Glucokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Glucokinase

Gene product:

glucokinase

Species:

Leishmania donovani

UniProt:

A0A3S7XAU3_LEIDO

TriTrypDb:

LdBPK_362450.1 , LdCL_360030200 , LDHU3_36.3260

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

A0A3S7XAU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAU3

PDB structure(s): 6edi_A , 6edi_B

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	10
GO:0006082	organic acid metabolic process	3	10
GO:0006090	pyruvate metabolic process	7	10
GO:0006091	generation of precursor metabolites and energy	3	10
GO:0006096	glycolytic process	5	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006163	purine nucleotide metabolic process	5	10
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006753	nucleoside phosphate metabolic process	4	10

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004340	glucokinase activity	6	10
GO:0004396	hexokinase activity	5	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0005536	glucose binding	4	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	94	96	PF00675	0.319
CLV_PCSK_KEX2_1	353	355	PF00082	0.407
CLV_PCSK_KEX2_1	64	66	PF00082	0.301
CLV_PCSK_KEX2_1	94	96	PF00082	0.280
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.407
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.301
CLV_PCSK_SKI1_1	137	141	PF00082	0.291
CLV_PCSK_SKI1_1	295	299	PF00082	0.309
CLV_PCSK_SKI1_1	366	370	PF00082	0.504
CLV_PCSK_SKI1_1	68	72	PF00082	0.292

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZF4	Leptomonas seymouri	67%	100%
A0A0S4JSI6	Bodo saltans	32%	100%
A0A3R7L110	Trypanosoma rangeli	42%	100%
A4HPA0	Leishmania braziliensis	87%	100%
A4IDK6	Leishmania infantum	100%	100%
E9AT09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q1I9	Leishmania major	96%	100%
Q9GTW8	Trichomonas vaginalis	26%	100%
Q9GTW9	Trichomonas vaginalis	27%	100%
V5BBU8	Trypanosoma cruzi	43%	100%

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