Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAU5_LEIDO

TriTrypDb:

LdBPK_362240.1 , LdCL_360028100 , LDHU3_36.2920

Length:

774

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.601
CLV_C14_Caspase3-7	74	78	PF00656	0.619
CLV_NRD_NRD_1	174	176	PF00675	0.659
CLV_NRD_NRD_1	239	241	PF00675	0.701
CLV_NRD_NRD_1	275	277	PF00675	0.656
CLV_NRD_NRD_1	411	413	PF00675	0.705
CLV_NRD_NRD_1	482	484	PF00675	0.564
CLV_NRD_NRD_1	496	498	PF00675	0.515
CLV_NRD_NRD_1	569	571	PF00675	0.660
CLV_NRD_NRD_1	606	608	PF00675	0.495
CLV_NRD_NRD_1	65	67	PF00675	0.644
CLV_NRD_NRD_1	677	679	PF00675	0.574
CLV_PCSK_FUR_1	675	679	PF00082	0.534
CLV_PCSK_KEX2_1	174	176	PF00082	0.761
CLV_PCSK_KEX2_1	275	277	PF00082	0.641
CLV_PCSK_KEX2_1	482	484	PF00082	0.564
CLV_PCSK_KEX2_1	496	498	PF00082	0.515
CLV_PCSK_KEX2_1	569	571	PF00082	0.642
CLV_PCSK_KEX2_1	606	608	PF00082	0.495
CLV_PCSK_KEX2_1	65	67	PF00082	0.644
CLV_PCSK_KEX2_1	677	679	PF00082	0.574
CLV_PCSK_SKI1_1	412	416	PF00082	0.665
CLV_PCSK_SKI1_1	482	486	PF00082	0.574
CLV_PCSK_SKI1_1	497	501	PF00082	0.508
CLV_PCSK_SKI1_1	558	562	PF00082	0.597
CLV_PCSK_SKI1_1	596	600	PF00082	0.471
CLV_PCSK_SKI1_1	606	610	PF00082	0.405
CLV_PCSK_SKI1_1	677	681	PF00082	0.571
CLV_Separin_Metazoa	114	118	PF03568	0.632
DEG_APCC_DBOX_1	174	182	PF00400	0.617
DEG_APCC_DBOX_1	411	419	PF00400	0.655
DEG_APCC_DBOX_1	481	489	PF00400	0.572
DEG_SCF_FBW7_2	741	747	PF00400	0.563
DEG_SPOP_SBC_1	520	524	PF00917	0.569
DOC_ANK_TNKS_1	130	137	PF00023	0.618
DOC_CKS1_1	741	746	PF01111	0.608
DOC_CKS1_1	86	91	PF01111	0.678
DOC_CYCLIN_RxL_1	674	684	PF00134	0.572
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.666
DOC_MAPK_DCC_7	174	183	PF00069	0.627
DOC_MAPK_gen_1	482	490	PF00069	0.666
DOC_MAPK_MEF2A_6	174	183	PF00069	0.627
DOC_PP1_RVXF_1	675	682	PF00149	0.506
DOC_PP2B_LxvP_1	499	502	PF13499	0.657
DOC_PP2B_LxvP_1	707	710	PF13499	0.565
DOC_PP4_FxxP_1	382	385	PF00568	0.553
DOC_PP4_FxxP_1	403	406	PF00568	0.818
DOC_PP4_FxxP_1	742	745	PF00568	0.583
DOC_USP7_MATH_1	177	181	PF00917	0.637
DOC_USP7_MATH_1	189	193	PF00917	0.531
DOC_USP7_MATH_1	196	200	PF00917	0.656
DOC_USP7_MATH_1	202	206	PF00917	0.602
DOC_USP7_MATH_1	212	216	PF00917	0.598
DOC_USP7_MATH_1	230	234	PF00917	0.532
DOC_USP7_MATH_1	289	293	PF00917	0.783
DOC_USP7_MATH_1	299	303	PF00917	0.602
DOC_USP7_MATH_1	363	367	PF00917	0.753
DOC_USP7_MATH_1	393	397	PF00917	0.642
DOC_USP7_MATH_1	457	461	PF00917	0.655
DOC_USP7_MATH_1	465	469	PF00917	0.552
DOC_USP7_MATH_1	504	508	PF00917	0.592
DOC_USP7_MATH_1	519	523	PF00917	0.544
DOC_USP7_MATH_1	539	543	PF00917	0.560
DOC_USP7_MATH_1	648	652	PF00917	0.699
DOC_USP7_MATH_1	686	690	PF00917	0.576
DOC_USP7_MATH_1	695	699	PF00917	0.556
DOC_USP7_MATH_1	710	714	PF00917	0.515
DOC_USP7_MATH_1	718	722	PF00917	0.551
DOC_USP7_MATH_1	745	749	PF00917	0.587
DOC_USP7_MATH_1	751	755	PF00917	0.573
DOC_WW_Pin1_4	1	6	PF00397	0.663
DOC_WW_Pin1_4	182	187	PF00397	0.660
DOC_WW_Pin1_4	282	287	PF00397	0.687
DOC_WW_Pin1_4	354	359	PF00397	0.658
DOC_WW_Pin1_4	39	44	PF00397	0.661
DOC_WW_Pin1_4	489	494	PF00397	0.555
DOC_WW_Pin1_4	497	502	PF00397	0.550
DOC_WW_Pin1_4	636	641	PF00397	0.646
DOC_WW_Pin1_4	644	649	PF00397	0.604
DOC_WW_Pin1_4	65	70	PF00397	0.645
DOC_WW_Pin1_4	668	673	PF00397	0.572
DOC_WW_Pin1_4	740	745	PF00397	0.611
DOC_WW_Pin1_4	757	762	PF00397	0.501
DOC_WW_Pin1_4	8	13	PF00397	0.606
DOC_WW_Pin1_4	85	90	PF00397	0.527
LIG_14-3-3_CanoR_1	197	201	PF00244	0.660
LIG_14-3-3_CanoR_1	266	273	PF00244	0.683
LIG_14-3-3_CanoR_1	596	602	PF00244	0.588
LIG_14-3-3_CanoR_1	634	640	PF00244	0.694
LIG_14-3-3_CanoR_1	65	69	PF00244	0.642
LIG_Actin_WH2_2	104	119	PF00022	0.625
LIG_BRCT_BRCA1_1	521	525	PF00533	0.575
LIG_BRCT_BRCA1_1	540	544	PF00533	0.596
LIG_BRCT_BRCA1_1	593	597	PF00533	0.602
LIG_CSL_BTD_1	86	89	PF09270	0.633
LIG_FHA_1	285	291	PF00498	0.620
LIG_FHA_1	55	61	PF00498	0.663
LIG_FHA_1	86	92	PF00498	0.602
LIG_FHA_2	202	208	PF00498	0.695
LIG_FHA_2	296	302	PF00498	0.694
LIG_FHA_2	400	406	PF00498	0.690
LIG_FHA_2	576	582	PF00498	0.579
LIG_FHA_2	597	603	PF00498	0.456
LIG_LIR_Apic_2	380	385	PF02991	0.553
LIG_LIR_Apic_2	401	407	PF02991	0.824
LIG_LIR_Gen_1	102	111	PF02991	0.629
LIG_LIR_Gen_1	279	289	PF02991	0.781
LIG_LIR_Nem_3	279	284	PF02991	0.712
LIG_LIR_Nem_3	541	547	PF02991	0.663
LIG_LYPXL_S_1	474	478	PF13949	0.590
LIG_LYPXL_SIV_4	24	32	PF13949	0.632
LIG_LYPXL_yS_3	475	478	PF13949	0.587
LIG_MYND_1	89	93	PF01753	0.613
LIG_NRBOX	675	681	PF00104	0.576
LIG_SH2_NCK_1	25	29	PF00017	0.629
LIG_SH2_PTP2	473	476	PF00017	0.613
LIG_SH2_SRC	473	476	PF00017	0.613
LIG_SH2_STAP1	120	124	PF00017	0.599
LIG_SH2_STAT3	120	123	PF00017	0.640
LIG_SH2_STAT5	473	476	PF00017	0.604
LIG_SH3_1	241	247	PF00018	0.614
LIG_SH3_1	533	539	PF00018	0.640
LIG_SH3_1	66	72	PF00018	0.642
LIG_SH3_3	16	22	PF00018	0.574
LIG_SH3_3	183	189	PF00018	0.659
LIG_SH3_3	241	247	PF00018	0.623
LIG_SH3_3	28	34	PF00018	0.543
LIG_SH3_3	280	286	PF00018	0.702
LIG_SH3_3	304	310	PF00018	0.706
LIG_SH3_3	362	368	PF00018	0.624
LIG_SH3_3	380	386	PF00018	0.619
LIG_SH3_3	498	504	PF00018	0.661
LIG_SH3_3	533	539	PF00018	0.645
LIG_SH3_3	553	559	PF00018	0.537
LIG_SH3_3	6	12	PF00018	0.666
LIG_SH3_3	626	632	PF00018	0.645
LIG_SH3_3	66	72	PF00018	0.658
LIG_SH3_3	738	744	PF00018	0.578
LIG_SH3_3	758	764	PF00018	0.523
LIG_SH3_3	86	92	PF00018	0.482
LIG_SUMO_SIM_anti_2	214	221	PF11976	0.567
LIG_TRAF2_1	205	208	PF00917	0.628
LIG_TRAF2_1	477	480	PF00917	0.573
LIG_TRAF2_1	667	670	PF00917	0.545
LIG_WW_3	500	504	PF00397	0.669
