LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7XAN3_LEIDO
TriTrypDb:
LdBPK_361780.1 , LdCL_360023300 , LDHU3_36.2340
Length:
546

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAN3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAN3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 150 154 PF00656 0.637
CLV_C14_Caspase3-7 412 416 PF00656 0.629
CLV_NRD_NRD_1 164 166 PF00675 0.625
CLV_NRD_NRD_1 17 19 PF00675 0.700
CLV_NRD_NRD_1 299 301 PF00675 0.621
CLV_NRD_NRD_1 421 423 PF00675 0.660
CLV_NRD_NRD_1 436 438 PF00675 0.563
CLV_NRD_NRD_1 474 476 PF00675 0.532
CLV_NRD_NRD_1 501 503 PF00675 0.655
CLV_PCSK_KEX2_1 164 166 PF00082 0.625
CLV_PCSK_KEX2_1 17 19 PF00082 0.679
CLV_PCSK_KEX2_1 299 301 PF00082 0.621
CLV_PCSK_KEX2_1 436 438 PF00082 0.670
CLV_PCSK_KEX2_1 474 476 PF00082 0.532
CLV_PCSK_KEX2_1 501 503 PF00082 0.655
CLV_PCSK_SKI1_1 272 276 PF00082 0.602
CLV_PCSK_SKI1_1 475 479 PF00082 0.554
CLV_PCSK_SKI1_1 55 59 PF00082 0.565
CLV_PCSK_SKI1_1 89 93 PF00082 0.574
CLV_Separin_Metazoa 166 170 PF03568 0.555
DEG_APCC_DBOX_1 298 306 PF00400 0.544
DEG_APCC_DBOX_1 474 482 PF00400 0.560
DEG_Nend_Nbox_1 1 3 PF02207 0.631
DEG_SCF_FBW7_1 243 250 PF00400 0.649
DEG_SCF_FBW7_1 327 334 PF00400 0.634
DEG_SPOP_SBC_1 255 259 PF00917 0.812
DOC_CKS1_1 130 135 PF01111 0.693
DOC_CKS1_1 244 249 PF01111 0.637
DOC_CKS1_1 319 324 PF01111 0.649
DOC_CKS1_1 68 73 PF01111 0.530
DOC_CYCLIN_yClb1_LxF_4 427 433 PF00134 0.613
DOC_CYCLIN_yCln2_LP_2 198 204 PF00134 0.585
DOC_CYCLIN_yCln2_LP_2 58 64 PF00134 0.586
DOC_CYCLIN_yCln2_LP_2 74 80 PF00134 0.658
DOC_MAPK_gen_1 472 480 PF00069 0.534
DOC_MAPK_MEF2A_6 303 312 PF00069 0.607
DOC_MAPK_MEF2A_6 472 480 PF00069 0.534
DOC_PP2B_LxvP_1 197 200 PF13499 0.595
DOC_PP2B_LxvP_1 58 61 PF13499 0.590
DOC_PP2B_LxvP_1 74 77 PF13499 0.682
DOC_PP4_FxxP_1 130 133 PF00568 0.651
DOC_PP4_FxxP_1 9 12 PF00568 0.575
DOC_USP7_MATH_1 110 114 PF00917 0.594
DOC_USP7_MATH_1 172 176 PF00917 0.598
DOC_USP7_MATH_1 180 184 PF00917 0.579
DOC_USP7_MATH_1 234 238 PF00917 0.669
DOC_USP7_MATH_1 255 259 PF00917 0.658
DOC_USP7_MATH_1 282 286 PF00917 0.658
DOC_USP7_MATH_1 331 335 PF00917 0.744
DOC_USP7_MATH_1 364 368 PF00917 0.634
DOC_USP7_MATH_1 441 445 PF00917 0.668
DOC_USP7_MATH_1 484 488 PF00917 0.577
DOC_USP7_MATH_1 87 91 PF00917 0.620
DOC_WW_Pin1_4 129 134 PF00397 0.600
DOC_WW_Pin1_4 243 248 PF00397 0.654
DOC_WW_Pin1_4 274 279 PF00397 0.611
DOC_WW_Pin1_4 318 323 PF00397 0.655
DOC_WW_Pin1_4 327 332 PF00397 0.617
DOC_WW_Pin1_4 345 350 PF00397 0.586
DOC_WW_Pin1_4 366 371 PF00397 0.605
DOC_WW_Pin1_4 413 418 PF00397 0.584
DOC_WW_Pin1_4 67 72 PF00397 0.554
LIG_14-3-3_CanoR_1 226 230 PF00244 0.541
LIG_BRCT_BRCA1_1 402 406 PF00533 0.559
LIG_BRCT_BRCA1_1 449 453 PF00533 0.632
LIG_CtBP_PxDLS_1 356 360 PF00389 0.691
