Endonuclease V, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease V, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAV3_LEIDO

TriTrypDb:

LdBPK_362460.1 , LdCL_360030300 , LDHU3_36.3280

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7XAV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAV3

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003727	single-stranded RNA binding	5	1
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004521	RNA endonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0005488	binding	1	1
GO:0016787	hydrolase activity	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.571
CLV_NRD_NRD_1	258	260	PF00675	0.346
CLV_PCSK_KEX2_1	258	260	PF00082	0.346
CLV_PCSK_SKI1_1	101	105	PF00082	0.669
CLV_PCSK_SKI1_1	279	283	PF00082	0.346
DEG_SPOP_SBC_1	302	306	PF00917	0.619
DOC_CYCLIN_RxL_1	308	319	PF00134	0.563
DOC_PP2B_LxvP_1	270	273	PF13499	0.546
DOC_PP2B_LxvP_1	83	86	PF13499	0.530
DOC_PP4_FxxP_1	102	105	PF00568	0.481

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN9	Leptomonas seymouri	54%	100%
A4HPA1	Leishmania braziliensis	71%	100%
A4IDK7	Leishmania infantum	99%	100%
E9AT10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1I8	Leishmania major	91%	100%

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