MOD_CDK_SPxK_1	497	503	PF00069	0.615
MOD_CDK_SPxK_1	757	763	PF00069	0.619
MOD_CDK_SPxxK_3	1	8	PF00069	0.647
MOD_CDK_SPxxK_3	489	496	PF00069	0.505
MOD_CDK_SPxxK_3	668	675	PF00069	0.525
MOD_CK1_1	192	198	PF00069	0.630
MOD_CK1_1	211	217	PF00069	0.537
MOD_CK1_1	221	227	PF00069	0.607
MOD_CK1_1	268	274	PF00069	0.701
MOD_CK1_1	285	291	PF00069	0.525
MOD_CK1_1	302	308	PF00069	0.644
MOD_CK1_1	329	335	PF00069	0.644
MOD_CK1_1	460	466	PF00069	0.635
MOD_CK1_1	523	529	PF00069	0.650
MOD_CK1_1	638	644	PF00069	0.688
MOD_CK1_1	64	70	PF00069	0.682
MOD_CK1_1	753	759	PF00069	0.572
MOD_CK1_1	768	774	PF00069	0.511
MOD_CK2_1	129	135	PF00069	0.684
MOD_CK2_1	17	23	PF00069	0.624
MOD_CK2_1	201	207	PF00069	0.651
MOD_CK2_1	268	274	PF00069	0.656
MOD_CK2_1	295	301	PF00069	0.685
MOD_CK2_1	575	581	PF00069	0.626
MOD_CK2_1	622	628	PF00069	0.690
MOD_CK2_1	664	670	PF00069	0.560
MOD_CK2_1	686	692	PF00069	0.539
MOD_CK2_1	768	774	PF00069	0.570
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.664
MOD_GlcNHglycan	131	134	PF01048	0.582
MOD_GlcNHglycan	162	165	PF01048	0.690
MOD_GlcNHglycan	191	194	PF01048	0.748
MOD_GlcNHglycan	204	207	PF01048	0.706
MOD_GlcNHglycan	210	213	PF01048	0.585
MOD_GlcNHglycan	220	223	PF01048	0.585
MOD_GlcNHglycan	301	304	PF01048	0.613
MOD_GlcNHglycan	318	321	PF01048	0.622
MOD_GlcNHglycan	35	38	PF01048	0.674
MOD_GlcNHglycan	371	374	PF01048	0.628
MOD_GlcNHglycan	391	394	PF01048	0.640
MOD_GlcNHglycan	395	398	PF01048	0.611
MOD_GlcNHglycan	448	451	PF01048	0.728
MOD_GlcNHglycan	453	456	PF01048	0.661
MOD_GlcNHglycan	459	462	PF01048	0.591
MOD_GlcNHglycan	506	510	PF01048	0.689
MOD_GlcNHglycan	512	515	PF01048	0.654
MOD_GlcNHglycan	526	529	PF01048	0.532
MOD_GlcNHglycan	541	544	PF01048	0.548
MOD_GlcNHglycan	650	653	PF01048	0.660
MOD_GlcNHglycan	699	702	PF01048	0.581
MOD_GlcNHglycan	73	76	PF01048	0.672
MOD_GlcNHglycan	755	758	PF01048	0.580
MOD_GSK3_1	147	154	PF00069	0.647
MOD_GSK3_1	192	199	PF00069	0.732
MOD_GSK3_1	207	214	PF00069	0.690
MOD_GSK3_1	218	225	PF00069	0.592
MOD_GSK3_1	264	271	PF00069	0.705
MOD_GSK3_1	284	291	PF00069	0.504
MOD_GSK3_1	295	302	PF00069	0.681
MOD_GSK3_1	305	312	PF00069	0.697
MOD_GSK3_1	314	321	PF00069	0.619
MOD_GSK3_1	322	329	PF00069	0.571
MOD_GSK3_1	33	40	PF00069	0.675
MOD_GSK3_1	332	339	PF00069	0.601
MOD_GSK3_1	389	396	PF00069	0.660
MOD_GSK3_1	435	442	PF00069	0.713
MOD_GSK3_1	510	517	PF00069	0.668
MOD_GSK3_1	519	526	PF00069	0.568
MOD_GSK3_1	539	546	PF00069	0.576
MOD_GSK3_1	61	68	PF00069	0.663
MOD_GSK3_1	616	623	PF00069	0.633
MOD_GSK3_1	644	651	PF00069	0.669
MOD_GSK3_1	664	671	PF00069	0.484
MOD_GSK3_1	695	702	PF00069	0.573
MOD_GSK3_1	751	758	PF00069	0.622
MOD_GSK3_1	8	15	PF00069	0.663
MOD_GSK3_1	95	102	PF00069	0.636
MOD_NEK2_1	116	121	PF00069	0.652
