOD_PKA_2 27 33 PF00069 0.613
MOD_PKA_2 322 328 PF00069 0.297
MOD_PKA_2 484 490 PF00069 0.627
MOD_PKA_2 75 81 PF00069 0.673
MOD_Plk_4 143 149 PF00069 0.374
MOD_Plk_4 169 175 PF00069 0.391
MOD_Plk_4 230 236 PF00069 0.473
MOD_Plk_4 300 306 PF00069 0.332
MOD_Plk_4 333 339 PF00069 0.319
MOD_Plk_4 390 396 PF00069 0.540
MOD_Plk_4 428 434 PF00069 0.393
MOD_Plk_4 457 463 PF00069 0.357
MOD_Plk_4 469 475 PF00069 0.431
MOD_Plk_4 88 94 PF00069 0.329
MOD_ProDKin_1 119 125 PF00069 0.478
MOD_ProDKin_1 286 292 PF00069 0.432
MOD_ProDKin_1 417 423 PF00069 0.268
TRG_DiLeu_BaLyEn_6 222 227 PF01217 0.567
TRG_ENDOCYTIC_2 134 137 PF00928 0.331
TRG_ENDOCYTIC_2 247 250 PF00928 0.407
TRG_ENDOCYTIC_2 271 274 PF00928 0.429
TRG_ENDOCYTIC_2 382 385 PF00928 0.469
TRG_ENDOCYTIC_2 492 495 PF00928 0.530
TRG_ENDOCYTIC_2 50 53 PF00928 0.707
TRG_ER_diArg_1 209 212 PF00400 0.408
TRG_Pf-PMV_PEXEL_1 346 350 PF00026 0.333

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9D8 Leptomonas seymouri 62% 100%
A0A0N1PA24 Leptomonas seymouri 33% 87%
A0A0S4IW21 Bodo saltans 37% 95%
A0A0S4KHP0 Bodo saltans 43% 100%
A0A1X0P8J3 Trypanosomatidae 47% 100%
A0A3Q8I9V7 Leishmania donovani 34% 84%
A0A3R7MAJ2 Trypanosoma rangeli 33% 100%
A0A3S5IRA1 Trypanosoma rangeli 46% 100%
A4H7J7 Leishmania braziliensis 36% 84%
A4HP90 Leishmania braziliensis 75% 99%
A4HVY0 Leishmania infantum 34% 84%
A4IDJ5 Leishmania infantum 100% 100%
A5PMW0 Danio rerio 24% 73%
D0A390 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
D0A391 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
D0A392 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
D0A393 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 99%
E9APN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 84%
E9ASZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
P0CM92 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 30% 93%
P0CM93 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 30% 93%
Q12412 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 95%
Q20026 Caenorhabditis elegans 24% 66%
Q4I8E9 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 28% 95%
Q4PIP8 Ustilago maydis (strain 521 / FGSC 9021) 28% 97%
Q4Q1K0 Leishmania major 92% 100%
Q4QFU7 Leishmania major 36% 84%
Q4WYG7 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 28% 95%
Q53GD3 Homo sapiens 23% 72%
Q54IJ2 Dictyostelium discoideum 25% 93%
Q5AB93 Candida albicans (strain SC5314 / ATCC MYA-2876) 28% 99%
Q6BIV4 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 29% 100%
Q6C938 Yarrowia lipolytica (strain CLIB 122 / E 150) 27% 89%
Q6CY85 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 26% 92%
Q6FLC9 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 27% 92%
Q6GN42 Xenopus laevis 23% 72%
Q75EG5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 28% 92%
Q870V7 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 92%
V5AWF7 Trypanosoma cruzi 46% 100%
V5BMB4 Trypanosoma cruzi 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS