LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S7XAU2_LEIDO
TriTrypDb:
LdBPK_362400.1 , LdCL_360029700 , LDHU3_36.3190
Length:
461

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAU2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAU2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 256 260 PF00656 0.715
CLV_MEL_PAP_1 78 84 PF00089 0.411
CLV_NRD_NRD_1 33 35 PF00675 0.577
CLV_NRD_NRD_1 338 340 PF00675 0.738
CLV_PCSK_KEX2_1 33 35 PF00082 0.577
CLV_PCSK_KEX2_1 338 340 PF00082 0.738
CLV_PCSK_SKI1_1 206 210 PF00082 0.600
CLV_PCSK_SKI1_1 333 337 PF00082 0.636
CLV_PCSK_SKI1_1 5 9 PF00082 0.568
CLV_PCSK_SKI1_1 72 76 PF00082 0.520
CLV_Separin_Metazoa 69 73 PF03568 0.492
DEG_APCC_DBOX_1 71 79 PF00400 0.427
DEG_COP1_1 229 237 PF00400 0.649
DOC_CKS1_1 214 219 PF01111 0.690
DOC_CYCLIN_yCln2_LP_2 130 136 PF00134 0.697
DOC_MAPK_MEF2A_6 59 66 PF00069 0.521
DOC_PP2B_LxvP_1 207 210 PF13499 0.635
DOC_USP7_MATH_1 101 105 PF00917 0.628
DOC_USP7_MATH_1 208 212 PF00917 0.710
DOC_USP7_MATH_1 228 232 PF00917 0.508
DOC_USP7_MATH_1 312 316 PF00917 0.785
DOC_WW_Pin1_4 209 214 PF00397 0.695
DOC_WW_Pin1_4 226 231 PF00397 0.585
DOC_WW_Pin1_4 257 262 PF00397 0.742
DOC_WW_Pin1_4 263 268 PF00397 0.669
LIG_14-3-3_CanoR_1 126 131 PF00244 0.641
LIG_14-3-3_CanoR_1 181 188 PF00244 0.629
LIG_14-3-3_CanoR_1 304 312 PF00244 0.691
LIG_14-3-3_CanoR_1 394 398 PF00244 0.561
LIG_BIR_II_1 1 5 PF00653 0.600
LIG_BIR_III_3 1 5 PF00653 0.600
LIG_deltaCOP1_diTrp_1 350 356 PF00928 0.617
LIG_FHA_1 125 131 PF00498 0.639
LIG_FHA_1 18 24 PF00498 0.457
LIG_FHA_1 263 269 PF00498 0.699
LIG_FHA_1 394 400 PF00498 0.665
LIG_FHA_1 53 59 PF00498 0.505
LIG_FHA_1 89 95 PF00498 0.676
LIG_FHA_2 214 220 PF00498 0.693
LIG_FHA_2 251 257 PF00498 0.692
LIG_FHA_2 335 341 PF00498 0.744
LIG_FHA_2 41 47 PF00498 0.524
LIG_FHA_2 436 442 PF00498 0.483
LIG_GBD_Chelix_1 66 74 PF00786 0.420
LIG_LIR_Gen_1 125 136 PF02991 0.670
LIG_LIR_Gen_1 198 207 PF02991 0.645
LIG_LIR_Gen_1 350 360 PF02991 0.668
LIG_LIR_Gen_1 386 393 PF02991 0.572
LIG_LIR_Gen_1 437 447 PF02991 0.635
LIG_LIR_Gen_1 60 67 PF02991 0.635
LIG_LIR_Gen_1 73 84 PF02991 0.578
LIG_LIR_Nem_3 198 202 PF02991 0.628
LIG_LIR_Nem_3 350 356 PF02991 0.665
LIG_LIR_Nem_3 386 392 PF02991 0.575
LIG_LIR_Nem_3 437 442 PF02991 0.628
LIG_LIR_Nem_3 60 64 PF02991 0.644
LIG_PCNA_yPIPBox_3 63 75 PF02747 0.576
LIG_Pex14_1 274 278 PF04695 0.637
LIG_RPA_C_Fungi 29 41 PF08784 0.581
LIG_SH2_NCK_1 439 443 PF00017 0.611
LIG_SH2_PTP2 389 392 PF00017 0.497
LIG_SH2_PTP2 458 461 PF00017 0.460
LIG_SH2_SRC 439 442 PF00017 0.551
LIG_SH2_STAP1 199 203 PF00017 0.633
LIG_SH2_STAP1 439 443 PF00017 0.468
LIG_SH2_STAT5 128 131 PF00017 0.647
LIG_SH2_STAT5 292 295 PF00017 0.692
LIG_SH2_STAT5 35 38 PF00017 0.604
