LeishMANIAdb
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Glucokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glucokinase
Gene product:
glucokinase
Species:
Leishmania donovani
UniProt:
A0A3S7XAU3_LEIDO
TriTrypDb:
LdBPK_362450.1 , LdCL_360030200 , LDHU3_36.3260
Length:
411

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0043226 organelle 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3S7XAU3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAU3

PDB structure(s): 6edi_A , 6edi_B

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 10
GO:0006082 organic acid metabolic process 3 10
GO:0006090 pyruvate metabolic process 7 10
GO:0006091 generation of precursor metabolites and energy 3 10
GO:0006096 glycolytic process 5 10
GO:0006139 nucleobase-containing compound metabolic process 3 10
GO:0006163 purine nucleotide metabolic process 5 10
GO:0006165 obsolete nucleoside diphosphate phosphorylation 6 10
GO:0006725 cellular aromatic compound metabolic process 3 10
GO:0006753 nucleoside phosphate metabolic process 4 10
GO:0006757 obsolete ATP generation from ADP 4 10
GO:0006793 phosphorus metabolic process 3 10
GO:0006796 phosphate-containing compound metabolic process 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0009056 catabolic process 2 10
GO:0009117 nucleotide metabolic process 5 10
GO:0009132 nucleoside diphosphate metabolic process 5 10
GO:0009135 purine nucleoside diphosphate metabolic process 6 10
GO:0009141 nucleoside triphosphate metabolic process 5 10
GO:0009144 purine nucleoside triphosphate metabolic process 6 10
GO:0009150 purine ribonucleotide metabolic process 6 10
GO:0009179 purine ribonucleoside diphosphate metabolic process 7 10
GO:0009185 ribonucleoside diphosphate metabolic process 6 10
GO:0009199 ribonucleoside triphosphate metabolic process 6 10
GO:0009205 purine ribonucleoside triphosphate metabolic process 7 10
GO:0009259 ribonucleotide metabolic process 5 10
GO:0009987 cellular process 1 10
GO:0016052 carbohydrate catabolic process 4 10
GO:0016310 phosphorylation 5 10
GO:0019637 organophosphate metabolic process 3 10
GO:0019693 ribose phosphate metabolic process 4 10
GO:0019752 carboxylic acid metabolic process 5 10
GO:0032787 monocarboxylic acid metabolic process 6 10
GO:0034641 cellular nitrogen compound metabolic process 3 10
GO:0043436 oxoacid metabolic process 4 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0044281 small molecule metabolic process 2 10
GO:0046031 ADP metabolic process 7 10
GO:0046034 ATP metabolic process 7 10
GO:0046483 heterocycle metabolic process 3 10
GO:0046939 obsolete nucleotide phosphorylation 6 10
GO:0055086 nucleobase-containing small molecule metabolic process 3 10
GO:0071704 organic substance metabolic process 2 10
GO:0072521 purine-containing compound metabolic process 4 10
GO:1901135 carbohydrate derivative metabolic process 3 10
GO:1901360 organic cyclic compound metabolic process 3 10