MOD_NEK2_1	170	175	PF00069	0.743
MOD_NEK2_1	218	223	PF00069	0.727
MOD_NEK2_1	316	321	PF00069	0.696
MOD_NEK2_1	505	510	PF00069	0.700
MOD_NEK2_1	699	704	PF00069	0.568
MOD_NEK2_1	766	771	PF00069	0.611
MOD_NEK2_2	318	323	PF00069	0.602
MOD_PIKK_1	12	18	PF00454	0.666
MOD_PIKK_1	266	272	PF00454	0.773
MOD_PIKK_1	622	628	PF00454	0.690
MOD_PK_1	336	342	PF00069	0.569
MOD_PKA_2	116	122	PF00069	0.633
MOD_PKA_2	137	143	PF00069	0.652
MOD_PKA_2	151	157	PF00069	0.580
MOD_PKA_2	196	202	PF00069	0.657
MOD_PKA_2	230	236	PF00069	0.641
MOD_PKA_2	265	271	PF00069	0.681
MOD_PKA_2	323	329	PF00069	0.545
MOD_PKA_2	363	369	PF00069	0.687
MOD_PKA_2	399	405	PF00069	0.582
MOD_PKA_2	439	445	PF00069	0.714
MOD_PKA_2	446	452	PF00069	0.678
MOD_PKA_2	635	641	PF00069	0.658
MOD_PKA_2	64	70	PF00069	0.675
MOD_PKA_2	718	724	PF00069	0.588
MOD_PKB_1	334	342	PF00069	0.568
MOD_Plk_1	49	55	PF00069	0.636
MOD_Plk_1	581	587	PF00069	0.619
MOD_Plk_1	664	670	PF00069	0.560
MOD_Plk_2-3	109	115	PF00069	0.576
MOD_Plk_2-3	23	29	PF00069	0.654
MOD_Plk_2-3	664	670	PF00069	0.560
MOD_Plk_4	102	108	PF00069	0.630
MOD_Plk_4	214	220	PF00069	0.691
MOD_Plk_4	268	274	PF00069	0.667
MOD_Plk_4	399	405	PF00069	0.731
MOD_Plk_4	581	587	PF00069	0.619
MOD_Plk_4	686	692	PF00069	0.585
MOD_Plk_4	745	751	PF00069	0.538
MOD_ProDKin_1	1	7	PF00069	0.662
MOD_ProDKin_1	182	188	PF00069	0.661
MOD_ProDKin_1	282	288	PF00069	0.685
MOD_ProDKin_1	354	360	PF00069	0.659
MOD_ProDKin_1	39	45	PF00069	0.663
MOD_ProDKin_1	489	495	PF00069	0.554
MOD_ProDKin_1	497	503	PF00069	0.556
MOD_ProDKin_1	636	642	PF00069	0.643
MOD_ProDKin_1	644	650	PF00069	0.604
MOD_ProDKin_1	65	71	PF00069	0.646
MOD_ProDKin_1	668	674	PF00069	0.569
MOD_ProDKin_1	740	746	PF00069	0.611
MOD_ProDKin_1	757	763	PF00069	0.504
MOD_ProDKin_1	8	14	PF00069	0.604
MOD_ProDKin_1	85	91	PF00069	0.527
MOD_SUMO_for_1	377	380	PF00179	0.616
MOD_SUMO_for_1	564	567	PF00179	0.593
TRG_DiLeu_BaEn_1	480	485	PF01217	0.565
TRG_DiLeu_BaEn_2	580	586	PF01217	0.593
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.667
TRG_DiLeu_BaLyEn_6	675	680	PF01217	0.576
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.663
TRG_DiLeu_LyEn_5	480	485	PF01217	0.565
TRG_ENDOCYTIC_2	475	478	PF00928	0.587
TRG_ER_diArg_1	482	484	PF00400	0.564
TRG_ER_diArg_1	495	497	PF00400	0.510
TRG_ER_diArg_1	569	571	PF00400	0.660
TRG_ER_diArg_1	605	607	PF00400	0.506
TRG_ER_diArg_1	634	637	PF00400	0.709
TRG_ER_diArg_1	675	678	PF00400	0.579
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	677	682	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HP80	Leishmania braziliensis	58%	100%
A4IDI5	Leishmania infantum	100%	100%
E9ASY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q1L0	Leishmania major	88%	100%