Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAS3_LEIDO

TriTrypDb:

LdBPK_362010.1 , LdCL_360025600 , LDHU3_36.2610

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.641
CLV_C14_Caspase3-7	268	272	PF00656	0.473
CLV_C14_Caspase3-7	70	74	PF00656	0.622
CLV_NRD_NRD_1	21	23	PF00675	0.647
CLV_NRD_NRD_1	219	221	PF00675	0.609
CLV_NRD_NRD_1	436	438	PF00675	0.440
CLV_PCSK_KEX2_1	145	147	PF00082	0.414
CLV_PCSK_KEX2_1	160	162	PF00082	0.561
CLV_PCSK_KEX2_1	219	221	PF00082	0.545
CLV_PCSK_KEX2_1	435	437	PF00082	0.441
CLV_PCSK_KEX2_1	485	487	PF00082	0.536
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.402
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.530
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.569
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.536
CLV_PCSK_SKI1_1	136	140	PF00082	0.375
CLV_PCSK_SKI1_1	160	164	PF00082	0.588
CLV_PCSK_SKI1_1	172	176	PF00082	0.463
CLV_PCSK_SKI1_1	300	304	PF00082	0.500
CLV_PCSK_SKI1_1	322	326	PF00082	0.514
CLV_PCSK_SKI1_1	414	418	PF00082	0.558
CLV_PCSK_SKI1_1	446	450	PF00082	0.565
DEG_APCC_DBOX_1	246	254	PF00400	0.503
DEG_Nend_UBRbox_3	1	3	PF02207	0.575
DOC_CYCLIN_RxL_1	297	307	PF00134	0.502
DOC_CYCLIN_RxL_1	319	326	PF00134	0.527
DOC_MAPK_gen_1	183	191	PF00069	0.528
DOC_MAPK_gen_1	225	234	PF00069	0.574
DOC_MAPK_MEF2A_6	330	337	PF00069	0.545
DOC_PP4_FxxP_1	162	165	PF00568	0.542
DOC_USP7_MATH_1	10	14	PF00917	0.601
DOC_USP7_MATH_1	108	112	PF00917	0.585
DOC_USP7_MATH_1	274	278	PF00917	0.520
DOC_USP7_MATH_1	360	364	PF00917	0.505
DOC_USP7_MATH_1	426	430	PF00917	0.601
DOC_USP7_MATH_1	453	457	PF00917	0.565
DOC_USP7_MATH_1	489	493	PF00917	0.648
DOC_USP7_MATH_1	64	68	PF00917	0.498
DOC_USP7_UBL2_3	472	476	PF12436	0.551
DOC_WW_Pin1_4	328	333	PF00397	0.601
DOC_WW_Pin1_4	422	427	PF00397	0.612
DOC_WW_Pin1_4	60	65	PF00397	0.521
LIG_14-3-3_CanoR_1	154	162	PF00244	0.594
LIG_14-3-3_CanoR_1	177	183	PF00244	0.545
LIG_14-3-3_CanoR_1	22	26	PF00244	0.720
LIG_14-3-3_CanoR_1	3	7	PF00244	0.545
LIG_14-3-3_CanoR_1	319	325	PF00244	0.387
LIG_14-3-3_CanoR_1	420	424	PF00244	0.483
LIG_Actin_WH2_2	7	24	PF00022	0.532
LIG_BRCT_BRCA1_1	276	280	PF00533	0.512
LIG_BRCT_BRCA1_1	385	389	PF00533	0.448
LIG_BRCT_BRCA1_1	50	54	PF00533	0.583
LIG_CaM_IQ_9	348	364	PF13499	0.515
LIG_eIF4E_1	290	296	PF01652	0.487
LIG_FAT_LD_1	175	183	PF03623	0.403
LIG_FHA_1	142	148	PF00498	0.455
LIG_FHA_1	184	190	PF00498	0.530
LIG_FHA_1	48	54	PF00498	0.624
LIG_FHA_2	107	113	PF00498	0.655
LIG_FHA_2	193	199	PF00498	0.510
LIG_FHA_2	249	255	PF00498	0.525
LIG_FHA_2	266	272	PF00498	0.347
LIG_FHA_2	321	327	PF00498	0.416
LIG_FHA_2	37	43	PF00498	0.694
LIG_FHA_2	428	434	PF00498	0.546
LIG_FHA_2	44	50	PF00498	0.599
LIG_Integrin_RGD_1	220	222	PF01839	0.485
LIG_LIR_Apic_2	159	165	PF02991	0.547
LIG_LIR_Apic_2	422	426	PF02991	0.611
LIG_LIR_Gen_1	201	211	PF02991	0.479
LIG_LIR_Gen_1	277	287	PF02991	0.488
LIG_LIR_Gen_1	306	317	PF02991	0.354
LIG_LIR_Gen_1	386	396	PF02991	0.565
LIG_LIR_Gen_1	463	471	PF02991	0.537
LIG_LIR_Nem_3	116	121	PF02991	0.417
LIG_LIR_Nem_3	201	207	PF02991	0.479
LIG_LIR_Nem_3	277	283	PF02991	0.427
LIG_LIR_Nem_3	306	312	PF02991	0.360
LIG_LIR_Nem_3	338	343	PF02991	0.609
LIG_LIR_Nem_3	386	392	PF02991	0.554
LIG_LIR_Nem_3	459	464	PF02991	0.466
LIG_LIR_Nem_3	5	11	PF02991	0.494
LIG_LYPXL_yS_3	273	276	PF13949	0.505
LIG_Pex14_1	461	465	PF04695	0.582
LIG_Pex14_2	280	284	PF04695	0.407
LIG_SH2_CRK	465	469	PF00017	0.555
LIG_SH2_PTP2	423	426	PF00017	0.614
LIG_SH2_STAP1	121	125	PF00017	0.446
LIG_SH2_STAP1	236	240	PF00017	0.429
LIG_SH2_STAP1	465	469	PF00017	0.500
LIG_SH2_STAT5	196	199	PF00017	0.537
LIG_SH2_STAT5	265	268	PF00017	0.504
LIG_SH2_STAT5	290	293	PF00017	0.482
LIG_SH2_STAT5	311	314	PF00017	0.483
LIG_SH2_STAT5	357	360	PF00017	0.432
LIG_SH2_STAT5	423	426	PF00017	0.502
LIG_SH2_STAT6	409	413	PF00017	0.541
LIG_SH3_3	326	332	PF00018	0.609
LIG_SUMO_SIM_par_1	331	336	PF11976	0.567
LIG_TRAF2_1	255	258	PF00917	0.545
LIG_TRAF2_1	286	289	PF00917	0.490
LIG_UBA3_1	178	185	PF00899	0.401
LIG_UBA3_1	324	330	PF00899	0.472
LIG_UBA3_1	53	60	PF00899	0.540
MOD_CK1_1	104	110	PF00069	0.616
MOD_CK1_1	181	187	PF00069	0.511
MOD_CK1_1	192	198	PF00069	0.454
MOD_CK2_1	248	254	PF00069	0.539
MOD_CK2_1	283	289	PF00069	0.509
MOD_CK2_1	312	318	PF00069	0.418
MOD_CK2_1	320	326	PF00069	0.363
MOD_CK2_1	339	345	PF00069	0.412
MOD_CK2_1	36	42	PF00069	0.749
MOD_CK2_1	427	433	PF00069	0.568
MOD_CK2_1	43	49	PF00069	0.614
MOD_CK2_1	453	459	PF00069	0.581
MOD_CK2_1	64	70	PF00069	0.497
MOD_Cter_Amidation	483	486	PF01082	0.602
MOD_GlcNHglycan	106	109	PF01048	0.590
MOD_GlcNHglycan	191	194	PF01048	0.531
MOD_GlcNHglycan	372	375	PF01048	0.598
MOD_GlcNHglycan	385	388	PF01048	0.398
MOD_GlcNHglycan	49	53	PF01048	0.572
MOD_GlcNHglycan	491	494	PF01048	0.525
MOD_GSK3_1	104	111	PF00069	0.683
MOD_GSK3_1	160	167	PF00069	0.483
MOD_GSK3_1	34	41	PF00069	0.752
MOD_GSK3_1	422	429	PF00069	0.517
MOD_GSK3_1	43	50	PF00069	0.620
MOD_GSK3_1	453	460	PF00069	0.563
MOD_GSK3_1	474	481	PF00069	0.589
MOD_GSK3_1	60	67	PF00069	0.433
MOD_NEK2_1	1	6	PF00069	0.555
MOD_NEK2_1	106	111	PF00069	0.591
MOD_NEK2_1	178	183	PF00069	0.461
MOD_NEK2_1	189	194	PF00069	0.431
MOD_NEK2_1	283	288	PF00069	0.530
MOD_NEK2_1	312	317	PF00069	0.377
MOD_NEK2_1	320	325	PF00069	0.352
MOD_NEK2_1	47	52	PF00069	0.664
MOD_NEK2_1	95	100	PF00069	0.522
MOD_PIKK_1	153	159	PF00454	0.537
MOD_PIKK_1	360	366	PF00454	0.657
MOD_PKA_1	160	166	PF00069	0.452
MOD_PKA_2	153	159	PF00069	0.535
MOD_PKA_2	160	166	PF00069	0.467
MOD_PKA_2	2	8	PF00069	0.541
MOD_PKA_2	21	27	PF00069	0.717
MOD_PKA_2	318	324	PF00069	0.405
MOD_PKA_2	33	39	PF00069	0.669
MOD_PKA_2	419	425	PF00069	0.516
MOD_Plk_1	34	40	PF00069	0.598
MOD_Plk_2-3	164	170	PF00069	0.491
MOD_Plk_2-3	478	484	PF00069	0.608
MOD_Plk_4	192	198	PF00069	0.435
MOD_Plk_4	320	326	PF00069	0.472
MOD_Plk_4	419	425	PF00069	0.465
MOD_Plk_4	427	433	PF00069	0.471
MOD_Plk_4	64	70	PF00069	0.616
MOD_ProDKin_1	328	334	PF00069	0.594
MOD_ProDKin_1	422	428	PF00069	0.612
MOD_ProDKin_1	60	66	PF00069	0.518
MOD_SUMO_for_1	475	478	PF00179	0.557
MOD_SUMO_rev_2	159	167	PF00179	0.579
MOD_SUMO_rev_2	226	232	PF00179	0.541
MOD_SUMO_rev_2	442	450	PF00179	0.452
MOD_SUMO_rev_2	466	474	PF00179	0.490
MOD_SUMO_rev_2	65	74	PF00179	0.701
TRG_ENDOCYTIC_2	273	276	PF00928	0.420
TRG_ENDOCYTIC_2	311	314	PF00928	0.483
TRG_ENDOCYTIC_2	410	413	PF00928	0.488
TRG_ENDOCYTIC_2	465	468	PF00928	0.561
TRG_ENDOCYTIC_2	8	11	PF00928	0.484
TRG_ER_diArg_1	218	220	PF00400	0.541
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	356	361	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT1	Leptomonas seymouri	62%	97%
A0A1X0P7R8	Trypanosomatidae	32%	97%
A0A422MV92	Trypanosoma rangeli	30%	100%
A4HP57	Leishmania braziliensis	76%	100%
A4IDG3	Leishmania infantum	100%	100%
D0A343	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ASW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q1N2	Leishmania major	92%	100%
V5DKS4	Trypanosoma cruzi	30%	100%