GO:1901564 organonitrogen compound metabolic process 3 10
GO:1901575 organic substance catabolic process 3 10
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0003824 catalytic activity 1 10
GO:0004340 glucokinase activity 6 10
GO:0004396 hexokinase activity 5 10
GO:0005488 binding 1 10
GO:0005524 ATP binding 5 10
GO:0005536 glucose binding 4 10
GO:0016301 kinase activity 4 10
GO:0016740 transferase activity 2 10
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 10
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 10
GO:0017076 purine nucleotide binding 4 10
GO:0019200 carbohydrate kinase activity 5 10
GO:0030246 carbohydrate binding 2 10
GO:0030554 adenyl nucleotide binding 5 10
GO:0032553 ribonucleotide binding 3 10
GO:0032555 purine ribonucleotide binding 4 10
GO:0032559 adenyl ribonucleotide binding 5 10
GO:0035639 purine ribonucleoside triphosphate binding 4 10
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0048029 monosaccharide binding 3 10
GO:0097159 organic cyclic compound binding 2 10
GO:0097367 carbohydrate derivative binding 2 10
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 94 96 PF00675 0.319
CLV_PCSK_KEX2_1 353 355 PF00082 0.407
CLV_PCSK_KEX2_1 64 66 PF00082 0.301
CLV_PCSK_KEX2_1 94 96 PF00082 0.280
CLV_PCSK_PC1ET2_1 353 355 PF00082 0.407
CLV_PCSK_PC1ET2_1 64 66 PF00082 0.301
CLV_PCSK_SKI1_1 137 141 PF00082 0.291
CLV_PCSK_SKI1_1 295 299 PF00082 0.309
CLV_PCSK_SKI1_1 366 370 PF00082 0.504
CLV_PCSK_SKI1_1 68 72 PF00082 0.292
DEG_APCC_DBOX_1 49 57 PF00400 0.460
DOC_CYCLIN_RxL_1 362 374 PF00134 0.426
DOC_MAPK_gen_1 311 319 PF00069 0.517
DOC_MAPK_gen_1 378 387 PF00069 0.330
DOC_MAPK_gen_1 64 73 PF00069 0.475
DOC_MAPK_MEF2A_6 378 387 PF00069 0.348
DOC_PP1_RVXF_1 163 169 PF00149 0.517
DOC_PP1_RVXF_1 364 371 PF00149 0.432
DOC_PP1_RVXF_1 37 43 PF00149 0.480
DOC_PP4_FxxP_1 346 349 PF00568 0.476
DOC_SPAK_OSR1_1 59 63 PF12202 0.519
DOC_USP7_MATH_1 181 185 PF00917 0.491
DOC_USP7_MATH_1 286 290 PF00917 0.560
DOC_USP7_MATH_1 406 410 PF00917 0.672
DOC_USP7_UBL2_3 165 169 PF12436 0.491
DOC_USP7_UBL2_3 247 251 PF12436 0.500
DOC_USP7_UBL2_3 278 282 PF12436 0.553
LIG_14-3-3_CanoR_1 373 377 PF00244 0.321
LIG_14-3-3_CanoR_1 378 384 PF00244 0.323
LIG_Actin_WH2_2 364 380 PF00022 0.455
LIG_Actin_WH2_2 78 96 PF00022 0.519
LIG_BIR_II_1 1 5 PF00653 0.498
LIG_BRCT_BRCA1_1 160 164 PF00533 0.480
LIG_BRCT_BRCA1_1 340 344 PF00533 0.441
LIG_FHA_1 120 126 PF00498 0.412
LIG_FHA_1 2 8 PF00498 0.492
LIG_FHA_1 22 28 PF00498 0.457
LIG_FHA_1 329 335 PF00498 0.437
LIG_FHA_1 372 378 PF00498 0.443
LIG_FHA_2 169 175 PF00498 0.519
LIG_FHA_2 61 67 PF00498 0.517
LIG_LIR_Apic_2 343 349 PF02991 0.462
LIG_LIR_Gen_1 171 181 PF02991 0.508
LIG_LIR_Gen_1 211 219 PF02991 0.455
LIG_LIR_Gen_1 72 81 PF02991 0.521
LIG_LIR_Nem_3 148 152 PF02991 0.495
LIG_LIR_Nem_3 161 166 PF02991 0.433
LIG_LIR_Nem_3 171 176 PF02991 0.492
LIG_LIR_Nem_3 211 217 PF02991 0.455
