Zinc finger protein family member, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein family member, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAM4_LEIDO

TriTrypDb:

LdBPK_360900.1 , LdCL_360014000 , LDHU3_36.1190

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAM4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	444	448	PF00656	0.667
CLV_C14_Caspase3-7	523	527	PF00656	0.601
CLV_C14_Caspase3-7	753	757	PF00656	0.729
CLV_NRD_NRD_1	404	406	PF00675	0.550
CLV_NRD_NRD_1	490	492	PF00675	0.635
CLV_NRD_NRD_1	568	570	PF00675	0.569
CLV_PCSK_FUR_1	243	247	PF00082	0.494
CLV_PCSK_FUR_1	402	406	PF00082	0.569
CLV_PCSK_KEX2_1	245	247	PF00082	0.518
CLV_PCSK_KEX2_1	404	406	PF00082	0.580
CLV_PCSK_KEX2_1	422	424	PF00082	0.409
CLV_PCSK_KEX2_1	490	492	PF00082	0.635
CLV_PCSK_KEX2_1	568	570	PF00082	0.569
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.604
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.475
CLV_PCSK_SKI1_1	342	346	PF00082	0.417
CLV_PCSK_SKI1_1	722	726	PF00082	0.725
CLV_PCSK_SKI1_1	749	753	PF00082	0.706
CLV_Separin_Metazoa	408	412	PF03568	0.454
DEG_Nend_Nbox_1	1	3	PF02207	0.689
DEG_SPOP_SBC_1	671	675	PF00917	0.723
DEG_SPOP_SBC_1	705	709	PF00917	0.701
DEG_SPOP_SBC_1	755	759	PF00917	0.649
DOC_CKS1_1	124	129	PF01111	0.469
DOC_CKS1_1	551	556	PF01111	0.607
DOC_CKS1_1	716	721	PF01111	0.730
DOC_CYCLIN_RxL_1	339	348	PF00134	0.422
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.529
DOC_MAPK_gen_1	277	287	PF00069	0.396
DOC_MAPK_gen_1	350	357	PF00069	0.409
DOC_MAPK_gen_1	400	409	PF00069	0.544
DOC_MAPK_gen_1	565	573	PF00069	0.576
DOC_MAPK_MEF2A_6	220	227	PF00069	0.389
DOC_MAPK_MEF2A_6	350	359	PF00069	0.492
DOC_PP2B_LxvP_1	119	122	PF13499	0.545
DOC_PP4_FxxP_1	140	143	PF00568	0.467
DOC_USP7_MATH_1	226	230	PF00917	0.361
DOC_USP7_MATH_1	427	431	PF00917	0.578
DOC_USP7_MATH_1	484	488	PF00917	0.646
DOC_USP7_MATH_1	517	521	PF00917	0.608
DOC_USP7_MATH_1	525	529	PF00917	0.650
DOC_USP7_MATH_1	57	61	PF00917	0.628
DOC_USP7_MATH_1	697	701	PF00917	0.676
DOC_USP7_MATH_1	705	709	PF00917	0.634
DOC_USP7_MATH_1	740	744	PF00917	0.668
DOC_USP7_MATH_1	747	751	PF00917	0.661
DOC_USP7_MATH_1	755	759	PF00917	0.562
DOC_WW_Pin1_4	123	128	PF00397	0.473
DOC_WW_Pin1_4	389	394	PF00397	0.553
DOC_WW_Pin1_4	5	10	PF00397	0.624
DOC_WW_Pin1_4	550	555	PF00397	0.618
DOC_WW_Pin1_4	572	577	PF00397	0.597
DOC_WW_Pin1_4	659	664	PF00397	0.693
DOC_WW_Pin1_4	715	720	PF00397	0.731
LIG_14-3-3_CanoR_1	201	205	PF00244	0.430
LIG_14-3-3_CanoR_1	309	314	PF00244	0.388
LIG_14-3-3_CanoR_1	491	497	PF00244	0.635
LIG_14-3-3_CanoR_1	505	515	PF00244	0.602
LIG_14-3-3_CanoR_1	749	755	PF00244	0.735
LIG_BRCT_BRCA1_1	228	232	PF00533	0.371
LIG_BRCT_BRCA1_1	511	515	PF00533	0.586
LIG_BRCT_BRCA1_1	657	661	PF00533	0.691
LIG_BRCT_BRCA1_2	228	234	PF00533	0.368
LIG_Clathr_ClatBox_1	666	670	PF01394	0.707
LIG_deltaCOP1_diTrp_1	656	661	PF00928	0.692
LIG_FHA_1	209	215	PF00498	0.411
LIG_FHA_1	231	237	PF00498	0.407
