Inosine-guanosine_transporter/GeneDB:LmjF.36.1940

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inosine-guanosine transporter

Species:

Leishmania donovani

UniProt:

A0A3S7XAS5_LEIDO

TriTrypDb:

LdBPK_362040.1 , LdCL_360025900 , LDHU3_36.2660

Length:

499

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 45

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 10

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 53
NetGPI	no	yes: 0, no: 53

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	54
GO:0110165	cellular anatomical entity	1	54
GO:0005886	plasma membrane	3	5

Expansion

Sequence features

A0A3S7XAS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAS5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0015851	nucleobase transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	54
GO:0005337	nucleoside transmembrane transporter activity	4	54
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	54
GO:0022857	transmembrane transporter activity	2	54
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	54
GO:0015205	nucleobase transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.577
CLV_NRD_NRD_1	251	253	PF00675	0.346
CLV_PCSK_KEX2_1	250	252	PF00082	0.379
CLV_PCSK_KEX2_1	343	345	PF00082	0.386
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.342
CLV_PCSK_SKI1_1	111	115	PF00082	0.351
CLV_PCSK_SKI1_1	280	284	PF00082	0.246
CLV_PCSK_SKI1_1	325	329	PF00082	0.454
CLV_PCSK_SKI1_1	393	397	PF00082	0.387
DOC_CKS1_1	459	464	PF01111	0.566
DOC_MAPK_DCC_7	415	424	PF00069	0.396
DOC_MAPK_DCC_7	427	435	PF00069	0.346
DOC_MAPK_gen_1	343	350	PF00069	0.563
DOC_MAPK_gen_1	399	409	PF00069	0.605
DOC_MAPK_HePTP_8	108	120	PF00069	0.576
DOC_MAPK_MEF2A_6	104	112	PF00069	0.598
DOC_MAPK_MEF2A_6	211	220	PF00069	0.459
DOC_MAPK_MEF2A_6	373	382	PF00069	0.451
DOC_MAPK_MEF2A_6	393	400	PF00069	0.507
DOC_MAPK_MEF2A_6	402	409	PF00069	0.565
DOC_MAPK_MEF2A_6	415	424	PF00069	0.422
DOC_MAPK_MEF2A_6	427	435	PF00069	0.360
DOC_MAPK_NFAT4_5	111	119	PF00069	0.500
DOC_PP1_RVXF_1	209	215	PF00149	0.333
DOC_PP2B_LxvP_1	116	119	PF13499	0.378
DOC_PP4_FxxP_1	368	371	PF00568	0.397
DOC_USP7_MATH_1	257	261	PF00917	0.606
DOC_USP7_MATH_1	295	299	PF00917	0.467
DOC_USP7_MATH_1	371	375	PF00917	0.435
DOC_USP7_MATH_1	47	51	PF00917	0.460
DOC_USP7_UBL2_3	276	280	PF12436	0.470
DOC_WW_Pin1_4	401	406	PF00397	0.544
DOC_WW_Pin1_4	458	463	PF00397	0.533
DOC_WW_Pin1_4	69	74	PF00397	0.532
DOC_WW_Pin1_4	97	102	PF00397	0.472
LIG_14-3-3_CanoR_1	335	339	PF00244	0.628
LIG_Actin_WH2_2	387	404	PF00022	0.436
LIG_BRCT_BRCA1_1	297	301	PF00533	0.455
LIG_EH_1	233	237	PF12763	0.553
LIG_eIF4E_1	31	37	PF01652	0.412
LIG_eIF4E_1	437	443	PF01652	0.417
LIG_FHA_1	160	166	PF00498	0.573
LIG_FHA_1	266	272	PF00498	0.655
LIG_FHA_1	31	37	PF00498	0.405
LIG_FHA_1	322	328	PF00498	0.537
LIG_FHA_1	356	362	PF00498	0.390
LIG_FHA_1	377	383	PF00498	0.426
LIG_FHA_1	43	49	PF00498	0.358
LIG_FHA_1	459	465	PF00498	0.515
LIG_FHA_2	200	206	PF00498	0.270
LIG_FHA_2	22	28	PF00498	0.586
LIG_FHA_2	281	287	PF00498	0.597
LIG_FHA_2	326	332	PF00498	0.573
LIG_IRF3_LxIS_1	203	210	PF10401	0.272
LIG_LIR_Gen_1	201	209	PF02991	0.365
LIG_LIR_Gen_1	30	39	PF02991	0.375
LIG_LIR_Gen_1	337	347	PF02991	0.618
LIG_LIR_Gen_1	354	364	PF02991	0.324
LIG_LIR_Gen_1	374	385	PF02991	0.407
LIG_LIR_LC3C_4	122	125	PF02991	0.267
LIG_LIR_Nem_3	201	206	PF02991	0.373
LIG_LIR_Nem_3	210	216	PF02991	0.298
LIG_LIR_Nem_3	27	31	PF02991	0.542
LIG_LIR_Nem_3	33	37	PF02991	0.392
LIG_LIR_Nem_3	337	342	PF02991	0.591
LIG_LIR_Nem_3	354	360	PF02991	0.340
LIG_LIR_Nem_3	374	380	PF02991	0.367
LIG_LIR_Nem_3	412	416	PF02991	0.425
LIG_LIR_Nem_3	56	61	PF02991	0.408
LIG_LYPXL_S_1	345	349	PF13949	0.426
LIG_LYPXL_yS_3	346	349	PF13949	0.626
LIG_PCNA_PIPBox_1	378	387	PF02747	0.385
LIG_Pex14_2	169	173	PF04695	0.515
LIG_Pex14_2	353	357	PF04695	0.350
LIG_Pex14_2	363	367	PF04695	0.331
LIG_PTB_Apo_2	444	451	PF02174	0.400
LIG_SH2_CRK	377	381	PF00017	0.332
LIG_SH2_PTP2	437	440	PF00017	0.479
LIG_SH2_STAP1	88	92	PF00017	0.469
LIG_SH2_STAT3	88	91	PF00017	0.508
LIG_SH2_STAT5	213	216	PF00017	0.367
LIG_SH2_STAT5	240	243	PF00017	0.575
LIG_SH2_STAT5	31	34	PF00017	0.399
LIG_SH2_STAT5	437	440	PF00017	0.406
LIG_SH2_STAT5	449	452	PF00017	0.396
LIG_SH2_STAT5	58	61	PF00017	0.391
LIG_SH3_3	397	403	PF00018	0.556
LIG_SH3_3	430	436	PF00018	0.359
LIG_SH3_3	456	462	PF00018	0.608
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.391
LIG_SUMO_SIM_par_1	205	210	PF11976	0.392
LIG_SUMO_SIM_par_1	316	322	PF11976	0.581
LIG_SUMO_SIM_par_1	378	383	PF11976	0.451
LIG_SUMO_SIM_par_1	406	412	PF11976	0.578
LIG_TRFH_1	367	371	PF08558	0.392
LIG_TYR_ITIM	435	440	PF00017	0.398
LIG_UBA3_1	149	155	PF00899	0.367
LIG_UBA3_1	397	406	PF00899	0.571
LIG_WRC_WIRS_1	31	36	PF05994	0.336
LIG_WRC_WIRS_1	410	415	PF05994	0.303
MOD_CDK_SPK_2	401	406	PF00069	0.511
MOD_CDK_SPxxK_3	97	104	PF00069	0.469
MOD_CK1_1	198	204	PF00069	0.314
MOD_CK1_1	260	266	PF00069	0.562
MOD_CK1_1	337	343	PF00069	0.579
MOD_CK1_1	46	52	PF00069	0.464
MOD_CK1_1	489	495	PF00069	0.408
MOD_CK2_1	21	27	PF00069	0.602
MOD_CK2_1	280	286	PF00069	0.621
MOD_CK2_1	325	331	PF00069	0.590
MOD_GlcNHglycan	12	15	PF01048	0.503
MOD_GlcNHglycan	304	307	PF01048	0.442
MOD_GlcNHglycan	373	376	PF01048	0.578
MOD_GlcNHglycan	4	7	PF01048	0.463
MOD_GlcNHglycan	45	48	PF01048	0.427
MOD_GlcNHglycan	49	52	PF01048	0.629
MOD_GSK3_1	195	202	PF00069	0.355
MOD_GSK3_1	321	328	PF00069	0.595
MOD_GSK3_1	351	358	PF00069	0.445
MOD_GSK3_1	376	383	PF00069	0.435
MOD_GSK3_1	42	49	PF00069	0.404
MOD_GSK3_1	489	496	PF00069	0.499
MOD_GSK3_1	91	98	PF00069	0.433
MOD_N-GLC_1	325	330	PF02516	0.361
MOD_N-GLC_1	489	494	PF02516	0.492
MOD_NEK2_1	102	107	PF00069	0.589
MOD_NEK2_1	157	162	PF00069	0.402
MOD_NEK2_1	186	191	PF00069	0.404
MOD_NEK2_1	195	200	PF00069	0.333
MOD_NEK2_1	207	212	PF00069	0.305
MOD_NEK2_1	321	326	PF00069	0.596
MOD_NEK2_1	334	339	PF00069	0.561
MOD_NEK2_1	356	361	PF00069	0.430
MOD_NEK2_1	37	42	PF00069	0.385
MOD_NEK2_1	43	48	PF00069	0.399
MOD_NEK2_1	443	448	PF00069	0.460
MOD_NEK2_1	493	498	PF00069	0.534
MOD_NEK2_2	351	356	PF00069	0.469
MOD_PIKK_1	133	139	PF00454	0.447
MOD_PIKK_1	257	263	PF00454	0.576
MOD_PKA_2	334	340	PF00069	0.604
MOD_Plk_1	280	286	PF00069	0.578
MOD_Plk_1	468	474	PF00069	0.547
MOD_Plk_1	489	495	PF00069	0.502
