Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAQ0_LEIDO

TriTrypDb:

LdBPK_361760.1 , LdCL_360023100 , LDHU3_36.2320

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAQ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.434
CLV_C14_Caspase3-7	342	346	PF00656	0.681
CLV_NRD_NRD_1	173	175	PF00675	0.676
CLV_NRD_NRD_1	178	180	PF00675	0.542
CLV_NRD_NRD_1	205	207	PF00675	0.585
CLV_NRD_NRD_1	347	349	PF00675	0.800
CLV_NRD_NRD_1	41	43	PF00675	0.694
CLV_NRD_NRD_1	48	50	PF00675	0.626
CLV_NRD_NRD_1	489	491	PF00675	0.564
CLV_NRD_NRD_1	56	58	PF00675	0.517
CLV_NRD_NRD_1	572	574	PF00675	0.690
CLV_NRD_NRD_1	604	606	PF00675	0.739
CLV_NRD_NRD_1	663	665	PF00675	0.713
CLV_NRD_NRD_1	689	691	PF00675	0.705
CLV_NRD_NRD_1	70	72	PF00675	0.604
CLV_NRD_NRD_1	750	752	PF00675	0.591
CLV_PCSK_FUR_1	661	665	PF00082	0.804
CLV_PCSK_KEX2_1	173	175	PF00082	0.676
CLV_PCSK_KEX2_1	178	180	PF00082	0.542
CLV_PCSK_KEX2_1	205	207	PF00082	0.585
CLV_PCSK_KEX2_1	347	349	PF00082	0.800
CLV_PCSK_KEX2_1	41	43	PF00082	0.645
CLV_PCSK_KEX2_1	489	491	PF00082	0.564
CLV_PCSK_KEX2_1	572	574	PF00082	0.690
CLV_PCSK_KEX2_1	604	606	PF00082	0.739
CLV_PCSK_KEX2_1	663	665	PF00082	0.711
CLV_PCSK_KEX2_1	688	690	PF00082	0.694
CLV_PCSK_KEX2_1	70	72	PF00082	0.649
CLV_PCSK_KEX2_1	750	752	PF00082	0.595
CLV_PCSK_PC7_1	174	180	PF00082	0.578
CLV_PCSK_SKI1_1	162	166	PF00082	0.684
CLV_PCSK_SKI1_1	174	178	PF00082	0.550
CLV_PCSK_SKI1_1	314	318	PF00082	0.616
CLV_PCSK_SKI1_1	323	327	PF00082	0.626
CLV_PCSK_SKI1_1	536	540	PF00082	0.782
CLV_PCSK_SKI1_1	741	745	PF00082	0.629
CLV_PCSK_SKI1_1	751	755	PF00082	0.652
DEG_SPOP_SBC_1	722	726	PF00917	0.765
DOC_CYCLIN_RxL_1	738	748	PF00134	0.689
DOC_MAPK_DCC_7	7	16	PF00069	0.681
DOC_MAPK_gen_1	178	184	PF00069	0.539
DOC_MAPK_MEF2A_6	589	598	PF00069	0.702
DOC_MAPK_MEF2A_6	7	16	PF00069	0.580
DOC_PP1_RVXF_1	160	167	PF00149	0.552
DOC_PP1_RVXF_1	312	318	PF00149	0.611
DOC_PP2B_LxvP_1	328	331	PF13499	0.573
DOC_PP2B_LxvP_1	364	367	PF13499	0.724
DOC_PP2B_LxvP_1	539	542	PF13499	0.726
DOC_PP2B_PxIxI_1	717	723	PF00149	0.511
DOC_PP4_FxxP_1	192	195	PF00568	0.643
DOC_PP4_FxxP_1	555	558	PF00568	0.695
DOC_SPAK_OSR1_1	301	305	PF12202	0.574
DOC_USP7_MATH_1	106	110	PF00917	0.647
DOC_USP7_MATH_1	200	204	PF00917	0.602
DOC_USP7_MATH_1	286	290	PF00917	0.668
DOC_USP7_MATH_1	382	386	PF00917	0.650
DOC_USP7_MATH_1	391	395	PF00917	0.629
DOC_USP7_MATH_1	405	409	PF00917	0.578
DOC_USP7_MATH_1	502	506	PF00917	0.705
DOC_USP7_MATH_1	532	536	PF00917	0.730
DOC_USP7_MATH_1	544	548	PF00917	0.625
