PhosphatidylinositolN-acetylglucosaminyltransfe_r a_sesubunit_c_putative/GeneDB:LmjF.36.1710

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositolN-acetylglucosaminyltransfe ra sesubunit c, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAV4_LEIDO

TriTrypDb:

LdBPK_361790.1 , LdCL_360023400 , LDHU3_36.2350

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	3	1
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3S7XAV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAV4

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006505	GPI anchor metabolic process	6	12
GO:0006506	GPI anchor biosynthetic process	6	12
GO:0006629	lipid metabolic process	3	12
GO:0006643	membrane lipid metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006664	glycolipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009247	glycolipid biosynthetic process	5	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019637	organophosphate metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046467	membrane lipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0046488	phosphatidylinositol metabolic process	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1903509	liposaccharide metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008194	UDP-glycosyltransferase activity	4	7
GO:0008375	acetylglucosaminyltransferase activity	5	7
GO:0016740	transferase activity	2	11
GO:0016757	glycosyltransferase activity	3	11
GO:0016758	hexosyltransferase activity	4	7
GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	9	13	PF00656	0.695
CLV_NRD_NRD_1	41	43	PF00675	0.527
CLV_NRD_NRD_1	71	73	PF00675	0.262
CLV_PCSK_KEX2_1	41	43	PF00082	0.572
CLV_PCSK_SKI1_1	191	195	PF00082	0.301
CLV_PCSK_SKI1_1	62	66	PF00082	0.476
CLV_PCSK_SKI1_1	72	76	PF00082	0.213
CLV_PCSK_SKI1_1	99	103	PF00082	0.334
DOC_CDC14_PxL_1	326	334	PF14671	0.308
DOC_MAPK_MEF2A_6	140	148	PF00069	0.321
DOC_MAPK_MEF2A_6	255	264	PF00069	0.537
DOC_PP4_FxxP_1	345	348	PF00568	0.375
DOC_USP7_MATH_1	279	283	PF00917	0.389
DOC_USP7_MATH_1	371	375	PF00917	0.588
DOC_WW_Pin1_4	180	185	PF00397	0.484
DOC_WW_Pin1_4	211	216	PF00397	0.304
DOC_WW_Pin1_4	275	280	PF00397	0.273
DOC_WW_Pin1_4	293	298	PF00397	0.255
DOC_WW_Pin1_4	40	45	PF00397	0.693
DOC_WW_Pin1_4	65	70	PF00397	0.669
LIG_14-3-3_CanoR_1	174	179	PF00244	0.537
LIG_14-3-3_CanoR_1	201	207	PF00244	0.512
LIG_14-3-3_CanoR_1	275	279	PF00244	0.292
LIG_14-3-3_CanoR_1	3	11	PF00244	0.760
LIG_14-3-3_CanoR_1	353	359	PF00244	0.537
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_BRCT_BRCA1_1	1	5	PF00533	0.755
LIG_BRCT_BRCA1_1	213	217	PF00533	0.412
LIG_Clathr_ClatBox_1	143	147	PF01394	0.424
LIG_deltaCOP1_diTrp_1	379	385	PF00928	0.654