LIG_SH2_STAT5 389 392 PF00017 0.497
LIG_SH2_STAT5 458 461 PF00017 0.635
LIG_SH2_STAT5 61 64 PF00017 0.658
LIG_SH3_3 207 213 PF00018 0.686
LIG_SH3_3 227 233 PF00018 0.596
LIG_SUMO_SIM_par_1 134 139 PF11976 0.738
LIG_SUMO_SIM_par_1 50 55 PF11976 0.383
LIG_TRAF2_1 329 332 PF00917 0.661
LIG_TYR_ITIM 197 202 PF00017 0.633
MOD_CK1_1 122 128 PF00069 0.615
MOD_CK1_1 212 218 PF00069 0.767
MOD_CK1_1 22 28 PF00069 0.561
MOD_CK1_1 245 251 PF00069 0.670
MOD_CK1_1 257 263 PF00069 0.665
MOD_CK1_1 305 311 PF00069 0.677
MOD_CK1_1 364 370 PF00069 0.729
MOD_CK2_1 158 164 PF00069 0.554
MOD_CK2_1 250 256 PF00069 0.739
MOD_CK2_1 334 340 PF00069 0.749
MOD_CK2_1 370 376 PF00069 0.743
MOD_GlcNHglycan 121 124 PF01048 0.618
MOD_GlcNHglycan 145 148 PF01048 0.626
MOD_GlcNHglycan 183 186 PF01048 0.639
MOD_GlcNHglycan 261 264 PF01048 0.774
MOD_GlcNHglycan 314 317 PF01048 0.732
MOD_GlcNHglycan 36 39 PF01048 0.459
MOD_GlcNHglycan 364 367 PF01048 0.571
MOD_GlcNHglycan 376 380 PF01048 0.537
MOD_GlcNHglycan 408 411 PF01048 0.730
MOD_GlcNHglycan 412 415 PF01048 0.714
MOD_GlcNHglycan 82 85 PF01048 0.568
MOD_GSK3_1 122 129 PF00069 0.633
MOD_GSK3_1 19 26 PF00069 0.528
MOD_GSK3_1 208 215 PF00069 0.795
MOD_GSK3_1 222 229 PF00069 0.625
MOD_GSK3_1 250 257 PF00069 0.722
MOD_GSK3_1 259 266 PF00069 0.619
MOD_GSK3_1 303 310 PF00069 0.714
MOD_GSK3_1 360 367 PF00069 0.710
MOD_GSK3_1 398 405 PF00069 0.674
MOD_GSK3_1 406 413 PF00069 0.625
MOD_NEK2_1 121 126 PF00069 0.597
MOD_NEK2_1 242 247 PF00069 0.768
MOD_NEK2_1 360 365 PF00069 0.721
MOD_NEK2_1 398 403 PF00069 0.620
MOD_NEK2_1 406 411 PF00069 0.566
MOD_NEK2_1 435 440 PF00069 0.612
MOD_NEK2_1 50 55 PF00069 0.609
MOD_PIKK_1 176 182 PF00454 0.647
MOD_PIKK_1 52 58 PF00454 0.391
MOD_PKA_2 242 248 PF00069 0.670
MOD_PKA_2 303 309 PF00069 0.679
MOD_PKA_2 393 399 PF00069 0.572
MOD_PKA_2 80 86 PF00069 0.462
MOD_Plk_1 17 23 PF00069 0.428
MOD_Plk_4 116 122 PF00069 0.561
MOD_Plk_4 126 132 PF00069 0.581
MOD_Plk_4 19 25 PF00069 0.452
MOD_Plk_4 242 248 PF00069 0.625
MOD_ProDKin_1 209 215 PF00069 0.701
MOD_ProDKin_1 226 232 PF00069 0.581
MOD_ProDKin_1 257 263 PF00069 0.740
MOD_SUMO_rev_2 215 223 PF00179 0.704
TRG_DiLeu_BaEn_4 331 337 PF01217 0.659
TRG_ENDOCYTIC_2 128 131 PF00928 0.583
TRG_ENDOCYTIC_2 199 202 PF00928 0.635
TRG_ENDOCYTIC_2 292 295 PF00928 0.692
TRG_ENDOCYTIC_2 389 392 PF00928 0.561
TRG_ENDOCYTIC_2 439 442 PF00928 0.614
TRG_ENDOCYTIC_2 61 64 PF00928 0.604
TRG_ER_diArg_1 33 35 PF00400 0.577
TRG_Pf-PMV_PEXEL_1 8 12 PF00026 0.578

Homologs

Protein Taxonomy Sequence identity Coverage
A4HP96 Leishmania braziliensis 71% 100%
A4IDK1 Leishmania infantum 100% 100%
E9AT04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q1J4 Leishmania major 90% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS