Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAM2_LEIDO

TriTrypDb:

LdBPK_361540.1 , LdCL_360020900 , LDHU3_36.1970

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	354	358	PF00656	0.463
CLV_C14_Caspase3-7	51	55	PF00656	0.524
CLV_NRD_NRD_1	232	234	PF00675	0.579
CLV_PCSK_SKI1_1	19	23	PF00082	0.439
CLV_PCSK_SKI1_1	196	200	PF00082	0.404
CLV_PCSK_SKI1_1	92	96	PF00082	0.504
DEG_Nend_UBRbox_2	1	3	PF02207	0.594
DEG_SPOP_SBC_1	405	409	PF00917	0.683
DOC_CKS1_1	283	288	PF01111	0.488
DOC_CYCLIN_RxL_1	122	132	PF00134	0.577
DOC_CYCLIN_RxL_1	200	211	PF00134	0.507
DOC_CYCLIN_RxL_1	308	318	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	280	286	PF00134	0.514
DOC_MAPK_gen_1	16	25	PF00069	0.457
DOC_MAPK_gen_1	300	309	PF00069	0.383
DOC_MAPK_gen_1	328	337	PF00069	0.584
DOC_MAPK_MEF2A_6	10	17	PF00069	0.490
DOC_MAPK_MEF2A_6	131	140	PF00069	0.397
DOC_USP7_MATH_1	115	119	PF00917	0.701
DOC_USP7_MATH_1	123	127	PF00917	0.487
DOC_USP7_MATH_1	406	410	PF00917	0.691
DOC_USP7_MATH_1	53	57	PF00917	0.734
DOC_WW_Pin1_4	156	161	PF00397	0.665
DOC_WW_Pin1_4	205	210	PF00397	0.396
DOC_WW_Pin1_4	282	287	PF00397	0.465
DOC_WW_Pin1_4	380	385	PF00397	0.446
DOC_WW_Pin1_4	57	62	PF00397	0.648
LIG_14-3-3_CanoR_1	135	141	PF00244	0.424
LIG_14-3-3_CanoR_1	276	281	PF00244	0.484
LIG_14-3-3_CanoR_1	324	328	PF00244	0.519
LIG_Actin_WH2_2	310	326	PF00022	0.501
LIG_APCC_ABBA_1	15	20	PF00400	0.460
LIG_APCC_ABBA_1	307	312	PF00400	0.395
LIG_BRCT_BRCA1_1	125	129	PF00533	0.487
LIG_BRCT_BRCA1_1	394	398	PF00533	0.422
LIG_FHA_1	145	151	PF00498	0.619
LIG_FHA_1	20	26	PF00498	0.450
LIG_FHA_1	200	206	PF00498	0.478
LIG_FHA_1	330	336	PF00498	0.545
LIG_FHA_1	387	393	PF00498	0.356
LIG_FHA_1	98	104	PF00498	0.686
LIG_FHA_2	137	143	PF00498	0.388
LIG_FHA_2	206	212	PF00498	0.415
LIG_FHA_2	283	289	PF00498	0.511
LIG_FHA_2	337	343	PF00498	0.386
LIG_FHA_2	58	64	PF00498	0.687
LIG_PTAP_UEV_1	249	254	PF05743	0.496
LIG_SH2_STAP1	294	298	PF00017	0.454
LIG_SH2_STAP1	359	363	PF00017	0.475
LIG_SH2_STAT3	294	297	PF00017	0.460
LIG_SH2_STAT5	179	182	PF00017	0.388
LIG_SH2_STAT5	305	308	PF00017	0.368
LIG_SH3_3	247	253	PF00018	0.449
LIG_SH3_3	280	286	PF00018	0.520
LIG_SH3_3	378	384	PF00018	0.376
LIG_SH3_3	399	405	PF00018	0.634
LIG_SH3_3	59	65	PF00018	0.665
LIG_SUMO_SIM_par_1	197	202	PF11976	0.414
LIG_SUMO_SIM_par_1	20	27	PF11976	0.580
LIG_TRAF2_1	272	275	PF00917	0.462
