tRNA pseudouridine synthase A, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA pseudouridine synthase A, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAP2_LEIDO

TriTrypDb:

LdBPK_361740.1 , LdCL_360022900 , LDHU3_36.2300

Length:

877

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAP2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006364	rRNA processing	8	4
GO:0006396	RNA processing	6	4
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0016072	rRNA metabolic process	7	4
GO:0034470	ncRNA processing	7	4
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034660	ncRNA metabolic process	6	4
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:0001522	pseudouridine synthesis	6	4
GO:0009451	RNA modification	5	4
GO:0043412	macromolecule modification	4	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004730	pseudouridylate synthase activity	5	8
GO:0005488	binding	1	12
GO:0009982	pseudouridine synthase activity	4	12
GO:0016829	lyase activity	2	8
GO:0016835	carbon-oxygen lyase activity	3	8
GO:0016836	hydro-lyase activity	4	8
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.533
CLV_C14_Caspase3-7	314	318	PF00656	0.601
CLV_C14_Caspase3-7	589	593	PF00656	0.414
CLV_C14_Caspase3-7	787	791	PF00656	0.432
CLV_C14_Caspase3-7	796	800	PF00656	0.479
CLV_NRD_NRD_1	120	122	PF00675	0.745
CLV_NRD_NRD_1	129	131	PF00675	0.513
CLV_NRD_NRD_1	132	134	PF00675	0.586
CLV_NRD_NRD_1	138	140	PF00675	0.810
CLV_NRD_NRD_1	141	143	PF00675	0.674
CLV_NRD_NRD_1	144	146	PF00675	0.624
CLV_NRD_NRD_1	148	150	PF00675	0.585
CLV_NRD_NRD_1	214	216	PF00675	0.550
CLV_NRD_NRD_1	239	241	PF00675	0.561
CLV_NRD_NRD_1	291	293	PF00675	0.697
CLV_NRD_NRD_1	344	346	PF00675	0.497
CLV_NRD_NRD_1	397	399	PF00675	0.757
CLV_NRD_NRD_1	438	440	PF00675	0.768
CLV_NRD_NRD_1	480	482	PF00675	0.667
CLV_NRD_NRD_1	491	493	PF00675	0.680
CLV_NRD_NRD_1	529	531	PF00675	0.237
CLV_NRD_NRD_1	765	767	PF00675	0.392
CLV_NRD_NRD_1	773	775	PF00675	0.438
CLV_NRD_NRD_1	820	822	PF00675	0.565
CLV_NRD_NRD_1	842	844	PF00675	0.588
CLV_NRD_NRD_1	9	11	PF00675	0.517
CLV_PCSK_FUR_1	130	134	PF00082	0.703
CLV_PCSK_FUR_1	139	143	PF00082	0.569
CLV_PCSK_FUR_1	212	216	PF00082	0.568
CLV_PCSK_FUR_1	237	241	PF00082	0.615
CLV_PCSK_FUR_1	771	775	PF00082	0.407
CLV_PCSK_KEX2_1	120	122	PF00082	0.552
CLV_PCSK_KEX2_1	129	131	PF00082	0.609
CLV_PCSK_KEX2_1	132	134	PF00082	0.706
CLV_PCSK_KEX2_1	137	139	PF00082	0.735
CLV_PCSK_KEX2_1	141	143	PF00082	0.631
CLV_PCSK_KEX2_1	144	146	PF00082	0.647
CLV_PCSK_KEX2_1	148	150	PF00082	0.594
CLV_PCSK_KEX2_1	214	216	PF00082	0.542
CLV_PCSK_KEX2_1	233	235	PF00082	0.731
CLV_PCSK_KEX2_1	239	241	PF00082	0.588
CLV_PCSK_KEX2_1	291	293	PF00082	0.697
CLV_PCSK_KEX2_1	438	440	PF00082	0.768
CLV_PCSK_KEX2_1	480	482	PF00082	0.675
CLV_PCSK_KEX2_1	491	493	PF00082	0.680
CLV_PCSK_KEX2_1	529	531	PF00082	0.237
CLV_PCSK_KEX2_1	765	767	PF00082	0.388
CLV_PCSK_KEX2_1	773	775	PF00082	0.404
CLV_PCSK_KEX2_1	820	822	PF00082	0.563
CLV_PCSK_KEX2_1	842	844	PF00082	0.588
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.762
CLV_PCSK_PC7_1	133	139	PF00082	0.557
CLV_PCSK_PC7_1	144	150	PF00082	0.542
CLV_PCSK_PC7_1	434	440	PF00082	0.571
CLV_PCSK_SKI1_1	148	152	PF00082	0.702
CLV_PCSK_SKI1_1	385	389	PF00082	0.708
CLV_PCSK_SKI1_1	444	448	PF00082	0.566
CLV_PCSK_SKI1_1	653	657	PF00082	0.291
CLV_PCSK_SKI1_1	737	741	PF00082	0.370
CLV_PCSK_SKI1_1	779	783	PF00082	0.426
CLV_PCSK_SKI1_1	798	802	PF00082	0.354
DEG_APCC_DBOX_1	335	343	PF00400	0.588
DEG_APCC_DBOX_1	645	653	PF00400	0.488
DEG_Nend_UBRbox_2	1	3	PF02207	0.547
DEG_SCF_TRCP1_1	41	47	PF00400	0.507
DOC_CKS1_1	228	233	PF01111	0.628
DOC_CKS1_1	390	395	PF01111	0.669
DOC_CYCLIN_RxL_1	5	18	PF00134	0.507
DOC_CYCLIN_yClb1_LxF_4	9	14	PF00134	0.507
DOC_MAPK_DCC_7	569	579	PF00069	0.355
DOC_MAPK_gen_1	291	298	PF00069	0.719
DOC_MAPK_gen_1	688	697	PF00069	0.425
DOC_MAPK_gen_1	823	832	PF00069	0.543
DOC_MAPK_gen_1	842	850	PF00069	0.508
DOC_MAPK_MEF2A_6	571	579	PF00069	0.353
DOC_MAPK_MEF2A_6	688	697	PF00069	0.389
DOC_MIT_MIM_1	333	343	PF04212	0.445
DOC_PP1_RVXF_1	567	573	PF00149	0.375
DOC_PP1_RVXF_1	68	74	PF00149	0.640
DOC_PP1_RVXF_1	718	724	PF00149	0.349
DOC_PP2B_LxvP_1	830	833	PF13499	0.569
DOC_PP4_FxxP_1	572	575	PF00568	0.359
DOC_PP4_FxxP_1	682	685	PF00568	0.431
DOC_USP7_MATH_1	105	109	PF00917	0.480
DOC_USP7_MATH_1	119	123	PF00917	0.563
DOC_USP7_MATH_1	208	212	PF00917	0.522
DOC_USP7_MATH_1	267	271	PF00917	0.741
DOC_USP7_MATH_1	299	303	PF00917	0.578
DOC_USP7_MATH_1	502	506	PF00917	0.667
DOC_USP7_MATH_1	613	617	PF00917	0.437
DOC_USP7_MATH_1	686	690	PF00917	0.465
DOC_USP7_MATH_1	732	736	PF00917	0.389
DOC_USP7_MATH_1	837	841	PF00917	0.622
DOC_USP7_MATH_1	90	94	PF00917	0.775
DOC_WW_Pin1_4	152	157	PF00397	0.645
DOC_WW_Pin1_4	227	232	PF00397	0.686
DOC_WW_Pin1_4	276	281	PF00397	0.595
DOC_WW_Pin1_4	29	34	PF00397	0.472
DOC_WW_Pin1_4	324	329	PF00397	0.504
DOC_WW_Pin1_4	389	394	PF00397	0.685
DOC_WW_Pin1_4	471	476	PF00397	0.654
DOC_WW_Pin1_4	779	784	PF00397	0.431
DOC_WW_Pin1_4	86	91	PF00397	0.671
DOC_WW_Pin1_4	97	102	PF00397	0.676
LIG_14-3-3_CanoR_1	148	156	PF00244	0.573
LIG_14-3-3_CanoR_1	385	390	PF00244	0.673
LIG_14-3-3_CanoR_1	44	50	PF00244	0.627
LIG_14-3-3_CanoR_1	491	496	PF00244	0.644
LIG_14-3-3_CanoR_1	690	694	PF00244	0.391
LIG_14-3-3_CanoR_1	720	724	PF00244	0.361
LIG_14-3-3_CanoR_1	842	846	PF00244	0.586
LIG_Actin_WH2_2	804	822	PF00022	0.568
LIG_BIR_III_2	168	172	PF00653	0.524
LIG_BIR_III_4	592	596	PF00653	0.414
LIG_BRCT_BRCA1_1	351	355	PF00533	0.610
LIG_deltaCOP1_diTrp_1	758	764	PF00928	0.376
LIG_EH_1	549	553	PF12763	0.437
LIG_FHA_1	218	224	PF00498	0.585
LIG_FHA_1	330	336	PF00498	0.456
LIG_FHA_1	645	651	PF00498	0.447
LIG_FHA_1	664	670	PF00498	0.281
LIG_FHA_2	161	167	PF00498	0.563
LIG_FHA_2	217	223	PF00498	0.571
LIG_FHA_2	409	415	PF00498	0.613
LIG_FHA_2	780	786	PF00498	0.441
LIG_FHA_2	791	797	PF00498	0.432
LIG_FHA_2	808	814	PF00498	0.418
LIG_Integrin_isoDGR_2	672	674	PF01839	0.558
LIG_Integrin_RGD_1	315	317	PF01839	0.725
LIG_IRF3_LxIS_1	172	179	PF10401	0.514
LIG_LIR_Apic_2	680	685	PF02991	0.410
LIG_LIR_Gen_1	793	801	PF02991	0.439
LIG_LIR_Nem_3	722	726	PF02991	0.352
LIG_LIR_Nem_3	758	764	PF02991	0.382
LIG_LIR_Nem_3	793	797	PF02991	0.484
LIG_PTB_Apo_2	675	682	PF02174	0.420
LIG_PTB_Apo_2	788	795	PF02174	0.454
LIG_PTB_Phospho_1	788	794	PF10480	0.455
LIG_RPA_C_Fungi	525	537	PF08784	0.417
LIG_SH2_CRK	580	584	PF00017	0.274
LIG_SH2_SRC	794	797	PF00017	0.496
LIG_SH2_STAP1	691	695	PF00017	0.462
LIG_SH2_STAP1	745	749	PF00017	0.439
LIG_SH2_STAT5	190	193	PF00017	0.687
LIG_SH2_STAT5	648	651	PF00017	0.267
LIG_SH2_STAT5	763	766	PF00017	0.516
LIG_SH2_STAT5	792	795	PF00017	0.575
LIG_SH3_1	153	159	PF00018	0.539
LIG_SH3_2	475	480	PF14604	0.509
LIG_SH3_2	6	11	PF14604	0.522
LIG_SH3_3	153	159	PF00018	0.662
LIG_SH3_3	3	9	PF00018	0.546
LIG_SH3_3	472	478	PF00018	0.646
LIG_SH3_3	736	742	PF00018	0.365
LIG_SH3_3	749	755	PF00018	0.355
LIG_SUMO_SIM_anti_2	26	32	PF11976	0.488
LIG_SUMO_SIM_par_1	623	628	PF11976	0.274
LIG_TRAF2_1	124	127	PF00917	0.579
LIG_TRAF2_1	207	210	PF00917	0.558
LIG_TRAF2_1	417	420	PF00917	0.678
LIG_TRAF2_1	793	796	PF00917	0.449
LIG_TRAF2_1	860	863	PF00917	0.620
LIG_TRAF2_2	328	333	PF00917	0.483
LIG_UBA3_1	339	346	PF00899	0.443
LIG_WRC_WIRS_1	244	249	PF05994	0.629
LIG_WW_1	742	745	PF00397	0.382
LIG_WW_3	145	149	PF00397	0.538
LIG_WW_3	573	577	PF00397	0.364
MOD_CDK_SPK_2	779	784	PF00069	0.431
MOD_CDK_SPK_2	97	102	PF00069	0.563
MOD_CDK_SPxK_1	227	233	PF00069	0.626
MOD_CDK_SPxxK_3	227	234	PF00069	0.628
MOD_CK1_1	108	114	PF00069	0.792
MOD_CK1_1	122	128	PF00069	0.681
MOD_CK1_1	154	160	PF00069	0.709
MOD_CK1_1	26	32	PF00069	0.488
MOD_CK1_1	48	54	PF00069	0.517
MOD_CK1_1	689	695	PF00069	0.388
MOD_CK2_1	12	18	PF00069	0.495
MOD_CK2_1	121	127	PF00069	0.571
MOD_CK2_1	176	182	PF00069	0.561
MOD_CK2_1	216	222	PF00069	0.698
MOD_CK2_1	525	531	PF00069	0.283
MOD_CK2_1	732	738	PF00069	0.383
MOD_CK2_1	779	785	PF00069	0.418
MOD_CK2_1	790	796	PF00069	0.412
MOD_CK2_1	807	813	PF00069	0.421
MOD_Cter_Amidation	231	234	PF01082	0.502
MOD_Cter_Amidation	489	492	PF01082	0.569
MOD_GlcNHglycan	177	181	PF01048	0.554
MOD_GlcNHglycan	2	5	PF01048	0.582
MOD_GlcNHglycan	203	206	PF01048	0.657
MOD_GlcNHglycan	241	244	PF01048	0.678
MOD_GlcNHglycan	264	267	PF01048	0.662
MOD_GlcNHglycan	269	272	PF01048	0.650
MOD_GlcNHglycan	404	407	PF01048	0.600
MOD_GlcNHglycan	41	44	PF01048	0.543
MOD_GlcNHglycan	463	466	PF01048	0.615
MOD_GlcNHglycan	50	53	PF01048	0.485
MOD_GlcNHglycan	504	507	PF01048	0.660
MOD_GlcNHglycan	537	540	PF01048	0.292
MOD_GSK3_1	105	112	PF00069	0.768
MOD_GSK3_1	121	128	PF00069	0.710
MOD_GSK3_1	148	155	PF00069	0.646
MOD_GSK3_1	172	179	PF00069	0.569
MOD_GSK3_1	239	246	PF00069	0.680
MOD_GSK3_1	385	392	PF00069	0.714
MOD_GSK3_1	44	51	PF00069	0.596
MOD_GSK3_1	491	498	PF00069	0.701
MOD_GSK3_1	803	810	PF00069	0.496
MOD_GSK3_1	837	844	PF00069	0.683
MOD_GSK3_1	86	93	PF00069	0.786
MOD_N-GLC_1	103	108	PF02516	0.553
MOD_N-GLC_1	544	549	PF02516	0.302
MOD_N-GLC_1	790	795	PF02516	0.461
MOD_NEK2_1	176	181	PF00069	0.650
MOD_NEK2_1	283	288	PF00069	0.574
MOD_NEK2_1	45	50	PF00069	0.576
MOD_NEK2_1	517	522	PF00069	0.414
MOD_NEK2_1	726	731	PF00069	0.375
MOD_NEK2_2	243	248	PF00069	0.649
MOD_NEK2_2	732	737	PF00069	0.381
MOD_NEK2_2	75	80	PF00069	0.644
MOD_NEK2_2	837	842	PF00069	0.626
MOD_PIKK_1	105	111	PF00454	0.612
MOD_PIKK_1	122	128	PF00454	0.559
MOD_PIKK_1	743	749	PF00454	0.447
MOD_PK_1	491	497	PF00069	0.593
MOD_PKA_1	120	126	PF00069	0.551
MOD_PKA_1	148	154	PF00069	0.764
MOD_PKA_1	239	245	PF00069	0.623
MOD_PKA_1	438	444	PF00069	0.510
MOD_PKA_1	491	497	PF00069	0.718
MOD_PKA_2	119	125	PF00069	0.766
MOD_PKA_2	148	154	PF00069	0.775
MOD_PKA_2	239	245	PF00069	0.754
MOD_PKA_2	438	444	PF00069	0.746
MOD_PKA_2	45	51	PF00069	0.601
MOD_PKA_2	491	497	PF00069	0.606
MOD_PKA_2	689	695	PF00069	0.387
MOD_PKA_2	719	725	PF00069	0.366
MOD_PKA_2	767	773	PF00069	0.390
MOD_PKA_2	841	847	PF00069	0.705
MOD_PKB_1	237	245	PF00069	0.620
MOD_Plk_1	307	313	PF00069	0.681
MOD_Plk_1	466	472	PF00069	0.756
MOD_Plk_1	631	637	PF00069	0.289
MOD_Plk_1	64	70	PF00069	0.487
MOD_Plk_1	737	743	PF00069	0.373
MOD_Plk_1	790	796	PF00069	0.485
MOD_Plk_1	846	852	PF00069	0.744
MOD_Plk_1	871	877	PF00069	0.555
MOD_Plk_2-3	249	255	PF00069	0.564
MOD_Plk_2-3	790	796	PF00069	0.427
MOD_Plk_2-3	807	813	PF00069	0.421
MOD_Plk_4	243	249	PF00069	0.569
MOD_Plk_4	26	32	PF00069	0.488
MOD_Plk_4	351	357	PF00069	0.581
MOD_Plk_4	424	430	PF00069	0.562
MOD_Plk_4	45	51	PF00069	0.465
MOD_Plk_4	491	497	PF00069	0.714
MOD_Plk_4	639	645	PF00069	0.294
MOD_ProDKin_1	152	158	PF00069	0.644
MOD_ProDKin_1	227	233	PF00069	0.686
MOD_ProDKin_1	276	282	PF00069	0.597
MOD_ProDKin_1	29	35	PF00069	0.474
MOD_ProDKin_1	324	330	PF00069	0.500
MOD_ProDKin_1	389	395	PF00069	0.683
MOD_ProDKin_1	471	477	PF00069	0.647
MOD_ProDKin_1	779	785	PF00069	0.425
MOD_ProDKin_1	86	92	PF00069	0.663
MOD_ProDKin_1	97	103	PF00069	0.675
MOD_SUMO_for_1	417	420	PF00179	0.601
MOD_SUMO_rev_2	419	427	PF00179	0.584
MOD_SUMO_rev_2	790	800	PF00179	0.432
TRG_DiLeu_BaEn_1	424	429	PF01217	0.621
TRG_DiLeu_BaEn_2	509	515	PF01217	0.469
TRG_DiLeu_BaEn_2	631	637	PF01217	0.334
TRG_ENDOCYTIC_2	321	324	PF00928	0.639
TRG_ENDOCYTIC_2	794	797	PF00928	0.580
TRG_ER_diArg_1	119	121	PF00400	0.540
TRG_ER_diArg_1	137	139	PF00400	0.806
TRG_ER_diArg_1	140	142	PF00400	0.602
TRG_ER_diArg_1	144	146	PF00400	0.700
TRG_ER_diArg_1	147	149	PF00400	0.717
TRG_ER_diArg_1	212	215	PF00400	0.600
TRG_ER_diArg_1	342	345	PF00400	0.517
TRG_ER_diArg_1	360	363	PF00400	0.517
TRG_ER_diArg_1	479	481	PF00400	0.687
TRG_ER_diArg_1	569	572	PF00400	0.365
TRG_ER_diArg_1	650	653	PF00400	0.289
TRG_ER_diArg_1	764	766	PF00400	0.389
TRG_ER_diArg_1	771	774	PF00400	0.406
TRG_ER_diArg_1	819	821	PF00400	0.578
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	444	448	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	604	609	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	773	777	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	784	788	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	823	827	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5W9	Leptomonas seymouri	63%	100%
A0A0S4IST3	Bodo saltans	40%	100%
A0A1X0P7U6	Trypanosomatidae	53%	100%
A0A3R7R867	Trypanosoma rangeli	54%	100%
A4HP30	Leishmania braziliensis	84%	100%
A4IDD7	Leishmania infantum	99%	100%
D0A313	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AST8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q1Q8	Leishmania major	93%	100%
V5BPI0	Trypanosoma cruzi	53%	100%