Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAV6_LEIDO

TriTrypDb:

LdBPK_362430.1 , LdCL_360030000 , LDHU3_36.3240

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7XAV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	257	259	PF00675	0.567
CLV_PCSK_KEX2_1	257	259	PF00082	0.567
CLV_PCSK_SKI1_1	257	261	PF00082	0.567
CLV_PCSK_SKI1_1	472	476	PF00082	0.816
DEG_Nend_UBRbox_2	1	3	PF02207	0.593
DOC_CKS1_1	227	232	PF01111	0.469
DOC_CKS1_1	350	355	PF01111	0.464
DOC_CYCLIN_RxL_1	95	105	PF00134	0.377
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.541
DOC_MAPK_gen_1	120	128	PF00069	0.785
DOC_MAPK_gen_1	257	265	PF00069	0.710
DOC_MAPK_gen_1	354	362	PF00069	0.385
DOC_MAPK_MEF2A_6	46	53	PF00069	0.465
DOC_PP1_RVXF_1	250	256	PF00149	0.452
DOC_PP2B_LxvP_1	224	227	PF13499	0.579
DOC_PP4_FxxP_1	147	150	PF00568	0.788
DOC_USP7_MATH_1	167	171	PF00917	0.459
DOC_USP7_MATH_1	380	384	PF00917	0.545
DOC_USP7_MATH_1	439	443	PF00917	0.502
DOC_USP7_MATH_1	450	454	PF00917	0.520
DOC_USP7_MATH_1	85	89	PF00917	0.520
DOC_USP7_MATH_1	9	13	PF00917	0.567
DOC_WW_Pin1_4	215	220	PF00397	0.521
DOC_WW_Pin1_4	226	231	PF00397	0.434
DOC_WW_Pin1_4	349	354	PF00397	0.477
DOC_WW_Pin1_4	422	427	PF00397	0.502
DOC_WW_Pin1_4	454	459	PF00397	0.610
DOC_WW_Pin1_4	476	481	PF00397	0.639
LIG_14-3-3_CanoR_1	114	119	PF00244	0.744
LIG_14-3-3_CanoR_1	257	266	PF00244	0.764
LIG_14-3-3_CanoR_1	289	295	PF00244	0.414
LIG_14-3-3_CanoR_1	343	349	PF00244	0.548
LIG_14-3-3_CanoR_1	37	44	PF00244	0.559
LIG_14-3-3_CanoR_1	71	79	PF00244	0.515
LIG_Actin_RPEL_3	91	110	PF02755	0.530
LIG_Actin_WH2_2	17	34	PF00022	0.557
LIG_Actin_WH2_2	186	204	PF00022	0.417
LIG_Actin_WH2_2	242	259	PF00022	0.429
LIG_APCC_ABBA_1	126	131	PF00400	0.639
LIG_BRCT_BRCA1_1	246	250	PF00533	0.452
LIG_BRCT_BRCA1_1	368	372	PF00533	0.527
LIG_BRCT_BRCA1_2	246	252	PF00533	0.452
LIG_FHA_1	103	109	PF00498	0.391
LIG_FHA_1	158	164	PF00498	0.605
LIG_FHA_1	179	185	PF00498	0.510
LIG_FHA_1	196	202	PF00498	0.518
LIG_FHA_1	234	240	PF00498	0.352
LIG_FHA_1	258	264	PF00498	0.764
LIG_FHA_1	398	404	PF00498	0.547
LIG_FHA_1	8	14	PF00498	0.530
LIG_FHA_2	227	233	PF00498	0.505
LIG_FHA_2	37	43	PF00498	0.522
LIG_FHA_2	384	390	PF00498	0.580
LIG_FHA_2	442	448	PF00498	0.578
LIG_GBD_Chelix_1	100	108	PF00786	0.398
LIG_GBD_Chelix_1	171	179	PF00786	0.530
LIG_GBD_Chelix_1	241	249	PF00786	0.413
LIG_GBD_Chelix_1	75	83	PF00786	0.740
LIG_LIR_Apic_2	145	150	PF02991	0.786
LIG_LIR_Apic_2	210	215	PF02991	0.440
LIG_LIR_Gen_1	105	115	PF02991	0.500
LIG_LIR_Gen_1	16	24	PF02991	0.447
LIG_LIR_Gen_1	236	245	PF02991	0.413
LIG_LIR_Gen_1	247	256	PF02991	0.515
LIG_LIR_Gen_1	59	69	PF02991	0.595
LIG_LIR_Nem_3	105	109	PF02991	0.364
LIG_LIR_Nem_3	16	20	PF02991	0.452
LIG_LIR_Nem_3	236	241	PF02991	0.487
LIG_LIR_Nem_3	247	253	PF02991	0.515
LIG_LIR_Nem_3	59	65	PF02991	0.600
LIG_NRBOX	189	195	PF00104	0.569
LIG_NRBOX	95	101	PF00104	0.369
LIG_Pex14_1	282	286	PF04695	0.530
LIG_RPA_C_Fungi	53	65	PF08784	0.541
LIG_SH2_STAP1	17	21	PF00017	0.708
LIG_SH2_STAP1	234	238	PF00017	0.530
LIG_SH2_STAP1	286	290	PF00017	0.647
LIG_SH2_STAP1	62	66	PF00017	0.551
LIG_SH2_STAT5	267	270	PF00017	0.530
LIG_SH2_STAT5	300	303	PF00017	0.740
LIG_SH2_STAT5	359	362	PF00017	0.670
LIG_SH3_3	224	230	PF00018	0.600
LIG_SH3_3	347	353	PF00018	0.659
LIG_SUMO_SIM_anti_2	187	192	PF11976	0.636
LIG_SUMO_SIM_anti_2	236	243	PF11976	0.413
LIG_SUMO_SIM_par_1	159	164	PF11976	0.369
LIG_SUMO_SIM_par_1	99	105	PF11976	0.452
LIG_TRAF2_1	433	436	PF00917	0.650
LIG_WW_1	14	17	PF00397	0.652
MOD_CDC14_SPxK_1	425	428	PF00782	0.584
MOD_CDK_SPK_2	349	354	PF00069	0.660
MOD_CDK_SPK_2	476	481	PF00069	0.639
MOD_CDK_SPxK_1	422	428	PF00069	0.596
MOD_CDK_SPxxK_3	349	356	PF00069	0.661
MOD_CK1_1	16	22	PF00069	0.629
MOD_CK1_1	237	243	PF00069	0.346
MOD_CK1_1	248	254	PF00069	0.316
MOD_CK1_1	383	389	PF00069	0.692
MOD_CK1_1	422	428	PF00069	0.694
MOD_CK1_1	453	459	PF00069	0.852
MOD_CK2_1	226	232	PF00069	0.621
MOD_CK2_1	383	389	PF00069	0.762
MOD_CK2_1	441	447	PF00069	0.695
MOD_GlcNHglycan	165	168	PF01048	0.503
MOD_GlcNHglycan	242	245	PF01048	0.445
MOD_GlcNHglycan	409	412	PF01048	0.786
MOD_GlcNHglycan	421	424	PF01048	0.595
MOD_GlcNHglycan	441	444	PF01048	0.531
MOD_GlcNHglycan	85	88	PF01048	0.683
MOD_GSK3_1	157	164	PF00069	0.516
MOD_GSK3_1	233	240	PF00069	0.469
MOD_GSK3_1	244	251	PF00069	0.504
MOD_GSK3_1	290	297	PF00069	0.591
MOD_GSK3_1	379	386	PF00069	0.790
MOD_GSK3_1	450	457	PF00069	0.684
MOD_GSK3_1	79	86	PF00069	0.737
MOD_GSK3_1	9	16	PF00069	0.736
MOD_N-GLC_1	157	162	PF02516	0.674
MOD_N-GLC_1	245	250	PF02516	0.452
MOD_N-GLC_1	294	299	PF02516	0.707
MOD_N-GLC_1	7	12	PF02516	0.619
MOD_NEK2_1	102	107	PF00069	0.452
MOD_NEK2_1	134	139	PF00069	0.538
MOD_NEK2_1	161	166	PF00069	0.516
MOD_NEK2_1	23	28	PF00069	0.535
MOD_NEK2_1	245	250	PF00069	0.417
MOD_NEK2_1	284	289	PF00069	0.579
MOD_NEK2_1	290	295	PF00069	0.526
MOD_NEK2_1	330	335	PF00069	0.648
MOD_NEK2_1	344	349	PF00069	0.523
MOD_NEK2_1	65	70	PF00069	0.680
MOD_NEK2_2	178	183	PF00069	0.579
MOD_PIKK_1	257	263	PF00454	0.710
MOD_PIKK_1	330	336	PF00454	0.594
MOD_PKA_1	257	263	PF00069	0.710
MOD_PKA_2	113	119	PF00069	0.650
MOD_PKA_2	257	263	PF00069	0.710
MOD_PKA_2	36	42	PF00069	0.697
MOD_PKA_2	70	76	PF00069	0.589
MOD_Plk_1	157	163	PF00069	0.530
MOD_Plk_1	245	251	PF00069	0.452
MOD_Plk_1	294	300	PF00069	0.715
MOD_Plk_4	102	108	PF00069	0.384
MOD_Plk_4	157	163	PF00069	0.465
MOD_Plk_4	16	22	PF00069	0.560
MOD_Plk_4	234	240	PF00069	0.530
MOD_Plk_4	245	251	PF00069	0.452
MOD_Plk_4	272	278	PF00069	0.445
MOD_Plk_4	65	71	PF00069	0.719
MOD_Plk_4	79	85	PF00069	0.551
MOD_ProDKin_1	215	221	PF00069	0.649
MOD_ProDKin_1	226	232	PF00069	0.526
MOD_ProDKin_1	349	355	PF00069	0.588
MOD_ProDKin_1	422	428	PF00069	0.621
MOD_ProDKin_1	454	460	PF00069	0.774
MOD_ProDKin_1	476	482	PF00069	0.818
TRG_DiLeu_BaEn_2	367	373	PF01217	0.562
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.718
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.556
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.530
TRG_DiLeu_LyEn_5	303	308	PF01217	0.724
TRG_ENDOCYTIC_2	17	20	PF00928	0.713
TRG_ENDOCYTIC_2	359	362	PF00928	0.670
TRG_ENDOCYTIC_2	62	65	PF00928	0.765
TRG_ER_diArg_1	119	122	PF00400	0.624
TRG_ER_diArg_1	256	258	PF00400	0.726
TRG_ER_diArg_1	353	356	PF00400	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HP98	Leishmania braziliensis	64%	100%
A4IDK4	Leishmania infantum	98%	100%
E9AT07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q1J1	Leishmania major	87%	99%