LIG_FHA_1	269	275	PF00498	0.562
LIG_FHA_1	316	322	PF00498	0.495
LIG_FHA_1	662	668	PF00498	0.638
LIG_FHA_2	183	189	PF00498	0.439
LIG_FHA_2	318	324	PF00498	0.431
LIG_FHA_2	442	448	PF00498	0.622
LIG_IBAR_NPY_1	516	518	PF08397	0.599
LIG_Integrin_isoDGR_2	87	89	PF01839	0.684
LIG_LIR_Apic_2	20	25	PF02991	0.688
LIG_LIR_Apic_2	37	42	PF02991	0.527
LIG_LIR_Apic_2	700	705	PF02991	0.699
LIG_LIR_Gen_1	209	219	PF02991	0.497
LIG_LIR_Gen_1	300	311	PF02991	0.380
LIG_LIR_Gen_1	385	393	PF02991	0.431
LIG_LIR_Gen_1	528	535	PF02991	0.686
LIG_LIR_Nem_3	16	22	PF02991	0.657
LIG_LIR_Nem_3	209	215	PF02991	0.411
LIG_LIR_Nem_3	300	306	PF02991	0.382
LIG_LIR_Nem_3	512	518	PF02991	0.588
LIG_LIR_Nem_3	528	534	PF02991	0.645
LIG_PALB2_WD40_1	298	306	PF16756	0.410
LIG_Pex14_2	299	303	PF04695	0.410
LIG_Pex14_2	655	659	PF04695	0.693
LIG_PTB_Apo_2	305	312	PF02174	0.416
LIG_SH2_CRK	22	26	PF00017	0.756
LIG_SH2_CRK	39	43	PF00017	0.528
LIG_SH2_CRK	518	522	PF00017	0.699
LIG_SH2_CRK	624	628	PF00017	0.723
LIG_SH2_NCK_1	22	26	PF00017	0.789
LIG_SH2_PTP2	237	240	PF00017	0.529
LIG_SH2_PTP2	702	705	PF00017	0.651
LIG_SH2_SRC	22	25	PF00017	0.682
LIG_SH2_SRC	237	240	PF00017	0.529
LIG_SH2_SRC	702	705	PF00017	0.651
LIG_SH2_STAP1	19	23	PF00017	0.705
LIG_SH2_STAT3	104	107	PF00017	0.716
LIG_SH2_STAT5	181	184	PF00017	0.506
LIG_SH2_STAT5	237	240	PF00017	0.529
LIG_SH2_STAT5	28	31	PF00017	0.648
LIG_SH2_STAT5	310	313	PF00017	0.402
LIG_SH2_STAT5	379	382	PF00017	0.365
LIG_SH2_STAT5	552	555	PF00017	0.698
LIG_SH2_STAT5	702	705	PF00017	0.651
LIG_SH3_3	121	127	PF00018	0.467
LIG_SH3_3	140	146	PF00018	0.369
LIG_SH3_3	220	226	PF00018	0.395
LIG_SH3_3	318	324	PF00018	0.407
LIG_SH3_3	428	434	PF00018	0.518
LIG_SH3_3	624	630	PF00018	0.668
LIG_SUMO_SIM_par_1	121	126	PF11976	0.416
LIG_SUMO_SIM_par_1	569	575	PF11976	0.574
LIG_SxIP_EBH_1	763	774	PF03271	0.609
LIG_TRAF2_1	160	163	PF00917	0.388
LIG_TRAF2_1	454	457	PF00917	0.640
LIG_TRFH_1	311	315	PF08558	0.407
MOD_CDK_SPxxK_3	715	722	PF00069	0.732
MOD_CK1_1	13	19	PF00069	0.629
MOD_CK1_1	208	214	PF00069	0.447
MOD_CK1_1	328	334	PF00069	0.413
MOD_CK1_1	483	489	PF00069	0.630
MOD_CK1_1	509	515	PF00069	0.586
MOD_CK1_1	520	526	PF00069	0.623
MOD_CK1_1	561	567	PF00069	0.747
MOD_CK1_1	575	581	PF00069	0.554
MOD_CK1_1	672	678	PF00069	0.727
MOD_CK1_1	698	704	PF00069	0.701
MOD_CK1_1	707	713	PF00069	0.613
MOD_CK1_1	726	732	PF00069	0.504
MOD_CK1_1	739	745	PF00069	0.573
MOD_CK1_1	750	756	PF00069	0.612
MOD_CK1_1	766	772	PF00069	0.533
MOD_CK2_1	107	113	PF00069	0.532
MOD_CK2_1	182	188	PF00069	0.448
MOD_CMANNOS	278	281	PF00535	0.420
MOD_GlcNHglycan	12	15	PF01048	0.623
MOD_GlcNHglycan	135	138	PF01048	0.516
MOD_GlcNHglycan	48	51	PF01048	0.605
MOD_GlcNHglycan	482	485	PF01048	0.736
MOD_GlcNHglycan	494	497	PF01048	0.577
MOD_GlcNHglycan	501	504	PF01048	0.499
MOD_GlcNHglycan	539	542	PF01048	0.737
MOD_GlcNHglycan	577	580	PF01048	0.663
MOD_GlcNHglycan	738	741	PF01048	0.660
MOD_GlcNHglycan	749	752	PF01048	0.623
MOD_GlcNHglycan	77	80	PF01048	0.626
MOD_GSK3_1	126	133	PF00069	0.429
MOD_GSK3_1	13	20	PF00069	0.625
MOD_GSK3_1	226	233	PF00069	0.388
MOD_GSK3_1	476	483	PF00069	0.679
MOD_GSK3_1	546	553	PF00069	0.678
MOD_GSK3_1	655	662	PF00069	0.693
MOD_GSK3_1	669	676	PF00069	0.567
MOD_GSK3_1	704	711	PF00069	0.669
MOD_GSK3_1	722	729	PF00069	0.523
MOD_GSK3_1	736	743	PF00069	0.555
MOD_GSK3_1	750	757	PF00069	0.577
MOD_GSK3_1	765	772	PF00069	0.546
MOD_N-GLC_1	10	15	PF02516	0.588
MOD_N-GLC_1	484	489	PF02516	0.664
MOD_N-GLC_1	492	497	PF02516	0.664
MOD_N-GLC_1	546	551	PF02516	0.626
MOD_N-GLC_1	678	683	PF02516	0.746
MOD_N-GLC_1	698	703	PF02516	0.478
MOD_N-GLC_1	726	731	PF02516	0.636
MOD_N-GLC_1	75	80	PF02516	0.737
MOD_NEK2_1	182	187	PF00069	0.446
MOD_NEK2_1	230	235	PF00069	0.453
MOD_NEK2_1	326	331	PF00069	0.426
MOD_NEK2_1	345	350	PF00069	0.503
MOD_NEK2_1	492	497	PF00069	0.654
MOD_NEK2_1	559	564	PF00069	0.543
MOD_NEK2_1	655	660	PF00069	0.693
MOD_NEK2_1	669	674	PF00069	0.566
MOD_NEK2_1	695	700	PF00069	0.696
MOD_NEK2_1	736	741	PF00069	0.710
MOD_NEK2_1	763	768	PF00069	0.732
MOD_NEK2_2	34	39	PF00069	0.709
MOD_OFUCOSY	364	369	PF10250	0.513
MOD_PIKK_1	441	447	PF00454	0.551
MOD_PIKK_1	708	714	PF00454	0.714
MOD_PK_1	210	216	PF00069	0.486
MOD_PK_1	351	357	PF00069	0.393
MOD_PK_1	678	684	PF00069	0.742
MOD_PKA_1	422	428	PF00069	0.495
MOD_PKA_2	200	206	PF00069	0.406
MOD_PKA_2	422	428	PF00069	0.510
MOD_PKA_2	537	543	PF00069	0.653
MOD_PKA_2	773	779	PF00069	0.704
MOD_Plk_1	187	193	PF00069	0.508
MOD_Plk_1	208	214	PF00069	0.529
MOD_Plk_1	315	321	PF00069	0.442
MOD_Plk_1	484	490	PF00069	0.632
MOD_Plk_1	497	503	PF00069	0.625
MOD_Plk_1	655	661	PF00069	0.694
MOD_Plk_1	698	704	PF00069	0.701
MOD_Plk_2-3	317	323	PF00069	0.403
MOD_Plk_4	126	132	PF00069	0.440
MOD_Plk_4	17	23	PF00069	0.737
MOD_Plk_4	188	194	PF00069	0.543
MOD_Plk_4	226	232	PF00069	0.375
MOD_Plk_4	698	704	PF00069	0.649
MOD_Plk_4	773	779	PF00069	0.704
MOD_ProDKin_1	123	129	PF00069	0.467
MOD_ProDKin_1	389	395	PF00069	0.553
MOD_ProDKin_1	5	11	PF00069	0.623
MOD_ProDKin_1	550	556	PF00069	0.607
MOD_ProDKin_1	572	578	PF00069	0.601
MOD_ProDKin_1	659	665	PF00069	0.693
MOD_ProDKin_1	715	721	PF00069	0.730
MOD_SUMO_for_1	415	418	PF00179	0.513
MOD_SUMO_rev_2	213	222	PF00179	0.496
MOD_SUMO_rev_2	446	454	PF00179	0.697
TRG_DiLeu_BaEn_4	398	404	PF01217	0.534
TRG_DiLeu_BaLyEn_6	662	667	PF01217	0.689
TRG_ENDOCYTIC_2	310	313	PF00928	0.402
TRG_ENDOCYTIC_2	379	382	PF00928	0.365
TRG_ENDOCYTIC_2	518	521	PF00928	0.612
TRG_ENDOCYTIC_2	531	534	PF00928	0.651
TRG_ENDOCYTIC_2	624	627	PF00928	0.723
TRG_ER_diArg_1	402	405	PF00400	0.543
TRG_ER_diArg_1	490	492	PF00400	0.635
TRG_ER_diArg_1	567	569	PF00400	0.587
TRG_NLS_MonoExtN_4	243	249	PF00514	0.598
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN9	Leptomonas seymouri	58%	100%
A4HNU4	Leishmania braziliensis	81%	100%
A4ICQ0	Leishmania infantum	99%	100%
E9ASK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q1Z2	Leishmania major	93%	100%