LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative tripartite motif protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative tripartite motif protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7XAN9_LEIDO
TriTrypDb:
LdBPK_361610.1 * , LdCL_360021600 , LDHU3_36.2080
Length:
848

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7XAN9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAN9

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0016567 protein ubiquitination 7 1
GO:0019538 protein metabolic process 3 1
GO:0032446 protein modification by small protein conjugation 6 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0070647 protein modification by small protein conjugation or removal 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 6
GO:0008270 zinc ion binding 6 6
GO:0043167 ion binding 2 6
GO:0043169 cation binding 3 6
GO:0046872 metal ion binding 4 6
GO:0046914 transition metal ion binding 5 6
GO:0003824 catalytic activity 1 1
GO:0004842 ubiquitin-protein transferase activity 4 1
GO:0016740 transferase activity 2 1
GO:0019787 ubiquitin-like protein transferase activity 3 1
GO:0061630 ubiquitin protein ligase activity 5 1
GO:0061659 ubiquitin-like protein ligase activity 4 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 679 683 PF00656 0.665
CLV_C14_Caspase3-7 783 787 PF00656 0.744
CLV_C14_Caspase3-7 821 825 PF00656 0.666
CLV_NRD_NRD_1 273 275 PF00675 0.682
CLV_NRD_NRD_1 397 399 PF00675 0.495
CLV_NRD_NRD_1 421 423 PF00675 0.608
CLV_NRD_NRD_1 812 814 PF00675 0.819
CLV_NRD_NRD_1 839 841 PF00675 0.849
CLV_PCSK_FUR_1 419 423 PF00082 0.611
CLV_PCSK_KEX2_1 272 274 PF00082 0.684
CLV_PCSK_KEX2_1 3 5 PF00082 0.810
CLV_PCSK_KEX2_1 397 399 PF00082 0.500
CLV_PCSK_KEX2_1 421 423 PF00082 0.683
CLV_PCSK_KEX2_1 498 500 PF00082 0.727
CLV_PCSK_KEX2_1 839 841 PF00082 0.818
CLV_PCSK_PC1ET2_1 3 5 PF00082 0.810
CLV_PCSK_PC1ET2_1 498 500 PF00082 0.649
CLV_PCSK_SKI1_1 374 378 PF00082 0.654
CLV_PCSK_SKI1_1 40 44 PF00082 0.737
CLV_PCSK_SKI1_1 498 502 PF00082 0.721
CLV_PCSK_SKI1_1 596 600 PF00082 0.632
CLV_PCSK_SKI1_1 703 707 PF00082 0.592
CLV_PCSK_SKI1_1 743 747 PF00082 0.580
CLV_PCSK_SKI1_1 774 778 PF00082 0.824
DOC_CKS1_1 597 602 PF01111 0.768
DOC_CYCLIN_RxL_1 771 782 PF00134 0.820
DOC_CYCLIN_RxL_1 803 816 PF00134 0.603
DOC_CYCLIN_yCln2_LP_2 80 86 PF00134 0.771
DOC_MAPK_gen_1 3 11 PF00069 0.724
DOC_MAPK_gen_1 734 742 PF00069 0.806
DOC_MAPK_gen_1 839 846 PF00069 0.844
DOC_MAPK_MEF2A_6 839 848 PF00069 0.843
DOC_MAPK_RevD_3 383 398 PF00069 0.580
DOC_PP2B_LxvP_1 62 65 PF13499 0.748
DOC_PP2B_LxvP_1 827 830 PF13499 0.725
