Tetratricopeptide repeat/TPR repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAR1_LEIDO

TriTrypDb:

LdBPK_361860.1 , LdCL_360024100 , LDHU3_36.2420

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.415
CLV_C14_Caspase3-7	394	398	PF00656	0.482
CLV_C14_Caspase3-7	497	501	PF00656	0.456
CLV_C14_Caspase3-7	548	552	PF00656	0.405
CLV_NRD_NRD_1	101	103	PF00675	0.491
CLV_NRD_NRD_1	345	347	PF00675	0.462
CLV_NRD_NRD_1	385	387	PF00675	0.595
CLV_NRD_NRD_1	445	447	PF00675	0.399
CLV_NRD_NRD_1	564	566	PF00675	0.413
CLV_NRD_NRD_1	646	648	PF00675	0.763
CLV_NRD_NRD_1	655	657	PF00675	0.705
CLV_NRD_NRD_1	683	685	PF00675	0.671
CLV_NRD_NRD_1	712	714	PF00675	0.652
CLV_NRD_NRD_1	735	737	PF00675	0.576
CLV_NRD_NRD_1	85	87	PF00675	0.344
CLV_PCSK_KEX2_1	101	103	PF00082	0.491
CLV_PCSK_KEX2_1	384	386	PF00082	0.598
CLV_PCSK_KEX2_1	445	447	PF00082	0.430
CLV_PCSK_KEX2_1	646	648	PF00082	0.763
CLV_PCSK_KEX2_1	654	656	PF00082	0.707
CLV_PCSK_KEX2_1	682	684	PF00082	0.633
CLV_PCSK_KEX2_1	712	714	PF00082	0.629
CLV_PCSK_KEX2_1	718	720	PF00082	0.468
CLV_PCSK_KEX2_1	735	737	PF00082	0.627
CLV_PCSK_KEX2_1	85	87	PF00082	0.344
CLV_PCSK_PC1ET2_1	654	656	PF00082	0.617
CLV_PCSK_PC1ET2_1	718	720	PF00082	0.554
CLV_PCSK_SKI1_1	342	346	PF00082	0.402
CLV_PCSK_SKI1_1	349	353	PF00082	0.411
CLV_PCSK_SKI1_1	406	410	PF00082	0.449
CLV_PCSK_SKI1_1	461	465	PF00082	0.385
CLV_PCSK_SKI1_1	565	569	PF00082	0.426
CLV_PCSK_SKI1_1	608	612	PF00082	0.391
CLV_PCSK_SKI1_1	85	89	PF00082	0.438
DEG_APCC_DBOX_1	233	241	PF00400	0.386
DEG_APCC_DBOX_1	607	615	PF00400	0.409
DEG_APCC_DBOX_1	84	92	PF00400	0.344
DEG_SPOP_SBC_1	5	9	PF00917	0.534
DOC_CYCLIN_RxL_1	346	356	PF00134	0.381
DOC_CYCLIN_RxL_1	403	411	PF00134	0.424
DOC_CYCLIN_RxL_1	82	90	PF00134	0.432
DOC_MAPK_gen_1	28	37	PF00069	0.478
DOC_MAPK_gen_1	346	352	PF00069	0.465
DOC_MAPK_gen_1	445	451	PF00069	0.436
DOC_MAPK_gen_1	510	519	PF00069	0.460
DOC_MAPK_gen_1	82	91	PF00069	0.372
DOC_MAPK_MEF2A_6	512	520	PF00069	0.390
DOC_PP2B_LxvP_1	219	222	PF13499	0.574
DOC_USP7_MATH_1	116	120	PF00917	0.619
DOC_USP7_MATH_1	170	174	PF00917	0.584
DOC_USP7_MATH_1	18	22	PF00917	0.486
DOC_USP7_MATH_1	398	402	PF00917	0.366
DOC_USP7_MATH_1	420	424	PF00917	0.456
DOC_USP7_MATH_1	5	9	PF00917	0.680
DOC_USP7_MATH_1	641	645	PF00917	0.778
DOC_USP7_MATH_1	658	662	PF00917	0.533
DOC_USP7_MATH_1	689	693	PF00917	0.717
DOC_USP7_UBL2_3	26	30	PF12436	0.497
DOC_USP7_UBL2_3	457	461	PF12436	0.409
DOC_WW_Pin1_4	124	129	PF00397	0.644
DOC_WW_Pin1_4	171	176	PF00397	0.802
DOC_WW_Pin1_4	284	289	PF00397	0.574
DOC_WW_Pin1_4	646	651	PF00397	0.605
LIG_14-3-3_CanoR_1	139	147	PF00244	0.551
LIG_14-3-3_CanoR_1	155	164	PF00244	0.468
LIG_14-3-3_CanoR_1	195	203	PF00244	0.636
LIG_14-3-3_CanoR_1	328	336	PF00244	0.406
LIG_14-3-3_CanoR_1	384	389	PF00244	0.593
LIG_14-3-3_CanoR_1	555	560	PF00244	0.414
LIG_14-3-3_CanoR_1	712	717	PF00244	0.689
LIG_14-3-3_CanoR_1	86	92	PF00244	0.371
LIG_Actin_WH2_2	244	261	PF00022	0.392
LIG_APCC_ABBA_1	47	52	PF00400	0.563
LIG_BIR_III_4	242	246	PF00653	0.398
LIG_BIR_III_4	397	401	PF00653	0.434
LIG_BRCT_BRCA1_1	286	290	PF00533	0.483
LIG_BRCT_BRCA1_1	436	440	PF00533	0.378
LIG_deltaCOP1_diTrp_1	561	568	PF00928	0.437
LIG_DLG_GKlike_1	555	562	PF00625	0.413
LIG_eIF4E_1	44	50	PF01652	0.364
LIG_FHA_1	106	112	PF00498	0.646
LIG_FHA_1	17	23	PF00498	0.555
LIG_FHA_1	216	222	PF00498	0.697
LIG_FHA_1	293	299	PF00498	0.445
LIG_FHA_1	329	335	PF00498	0.416
LIG_FHA_1	416	422	PF00498	0.429
LIG_FHA_1	428	434	PF00498	0.300
LIG_FHA_1	480	486	PF00498	0.359
LIG_FHA_1	579	585	PF00498	0.411
LIG_FHA_1	702	708	PF00498	0.663
LIG_FHA_2	108	114	PF00498	0.681
LIG_FHA_2	156	162	PF00498	0.613
LIG_FHA_2	227	233	PF00498	0.554
LIG_FHA_2	468	474	PF00498	0.490
LIG_FHA_2	525	531	PF00498	0.440
LIG_GBD_Chelix_1	404	412	PF00786	0.447
LIG_HP1_1	63	67	PF01393	0.413
LIG_Integrin_RGD_1	522	524	PF01839	0.365
LIG_LIR_Apic_2	12	18	PF02991	0.553
LIG_LIR_Gen_1	318	329	PF02991	0.472
LIG_LIR_Gen_1	437	447	PF02991	0.357
LIG_LIR_Gen_1	524	532	PF02991	0.343
LIG_LIR_Gen_1	538	545	PF02991	0.368
LIG_LIR_Gen_1	69	77	PF02991	0.392
LIG_LIR_Nem_3	318	324	PF02991	0.441
LIG_LIR_Nem_3	410	416	PF02991	0.352
LIG_LIR_Nem_3	437	443	PF02991	0.490
LIG_LIR_Nem_3	462	467	PF02991	0.356
LIG_LIR_Nem_3	538	542	PF02991	0.352
LIG_LIR_Nem_3	69	74	PF02991	0.421
LIG_Pex14_2	440	444	PF04695	0.346
LIG_PTAP_UEV_1	621	626	PF05743	0.426
LIG_PTB_Apo_2	587	594	PF02174	0.463
LIG_Rb_LxCxE_1	613	623	PF01857	0.454
LIG_SH2_GRB2like	436	439	PF00017	0.378
LIG_SH2_NCK_1	44	48	PF00017	0.427
LIG_SH2_PTP2	71	74	PF00017	0.396
LIG_SH2_SRC	303	306	PF00017	0.298
LIG_SH2_SRC	634	637	PF00017	0.472
LIG_SH2_STAP1	436	440	PF00017	0.378
LIG_SH2_STAP1	505	509	PF00017	0.353
LIG_SH2_STAP1	539	543	PF00017	0.423
LIG_SH2_STAT5	303	306	PF00017	0.397
LIG_SH2_STAT5	339	342	PF00017	0.345
LIG_SH2_STAT5	407	410	PF00017	0.446
LIG_SH2_STAT5	526	529	PF00017	0.384
LIG_SH2_STAT5	634	637	PF00017	0.630
LIG_SH2_STAT5	71	74	PF00017	0.445
LIG_SH2_STAT5	99	102	PF00017	0.571
LIG_SH3_1	634	640	PF00018	0.493
LIG_SH3_2	125	130	PF14604	0.540
LIG_SH3_3	119	125	PF00018	0.558
LIG_SH3_3	387	393	PF00018	0.641
LIG_SH3_3	619	625	PF00018	0.399
LIG_SH3_3	634	640	PF00018	0.494
LIG_SH3_3	737	743	PF00018	0.537
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.375
LIG_SUMO_SIM_anti_2	476	483	PF11976	0.369
LIG_SUMO_SIM_anti_2	514	520	PF11976	0.442
LIG_SUMO_SIM_par_1	63	69	PF11976	0.416
LIG_TRAF2_1	354	357	PF00917	0.398
LIG_TYR_ITIM	42	47	PF00017	0.423
LIG_UBA3_1	88	94	PF00899	0.407
MOD_CDC14_SPxK_1	127	130	PF00782	0.595
MOD_CDK_SPxK_1	124	130	PF00069	0.592
MOD_CK1_1	166	172	PF00069	0.614
MOD_CK1_1	173	179	PF00069	0.579
MOD_CK1_1	20	26	PF00069	0.399
MOD_CK1_1	206	212	PF00069	0.681
MOD_CK1_1	284	290	PF00069	0.637
MOD_CK1_1	391	397	PF00069	0.548
MOD_CK1_1	434	440	PF00069	0.376
MOD_CK1_1	701	707	PF00069	0.687
MOD_CK1_1	8	14	PF00069	0.622
MOD_CK2_1	107	113	PF00069	0.538
MOD_CK2_1	420	426	PF00069	0.459
MOD_CK2_1	467	473	PF00069	0.431
MOD_CK2_1	524	530	PF00069	0.441
MOD_CK2_1	613	619	PF00069	0.468
MOD_CK2_1	669	675	PF00069	0.508
MOD_Cter_Amidation	563	566	PF01082	0.410
MOD_GlcNHglycan	112	117	PF01048	0.684
MOD_GlcNHglycan	168	171	PF01048	0.552
MOD_GlcNHglycan	208	211	PF01048	0.713
MOD_GlcNHglycan	381	384	PF01048	0.746
MOD_GlcNHglycan	394	397	PF01048	0.402
MOD_GlcNHglycan	719	722	PF01048	0.644
MOD_GlcNHglycan	78	81	PF01048	0.457
MOD_GSK3_1	112	119	PF00069	0.604
MOD_GSK3_1	124	131	PF00069	0.686
MOD_GSK3_1	16	23	PF00069	0.510
MOD_GSK3_1	166	173	PF00069	0.610
MOD_GSK3_1	199	206	PF00069	0.643
MOD_GSK3_1	384	391	PF00069	0.612
MOD_GSK3_1	4	11	PF00069	0.642
MOD_GSK3_1	427	434	PF00069	0.420
MOD_GSK3_1	480	487	PF00069	0.380
MOD_GSK3_1	685	692	PF00069	0.589
MOD_NEK2_1	244	249	PF00069	0.402
MOD_NEK2_1	6	11	PF00069	0.712
MOD_NEK2_2	116	121	PF00069	0.560
MOD_NEK2_2	505	510	PF00069	0.423
MOD_NEK2_2	689	694	PF00069	0.582
MOD_NEK2_2	729	734	PF00069	0.550
MOD_NEK2_2	87	92	PF00069	0.437
MOD_PIKK_1	641	647	PF00454	0.655
MOD_PK_1	431	437	PF00069	0.463
MOD_PKA_1	384	390	PF00069	0.569
MOD_PKA_1	683	689	PF00069	0.541
MOD_PKA_1	712	718	PF00069	0.627
MOD_PKA_1	735	741	PF00069	0.541
MOD_PKA_2	138	144	PF00069	0.741
MOD_PKA_2	194	200	PF00069	0.613
MOD_PKA_2	258	264	PF00069	0.416
MOD_PKA_2	384	390	PF00069	0.588
MOD_PKA_2	467	473	PF00069	0.458
MOD_PKA_2	683	689	PF00069	0.650
MOD_PKA_2	712	718	PF00069	0.568
MOD_PKA_2	735	741	PF00069	0.610
MOD_PKB_1	326	334	PF00069	0.287
MOD_PKB_1	553	561	PF00069	0.425
MOD_Plk_1	128	134	PF00069	0.638
MOD_Plk_1	176	182	PF00069	0.623
MOD_Plk_1	425	431	PF00069	0.395
MOD_Plk_1	51	57	PF00069	0.469
MOD_Plk_1	689	695	PF00069	0.627
MOD_Plk_4	244	250	PF00069	0.393
MOD_Plk_4	431	437	PF00069	0.456
MOD_Plk_4	480	486	PF00069	0.342
MOD_Plk_4	500	506	PF00069	0.520
MOD_Plk_4	51	57	PF00069	0.375
MOD_ProDKin_1	124	130	PF00069	0.647
MOD_ProDKin_1	171	177	PF00069	0.802
MOD_ProDKin_1	284	290	PF00069	0.565
MOD_ProDKin_1	646	652	PF00069	0.604
MOD_SUMO_rev_2	353	360	PF00179	0.569
MOD_SUMO_rev_2	469	477	PF00179	0.486
TRG_DiLeu_BaEn_1	263	268	PF01217	0.380
TRG_DiLeu_BaEn_1	312	317	PF01217	0.440
TRG_DiLeu_BaEn_2	68	74	PF01217	0.440
TRG_DiLeu_BaEn_4	675	681	PF01217	0.533
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.468
TRG_ENDOCYTIC_2	44	47	PF00928	0.421
TRG_ENDOCYTIC_2	526	529	PF00928	0.348
TRG_ENDOCYTIC_2	539	542	PF00928	0.355
TRG_ENDOCYTIC_2	71	74	PF00928	0.427
TRG_ER_diArg_1	233	236	PF00400	0.462
TRG_ER_diArg_1	384	386	PF00400	0.523
TRG_ER_diArg_1	444	446	PF00400	0.429
TRG_ER_diArg_1	553	556	PF00400	0.448
TRG_ER_diArg_1	682	684	PF00400	0.783
TRG_ER_diArg_1	84	86	PF00400	0.342
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	565	570	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L1	Leptomonas seymouri	53%	89%
A0A1X0P7U7	Trypanosomatidae	34%	100%
A4HP42	Leishmania braziliensis	71%	100%
A4IDE9	Leishmania infantum	100%	100%
D0A326	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ASV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1P6	Leishmania major	90%	100%