LIG_deltaCOP1_diTrp_1 40 45 PF00928 0.550
LIG_deltaCOP1_diTrp_1 537 544 PF00928 0.594
LIG_FHA_1 257 263 PF00498 0.674
LIG_FHA_1 319 325 PF00498 0.738
LIG_FHA_1 328 334 PF00498 0.643
LIG_FHA_1 346 352 PF00498 0.579
LIG_FHA_1 6 12 PF00498 0.594
LIG_FHA_1 68 74 PF00498 0.533
LIG_LIR_Apic_2 128 133 PF02991 0.653
LIG_LIR_Apic_2 6 12 PF02991 0.573
LIG_LIR_Gen_1 175 186 PF02991 0.584
LIG_LIR_Gen_1 28 36 PF02991 0.785
LIG_LIR_Gen_1 425 433 PF02991 0.639
LIG_LIR_Gen_1 448 457 PF02991 0.630
LIG_LIR_Gen_1 519 528 PF02991 0.594
LIG_LIR_Gen_1 538 545 PF02991 0.614
LIG_LIR_Gen_1 90 96 PF02991 0.639
LIG_LIR_Nem_3 175 181 PF02991 0.584
LIG_LIR_Nem_3 264 269 PF02991 0.613
LIG_LIR_Nem_3 28 33 PF02991 0.742
LIG_LIR_Nem_3 425 430 PF02991 0.607
LIG_LIR_Nem_3 448 452 PF02991 0.629
LIG_LIR_Nem_3 519 524 PF02991 0.586
LIG_LIR_Nem_3 538 544 PF02991 0.593
LIG_MLH1_MIPbox_1 449 453 PF16413 0.632
LIG_MYND_1 322 326 PF01753 0.623
LIG_MYND_1 56 60 PF01753 0.575
LIG_Pex14_1 41 45 PF04695 0.555
LIG_Pex14_2 221 225 PF04695 0.569
LIG_Pex14_2 91 95 PF04695 0.572
LIG_RPA_C_Fungi 431 443 PF08784 0.623
LIG_SH2_STAP1 449 453 PF00017 0.567
LIG_SH2_STAT5 521 524 PF00017 0.620
LIG_SH3_1 164 170 PF00018 0.605
LIG_SH3_1 236 242 PF00018 0.611
LIG_SH3_3 164 170 PF00018 0.614
LIG_SH3_3 181 187 PF00018 0.585
LIG_SH3_3 236 242 PF00018 0.594
LIG_SH3_3 245 251 PF00018 0.636
LIG_SH3_3 265 271 PF00018 0.603
LIG_SH3_3 305 311 PF00018 0.594
LIG_SH3_3 316 322 PF00018 0.590
LIG_SH3_3 33 39 PF00018 0.572
LIG_SH3_3 348 354 PF00018 0.639
LIG_SH3_3 489 495 PF00018 0.689
LIG_SH3_3 57 63 PF00018 0.591
LIG_SH3_3 65 71 PF00018 0.601
LIG_SUMO_SIM_par_1 62 67 PF11976 0.623
LIG_TRAF2_1 326 329 PF00917 0.583
LIG_UBA3_1 478 485 PF00899 0.574
LIG_WRC_WIRS_1 42 47 PF05994 0.559
LIG_WRC_WIRS_1 449 454 PF05994 0.572
LIG_WW_3 166 170 PF00397 0.580
LIG_WW_3 246 250 PF00397 0.653
MOD_CDC14_SPxK_1 277 280 PF00782 0.605
MOD_CDK_SPK_2 67 72 PF00069 0.532
MOD_CDK_SPxK_1 243 249 PF00069 0.650
MOD_CDK_SPxK_1 274 280 PF00069 0.600
MOD_CDK_SPxxK_3 129 136 PF00069 0.588
MOD_CDK_SPxxK_3 318 325 PF00069 0.625
MOD_CK1_1 114 120 PF00069 0.673
MOD_CK1_1 209 215 PF00069 0.753
MOD_CK1_1 217 223 PF00069 0.565
MOD_CK1_1 258 264 PF00069 0.647
MOD_CK1_1 28 34 PF00069 0.726
MOD_CK1_1 334 340 PF00069 0.667
MOD_CK1_1 380 386 PF00069 0.612
MOD_CK1_1 411 417 PF00069 0.624
MOD_CK1_1 43 49 PF00069 0.515
MOD_CK1_1 519 525 PF00069 0.677
MOD_CK1_1 527 533 PF00069 0.731
MOD_CK1_1 90 96 PF00069 0.616
MOD_CK1_1 99 105 PF00069 0.585
MOD_CK2_1 282 288 PF00069 0.623
MOD_CK2_1 359 365 PF00069 0.695
MOD_CK2_1 453 459 PF00069 0.581
MOD_DYRK1A_RPxSP_1 366 370 PF00069 0.569
MOD_GlcNHglycan 113 116 PF01048 0.686
MOD_GlcNHglycan 12 15 PF01048 0.602
MOD_GlcNHglycan 120 123 PF01048 0.772
MOD_GlcNHglycan 159 162 PF01048 0.660