LIG_EH1_1	335	343	PF00400	0.424
LIG_eIF4E_1	336	342	PF01652	0.451
LIG_FHA_1	106	112	PF00498	0.465
LIG_FHA_1	115	121	PF00498	0.278
LIG_FHA_1	133	139	PF00498	0.216
LIG_FHA_1	217	223	PF00498	0.338
LIG_FHA_1	229	235	PF00498	0.338
LIG_FHA_1	307	313	PF00498	0.458
LIG_FHA_1	335	341	PF00498	0.452
LIG_FHA_2	221	227	PF00498	0.316
LIG_FHA_2	25	31	PF00498	0.689
LIG_IRF3_LxIS_1	338	344	PF10401	0.426
LIG_LIR_Apic_2	344	348	PF02991	0.424
LIG_LIR_Apic_2	82	88	PF02991	0.448
LIG_LIR_Gen_1	105	114	PF02991	0.462
LIG_LIR_Gen_1	142	153	PF02991	0.390
LIG_LIR_Gen_1	214	224	PF02991	0.412
LIG_LIR_Gen_1	244	252	PF02991	0.474
LIG_LIR_Nem_3	105	109	PF02991	0.456
LIG_LIR_Nem_3	142	148	PF02991	0.366
LIG_LIR_Nem_3	214	220	PF02991	0.412
LIG_LIR_Nem_3	244	249	PF02991	0.461
LIG_LIR_Nem_3	315	319	PF02991	0.445
LIG_LIR_Nem_3	68	74	PF02991	0.536
LIG_NRBOX	238	244	PF00104	0.389
LIG_PDZ_Class_2	382	387	PF00595	0.667
LIG_Pex14_2	126	130	PF04695	0.334
LIG_Pex14_2	345	349	PF04695	0.424
LIG_PTB_Apo_2	100	107	PF02174	0.501
LIG_PTB_Phospho_1	100	106	PF10480	0.501
LIG_SH2_CRK	106	110	PF00017	0.476
LIG_SH2_CRK	246	250	PF00017	0.451
LIG_SH2_GRB2like	248	251	PF00017	0.451
LIG_SH2_PTP2	85	88	PF00017	0.451
LIG_SH2_SRC	104	107	PF00017	0.451
LIG_SH2_SRC	248	251	PF00017	0.492
LIG_SH2_SRC	85	88	PF00017	0.451
LIG_SH2_STAP1	106	110	PF00017	0.512
LIG_SH2_STAP1	141	145	PF00017	0.389
LIG_SH2_STAP1	252	256	PF00017	0.460
LIG_SH2_STAP1	306	310	PF00017	0.537
LIG_SH2_STAP1	336	340	PF00017	0.451
LIG_SH2_STAT3	76	79	PF00017	0.451
LIG_SH2_STAT5	158	161	PF00017	0.361
LIG_SH2_STAT5	248	251	PF00017	0.449
LIG_SH2_STAT5	252	255	PF00017	0.450
LIG_SH2_STAT5	267	270	PF00017	0.290
LIG_SH2_STAT5	336	339	PF00017	0.351
LIG_SH2_STAT5	85	88	PF00017	0.456
LIG_SH3_2	186	191	PF14604	0.523
LIG_SH3_3	183	189	PF00018	0.510
LIG_SUMO_SIM_anti_2	119	124	PF11976	0.404
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.419
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.390
LIG_SUMO_SIM_anti_2	231	236	PF11976	0.451
LIG_SUMO_SIM_anti_2	337	342	PF11976	0.451
LIG_SUMO_SIM_par_1	107	113	PF11976	0.543
LIG_SUMO_SIM_par_1	202	208	PF11976	0.327
LIG_SUMO_SIM_par_1	218	223	PF11976	0.296
LIG_SUMO_SIM_par_1	225	233	PF11976	0.234
LIG_SUMO_SIM_par_1	339	344	PF11976	0.321
LIG_TRAF2_1	26	29	PF00917	0.735
LIG_TRFH_1	293	297	PF08558	0.304
LIG_UBA3_1	350	359	PF00899	0.424
LIG_WRC_WIRS_1	342	347	PF05994	0.424
LIG_WW_3	184	188	PF00397	0.473
MOD_CDK_SPxxK_3	180	187	PF00069	0.540
MOD_CDK_SPxxK_3	293	300	PF00069	0.304
MOD_CDK_SPxxK_3	65	72	PF00069	0.676
MOD_CK1_1	177	183	PF00069	0.556
MOD_CK1_1	205	211	PF00069	0.424
MOD_CK1_1	218	224	PF00069	0.282
MOD_CK1_1	225	231	PF00069	0.240
MOD_CK1_1	233	239	PF00069	0.210
MOD_CK1_1	274	280	PF00069	0.316
MOD_CK1_1	357	363	PF00069	0.537
MOD_CK1_1	43	49	PF00069	0.728
MOD_CK1_1	7	13	PF00069	0.697
MOD_CK2_1	23	29	PF00069	0.505
MOD_CK2_1	3	9	PF00069	0.748
MOD_GlcNHglycan	281	284	PF01048	0.352
MOD_GlcNHglycan	35	38	PF01048	0.540
MOD_GlcNHglycan	373	376	PF01048	0.387
MOD_GlcNHglycan	382	385	PF01048	0.383
MOD_GSK3_1	110	117	PF00069	0.514
MOD_GSK3_1	176	183	PF00069	0.556
MOD_GSK3_1	211	218	PF00069	0.371
MOD_GSK3_1	24	31	PF00069	0.669
MOD_GSK3_1	267	274	PF00069	0.351
MOD_GSK3_1	275	282	PF00069	0.261
MOD_GSK3_1	3	10	PF00069	0.701
MOD_GSK3_1	353	360	PF00069	0.483
MOD_GSK3_1	43	50	PF00069	0.594
MOD_GSK3_1	58	65	PF00069	0.649
MOD_N-GLC_1	258	263	PF02516	0.389
MOD_NEK2_1	11	16	PF00069	0.666
MOD_NEK2_1	134	139	PF00069	0.320
MOD_NEK2_1	220	225	PF00069	0.262
MOD_NEK2_1	235	240	PF00069	0.319
MOD_NEK2_1	271	276	PF00069	0.292
MOD_NEK2_1	291	296	PF00069	0.345
MOD_NEK2_1	341	346	PF00069	0.377
MOD_NEK2_1	354	359	PF00069	0.407
MOD_PIKK_1	11	17	PF00454	0.705
MOD_PIKK_1	114	120	PF00454	0.390
MOD_PIKK_1	250	256	PF00454	0.537
MOD_PIKK_1	324	330	PF00454	0.389
MOD_PIKK_1	357	363	PF00454	0.537
MOD_PKA_2	274	280	PF00069	0.312
MOD_Plk_1	118	124	PF00069	0.424
MOD_Plk_1	225	231	PF00069	0.241
MOD_Plk_1	244	250	PF00069	0.505
MOD_Plk_1	258	264	PF00069	0.314
MOD_Plk_1	28	34	PF00069	0.703
MOD_Plk_2-3	29	35	PF00069	0.715
MOD_Plk_4	105	111	PF00069	0.460
MOD_Plk_4	139	145	PF00069	0.286
MOD_Plk_4	147	153	PF00069	0.181
MOD_Plk_4	202	208	PF00069	0.367
MOD_Plk_4	225	231	PF00069	0.251
MOD_Plk_4	244	250	PF00069	0.502
MOD_Plk_4	267	273	PF00069	0.323
MOD_Plk_4	336	342	PF00069	0.381
MOD_ProDKin_1	180	186	PF00069	0.484
MOD_ProDKin_1	211	217	PF00069	0.304
MOD_ProDKin_1	275	281	PF00069	0.273
MOD_ProDKin_1	293	299	PF00069	0.255
MOD_ProDKin_1	40	46	PF00069	0.693
MOD_ProDKin_1	65	71	PF00069	0.659
MOD_SUMO_rev_2	367	372	PF00179	0.578
TRG_DiLeu_BaEn_4	28	34	PF01217	0.744
TRG_ENDOCYTIC_2	106	109	PF00928	0.460
TRG_ENDOCYTIC_2	141	144	PF00928	0.389
TRG_ENDOCYTIC_2	246	249	PF00928	0.448
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE33	Leptomonas seymouri	73%	97%
A0A0S4IX12	Bodo saltans	46%	100%
A0A1X0P843	Trypanosomatidae	53%	100%
A0A3R7MPS8	Trypanosoma rangeli	51%	100%
A4HP35	Leishmania braziliensis	87%	100%
A4IDE2	Leishmania infantum	100%	100%
D0A318	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ASU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O59802	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q3ZBX1	Bos taurus	30%	100%
Q4Q1Q3	Leishmania major	97%	100%
Q54M40	Dictyostelium discoideum	33%	100%
Q5PQQ4	Rattus norvegicus	31%	100%
Q92535	Homo sapiens	29%	100%
Q9CXR4	Mus musculus	30%	100%
V5BU34	Trypanosoma cruzi	50%	100%