LIG_TRAF2_1	49	52	PF00917	0.608
LIG_WW_3	401	405	PF00397	0.442
MOD_CK1_1	154	160	PF00069	0.661
MOD_CK2_1	136	142	PF00069	0.382
MOD_CK2_1	282	288	PF00069	0.467
MOD_CK2_1	323	329	PF00069	0.501
MOD_CK2_1	336	342	PF00069	0.559
MOD_CK2_1	57	63	PF00069	0.701
MOD_GlcNHglycan	104	107	PF01048	0.634
MOD_GlcNHglycan	117	120	PF01048	0.693
MOD_GlcNHglycan	218	221	PF01048	0.624
MOD_GlcNHglycan	250	253	PF01048	0.623
MOD_GlcNHglycan	29	32	PF01048	0.594
MOD_GlcNHglycan	318	322	PF01048	0.584
MOD_GlcNHglycan	359	362	PF01048	0.520
MOD_GSK3_1	136	143	PF00069	0.422
MOD_GSK3_1	201	208	PF00069	0.452
MOD_GSK3_1	248	255	PF00069	0.576
MOD_GSK3_1	256	263	PF00069	0.576
MOD_GSK3_1	329	336	PF00069	0.608
MOD_GSK3_1	35	42	PF00069	0.549
MOD_GSK3_1	357	364	PF00069	0.553
MOD_GSK3_1	392	399	PF00069	0.516
MOD_GSK3_1	53	60	PF00069	0.482
MOD_GSK3_1	65	72	PF00069	0.725
MOD_GSK3_1	97	104	PF00069	0.556
MOD_N-GLC_1	361	366	PF02516	0.542
MOD_NEK2_1	136	141	PF00069	0.383
MOD_NEK2_1	199	204	PF00069	0.557
MOD_NEK2_1	238	243	PF00069	0.537
MOD_NEK2_1	296	301	PF00069	0.372
MOD_NEK2_1	317	322	PF00069	0.490
MOD_NEK2_1	323	328	PF00069	0.533
MOD_NEK2_1	370	375	PF00069	0.557
MOD_NEK2_1	392	397	PF00069	0.436
MOD_NEK2_1	40	45	PF00069	0.518
MOD_PIKK_1	151	157	PF00454	0.604
MOD_PIKK_1	69	75	PF00454	0.805
MOD_PKA_2	108	114	PF00069	0.581
MOD_PKA_2	260	266	PF00069	0.619
MOD_PKA_2	275	281	PF00069	0.505
MOD_PKA_2	323	329	PF00069	0.427
MOD_Plk_1	123	129	PF00069	0.509
MOD_Plk_1	141	147	PF00069	0.418
MOD_Plk_1	19	25	PF00069	0.450
MOD_Plk_1	333	339	PF00069	0.660
MOD_Plk_1	97	103	PF00069	0.608
MOD_Plk_4	136	142	PF00069	0.364
MOD_Plk_4	35	41	PF00069	0.474
MOD_Plk_4	392	398	PF00069	0.516
MOD_ProDKin_1	156	162	PF00069	0.656
MOD_ProDKin_1	205	211	PF00069	0.399
MOD_ProDKin_1	282	288	PF00069	0.464
MOD_ProDKin_1	380	386	PF00069	0.442
MOD_ProDKin_1	57	63	PF00069	0.653
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK24	Leptomonas seymouri	54%	93%
A0A0S4JIK9	Bodo saltans	32%	96%
A0A1X0P835	Trypanosomatidae	36%	83%
A0A3R7KEY6	Trypanosoma rangeli	41%	88%
A4HP08	Leishmania braziliensis	79%	100%
A4HP27	Leishmania braziliensis	78%	100%
A4IDB7	Leishmania infantum	99%	100%
D0A2Y8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ASR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q1S8	Leishmania major	93%	100%
V5B4F6	Trypanosoma cruzi	40%	91%