LIG_LIR_Nem_3 310 316 PF02991 0.480
LIG_LIR_Nem_3 324 330 PF02991 0.480
LIG_LIR_Nem_3 72 77 PF02991 0.521
LIG_MLH1_MIPbox_1 160 164 PF16413 0.480
LIG_MLH1_MIPbox_1 342 346 PF16413 0.439
LIG_PDZ_Class_1 406 411 PF00595 0.645
LIG_Pex14_2 164 168 PF04695 0.447
LIG_PTB_Apo_2 339 346 PF02174 0.353
LIG_PTB_Phospho_1 339 345 PF10480 0.444
LIG_SH2_CRK 149 153 PF00017 0.480
LIG_SH2_CRK 313 317 PF00017 0.517
LIG_SH2_PTP2 207 210 PF00017 0.504
LIG_SH2_PTP2 214 217 PF00017 0.453
LIG_SH2_STAT5 163 166 PF00017 0.437
LIG_SH2_STAT5 207 210 PF00017 0.481
LIG_SH2_STAT5 214 217 PF00017 0.428
LIG_SH2_STAT5 236 239 PF00017 0.492
LIG_SH2_STAT5 28 31 PF00017 0.423
LIG_SH2_STAT5 345 348 PF00017 0.407
LIG_SH2_STAT5 57 60 PF00017 0.483
LIG_SH3_3 190 196 PF00018 0.465
LIG_SH3_3 98 104 PF00018 0.449
LIG_SUMO_SIM_par_1 150 155 PF11976 0.448
LIG_SUMO_SIM_par_1 215 220 PF11976 0.486
LIG_TYR_ITIM 205 210 PF00017 0.392
MOD_CK1_1 21 27 PF00069 0.468
MOD_CK1_1 338 344 PF00069 0.502
MOD_CK1_1 372 378 PF00069 0.318
MOD_CK1_1 395 401 PF00069 0.543
MOD_CK2_1 265 271 PF00069 0.465
MOD_CK2_1 286 292 PF00069 0.349
MOD_GlcNHglycan 137 140 PF01048 0.296
MOD_GlcNHglycan 267 270 PF01048 0.276
MOD_GlcNHglycan 288 291 PF01048 0.369
MOD_GlcNHglycan 49 53 PF01048 0.468
MOD_GlcNHglycan 97 100 PF01048 0.369
MOD_GSK3_1 195 202 PF00069 0.305
MOD_GSK3_1 317 324 PF00069 0.402
MOD_GSK3_1 95 102 PF00069 0.407
MOD_N-GLC_1 265 270 PF02516 0.451
MOD_N-GLC_1 406 411 PF02516 0.659
MOD_NEK2_1 119 124 PF00069 0.430
MOD_NEK2_1 152 157 PF00069 0.392
MOD_NEK2_1 224 229 PF00069 0.418
MOD_NEK2_1 253 258 PF00069 0.430
MOD_NEK2_1 335 340 PF00069 0.395
MOD_NEK2_1 371 376 PF00069 0.465
MOD_NEK2_1 60 65 PF00069 0.426
MOD_PIKK_1 168 174 PF00454 0.340
MOD_PIKK_1 392 398 PF00454 0.467
MOD_PKA_2 372 378 PF00069 0.324
MOD_PKA_2 60 66 PF00069 0.313
MOD_Plk_1 18 24 PF00069 0.518
MOD_Plk_1 253 259 PF00069 0.362
MOD_Plk_1 321 327 PF00069 0.305
MOD_Plk_1 360 366 PF00069 0.486
MOD_Plk_4 200 206 PF00069 0.392
MOD_Plk_4 210 216 PF00069 0.344
MOD_Plk_4 335 341 PF00069 0.314
MOD_Plk_4 372 378 PF00069 0.318
MOD_SUMO_rev_2 174 182 PF00179 0.395
MOD_SUMO_rev_2 227 237 PF00179 0.399
TRG_ENDOCYTIC_2 149 152 PF00928 0.318
TRG_ENDOCYTIC_2 163 166 PF00928 0.250
TRG_ENDOCYTIC_2 207 210 PF00928 0.280
TRG_ENDOCYTIC_2 214 217 PF00928 0.280
TRG_ENDOCYTIC_2 313 316 PF00928 0.342
TRG_ENDOCYTIC_2 57 60 PF00928 0.350
TRG_ER_diArg_1 93 95 PF00400 0.395
TRG_Pf-PMV_PEXEL_1 65 69 PF00026 0.405
TRG_PTS1 408 411 PF00515 0.611

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZF4 Leptomonas seymouri 67% 100%
A0A0S4JSI6 Bodo saltans 32% 100%
A0A3R7L110 Trypanosoma rangeli 42% 100%
A4HPA0 Leishmania braziliensis 87% 100%
A4IDK6 Leishmania infantum 100% 100%
E9AT09 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q1I9 Leishmania major 96% 100%
Q9GTW8 Trichomonas vaginalis 26% 100%
Q9GTW9 Trichomonas vaginalis 27% 100%
V5BBU8 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS