Endonuclease V, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease V, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAV3_LEIDO

TriTrypDb:

LdBPK_362460.1 , LdCL_360030300 , LDHU3_36.3280

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAV3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003727	single-stranded RNA binding	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0005488	binding	1	1
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.571
CLV_NRD_NRD_1	258	260	PF00675	0.346
CLV_PCSK_KEX2_1	258	260	PF00082	0.346
CLV_PCSK_SKI1_1	101	105	PF00082	0.669
CLV_PCSK_SKI1_1	279	283	PF00082	0.346
DEG_SPOP_SBC_1	302	306	PF00917	0.619
DOC_CYCLIN_RxL_1	308	319	PF00134	0.563
DOC_PP2B_LxvP_1	270	273	PF13499	0.546
DOC_PP2B_LxvP_1	83	86	PF13499	0.530
DOC_PP4_FxxP_1	102	105	PF00568	0.481
DOC_PP4_FxxP_1	138	141	PF00568	0.414
DOC_USP7_MATH_1	154	158	PF00917	0.513
DOC_USP7_MATH_1	302	306	PF00917	0.619
DOC_USP7_MATH_1	383	387	PF00917	0.646
DOC_USP7_MATH_1	39	43	PF00917	0.545
DOC_WW_Pin1_4	137	142	PF00397	0.446
DOC_WW_Pin1_4	26	31	PF00397	0.589
DOC_WW_Pin1_4	303	308	PF00397	0.530
DOC_WW_Pin1_4	317	322	PF00397	0.530
DOC_WW_Pin1_4	340	345	PF00397	0.589
LIG_14-3-3_CanoR_1	155	161	PF00244	0.436
LIG_14-3-3_CanoR_1	206	210	PF00244	0.546
LIG_14-3-3_CanoR_1	331	337	PF00244	0.466
LIG_BIR_III_4	19	23	PF00653	0.582
LIG_Clathr_ClatBox_1	246	250	PF01394	0.530
LIG_deltaCOP1_diTrp_1	143	151	PF00928	0.467
LIG_FHA_1	129	135	PF00498	0.535
LIG_FHA_1	165	171	PF00498	0.384
LIG_FHA_1	213	219	PF00498	0.547
LIG_FHA_1	352	358	PF00498	0.523
LIG_FHA_1	78	84	PF00498	0.536
LIG_FHA_2	206	212	PF00498	0.546
LIG_FHA_2	296	302	PF00498	0.613
LIG_GBD_Chelix_1	262	270	PF00786	0.346
LIG_GBD_Chelix_1	352	360	PF00786	0.346
LIG_LIR_Apic_2	136	141	PF02991	0.439
LIG_LIR_Gen_1	139	149	PF02991	0.468
LIG_LIR_Gen_1	215	225	PF02991	0.533
LIG_LIR_Gen_1	228	238	PF02991	0.546
LIG_LIR_Nem_3	139	145	PF02991	0.474
LIG_LIR_Nem_3	215	220	PF02991	0.533
LIG_LIR_Nem_3	228	233	PF02991	0.546
LIG_LIR_Nem_3	322	328	PF02991	0.536
LIG_LYPXL_yS_3	194	197	PF13949	0.546
LIG_MYND_1	310	314	PF01753	0.563
LIG_Pex14_2	138	142	PF04695	0.407
LIG_Rb_pABgroove_1	224	232	PF01858	0.500
LIG_SH2_CRK	325	329	PF00017	0.536
LIG_SH2_PTP2	341	344	PF00017	0.619
LIG_SH2_STAT5	327	330	PF00017	0.561
LIG_SH2_STAT5	341	344	PF00017	0.512
LIG_SH2_STAT5	379	382	PF00017	0.687
LIG_SH2_STAT5	69	72	PF00017	0.442
LIG_SH3_3	158	164	PF00018	0.397
LIG_SH3_3	251	257	PF00018	0.524
LIG_SH3_3	27	33	PF00018	0.521
LIG_SH3_3	304	310	PF00018	0.530
LIG_SH3_4	4	11	PF00018	0.583
LIG_Sin3_3	353	360	PF02671	0.546
LIG_SUMO_SIM_anti_2	167	172	PF11976	0.536
LIG_SUMO_SIM_par_1	245	250	PF11976	0.546
LIG_TRAF2_1	41	44	PF00917	0.550
MOD_CDK_SPK_2	26	31	PF00069	0.499
MOD_CK1_1	136	142	PF00069	0.509
MOD_CK1_1	305	311	PF00069	0.555
MOD_CK1_1	319	325	PF00069	0.449
MOD_CK1_1	386	392	PF00069	0.656
MOD_CK1_1	74	80	PF00069	0.411
MOD_CK2_1	137	143	PF00069	0.447
MOD_CK2_1	205	211	PF00069	0.506
MOD_CK2_1	295	301	PF00069	0.613
MOD_GlcNHglycan	122	125	PF01048	0.741
MOD_GlcNHglycan	156	159	PF01048	0.473
MOD_GlcNHglycan	23	26	PF01048	0.801
MOD_GlcNHglycan	34	37	PF01048	0.802
MOD_GlcNHglycan	385	388	PF01048	0.462
MOD_GSK3_1	133	140	PF00069	0.488
MOD_GSK3_1	271	278	PF00069	0.546
MOD_GSK3_1	301	308	PF00069	0.548
MOD_GSK3_1	315	322	PF00069	0.431
MOD_GSK3_1	39	46	PF00069	0.479
MOD_GSK3_1	71	78	PF00069	0.477
MOD_N-GLC_1	389	394	PF02516	0.451
MOD_N-GLC_1	74	79	PF02516	0.676
MOD_NEK2_1	107	112	PF00069	0.424
MOD_NEK2_1	229	234	PF00069	0.560
MOD_NEK2_1	237	242	PF00069	0.499
MOD_NEK2_1	315	320	PF00069	0.619
MOD_NEK2_1	356	361	PF00069	0.514
MOD_PIKK_1	237	243	PF00454	0.619
MOD_PIKK_1	319	325	PF00454	0.619
MOD_PKA_2	154	160	PF00069	0.436
MOD_PKA_2	205	211	PF00069	0.546
MOD_Plk_1	107	113	PF00069	0.464
MOD_Plk_1	174	180	PF00069	0.546
MOD_Plk_4	107	113	PF00069	0.481
MOD_Plk_4	166	172	PF00069	0.619
MOD_Plk_4	199	205	PF00069	0.483
MOD_Plk_4	356	362	PF00069	0.512
MOD_ProDKin_1	137	143	PF00069	0.444
MOD_ProDKin_1	26	32	PF00069	0.589
MOD_ProDKin_1	303	309	PF00069	0.530
MOD_ProDKin_1	317	323	PF00069	0.530
MOD_ProDKin_1	340	346	PF00069	0.589
MOD_SUMO_rev_2	42	46	PF00179	0.416
TRG_DiLeu_BaLyEn_6	308	313	PF01217	0.611
TRG_ENDOCYTIC_2	194	197	PF00928	0.529
TRG_ENDOCYTIC_2	325	328	PF00928	0.536
TRG_ER_diArg_1	257	259	PF00400	0.546
TRG_ER_diArg_1	361	364	PF00400	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN9	Leptomonas seymouri	54%	100%
A4HPA1	Leishmania braziliensis	71%	100%
A4IDK7	Leishmania infantum	99%	100%
E9AT10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1I8	Leishmania major	91%	100%