Phosphomannomutase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphomannomutase

Gene product:

phosphomannomutase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAQ9_LEIDO

TriTrypDb:

LdBPK_362070.1 , LdCL_360026200 , LDHU3_36.2690

Length:

247

Annotations

Annotations by Jardim et al.

Carbohydrate metabolism, Phosphomannomutase PMM

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7XAQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAQ9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009225	nucleotide-sugar metabolic process	4	12
GO:0009226	nucleotide-sugar biosynthetic process	5	12
GO:0009298	GDP-mannose biosynthetic process	6	12
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0019673	GDP-mannose metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0005975	carbohydrate metabolic process	3	1
GO:0005996	monosaccharide metabolic process	3	1
GO:0006013	mannose metabolic process	5	1
GO:0006486	protein glycosylation	4	1
GO:0006487	protein N-linked glycosylation	5	1
GO:0019318	hexose metabolic process	4	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043413	macromolecule glycosylation	3	1
GO:0070085	glycosylation	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004615	phosphomannomutase activity	5	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0016868	intramolecular transferase activity, phosphotransferases	4	12
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	158	162	PF00082	0.328
CLV_PCSK_SKI1_1	4	8	PF00082	0.544
DOC_CYCLIN_RxL_1	98	108	PF00134	0.501
DOC_MAPK_gen_1	230	238	PF00069	0.544
DOC_PP1_RVXF_1	92	99	PF00149	0.467
DOC_PP2B_LxvP_1	109	112	PF13499	0.479
DOC_PP2B_LxvP_1	15	18	PF13499	0.591
DOC_USP7_UBL2_3	184	188	PF12436	0.556
DOC_WW_Pin1_4	126	131	PF00397	0.494
DOC_WW_Pin1_4	13	18	PF00397	0.583
LIG_14-3-3_CanoR_1	83	87	PF00244	0.503
LIG_Clathr_ClatBox_1	8	12	PF01394	0.537
LIG_FHA_1	187	193	PF00498	0.463
LIG_FHA_1	233	239	PF00498	0.521
LIG_FHA_2	115	121	PF00498	0.454
LIG_FHA_2	229	235	PF00498	0.497
LIG_FXI_DFP_1	60	64	PF00024	0.356
LIG_LIR_Gen_1	117	126	PF02991	0.500
LIG_LIR_Gen_1	141	149	PF02991	0.555
LIG_LIR_Gen_1	178	183	PF02991	0.457
LIG_LIR_Gen_1	196	205	PF02991	0.562
LIG_LIR_Gen_1	61	67	PF02991	0.482
LIG_LIR_Nem_3	117	121	PF02991	0.454
LIG_LIR_Nem_3	141	146	PF02991	0.454
LIG_LIR_Nem_3	162	167	PF02991	0.453
LIG_LIR_Nem_3	178	182	PF02991	0.501
LIG_LIR_Nem_3	196	202	PF02991	0.532
LIG_LIR_Nem_3	215	219	PF02991	0.516
LIG_LIR_Nem_3	61	66	PF02991	0.499
LIG_NRBOX	238	244	PF00104	0.474
LIG_PCNA_yPIPBox_3	88	99	PF02747	0.460
LIG_Pex14_1	186	190	PF04695	0.454
LIG_Pex14_2	182	186	PF04695	0.454
LIG_Pex14_2	63	67	PF04695	0.465
LIG_PTB_Apo_2	120	127	PF02174	0.505
LIG_Rb_pABgroove_1	3	11	PF01858	0.520
LIG_REV1ctd_RIR_1	202	212	PF16727	0.454
LIG_SH2_STAT3	190	193	PF00017	0.497
LIG_SH2_STAT5	190	193	PF00017	0.467
LIG_SH2_STAT5	219	222	PF00017	0.489
LIG_SH2_STAT5	65	68	PF00017	0.454
LIG_SH3_3	15	21	PF00018	0.649
LIG_SH3_3	162	168	PF00018	0.535
LIG_SUMO_SIM_anti_2	2	10	PF11976	0.623
LIG_SUMO_SIM_anti_2	234	241	PF11976	0.521
LIG_SUMO_SIM_par_1	2	10	PF11976	0.522
LIG_SUMO_SIM_par_1	234	241	PF11976	0.508
LIG_TRAF2_1	136	139	PF00917	0.521
LIG_UBA3_1	156	161	PF00899	0.497
LIG_UBA3_1	86	94	PF00899	0.521
LIG_WW_3	16	20	PF00397	0.610
MOD_CDK_SPxK_1	13	19	PF00069	0.596
MOD_CDK_SPxxK_3	126	133	PF00069	0.465
MOD_CK1_1	228	234	PF00069	0.497
MOD_CK2_1	114	120	PF00069	0.454
MOD_CK2_1	133	139	PF00069	0.454
MOD_CK2_1	238	244	PF00069	0.489
MOD_CK2_1	55	61	PF00069	0.556
MOD_GSK3_1	217	224	PF00069	0.488
MOD_GSK3_1	228	235	PF00069	0.428
MOD_N-GLC_1	126	131	PF02516	0.258
MOD_N-GLC_1	133	138	PF02516	0.249
MOD_NEK2_1	169	174	PF00069	0.495
MOD_NEK2_1	26	31	PF00069	0.457
MOD_NEK2_1	55	60	PF00069	0.568
MOD_PIKK_1	133	139	PF00454	0.454
MOD_PKA_2	114	120	PF00069	0.489
MOD_PKA_2	82	88	PF00069	0.507
MOD_Plk_1	186	192	PF00069	0.479
MOD_Plk_4	114	120	PF00069	0.481
MOD_Plk_4	238	244	PF00069	0.413
MOD_Plk_4	55	61	PF00069	0.556
MOD_Plk_4	82	88	PF00069	0.507
MOD_ProDKin_1	126	132	PF00069	0.494
MOD_ProDKin_1	13	19	PF00069	0.586
MOD_SUMO_rev_2	22	29	PF00179	0.661
TRG_AP2beta_CARGO_1	141	150	PF09066	0.474
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.229

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0K9RL25	Spinacia oleracea	58%	100%
A0A0N1I6J7	Leptomonas seymouri	81%	100%
A0A0S4ITP3	Bodo saltans	63%	100%
A0A0U1WZ18	Dendrobium officinale	59%	98%
A0A1S4A695	Nicotiana tabacum	58%	98%
A0A1X0P803	Trypanosomatidae	70%	100%
A0A3R7K9A3	Trypanosoma rangeli	68%	98%
A4HP63	Leishmania braziliensis	83%	100%
A4IDG8	Leishmania infantum	100%	100%
D0A356	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9ASX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
M2VWL5	Galdieria sulphuraria	60%	98%
O15305	Homo sapiens	56%	100%
O35621	Mus musculus	52%	94%
O43976	Babesia bovis	45%	100%
O80840	Arabidopsis thaliana	61%	100%
P07283	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	58%	97%
P31353	Candida albicans (strain SC5314 / ATCC MYA-2876)	61%	98%
Q1W374	Triticum aestivum	56%	99%
Q1W375	Nicotiana benthamiana	57%	98%
Q1W376	Glycine max	58%	100%
Q1W377	Solanum lycopersicum	58%	98%
Q259G4	Oryza sativa subsp. indica	57%	100%
Q3SZJ9	Bos taurus	54%	100%
Q4Q1M7	Leishmania major	97%	100%
Q54X03	Dictyostelium discoideum	57%	99%
Q60HD6	Macaca fascicularis	55%	100%
Q7XPW5	Oryza sativa subsp. japonica	57%	100%
Q86B09	Dictyostelium discoideum	59%	99%
Q8SVM5	Encephalitozoon cuniculi (strain GB-M1)	47%	96%
Q92871	Homo sapiens	51%	94%
Q9UTJ2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	59%	96%
Q9VTZ6	Drosophila melanogaster	53%	97%
Q9XUE6	Caenorhabditis elegans	50%	97%
Q9Z2M7	Mus musculus	53%	100%
V5AWD8	Trypanosoma cruzi	67%	100%