DOC_USP7_MATH_1	672	676	PF00917	0.637
DOC_USP7_MATH_1	703	707	PF00917	0.668
DOC_USP7_MATH_1	771	775	PF00917	0.682
DOC_USP7_UBL2_3	515	519	PF12436	0.630
DOC_WW_Pin1_4	248	253	PF00397	0.747
DOC_WW_Pin1_4	255	260	PF00397	0.809
DOC_WW_Pin1_4	272	277	PF00397	0.596
DOC_WW_Pin1_4	315	320	PF00397	0.567
DOC_WW_Pin1_4	521	526	PF00397	0.648
DOC_WW_Pin1_4	527	532	PF00397	0.671
DOC_WW_Pin1_4	537	542	PF00397	0.708
DOC_WW_Pin1_4	636	641	PF00397	0.763
DOC_WW_Pin1_4	653	658	PF00397	0.744
DOC_WW_Pin1_4	714	719	PF00397	0.705
LIG_14-3-3_CanoR_1	115	123	PF00244	0.621
LIG_14-3-3_CanoR_1	148	156	PF00244	0.689
LIG_14-3-3_CanoR_1	228	234	PF00244	0.732
LIG_14-3-3_CanoR_1	410	414	PF00244	0.722
LIG_14-3-3_CanoR_1	420	425	PF00244	0.492
LIG_14-3-3_CanoR_1	572	579	PF00244	0.591
LIG_14-3-3_CanoR_1	604	613	PF00244	0.742
LIG_Actin_WH2_2	149	164	PF00022	0.650
LIG_Actin_WH2_2	504	521	PF00022	0.586
LIG_BIR_III_2	30	34	PF00653	0.756
LIG_BIR_III_4	352	356	PF00653	0.728
LIG_BRCT_BRCA1_1	256	260	PF00533	0.696
LIG_BRCT_BRCA1_1	336	340	PF00533	0.741
LIG_BRCT_BRCA1_1	91	95	PF00533	0.615
LIG_CaM_IQ_9	107	123	PF13499	0.583
LIG_CaM_IQ_9	62	78	PF13499	0.637
LIG_CaM_NSCaTE_8	617	624	PF13499	0.653
LIG_eIF4E_1	210	216	PF01652	0.623
LIG_FHA_1	133	139	PF00498	0.625
LIG_FHA_1	148	154	PF00498	0.477
LIG_FHA_1	216	222	PF00498	0.672
LIG_FHA_1	22	28	PF00498	0.656
LIG_FHA_1	261	267	PF00498	0.784
LIG_FHA_1	558	564	PF00498	0.607
LIG_FHA_1	591	597	PF00498	0.640
LIG_FHA_1	6	12	PF00498	0.694
LIG_FHA_1	73	79	PF00498	0.640
LIG_FHA_2	135	141	PF00498	0.532
LIG_FHA_2	622	628	PF00498	0.704
LIG_FHA_2	637	643	PF00498	0.725
LIG_Integrin_RGD_1	245	247	PF01839	0.746
LIG_Integrin_RGD_1	456	458	PF01839	0.724
LIG_LIR_Apic_2	553	558	PF02991	0.696
LIG_LIR_Apic_2	561	567	PF02991	0.706
LIG_LIR_Nem_3	312	316	PF02991	0.656
LIG_LIR_Nem_3	320	325	PF02991	0.653
LIG_LIR_Nem_3	92	98	PF02991	0.626
LIG_PCNA_yPIPBox_3	63	73	PF02747	0.537
LIG_PTB_Apo_2	443	450	PF02174	0.579
LIG_SH2_CRK	313	317	PF00017	0.726
LIG_SH2_CRK	451	455	PF00017	0.627
LIG_SH2_CRK	564	568	PF00017	0.682
LIG_SH2_GRB2like	388	391	PF00017	0.497
LIG_SH2_GRB2like	747	750	PF00017	0.668
LIG_SH2_NCK_1	388	392	PF00017	0.569
LIG_SH2_SRC	388	391	PF00017	0.497
LIG_SH2_STAP1	388	392	PF00017	0.569
LIG_SH2_STAT3	677	680	PF00017	0.669
LIG_SH2_STAT5	4	7	PF00017	0.684
LIG_SH2_STAT5	677	680	PF00017	0.629
LIG_SH2_STAT5	747	750	PF00017	0.742
LIG_SH3_1	205	211	PF00018	0.533
LIG_SH3_1	7	13	PF00018	0.673
LIG_SH3_3	205	211	PF00018	0.533
LIG_SH3_3	246	252	PF00018	0.741
LIG_SH3_3	525	531	PF00018	0.609
LIG_SH3_3	651	657	PF00018	0.754
LIG_SH3_3	7	13	PF00018	0.629
LIG_SUMO_SIM_anti_2	762	768	PF11976	0.670
LIG_SUMO_SIM_par_1	12	17	PF11976	0.644
LIG_SUMO_SIM_par_1	507	513	PF11976	0.760
LIG_TRAF2_1	318	321	PF00917	0.706
LIG_TRAF2_1	510	513	PF00917	0.628
LIG_UBA3_1	324	329	PF00899	0.657
LIG_WW_3	540	544	PF00397	0.676
MOD_CDC14_SPxK_1	540	543	PF00782	0.626
MOD_CDK_SPxK_1	537	543	PF00069	0.632
MOD_CK1_1	19	25	PF00069	0.718
MOD_CK1_1	217	223	PF00069	0.714
MOD_CK1_1	258	264	PF00069	0.813
MOD_CK1_1	332	338	PF00069	0.675
MOD_CK1_1	341	347	PF00069	0.718
MOD_CK1_1	394	400	PF00069	0.641
MOD_CK1_1	462	468	PF00069	0.663
MOD_CK1_1	537	543	PF00069	0.801
MOD_CK1_1	583	589	PF00069	0.784
MOD_CK1_1	652	658	PF00069	0.671
MOD_CK1_1	716	722	PF00069	0.706
MOD_CK1_1	723	729	PF00069	0.738
MOD_CK1_1	84	90	PF00069	0.727
MOD_CK2_1	19	25	PF00069	0.654
MOD_CK2_1	315	321	PF00069	0.712
MOD_CK2_1	419	425	PF00069	0.597
MOD_CK2_1	606	612	PF00069	0.673
MOD_CK2_1	621	627	PF00069	0.563
MOD_CK2_1	636	642	PF00069	0.677
MOD_CK2_1	771	777	PF00069	0.775
MOD_Cter_Amidation	345	348	PF01082	0.719
MOD_GlcNHglycan	18	21	PF01048	0.736
MOD_GlcNHglycan	230	233	PF01048	0.612
MOD_GlcNHglycan	235	238	PF01048	0.613
MOD_GlcNHglycan	260	263	PF01048	0.717
MOD_GlcNHglycan	288	291	PF01048	0.613
MOD_GlcNHglycan	334	337	PF01048	0.625
MOD_GlcNHglycan	393	396	PF01048	0.560
MOD_GlcNHglycan	467	470	PF01048	0.691
MOD_GlcNHglycan	498	501	PF01048	0.639
MOD_GlcNHglycan	546	549	PF01048	0.651
MOD_GlcNHglycan	608	611	PF01048	0.627
MOD_GlcNHglycan	692	695	PF01048	0.674
MOD_GlcNHglycan	773	776	PF01048	0.701
MOD_GlcNHglycan	777	780	PF01048	0.676
MOD_GSK3_1	106	113	PF00069	0.681
MOD_GSK3_1	143	150	PF00069	0.564
MOD_GSK3_1	16	23	PF00069	0.710
MOD_GSK3_1	224	231	PF00069	0.633
MOD_GSK3_1	254	261	PF00069	0.746
MOD_GSK3_1	334	341	PF00069	0.740
MOD_GSK3_1	405	412	PF00069	0.697
MOD_GSK3_1	459	466	PF00069	0.685
MOD_GSK3_1	523	530	PF00069	0.683
MOD_GSK3_1	567	574	PF00069	0.676
MOD_GSK3_1	577	584	PF00069	0.635
MOD_GSK3_1	585	592	PF00069	0.690
MOD_GSK3_1	649	656	PF00069	0.695
MOD_GSK3_1	714	721	PF00069	0.752
MOD_GSK3_1	767	774	PF00069	0.688
MOD_GSK3_1	81	88	PF00069	0.724
MOD_LATS_1	79	85	PF00433	0.557
MOD_N-GLC_1	20	25	PF02516	0.761
MOD_NEK2_1	116	121	PF00069	0.655
MOD_NEK2_1	147	152	PF00069	0.590
MOD_NEK2_1	16	21	PF00069	0.751
MOD_NEK2_1	260	265	PF00069	0.740
MOD_NEK2_1	279	284	PF00069	0.446
MOD_NEK2_1	339	344	PF00069	0.779
MOD_NEK2_1	464	469	PF00069	0.553
MOD_NEK2_1	5	10	PF00069	0.754
MOD_NEK2_1	620	625	PF00069	0.548
MOD_NEK2_1	767	772	PF00069	0.754
MOD_NEK2_2	149	154	PF00069	0.706
MOD_NEK2_2	200	205	PF00069	0.600
MOD_NEK2_2	459	464	PF00069	0.669
MOD_NEK2_2	469	474	PF00069	0.572
MOD_OFUCOSY	575	581	PF10250	0.593
MOD_PIKK_1	523	529	PF00454	0.712
MOD_PK_1	81	87	PF00069	0.663
MOD_PKA_1	57	63	PF00069	0.592
MOD_PKA_2	147	153	PF00069	0.605
MOD_PKA_2	227	233	PF00069	0.698
MOD_PKA_2	409	415	PF00069	0.723
MOD_PKA_2	419	425	PF00069	0.560
MOD_PKA_2	571	577	PF00069	0.657
MOD_PKA_2	760	766	PF00069	0.622
MOD_PKA_2	767	773	PF00069	0.644
MOD_PKA_2	89	95	PF00069	0.616
MOD_PKB_1	688	696	PF00069	0.655
MOD_Plk_1	279	285	PF00069	0.595
MOD_Plk_1	459	465	PF00069	0.705
MOD_Plk_4	134	140	PF00069	0.630
MOD_Plk_4	279	285	PF00069	0.720
MOD_Plk_4	335	341	PF00069	0.682
MOD_Plk_4	394	400	PF00069	0.570
MOD_Plk_4	502	508	PF00069	0.777
MOD_Plk_4	673	679	PF00069	0.754
MOD_Plk_4	682	688	PF00069	0.568
MOD_ProDKin_1	248	254	PF00069	0.748
MOD_ProDKin_1	255	261	PF00069	0.809
MOD_ProDKin_1	272	278	PF00069	0.596
MOD_ProDKin_1	315	321	PF00069	0.565
MOD_ProDKin_1	521	527	PF00069	0.651
MOD_ProDKin_1	537	543	PF00069	0.742
MOD_ProDKin_1	636	642	PF00069	0.764
MOD_ProDKin_1	653	659	PF00069	0.745
MOD_ProDKin_1	714	720	PF00069	0.705
MOD_SUMO_rev_2	321	331	PF00179	0.678
MOD_SUMO_rev_2	512	517	PF00179	0.628
TRG_DiLeu_BaEn_1	172	177	PF01217	0.665
TRG_DiLeu_BaEn_1	320	325	PF01217	0.712
TRG_DiLeu_BaEn_4	320	326	PF01217	0.714
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.634
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.611
TRG_DiLeu_BaLyEn_6	738	743	PF01217	0.574
TRG_DiLeu_LyEn_5	320	325	PF01217	0.637
TRG_ENDOCYTIC_2	313	316	PF00928	0.633
TRG_ENDOCYTIC_2	451	454	PF00928	0.635
TRG_ER_diArg_1	177	179	PF00400	0.637
TRG_ER_diArg_1	204	206	PF00400	0.570
TRG_ER_diArg_1	40	42	PF00400	0.642
TRG_ER_diArg_1	488	490	PF00400	0.619
TRG_ER_diArg_1	604	606	PF00400	0.739
TRG_ER_diArg_1	660	663	PF00400	0.713
TRG_ER_diArg_1	687	690	PF00400	0.690
TRG_ER_diArg_1	69	71	PF00400	0.690
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.731
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	323	327	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	741	746	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF83	Leptomonas seymouri	32%	87%
A4HP32	Leishmania braziliensis	62%	100%
A4IDD9	Leishmania infantum	99%	100%
E9ASU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q1Q6	Leishmania major	87%	100%