DOC_PP4_FxxP_1 70 73 PF00568 0.761
DOC_USP7_MATH_1 188 192 PF00917 0.585
DOC_USP7_MATH_1 219 223 PF00917 0.764
DOC_USP7_MATH_1 22 26 PF00917 0.706
DOC_USP7_MATH_1 225 229 PF00917 0.523
DOC_USP7_MATH_1 598 602 PF00917 0.798
DOC_USP7_MATH_1 608 612 PF00917 0.657
DOC_USP7_MATH_1 73 77 PF00917 0.754
DOC_USP7_MATH_1 791 795 PF00917 0.704
DOC_USP7_MATH_1 822 826 PF00917 0.763
DOC_WW_Pin1_4 145 150 PF00397 0.782
DOC_WW_Pin1_4 221 226 PF00397 0.705
DOC_WW_Pin1_4 425 430 PF00397 0.615
DOC_WW_Pin1_4 485 490 PF00397 0.750
DOC_WW_Pin1_4 596 601 PF00397 0.770
DOC_WW_Pin1_4 606 611 PF00397 0.636
DOC_WW_Pin1_4 723 728 PF00397 0.607
DOC_WW_Pin1_4 92 97 PF00397 0.765
LIG_14-3-3_CanoR_1 252 260 PF00244 0.572
LIG_14-3-3_CanoR_1 278 285 PF00244 0.491
LIG_14-3-3_CanoR_1 387 395 PF00244 0.444
LIG_14-3-3_CanoR_1 397 406 PF00244 0.568
LIG_14-3-3_CanoR_1 4 11 PF00244 0.586
LIG_14-3-3_CanoR_1 40 47 PF00244 0.736
LIG_14-3-3_CanoR_1 448 454 PF00244 0.501
LIG_14-3-3_CanoR_1 477 482 PF00244 0.655
LIG_14-3-3_CanoR_1 629 636 PF00244 0.821
LIG_14-3-3_CanoR_1 797 807 PF00244 0.698
LIG_14-3-3_CanoR_1 839 846 PF00244 0.844
LIG_Actin_WH2_2 359 376 PF00022 0.641
LIG_Actin_WH2_2 388 405 PF00022 0.655
LIG_APCC_ABBA_1 287 292 PF00400 0.530
LIG_BIR_II_1 1 5 PF00653 0.650
LIG_BIR_III_4 342 346 PF00653 0.526
LIG_BRCT_BRCA1_1 66 70 PF00533 0.778
LIG_deltaCOP1_diTrp_1 118 127 PF00928 0.657
LIG_DLG_GKlike_1 477 484 PF00625 0.760
LIG_EH1_1 406 414 PF00400 0.567
LIG_EVH1_2 642 646 PF00568 0.626
LIG_FHA_1 449 455 PF00498 0.625
LIG_FHA_1 585 591 PF00498 0.804
LIG_FHA_1 597 603 PF00498 0.679
LIG_FHA_1 659 665 PF00498 0.792
LIG_FHA_1 687 693 PF00498 0.830
LIG_FHA_1 799 805 PF00498 0.814
LIG_FHA_1 839 845 PF00498 0.846
LIG_FHA_2 101 107 PF00498 0.630
LIG_FHA_2 166 172 PF00498 0.503
LIG_FHA_2 28 34 PF00498 0.623
LIG_FHA_2 3 9 PF00498 0.623
LIG_FHA_2 436 442 PF00498 0.596
LIG_FHA_2 486 492 PF00498 0.705
LIG_FHA_2 50 56 PF00498 0.693
LIG_LIR_Apic_2 67 73 PF02991 0.767
LIG_LIR_Gen_1 224 233 PF02991 0.552
LIG_LIR_Gen_1 480 489 PF02991 0.664
LIG_LIR_Gen_1 572 581 PF02991 0.600
LIG_LIR_Nem_3 145 150 PF02991 0.698
LIG_LIR_Nem_3 224 229 PF02991 0.553
LIG_LIR_Nem_3 349 355 PF02991 0.551
LIG_LIR_Nem_3 480 484 PF02991 0.667
LIG_LIR_Nem_3 572 578 PF02991 0.600
LIG_LIR_Nem_3 67 71 PF02991 0.774
LIG_LIR_Nem_3 697 702 PF02991 0.804
LIG_MYND_1 69 73 PF01753 0.723
LIG_MYND_2 747 751 PF01753 0.591
LIG_PDZ_Class_2 843 848 PF00595 0.840
LIG_Pex14_2 348 352 PF04695 0.420
LIG_PTAP_UEV_1 215 220 PF05743 0.786
LIG_SH2_CRK 497 501 PF00017 0.719
LIG_SH2_STAP1 355 359 PF00017 0.628
LIG_SH2_STAP1 662 666 PF00017 0.828
LIG_SH2_STAT5 197 200 PF00017 0.695
LIG_SH2_STAT5 806 809 PF00017 0.821
LIG_SH3_3 210 216 PF00018 0.798
LIG_SH3_3 510 516 PF00018 0.811
LIG_SH3_3 594 600 PF00018 0.844
LIG_SH3_3 637 643 PF00018 0.752
LIG_SH3_3 741 747 PF00018 0.792
LIG_SUMO_SIM_par_1 82 88 PF11976 0.782
LIG_TRAF2_1 438 441 PF00917 0.489
LIG_WRC_WIRS_1 478 483 PF05994 0.761
LIG_WW_3 746 750 PF00397 0.704
MOD_CDC14_SPxK_1 609 612 PF00782 0.538
MOD_CDK_SPxK_1 606 612 PF00069 0.548
MOD_CK1_1 148 154 PF00069 0.677
MOD_CK1_1 204 210 PF00069 0.669
MOD_CK1_1 25 31 PF00069 0.703
MOD_CK1_1 386 392 PF00069 0.446
MOD_CK1_1 428 434 PF00069 0.677
MOD_CK1_1 447 453 PF00069 0.667
MOD_CK1_1 522 528 PF00069 0.848
MOD_CK1_1 632 638 PF00069 0.832
MOD_CK1_1 651 657 PF00069 0.542
MOD_CK1_1 790 796 PF00069 0.833
MOD_CK1_1 825 831 PF00069 0.707
MOD_CK1_1 95 101 PF00069 0.727
MOD_CK2_1 100 106 PF00069 0.628
MOD_CK2_1 2 8 PF00069 0.652
MOD_CK2_1 225 231 PF00069 0.622
MOD_CK2_1 412 418 PF00069 0.585
MOD_CK2_1 435 441 PF00069 0.593
MOD_CK2_1 49 55 PF00069 0.693
MOD_CK2_1 73 79 PF00069 0.752
MOD_CK2_1 760 766 PF00069 0.764
MOD_Cter_Amidation 395 398 PF01082 0.554
MOD_DYRK1A_RPxSP_1 596 600 PF00069 0.632
MOD_GlcNHglycan 121 124 PF01048 0.665
MOD_GlcNHglycan 150 153 PF01048 0.633
MOD_GlcNHglycan 177 180 PF01048 0.753
MOD_GlcNHglycan 216 219 PF01048 0.789
MOD_GlcNHglycan 221 224 PF01048 0.604
MOD_GlcNHglycan 390 394 PF01048 0.581
MOD_GlcNHglycan 403 406 PF01048 0.329
MOD_GlcNHglycan 508 512 PF01048 0.762
MOD_GlcNHglycan 521 524 PF01048 0.652
MOD_GlcNHglycan 631 634 PF01048 0.808
MOD_GlcNHglycan 678 681 PF01048 0.783
MOD_GlcNHglycan 686 689 PF01048 0.756
MOD_GlcNHglycan 75 78 PF01048 0.685
MOD_GlcNHglycan 789 792 PF01048 0.706
MOD_GlcNHglycan 827 830 PF01048 0.694
MOD_GSK3_1 125 132 PF00069 0.708
MOD_GSK3_1 135 142 PF00069 0.726
MOD_GSK3_1 166 173 PF00069 0.621
MOD_GSK3_1 197 204 PF00069 0.736
MOD_GSK3_1 221 228 PF00069 0.560
MOD_GSK3_1 325 332 PF00069 0.595
MOD_GSK3_1 397 404 PF00069 0.512
MOD_GSK3_1 444 451 PF00069 0.625
MOD_GSK3_1 462 469 PF00069 0.446
MOD_GSK3_1 553 560 PF00069 0.705
MOD_GSK3_1 60 67 PF00069 0.672
MOD_GSK3_1 608 615 PF00069 0.692
MOD_GSK3_1 631 638 PF00069 0.758
MOD_GSK3_1 644 651 PF00069 0.660
MOD_GSK3_1 682 689 PF00069 0.756
MOD_GSK3_1 787 794 PF00069 0.839
MOD_GSK3_1 834 841 PF00069 0.804
MOD_GSK3_1 90 97 PF00069 0.815
MOD_N-GLC_1 166 171 PF02516 0.596
MOD_N-GLC_1 629 634 PF02516 0.628
MOD_N-GLC_1 780 785 PF02516 0.772
MOD_N-GLC_2 474 476 PF02516 0.736
MOD_NEK2_1 135 140 PF00069 0.791
MOD_NEK2_1 150 155 PF00069 0.458
MOD_NEK2_1 165 170 PF00069 0.470
MOD_NEK2_1 175 180 PF00069 0.615
MOD_NEK2_1 246 251 PF00069 0.449
MOD_NEK2_1 290 295 PF00069 0.374
MOD_NEK2_1 412 417 PF00069 0.660
MOD_NEK2_1 631 636 PF00069 0.745
MOD_NEK2_1 823 828 PF00069 0.759
MOD_NEK2_2 369 374 PF00069 0.643
MOD_OFUCOSY 163 170 PF10250 0.600
MOD_OFUCOSY 291 297 PF10250 0.530
MOD_PIKK_1 197 203 PF00454 0.779
MOD_PIKK_1 277 283 PF00454 0.491
MOD_PIKK_1 325 331 PF00454 0.594
MOD_PIKK_1 34 40 PF00454 0.785
MOD_PIKK_1 635 641 PF00454 0.812
MOD_PIKK_1 649 655 PF00454 0.622
MOD_PIKK_1 834 840 PF00454 0.852
MOD_PKA_1 397 403 PF00069 0.654
MOD_PKA_1 813 819 PF00069 0.818
MOD_PKA_1 839 845 PF00069 0.846
MOD_PKA_2 195 201 PF00069 0.756
MOD_PKA_2 251 257 PF00069 0.554
MOD_PKA_2 277 283 PF00069 0.491
MOD_PKA_2 386 392 PF00069 0.448
MOD_PKA_2 396 402 PF00069 0.587
MOD_PKA_2 447 453 PF00069 0.589
MOD_PKA_2 590 596 PF00069 0.852
MOD_PKA_2 736 742 PF00069 0.799
MOD_PKA_2 838 844 PF00069 0.846
MOD_PKB_1 621 629 PF00069 0.771
MOD_Plk_1 170 176 PF00069 0.655
MOD_Plk_1 188 194 PF00069 0.574
MOD_Plk_1 389 395 PF00069 0.576
MOD_Plk_1 455 461 PF00069 0.570
MOD_Plk_1 48 54 PF00069 0.613
MOD_Plk_1 584 590 PF00069 0.754
MOD_Plk_1 612 618 PF00069 0.773
MOD_Plk_1 760 766 PF00069 0.764
MOD_Plk_1 780 786 PF00069 0.562
MOD_Plk_1 823 829 PF00069 0.728
MOD_Plk_2-3 49 55 PF00069 0.596
MOD_Plk_2-3 760 766 PF00069 0.764
MOD_Plk_4 142 148 PF00069 0.593
MOD_Plk_4 156 162 PF00069 0.589
MOD_Plk_4 170 176 PF00069 0.521
MOD_Plk_4 188 194 PF00069 0.574
MOD_Plk_4 347 353 PF00069 0.555
MOD_Plk_4 428 434 PF00069 0.463
MOD_Plk_4 477 483 PF00069 0.652
MOD_Plk_4 584 590 PF00069 0.793
MOD_ProDKin_1 145 151 PF00069 0.775
MOD_ProDKin_1 221 227 PF00069 0.684
MOD_ProDKin_1 425 431 PF00069 0.609
MOD_ProDKin_1 485 491 PF00069 0.749
MOD_ProDKin_1 596 602 PF00069 0.770
MOD_ProDKin_1 606 612 PF00069 0.635
MOD_ProDKin_1 723 729 PF00069 0.609
MOD_ProDKin_1 92 98 PF00069 0.764
MOD_SUMO_rev_2 228 236 PF00179 0.544
MOD_SUMO_rev_2 350 359 PF00179 0.552
MOD_SUMO_rev_2 697 705 PF00179 0.588
TRG_DiLeu_BaEn_1 585 590 PF01217 0.757
TRG_DiLeu_BaLyEn_6 655 660 PF01217 0.743
TRG_DiLeu_BaLyEn_6 746 751 PF01217 0.589
TRG_ENDOCYTIC_2 497 500 PF00928 0.721
TRG_ER_diArg_1 193 196 PF00400 0.583
TRG_ER_diArg_1 272 274 PF00400 0.684
TRG_ER_diArg_1 419 422 PF00400 0.616
TRG_ER_diArg_1 618 621 PF00400 0.780
TRG_Pf-PMV_PEXEL_1 452 456 PF00026 0.665
TRG_Pf-PMV_PEXEL_1 499 503 PF00026 0.719

Homologs

Protein Taxonomy Sequence identity Coverage
A4HP15 Leishmania braziliensis 65% 100%
A4IDC4 Leishmania infantum 99% 100%
E9ASS5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q1S1 Leishmania major 88% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS