Engulfment and cell motility domain 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

engulfment and cell motility domain 2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAP8_LEIDO

TriTrypDb:

LdBPK_361600.1 , LdCL_360021500 , LDHU3_36.2060

Length:

935

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAP8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.641
CLV_C14_Caspase3-7	457	461	PF00656	0.755
CLV_NRD_NRD_1	14	16	PF00675	0.606
CLV_NRD_NRD_1	197	199	PF00675	0.747
CLV_NRD_NRD_1	450	452	PF00675	0.758
CLV_NRD_NRD_1	557	559	PF00675	0.453
CLV_NRD_NRD_1	675	677	PF00675	0.411
CLV_NRD_NRD_1	912	914	PF00675	0.580
CLV_PCSK_KEX2_1	14	16	PF00082	0.604
CLV_PCSK_KEX2_1	197	199	PF00082	0.747
CLV_PCSK_KEX2_1	450	452	PF00082	0.758
CLV_PCSK_KEX2_1	557	559	PF00082	0.460
CLV_PCSK_KEX2_1	675	677	PF00082	0.411
CLV_PCSK_KEX2_1	786	788	PF00082	0.503
CLV_PCSK_KEX2_1	827	829	PF00082	0.408
CLV_PCSK_PC1ET2_1	786	788	PF00082	0.368
CLV_PCSK_PC1ET2_1	827	829	PF00082	0.408
CLV_PCSK_SKI1_1	660	664	PF00082	0.492
CLV_PCSK_SKI1_1	675	679	PF00082	0.294
DEG_APCC_DBOX_1	632	640	PF00400	0.713
DEG_APCC_DBOX_1	674	682	PF00400	0.411
DEG_COP1_1	267	276	PF00400	0.607
DEG_SPOP_SBC_1	23	27	PF00917	0.637
DEG_SPOP_SBC_1	337	341	PF00917	0.708
DEG_SPOP_SBC_1	420	424	PF00917	0.626
DEG_SPOP_SBC_1	575	579	PF00917	0.760
DEG_SPOP_SBC_1	703	707	PF00917	0.440
DEG_SPOP_SBC_1	708	712	PF00917	0.394
DOC_CKS1_1	299	304	PF01111	0.760
DOC_CYCLIN_RxL_1	368	381	PF00134	0.607
DOC_CYCLIN_RxL_1	673	680	PF00134	0.512
DOC_CYCLIN_yClb1_LxF_4	791	797	PF00134	0.394
DOC_MAPK_DCC_7	789	799	PF00069	0.394
DOC_MAPK_gen_1	660	669	PF00069	0.492
DOC_MAPK_gen_1	675	681	PF00069	0.294
DOC_MAPK_gen_1	786	796	PF00069	0.448
DOC_MAPK_GRA24_9	783	799	PF00069	0.306
DOC_MAPK_HePTP_8	783	799	PF00069	0.306
DOC_MAPK_MEF2A_6	538	545	PF00069	0.537
DOC_MAPK_MEF2A_6	663	671	PF00069	0.512
DOC_PP2B_LxvP_1	178	181	PF13499	0.803
DOC_PP2B_LxvP_1	410	413	PF13499	0.661
DOC_PP4_FxxP_1	171	174	PF00568	0.700
DOC_USP7_MATH_1	104	108	PF00917	0.776
DOC_USP7_MATH_1	118	122	PF00917	0.632
DOC_USP7_MATH_1	23	27	PF00917	0.791
DOC_USP7_MATH_1	247	251	PF00917	0.813
DOC_USP7_MATH_1	257	261	PF00917	0.658
DOC_USP7_MATH_1	282	286	PF00917	0.715
DOC_USP7_MATH_1	378	382	PF00917	0.644
DOC_USP7_MATH_1	443	447	PF00917	0.743
DOC_USP7_MATH_1	459	463	PF00917	0.731
DOC_USP7_MATH_1	575	579	PF00917	0.635
DOC_USP7_MATH_1	621	625	PF00917	0.698
DOC_USP7_MATH_1	626	630	PF00917	0.702
DOC_USP7_MATH_1	661	665	PF00917	0.509
DOC_USP7_MATH_1	690	694	PF00917	0.384
DOC_USP7_MATH_1	703	707	PF00917	0.501
DOC_USP7_MATH_1	709	713	PF00917	0.370
DOC_USP7_MATH_1	845	849	PF00917	0.471
DOC_USP7_MATH_1	870	874	PF00917	0.306