MOD_Plk_4	179	185	PF00069	0.422
MOD_Plk_4	186	192	PF00069	0.391
MOD_Plk_4	27	33	PF00069	0.545
MOD_Plk_4	334	340	PF00069	0.536
MOD_Plk_4	356	362	PF00069	0.379
MOD_Plk_4	37	43	PF00069	0.413
MOD_Plk_4	376	382	PF00069	0.398
MOD_Plk_4	78	84	PF00069	0.366
MOD_ProDKin_1	401	407	PF00069	0.544
MOD_ProDKin_1	458	464	PF00069	0.533
MOD_ProDKin_1	69	75	PF00069	0.526
MOD_ProDKin_1	97	103	PF00069	0.469
MOD_SUMO_rev_2	256	266	PF00179	0.552
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.445
TRG_ENDOCYTIC_2	213	216	PF00928	0.343
TRG_ENDOCYTIC_2	233	236	PF00928	0.554
TRG_ENDOCYTIC_2	31	34	PF00928	0.399
TRG_ENDOCYTIC_2	346	349	PF00928	0.606
TRG_ENDOCYTIC_2	377	380	PF00928	0.302
TRG_ENDOCYTIC_2	437	440	PF00928	0.446
TRG_ER_diArg_1	249	252	PF00400	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P486	Leptomonas seymouri	32%	100%
A0A0N0P6Z5	Leptomonas seymouri	68%	100%
A0A0N1I1J0	Leptomonas seymouri	30%	100%
A0A0N1I8E8	Leptomonas seymouri	25%	100%
A0A0N1PBQ1	Leptomonas seymouri	33%	99%
A0A0S4JBS4	Bodo saltans	31%	100%
A0A1X0NN91	Trypanosomatidae	33%	100%
A0A1X0NPL0	Trypanosomatidae	35%	100%
A0A1X0NV38	Trypanosomatidae	34%	100%
A0A1X0NWJ5	Trypanosomatidae	32%	100%
A0A3Q8ICX7	Leishmania donovani	33%	99%
A0A3R7NQR3	Trypanosoma rangeli	33%	100%
A0A3S7WTL0	Leishmania donovani	31%	100%
A0A422MQ08	Trypanosoma rangeli	33%	100%
A0A422N8M2	Trypanosoma rangeli	45%	100%
A0A422NHH9	Trypanosoma rangeli	46%	100%
A0A422NR81	Trypanosoma rangeli	28%	100%
A1L272	Danio rerio	23%	96%
A4H6I0	Leishmania braziliensis	31%	100%
A4H7A5	Leishmania braziliensis	34%	100%
A4HG96	Leishmania braziliensis	26%	100%
A4HP60	Leishmania braziliensis	80%	100%
A4HUW2	Leishmania infantum	33%	100%
A4HVP9	Leishmania infantum	33%	99%
A4HWK9	Leishmania infantum	31%	100%
A4IDG6	Leishmania infantum	100%	100%
C9ZJU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZJU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
C9ZJU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
C9ZKT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
C9ZN88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZY31	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
C9ZZR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A6J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A6J4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A6J6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AGM5	Leishmania infantum	31%	100%
E9AGM6	Leishmania infantum	31%	100%
E9AGM7	Leishmania infantum	31%	100%
E9ANK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9APE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	99%
E9AQB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AQB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ASW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O76343	Leishmania donovani	32%	100%
Q4Q1M9	Leishmania major	95%	100%
Q4QF58	Leishmania major	32%	100%
Q4QF59	Leishmania major	32%	100%
Q4QG33	Leishmania major	33%	99%
Q4QH25	Leishmania major	31%	100%
Q7RTT9	Homo sapiens	23%	94%
Q8R139	Mus musculus	22%	95%
V5BGB1	Trypanosoma cruzi	34%	100%
V5BRM5	Trypanosoma cruzi	31%	100%
V5DSF4	Trypanosoma cruzi	47%	100%