N-acetyltransferase subunit Nat1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-acetyltransferase subunit Nat1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAS1_LEIDO

TriTrypDb:

LdBPK_361390.1 , LdCL_360019000 , LDHU3_36.1740

Length:

711

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAS1

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	1
GO:0006474	N-terminal protein amino acid acetylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0017196	N-terminal peptidyl-methionine acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0031365	N-terminal protein amino acid modification	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.415
CLV_C14_Caspase3-7	254	258	PF00656	0.540
CLV_C14_Caspase3-7	692	696	PF00656	0.487
CLV_NRD_NRD_1	265	267	PF00675	0.242
CLV_NRD_NRD_1	390	392	PF00675	0.340
CLV_NRD_NRD_1	440	442	PF00675	0.315
CLV_NRD_NRD_1	505	507	PF00675	0.280
CLV_NRD_NRD_1	539	541	PF00675	0.247
CLV_PCSK_KEX2_1	104	106	PF00082	0.427
CLV_PCSK_KEX2_1	243	245	PF00082	0.279
CLV_PCSK_KEX2_1	302	304	PF00082	0.254
CLV_PCSK_KEX2_1	390	392	PF00082	0.340
CLV_PCSK_KEX2_1	440	442	PF00082	0.315
CLV_PCSK_KEX2_1	505	507	PF00082	0.322
CLV_PCSK_KEX2_1	539	541	PF00082	0.267
CLV_PCSK_KEX2_1	605	607	PF00082	0.258
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.427
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.271
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.324
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.254
CLV_PCSK_SKI1_1	101	105	PF00082	0.322
CLV_PCSK_SKI1_1	139	143	PF00082	0.394
CLV_PCSK_SKI1_1	224	228	PF00082	0.271
CLV_PCSK_SKI1_1	290	294	PF00082	0.359
CLV_PCSK_SKI1_1	303	307	PF00082	0.123
CLV_PCSK_SKI1_1	452	456	PF00082	0.254
CLV_PCSK_SKI1_1	560	564	PF00082	0.295
CLV_PCSK_SKI1_1	605	609	PF00082	0.295
CLV_PCSK_SKI1_1	658	662	PF00082	0.374
CLV_PCSK_SKI1_1	664	668	PF00082	0.353
CLV_Separin_Metazoa	115	119	PF03568	0.490
DEG_APCC_DBOX_1	302	310	PF00400	0.437
DEG_SCF_FBW7_2	406	413	PF00400	0.465
DOC_CKS1_1	321	326	PF01111	0.540
DOC_CYCLIN_RxL_1	101	110	PF00134	0.427
DOC_CYCLIN_RxL_1	437	446	PF00134	0.434
DOC_CYCLIN_RxL_1	49	60	PF00134	0.383
DOC_CYCLIN_RxL_1	655	665	PF00134	0.303
DOC_MAPK_gen_1	101	109	PF00069	0.427
DOC_MAPK_gen_1	558	565	PF00069	0.518
DOC_MAPK_gen_1	673	682	PF00069	0.553
DOC_MAPK_MEF2A_6	676	684	PF00069	0.452
DOC_PP1_RVXF_1	103	110	PF00149	0.427
DOC_PP4_FxxP_1	321	324	PF00568	0.540
DOC_PP4_FxxP_1	473	476	PF00568	0.495
DOC_USP7_MATH_1	143	147	PF00917	0.517
DOC_USP7_MATH_1	487	491	PF00917	0.454
DOC_USP7_UBL2_3	293	297	PF12436	0.490
DOC_USP7_UBL2_3	560	564	PF12436	0.479
DOC_USP7_UBL2_3	608	612	PF12436	0.532
DOC_WW_Pin1_4	320	325	PF00397	0.540
DOC_WW_Pin1_4	406	411	PF00397	0.454
LIG_14-3-3_CanoR_1	105	110	PF00244	0.392
LIG_14-3-3_CanoR_1	33	41	PF00244	0.506
LIG_14-3-3_CanoR_1	539	544	PF00244	0.465
LIG_14-3-3_CanoR_1	664	670	PF00244	0.501
LIG_Actin_WH2_2	261	277	PF00022	0.559
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_Clathr_ClatBox_1	414	418	PF01394	0.540
LIG_Clathr_ClatBox_1	516	520	PF01394	0.540
LIG_deltaCOP1_diTrp_1	129	133	PF00928	0.351
LIG_FHA_1	112	118	PF00498	0.457
LIG_FHA_1	221	227	PF00498	0.524
LIG_FHA_1	321	327	PF00498	0.499
LIG_FHA_1	407	413	PF00498	0.458
LIG_FHA_1	467	473	PF00498	0.514
LIG_FHA_1	643	649	PF00498	0.479
LIG_FHA_1	675	681	PF00498	0.440
LIG_FHA_2	484	490	PF00498	0.465
LIG_FHA_2	690	696	PF00498	0.548
LIG_GBD_Chelix_1	701	709	PF00786	0.300
LIG_Integrin_RGD_1	506	508	PF01839	0.326
LIG_KLC1_Yacidic_2	413	418	PF13176	0.540
LIG_LIR_Apic_2	271	276	PF02991	0.540
LIG_LIR_Gen_1	242	253	PF02991	0.454
LIG_LIR_Gen_1	281	292	PF02991	0.479
LIG_LIR_Gen_1	332	342	PF02991	0.463
LIG_LIR_Gen_1	352	361	PF02991	0.323
LIG_LIR_Gen_1	365	373	PF02991	0.425
LIG_LIR_Gen_1	572	578	PF02991	0.455
LIG_LIR_Gen_1	593	604	PF02991	0.559
LIG_LIR_Gen_1	63	74	PF02991	0.522
LIG_LIR_Nem_3	129	133	PF02991	0.351
LIG_LIR_Nem_3	242	248	PF02991	0.454
LIG_LIR_Nem_3	281	287	PF02991	0.496
LIG_LIR_Nem_3	332	337	PF02991	0.463
LIG_LIR_Nem_3	365	369	PF02991	0.445
LIG_LIR_Nem_3	531	536	PF02991	0.456
LIG_LIR_Nem_3	572	576	PF02991	0.465
LIG_LIR_Nem_3	593	599	PF02991	0.559
LIG_LIR_Nem_3	629	634	PF02991	0.433
LIG_LIR_Nem_3	63	69	PF02991	0.482
LIG_NRBOX	512	518	PF00104	0.540
LIG_NRBOX	705	711	PF00104	0.304
LIG_PALB2_WD40_1	542	550	PF16756	0.479
LIG_PCNA_TLS_4	267	274	PF02747	0.540
LIG_Pex14_1	380	384	PF04695	0.454
LIG_Pex14_2	561	565	PF04695	0.528
LIG_PTB_Apo_2	22	29	PF02174	0.472
LIG_PTB_Apo_2	371	378	PF02174	0.463
LIG_PTB_Apo_2	532	539	PF02174	0.465
LIG_PTB_Phospho_1	22	28	PF10480	0.471
LIG_PTB_Phospho_1	371	377	PF10480	0.502
LIG_REV1ctd_RIR_1	559	566	PF16727	0.465
LIG_SH2_CRK	573	577	PF00017	0.495
LIG_SH2_GRB2like	23	26	PF00017	0.556
LIG_SH2_GRB2like	448	451	PF00017	0.454
LIG_SH2_NCK_1	653	657	PF00017	0.484
LIG_SH2_PTP2	245	248	PF00017	0.504
LIG_SH2_SRC	245	248	PF00017	0.504
LIG_SH2_SRC	341	344	PF00017	0.540
LIG_SH2_SRC	448	451	PF00017	0.454
LIG_SH2_STAP1	28	32	PF00017	0.417
LIG_SH2_STAP1	280	284	PF00017	0.559
LIG_SH2_STAP1	495	499	PF00017	0.454
LIG_SH2_STAP1	653	657	PF00017	0.296
LIG_SH2_STAT5	245	248	PF00017	0.504
LIG_SH2_STAT5	273	276	PF00017	0.502
LIG_SH2_STAT5	280	283	PF00017	0.455
LIG_SH2_STAT5	325	328	PF00017	0.536
LIG_SH2_STAT5	341	344	PF00017	0.454
LIG_SH2_STAT5	377	380	PF00017	0.490
LIG_SH2_STAT5	401	404	PF00017	0.485
LIG_SH2_STAT5	416	419	PF00017	0.444
LIG_SH2_STAT5	448	451	PF00017	0.454
LIG_SH2_STAT5	457	460	PF00017	0.454
LIG_SH2_STAT5	484	487	PF00017	0.465
LIG_SH2_STAT5	509	512	PF00017	0.458
LIG_SH2_STAT5	536	539	PF00017	0.454
LIG_SH2_STAT5	615	618	PF00017	0.387
LIG_SH2_STAT5	634	637	PF00017	0.360
LIG_SH2_STAT5	653	656	PF00017	0.299
LIG_SH2_STAT5	689	692	PF00017	0.551
LIG_SH3_3	586	592	PF00018	0.479
LIG_SH3_5	296	300	PF00018	0.458
LIG_SUMO_SIM_anti_2	411	416	PF11976	0.479
LIG_SUMO_SIM_par_1	182	189	PF11976	0.471
LIG_SUMO_SIM_par_1	215	223	PF11976	0.554
LIG_SUMO_SIM_par_1	644	651	PF11976	0.443
LIG_UBA3_1	329	338	PF00899	0.298
LIG_UBA3_1	414	421	PF00899	0.307
LIG_WRC_WIRS_1	381	386	PF05994	0.384
LIG_WRC_WIRS_1	46	51	PF05994	0.497
MOD_CK1_1	3	9	PF00069	0.591
MOD_CK1_1	332	338	PF00069	0.303
MOD_CK1_1	644	650	PF00069	0.503
MOD_CK1_1	665	671	PF00069	0.300
MOD_CK2_1	21	27	PF00069	0.542
MOD_CK2_1	483	489	PF00069	0.341
MOD_CK2_1	705	711	PF00069	0.397
MOD_GlcNHglycan	121	124	PF01048	0.439
MOD_GlcNHglycan	2	5	PF01048	0.674
MOD_GlcNHglycan	200	203	PF01048	0.427
MOD_GlcNHglycan	510	513	PF01048	0.297
MOD_GlcNHglycan	8	11	PF01048	0.549
MOD_GSK3_1	139	146	PF00069	0.501
MOD_GSK3_1	247	254	PF00069	0.434
MOD_GSK3_1	332	339	PF00069	0.300
MOD_GSK3_1	380	387	PF00069	0.417
MOD_GSK3_1	483	490	PF00069	0.322
MOD_GSK3_1	638	645	PF00069	0.455
MOD_GSK3_1	683	690	PF00069	0.496
MOD_N-GLC_1	406	411	PF02516	0.415
MOD_N-GLC_1	674	679	PF02516	0.411
MOD_N-GLC_2	526	528	PF02516	0.427
MOD_NEK2_1	161	166	PF00069	0.474
MOD_NEK2_1	384	389	PF00069	0.343
MOD_NEK2_1	688	693	PF00069	0.475
MOD_NEK2_2	143	148	PF00069	0.542
MOD_NEK2_2	65	70	PF00069	0.493
MOD_PIKK_1	487	493	PF00454	0.307
MOD_PIKK_1	638	644	PF00454	0.389
MOD_PKA_1	539	545	PF00069	0.322
MOD_PKA_2	32	38	PF00069	0.494
MOD_PKA_2	389	395	PF00069	0.454
MOD_PKA_2	539	545	PF00069	0.322
MOD_PKA_2	638	644	PF00069	0.428
MOD_Plk_1	364	370	PF00069	0.341
MOD_Plk_1	466	472	PF00069	0.372
MOD_Plk_4	173	179	PF00069	0.432
MOD_Plk_4	329	335	PF00069	0.320
MOD_Plk_4	336	342	PF00069	0.328
MOD_Plk_4	380	386	PF00069	0.234
MOD_Plk_4	474	480	PF00069	0.336
MOD_Plk_4	705	711	PF00069	0.497
MOD_Plk_4	76	82	PF00069	0.477
MOD_ProDKin_1	320	326	PF00069	0.427
MOD_ProDKin_1	406	412	PF00069	0.307
MOD_SUMO_rev_2	216	226	PF00179	0.353
MOD_SUMO_rev_2	358	366	PF00179	0.425
MOD_SUMO_rev_2	597	607	PF00179	0.326
TRG_DiLeu_BaEn_1	222	227	PF01217	0.392
TRG_DiLeu_BaLyEn_6	656	661	PF01217	0.399
TRG_ENDOCYTIC_2	245	248	PF00928	0.307
TRG_ENDOCYTIC_2	284	287	PF00928	0.315
TRG_ENDOCYTIC_2	573	576	PF00928	0.299
TRG_ENDOCYTIC_2	66	69	PF00928	0.474
TRG_ER_diArg_1	389	391	PF00400	0.427
TRG_ER_diArg_1	440	442	PF00400	0.392
TRG_ER_diArg_1	504	506	PF00400	0.407
TRG_ER_diArg_1	538	540	PF00400	0.296
TRG_ER_diArg_1	671	674	PF00400	0.516
TRG_NES_CRM1_1	508	520	PF08389	0.427
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	440	445	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R8	Leptomonas seymouri	79%	100%
A0A0S4IZ29	Bodo saltans	53%	100%
A0A1X0P802	Trypanosomatidae	56%	100%
A0A422N0I1	Trypanosoma rangeli	60%	100%
A4HNZ1	Leishmania braziliensis	91%	100%
A4ICK2	Leishmania infantum	99%	100%
D0A2V9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ASQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O74985	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	98%
P12945	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	83%
Q4Q1U2	Leishmania major	96%	100%
Q5R4J9	Pongo abelii	29%	82%
Q6N069	Homo sapiens	29%	82%
Q80UM3	Mus musculus	29%	82%
Q8VZM1	Arabidopsis thaliana	29%	79%
Q9BXJ9	Homo sapiens	29%	82%
Q9DBB4	Mus musculus	29%	82%
Q9Y7X2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
V5DRE7	Trypanosoma cruzi	58%	100%