TLD, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

TLD, putative

Gene product:

TLD, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAT0_LEIDO

TriTrypDb:

LdBPK_362060.1 , LdCL_360026100 , LDHU3_36.2680

Length:

374

Annotations

LeishMANIAdb annotations

Distantly related to a domain found in MEAK7, a regulatory subunit of animal mTOR complex. The hydrophobic segment is likely a perimembrane anchor, not a TM region (used instead of a mirystoylation site found in mammals)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7XAT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAT0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004386	helicase activity	2	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3
GO:0140657	ATP-dependent activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.346
CLV_C14_Caspase3-7	347	351	PF00656	0.658
CLV_NRD_NRD_1	368	370	PF00675	0.516
CLV_PCSK_KEX2_1	102	104	PF00082	0.398
CLV_PCSK_KEX2_1	368	370	PF00082	0.516
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.368
CLV_PCSK_SKI1_1	102	106	PF00082	0.523
CLV_PCSK_SKI1_1	189	193	PF00082	0.346
DOC_ANK_TNKS_1	230	237	PF00023	0.378
DOC_CKS1_1	106	111	PF01111	0.550
DOC_CKS1_1	59	64	PF01111	0.641
DOC_MAPK_HePTP_8	154	166	PF00069	0.428
DOC_MAPK_MEF2A_6	157	166	PF00069	0.428
DOC_MAPK_MEF2A_6	352	360	PF00069	0.611
DOC_PP2B_PxIxI_1	158	164	PF00149	0.432
DOC_PP4_FxxP_1	302	305	PF00568	0.312
DOC_PP4_FxxP_1	59	62	PF00568	0.647
DOC_USP7_MATH_1	195	199	PF00917	0.431
DOC_USP7_UBL2_3	77	81	PF12436	0.616
DOC_WW_Pin1_4	105	110	PF00397	0.339
DOC_WW_Pin1_4	166	171	PF00397	0.432
DOC_WW_Pin1_4	58	63	PF00397	0.780
DOC_WW_Pin1_4	88	93	PF00397	0.540
LIG_14-3-3_CanoR_1	153	161	PF00244	0.443
LIG_14-3-3_CanoR_1	209	214	PF00244	0.332
LIG_14-3-3_CanoR_1	298	303	PF00244	0.344
LIG_14-3-3_CanoR_1	306	315	PF00244	0.332
LIG_BIR_III_2	117	121	PF00653	0.480
LIG_BRCT_BRCA1_1	217	221	PF00533	0.318
LIG_FHA_1	106	112	PF00498	0.471
LIG_FHA_1	158	164	PF00498	0.332
LIG_FHA_1	235	241	PF00498	0.345
LIG_FHA_1	261	267	PF00498	0.416
LIG_FHA_1	28	34	PF00498	0.344
LIG_FHA_1	337	343	PF00498	0.689
LIG_FHA_2	2	8	PF00498	0.410
LIG_FHA_2	240	246	PF00498	0.459
LIG_GBD_Chelix_1	111	119	PF00786	0.461
LIG_LIR_Apic_2	300	305	PF02991	0.319
LIG_LIR_Apic_2	58	62	PF02991	0.644
LIG_LIR_Gen_1	146	154	PF02991	0.300
LIG_LIR_Gen_1	17	27	PF02991	0.348
LIG_LIR_Gen_1	178	185	PF02991	0.332
LIG_LIR_Gen_1	255	265	PF02991	0.388
LIG_LIR_Gen_1	30	39	PF02991	0.389
LIG_LIR_Nem_3	13	19	PF02991	0.419
LIG_LIR_Nem_3	132	138	PF02991	0.393
LIG_LIR_Nem_3	146	150	PF02991	0.236
LIG_LIR_Nem_3	178	184	PF02991	0.339
LIG_LIR_Nem_3	220	225	PF02991	0.312
LIG_LIR_Nem_3	255	260	PF02991	0.388
LIG_LIR_Nem_3	30	34	PF02991	0.516
LIG_PDZ_Class_1	369	374	PF00595	0.688
LIG_Pex14_1	134	138	PF04695	0.315
LIG_Pex14_2	257	261	PF04695	0.312
LIG_Pex14_2	284	288	PF04695	0.328
LIG_SH2_CRK	31	35	PF00017	0.383
LIG_SH2_CRK	83	87	PF00017	0.656
LIG_SH2_PTP2	19	22	PF00017	0.351
LIG_SH2_PTP2	35	38	PF00017	0.356
LIG_SH2_SRC	141	144	PF00017	0.295
LIG_SH2_SRC	19	22	PF00017	0.351
LIG_SH2_SRC	233	236	PF00017	0.312
LIG_SH2_STAP1	138	142	PF00017	0.388
LIG_SH2_STAP1	29	33	PF00017	0.361
LIG_SH2_STAT5	135	138	PF00017	0.360
LIG_SH2_STAT5	141	144	PF00017	0.356
LIG_SH2_STAT5	19	22	PF00017	0.388
LIG_SH2_STAT5	23	26	PF00017	0.353
LIG_SH2_STAT5	259	262	PF00017	0.296
LIG_SH2_STAT5	29	32	PF00017	0.383
LIG_SH2_STAT5	35	38	PF00017	0.391
LIG_SH3_3	103	109	PF00018	0.230
LIG_SH3_3	84	90	PF00018	0.553
LIG_SUMO_SIM_anti_2	160	165	PF11976	0.312
LIG_SUMO_SIM_par_1	103	108	PF11976	0.526
LIG_TRAF2_1	265	268	PF00917	0.432
LIG_TRAF2_1	76	79	PF00917	0.707
LIG_TYR_ITIM	33	38	PF00017	0.386
LIG_UBA3_1	104	110	PF00899	0.412
LIG_UBA3_1	161	167	PF00899	0.432
MOD_CDK_SPK_2	105	110	PF00069	0.506
MOD_CDK_SPK_2	166	171	PF00069	0.411
MOD_CK1_1	129	135	PF00069	0.524
MOD_CK1_1	249	255	PF00069	0.352
MOD_CK1_1	309	315	PF00069	0.435
MOD_CK1_1	336	342	PF00069	0.644
MOD_CK1_1	5	11	PF00069	0.410
MOD_CK1_1	58	64	PF00069	0.786
MOD_CK2_1	1	7	PF00069	0.413
MOD_CK2_1	209	215	PF00069	0.235
MOD_CK2_1	239	245	PF00069	0.378
MOD_CK2_1	305	311	PF00069	0.337
MOD_GlcNHglycan	128	131	PF01048	0.506
MOD_GlcNHglycan	192	195	PF01048	0.317
MOD_GlcNHglycan	197	200	PF01048	0.293
MOD_GlcNHglycan	211	214	PF01048	0.312
MOD_GlcNHglycan	339	342	PF01048	0.693
MOD_GSK3_1	1	8	PF00069	0.410
MOD_GSK3_1	153	160	PF00069	0.432
MOD_GSK3_1	176	183	PF00069	0.417
MOD_GSK3_1	195	202	PF00069	0.145
MOD_GSK3_1	23	30	PF00069	0.316
MOD_GSK3_1	234	241	PF00069	0.390
MOD_GSK3_1	248	255	PF00069	0.357
MOD_GSK3_1	305	312	PF00069	0.360
MOD_GSK3_1	333	340	PF00069	0.538
MOD_GSK3_1	47	54	PF00069	0.681
MOD_N-GLC_1	360	365	PF02516	0.614
MOD_N-GLC_2	69	71	PF02516	0.707
MOD_NEK2_1	1	6	PF00069	0.462
MOD_NEK2_1	136	141	PF00069	0.298
MOD_NEK2_1	260	265	PF00069	0.406
MOD_NEK2_1	331	336	PF00069	0.521
MOD_NEK2_1	55	60	PF00069	0.681
MOD_PKA_2	152	158	PF00069	0.295
MOD_PKA_2	199	205	PF00069	0.383
MOD_PKA_2	208	214	PF00069	0.302
MOD_PKA_2	297	303	PF00069	0.348
MOD_PKA_2	305	311	PF00069	0.298
MOD_PKA_2	337	343	PF00069	0.613
MOD_Plk_2-3	239	245	PF00069	0.312
MOD_Plk_4	137	143	PF00069	0.402
MOD_Plk_4	15	21	PF00069	0.303
MOD_Plk_4	157	163	PF00069	0.145
MOD_Plk_4	217	223	PF00069	0.424
MOD_Plk_4	23	29	PF00069	0.438
MOD_Plk_4	309	315	PF00069	0.469
MOD_ProDKin_1	105	111	PF00069	0.334
MOD_ProDKin_1	166	172	PF00069	0.432
MOD_ProDKin_1	58	64	PF00069	0.780
MOD_ProDKin_1	88	94	PF00069	0.531
MOD_SUMO_for_1	76	79	PF00179	0.656
MOD_SUMO_rev_2	262	270	PF00179	0.388
MOD_SUMO_rev_2	73	82	PF00179	0.718
TRG_ENDOCYTIC_2	19	22	PF00928	0.358
TRG_ENDOCYTIC_2	281	284	PF00928	0.432
TRG_ENDOCYTIC_2	29	32	PF00928	0.380
TRG_ENDOCYTIC_2	35	38	PF00928	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZW5	Leptomonas seymouri	61%	100%
A0A0S4JCM6	Bodo saltans	26%	100%
A0A0S4JIE3	Bodo saltans	42%	100%
A0A1X0P7Q9	Trypanosomatidae	49%	100%
A0A3R7M9V1	Trypanosoma rangeli	46%	100%
A4HP62	Leishmania braziliensis	79%	100%
E9AG16	Leishmania major	85%	100%
E9AHX4	Leishmania infantum	96%	100%
E9ASX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BGD9	Trypanosoma cruzi	47%	100%