DOC_USP7_MATH_2	333	339	PF00917	0.613
DOC_USP7_UBL2_3	910	914	PF12436	0.615
DOC_WW_Pin1_4	125	130	PF00397	0.779
DOC_WW_Pin1_4	234	239	PF00397	0.709
DOC_WW_Pin1_4	298	303	PF00397	0.648
DOC_WW_Pin1_4	309	314	PF00397	0.667
DOC_WW_Pin1_4	465	470	PF00397	0.753
DOC_WW_Pin1_4	60	65	PF00397	0.725
DOC_WW_Pin1_4	699	704	PF00397	0.503
DOC_WW_Pin1_4	768	773	PF00397	0.414
DOC_WW_Pin1_4	827	832	PF00397	0.336
LIG_14-3-3_CanoR_1	151	156	PF00244	0.770
LIG_14-3-3_CanoR_1	206	212	PF00244	0.631
LIG_14-3-3_CanoR_1	265	274	PF00244	0.753
LIG_14-3-3_CanoR_1	478	482	PF00244	0.755
LIG_14-3-3_CanoR_1	574	583	PF00244	0.707
LIG_14-3-3_CanoR_1	613	618	PF00244	0.800
LIG_14-3-3_CanoR_1	660	669	PF00244	0.498
LIG_14-3-3_CanoR_1	676	682	PF00244	0.289
LIG_14-3-3_CanoR_1	694	704	PF00244	0.490
LIG_Actin_WH2_2	900	915	PF00022	0.618
LIG_APCC_ABBA_1	864	869	PF00400	0.411
LIG_BIR_II_1	1	5	PF00653	0.671
LIG_BIR_III_4	359	363	PF00653	0.609
LIG_BIR_III_4	560	564	PF00653	0.493
LIG_BIR_III_4	809	813	PF00653	0.411
LIG_BRCT_BRCA1_1	344	348	PF00533	0.760
LIG_BRCT_BRCA1_1	718	722	PF00533	0.512
LIG_BRCT_BRCA1_1	94	98	PF00533	0.726
LIG_EVH1_1	178	182	PF00568	0.709
LIG_EVH1_2	541	545	PF00568	0.484
LIG_FHA_1	170	176	PF00498	0.598
LIG_FHA_1	238	244	PF00498	0.760
LIG_FHA_1	267	273	PF00498	0.753
LIG_FHA_1	412	418	PF00498	0.705
LIG_FHA_1	420	426	PF00498	0.731
LIG_FHA_1	551	557	PF00498	0.576
LIG_FHA_1	684	690	PF00498	0.390
LIG_FHA_1	732	738	PF00498	0.407
LIG_FHA_1	802	808	PF00498	0.411
LIG_FHA_2	347	353	PF00498	0.775
LIG_FHA_2	364	370	PF00498	0.536
LIG_FHA_2	542	548	PF00498	0.481
LIG_FHA_2	830	836	PF00498	0.306
LIG_Integrin_RGD_1	558	560	PF01839	0.474
LIG_LIR_Apic_2	169	174	PF02991	0.697
LIG_LIR_Gen_1	102	112	PF02991	0.655
LIG_LIR_Gen_1	210	218	PF02991	0.608
LIG_LIR_Gen_1	246	255	PF02991	0.798
LIG_LIR_Gen_1	48	57	PF02991	0.694
LIG_LIR_Gen_1	547	556	PF02991	0.504
LIG_LIR_Gen_1	680	690	PF02991	0.411
LIG_LIR_Gen_1	793	803	PF02991	0.352
LIG_LIR_Nem_3	162	168	PF02991	0.794
LIG_LIR_Nem_3	210	214	PF02991	0.641
LIG_LIR_Nem_3	246	251	PF02991	0.803
LIG_LIR_Nem_3	41	47	PF02991	0.712
LIG_LIR_Nem_3	464	470	PF02991	0.707
LIG_LIR_Nem_3	48	53	PF02991	0.695
LIG_LIR_Nem_3	544	549	PF02991	0.473
LIG_LIR_Nem_3	680	685	PF02991	0.411
LIG_LIR_Nem_3	747	752	PF02991	0.382
LIG_LIR_Nem_3	793	799	PF02991	0.352
LIG_LIR_Nem_3	899	903	PF02991	0.609
LIG_LYPXL_S_1	43	47	PF13949	0.747
LIG_LYPXL_yS_3	44	47	PF13949	0.807
LIG_MYND_1	190	194	PF01753	0.734
LIG_Pex14_2	867	871	PF04695	0.411
LIG_SH2_STAP1	546	550	PF00017	0.477
LIG_SH2_STAT3	17	20	PF00017	0.637
LIG_SH2_STAT5	165	168	PF00017	0.691
LIG_SH2_STAT5	549	552	PF00017	0.581
LIG_SH2_STAT5	744	747	PF00017	0.364
LIG_SH2_STAT5	860	863	PF00017	0.481
LIG_SH3_3	141	147	PF00018	0.672
LIG_SH3_3	171	177	PF00018	0.704
LIG_SH3_3	178	184	PF00018	0.716
LIG_SH3_3	228	234	PF00018	0.740
LIG_SH3_3	296	302	PF00018	0.701
LIG_SH3_3	316	322	PF00018	0.476
LIG_SH3_3	580	586	PF00018	0.615
LIG_SH3_3	646	652	PF00018	0.579
LIG_SH3_3	924	930	PF00018	0.562
LIG_SH3_CIN85_PxpxPR_1	64	69	PF14604	0.612
LIG_Sin3_3	803	810	PF02671	0.401
LIG_SUMO_SIM_par_1	321	327	PF11976	0.749
LIG_TRAF2_1	215	218	PF00917	0.816
LIG_TRAF2_1	333	336	PF00917	0.746
LIG_WRC_WIRS_1	504	509	PF05994	0.620
MOD_CDK_SPK_2	64	69	PF00069	0.716
MOD_CDK_SPxxK_3	62	69	PF00069	0.611
MOD_CK1_1	121	127	PF00069	0.669
MOD_CK1_1	212	218	PF00069	0.704
MOD_CK1_1	229	235	PF00069	0.674
MOD_CK1_1	237	243	PF00069	0.663
MOD_CK1_1	338	344	PF00069	0.670
MOD_CK1_1	346	352	PF00069	0.650
MOD_CK1_1	395	401	PF00069	0.777
MOD_CK1_1	415	421	PF00069	0.570
MOD_CK1_1	431	437	PF00069	0.723
MOD_CK1_1	446	452	PF00069	0.689
MOD_CK1_1	468	474	PF00069	0.691
MOD_CK1_1	612	618	PF00069	0.757
MOD_CK1_1	698	704	PF00069	0.462
MOD_CK1_1	707	713	PF00069	0.417
MOD_CK1_1	830	836	PF00069	0.409
MOD_CK1_1	92	98	PF00069	0.751
MOD_CK2_1	212	218	PF00069	0.800
MOD_CK2_1	24	30	PF00069	0.753
MOD_CK2_1	272	278	PF00069	0.754
MOD_CK2_1	346	352	PF00069	0.697
MOD_CK2_1	363	369	PF00069	0.539
MOD_CK2_1	541	547	PF00069	0.472
MOD_CK2_1	829	835	PF00069	0.428
MOD_CMANNOS	208	211	PF00535	0.610
MOD_Cter_Amidation	195	198	PF01082	0.791
MOD_Cter_Amidation	825	828	PF01082	0.450
MOD_GlcNHglycan	213	217	PF01048	0.768
MOD_GlcNHglycan	228	231	PF01048	0.621
MOD_GlcNHglycan	269	272	PF01048	0.818
MOD_GlcNHglycan	394	397	PF01048	0.765
MOD_GlcNHglycan	429	433	PF01048	0.825
MOD_GlcNHglycan	437	440	PF01048	0.723
MOD_GlcNHglycan	470	473	PF01048	0.669
MOD_GlcNHglycan	507	510	PF01048	0.782
MOD_GlcNHglycan	609	612	PF01048	0.656
MOD_GlcNHglycan	628	631	PF01048	0.672
MOD_GlcNHglycan	634	639	PF01048	0.778
MOD_GlcNHglycan	646	649	PF01048	0.556
MOD_GlcNHglycan	91	94	PF01048	0.735
MOD_GlcNHglycan	95	98	PF01048	0.695
MOD_GSK3_1	110	117	PF00069	0.733
MOD_GSK3_1	118	125	PF00069	0.600
MOD_GSK3_1	145	152	PF00069	0.742
MOD_GSK3_1	222	229	PF00069	0.805
MOD_GSK3_1	232	239	PF00069	0.743
MOD_GSK3_1	272	279	PF00069	0.749
MOD_GSK3_1	294	301	PF00069	0.623
MOD_GSK3_1	331	338	PF00069	0.735
MOD_GSK3_1	339	346	PF00069	0.711
MOD_GSK3_1	411	418	PF00069	0.657
MOD_GSK3_1	420	427	PF00069	0.699
MOD_GSK3_1	431	438	PF00069	0.494
MOD_GSK3_1	503	510	PF00069	0.737
MOD_GSK3_1	60	67	PF00069	0.732
MOD_GSK3_1	609	616	PF00069	0.667
MOD_GSK3_1	622	629	PF00069	0.710
MOD_GSK3_1	661	668	PF00069	0.385
MOD_GSK3_1	677	684	PF00069	0.451
MOD_GSK3_1	695	702	PF00069	0.216
MOD_GSK3_1	703	710	PF00069	0.357
MOD_GSK3_1	722	729	PF00069	0.505
MOD_GSK3_1	766	773	PF00069	0.433
MOD_GSK3_1	877	884	PF00069	0.372
MOD_GSK3_1	88	95	PF00069	0.754
MOD_LATS_1	426	432	PF00433	0.624
MOD_N-GLC_1	110	115	PF02516	0.659
MOD_N-GLC_1	169	174	PF02516	0.591
MOD_N-GLC_1	443	448	PF02516	0.724
MOD_N-GLC_1	510	515	PF02516	0.590
MOD_N-GLC_1	696	701	PF02516	0.440
MOD_N-GLC_1	801	806	PF02516	0.394
MOD_NEK2_1	294	299	PF00069	0.717
MOD_NEK2_1	505	510	PF00069	0.690
MOD_NEK2_1	550	555	PF00069	0.574
MOD_NEK2_1	669	674	PF00069	0.443
MOD_NEK2_1	677	682	PF00069	0.485
MOD_NEK2_1	722	727	PF00069	0.408
MOD_NEK2_1	801	806	PF00069	0.411
MOD_NEK2_1	885	890	PF00069	0.619
MOD_NEK2_1	98	103	PF00069	0.806
MOD_NEK2_2	104	109	PF00069	0.756
MOD_PIKK_1	224	230	PF00454	0.674
MOD_PIKK_1	661	667	PF00454	0.471
MOD_PIKK_1	74	80	PF00454	0.775
MOD_PK_1	663	669	PF00069	0.347
MOD_PK_1	716	722	PF00069	0.512
MOD_PKA_2	145	151	PF00069	0.793
MOD_PKA_2	219	225	PF00069	0.724
MOD_PKA_2	23	29	PF00069	0.749
MOD_PKA_2	264	270	PF00069	0.817
MOD_PKA_2	435	441	PF00069	0.679
MOD_PKA_2	477	483	PF00069	0.750
MOD_PKA_2	612	618	PF00069	0.700
MOD_PKA_2	731	737	PF00069	0.387
MOD_PKA_2	788	794	PF00069	0.394
MOD_PKA_2	893	899	PF00069	0.557
MOD_Plk_1	38	44	PF00069	0.748
MOD_Plk_1	428	434	PF00069	0.829
MOD_Plk_1	510	516	PF00069	0.657
MOD_Plk_1	74	80	PF00069	0.713
MOD_Plk_1	801	807	PF00069	0.394
MOD_Plk_2-3	30	36	PF00069	0.744
MOD_Plk_4	405	411	PF00069	0.675
MOD_Plk_4	412	418	PF00069	0.646
MOD_Plk_4	576	582	PF00069	0.714
MOD_Plk_4	677	683	PF00069	0.439
MOD_ProDKin_1	125	131	PF00069	0.774
MOD_ProDKin_1	234	240	PF00069	0.709
MOD_ProDKin_1	298	304	PF00069	0.651
MOD_ProDKin_1	309	315	PF00069	0.664
MOD_ProDKin_1	465	471	PF00069	0.753
MOD_ProDKin_1	60	66	PF00069	0.721
MOD_ProDKin_1	699	705	PF00069	0.503
MOD_ProDKin_1	768	774	PF00069	0.414
MOD_ProDKin_1	827	833	PF00069	0.336
MOD_SUMO_for_1	715	718	PF00179	0.512
MOD_SUMO_rev_2	356	365	PF00179	0.775
MOD_SUMO_rev_2	896	905	PF00179	0.521
TRG_ENDOCYTIC_2	165	168	PF00928	0.732
TRG_ENDOCYTIC_2	44	47	PF00928	0.807
TRG_ENDOCYTIC_2	481	484	PF00928	0.721
TRG_ENDOCYTIC_2	549	552	PF00928	0.493
TRG_ENDOCYTIC_2	749	752	PF00928	0.411
TRG_ENDOCYTIC_2	850	853	PF00928	0.512
TRG_ER_diArg_1	13	15	PF00400	0.616
TRG_ER_diArg_1	450	452	PF00400	0.810
TRG_ER_diArg_1	556	558	PF00400	0.411
TRG_ER_diArg_1	675	677	PF00400	0.352
TRG_ER_diArg_1	787	790	PF00400	0.445
TRG_ER_diArg_1	871	874	PF00400	0.424
TRG_NLS_MonoExtC_3	10	15	PF00514	0.711
TRG_Pf-PMV_PEXEL_1	660	665	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB6	Leptomonas seymouri	34%	98%
A4HP14	Leishmania braziliensis	58%	100%
A4IDC3	Leishmania infantum	100%	100%
E9ASS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q1S2	Leishmania major	86%	100%