MOD_GlcNHglycan 193 196 PF01048 0.595
MOD_GlcNHglycan 236 239 PF01048 0.570
MOD_GlcNHglycan 27 30 PF01048 0.583
MOD_GlcNHglycan 285 288 PF01048 0.580
MOD_GlcNHglycan 336 339 PF01048 0.675
MOD_GlcNHglycan 365 369 PF01048 0.654
MOD_GlcNHglycan 406 409 PF01048 0.716
MOD_GlcNHglycan 45 48 PF01048 0.520
MOD_GlcNHglycan 482 485 PF01048 0.563
MOD_GlcNHglycan 523 527 PF01048 0.595
MOD_GSK3_1 110 117 PF00069 0.632
MOD_GSK3_1 187 194 PF00069 0.611
MOD_GSK3_1 220 227 PF00069 0.557
MOD_GSK3_1 243 250 PF00069 0.693
MOD_GSK3_1 254 261 PF00069 0.583
MOD_GSK3_1 327 334 PF00069 0.657
MOD_GSK3_1 341 348 PF00069 0.581
MOD_GSK3_1 355 362 PF00069 0.664
MOD_GSK3_1 366 373 PF00069 0.791
MOD_GSK3_1 400 407 PF00069 0.564
MOD_GSK3_1 41 48 PF00069 0.570
MOD_GSK3_1 411 418 PF00069 0.626
MOD_GSK3_1 448 455 PF00069 0.603
MOD_GSK3_1 480 487 PF00069 0.560
MOD_GSK3_1 512 519 PF00069 0.619
MOD_GSK3_1 97 104 PF00069 0.606
MOD_N-GLC_1 345 350 PF02516 0.641
MOD_N-GLC_1 453 458 PF02516 0.580
MOD_NEK2_1 219 224 PF00069 0.602
MOD_NEK2_1 225 230 PF00069 0.566
MOD_NEK2_1 332 337 PF00069 0.647
MOD_NEK2_1 375 380 PF00069 0.615
MOD_NEK2_1 401 406 PF00069 0.559
MOD_NEK2_1 45 50 PF00069 0.519
MOD_NEK2_1 452 457 PF00069 0.591
MOD_NEK2_1 524 529 PF00069 0.617
MOD_PIKK_1 441 447 PF00454 0.642
MOD_PIKK_1 46 52 PF00454 0.521
MOD_PKA_2 209 215 PF00069 0.719
MOD_PKA_2 225 231 PF00069 0.516
MOD_PKA_2 380 386 PF00069 0.612
MOD_PKA_2 96 102 PF00069 0.586
MOD_Plk_1 155 161 PF00069 0.609
MOD_Plk_1 217 223 PF00069 0.579
MOD_Plk_1 447 453 PF00069 0.635
MOD_Plk_1 5 11 PF00069 0.558
MOD_Plk_2-3 463 469 PF00069 0.584
MOD_Plk_4 115 121 PF00069 0.552
MOD_Plk_4 401 407 PF00069 0.564
MOD_Plk_4 448 454 PF00069 0.635
MOD_Plk_4 87 93 PF00069 0.680
MOD_ProDKin_1 129 135 PF00069 0.598
MOD_ProDKin_1 243 249 PF00069 0.657
MOD_ProDKin_1 274 280 PF00069 0.612
MOD_ProDKin_1 318 324 PF00069 0.657
MOD_ProDKin_1 327 333 PF00069 0.619
MOD_ProDKin_1 345 351 PF00069 0.586
MOD_ProDKin_1 366 372 PF00069 0.602
MOD_ProDKin_1 413 419 PF00069 0.584
MOD_ProDKin_1 67 73 PF00069 0.555
MOD_SUMO_rev_2 205 215 PF00179 0.588
TRG_DiLeu_BaLyEn_6 193 198 PF01217 0.662
TRG_DiLeu_BaLyEn_6 319 324 PF01217 0.625
TRG_DiLeu_BaLyEn_6 69 74 PF01217 0.642
TRG_ENDOCYTIC_2 449 452 PF00928 0.565
TRG_ENDOCYTIC_2 521 524 PF00928 0.586
TRG_ER_diArg_1 16 18 PF00400 0.683
TRG_ER_diArg_1 163 165 PF00400 0.595
TRG_ER_diArg_1 473 475 PF00400 0.542
TRG_ER_FFAT_2 217 227 PF00635 0.507
TRG_NES_CRM1_1 468 482 PF08389 0.513
TRG_Pf-PMV_PEXEL_1 136 141 PF00026 0.649

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILH7 Leptomonas seymouri 51% 100%
A4HP34 Leishmania braziliensis 68% 100%
A4IDE1 Leishmania infantum 100% 100%
E9ASU2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q1Q4 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS