Cilia- and flagella-associated protein 36

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

The ARF-like 2 binding protein BART, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAM0_LEIDO

TriTrypDb:

LdBPK_361460.1 , LdCL_360020100 , LDHU3_36.1870

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0005930	axoneme	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0097546	ciliary base	2	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S7XAM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.544
CLV_NRD_NRD_1	435	437	PF00675	0.434
CLV_NRD_NRD_1	445	447	PF00675	0.544
CLV_PCSK_KEX2_1	120	122	PF00082	0.265
CLV_PCSK_KEX2_1	178	180	PF00082	0.576
CLV_PCSK_KEX2_1	377	379	PF00082	0.624
CLV_PCSK_KEX2_1	435	437	PF00082	0.434
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.330
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.563
CLV_PCSK_SKI1_1	5	9	PF00082	0.362
CLV_PCSK_SKI1_1	99	103	PF00082	0.312
DEG_SPOP_SBC_1	413	417	PF00917	0.525
DOC_CKS1_1	20	25	PF01111	0.465
DOC_CYCLIN_RxL_1	115	126	PF00134	0.537
DOC_MAPK_gen_1	120	127	PF00069	0.465
DOC_MAPK_gen_1	178	185	PF00069	0.594
DOC_MAPK_MEF2A_6	120	127	PF00069	0.465
DOC_MAPK_MEF2A_6	178	185	PF00069	0.543
DOC_MAPK_NFAT4_5	120	128	PF00069	0.465
DOC_PP2B_LxvP_1	264	267	PF13499	0.441
DOC_PP4_FxxP_1	284	287	PF00568	0.678
DOC_PP4_FxxP_1	291	294	PF00568	0.669
DOC_USP7_MATH_1	132	136	PF00917	0.509
DOC_USP7_MATH_1	307	311	PF00917	0.663
DOC_USP7_MATH_1	321	325	PF00917	0.636
DOC_USP7_MATH_1	334	338	PF00917	0.582
DOC_USP7_MATH_1	341	345	PF00917	0.472
DOC_USP7_MATH_1	413	417	PF00917	0.683
DOC_USP7_MATH_1	425	429	PF00917	0.703
DOC_USP7_MATH_1	445	449	PF00917	0.483
DOC_USP7_MATH_1	77	81	PF00917	0.502
DOC_USP7_MATH_1	86	90	PF00917	0.406
DOC_USP7_UBL2_3	99	103	PF12436	0.536
DOC_WW_Pin1_4	14	19	PF00397	0.447
DOC_WW_Pin1_4	152	157	PF00397	0.651
DOC_WW_Pin1_4	283	288	PF00397	0.805
DOC_WW_Pin1_4	344	349	PF00397	0.644
DOC_WW_Pin1_4	360	365	PF00397	0.704
LIG_14-3-3_CanoR_1	113	118	PF00244	0.500
LIG_14-3-3_CanoR_1	5	14	PF00244	0.508
LIG_14-3-3_CterR_2	446	450	PF00244	0.629
LIG_Actin_WH2_2	164	180	PF00022	0.493
LIG_FHA_1	114	120	PF00498	0.516
LIG_FHA_1	338	344	PF00498	0.622
LIG_FHA_1	428	434	PF00498	0.501
LIG_FHA_1	59	65	PF00498	0.459
LIG_FHA_1	6	12	PF00498	0.514
LIG_FHA_2	20	26	PF00498	0.490
LIG_FHA_2	369	375	PF00498	0.568
LIG_FHA_2	71	77	PF00498	0.473
LIG_GBD_Chelix_1	433	441	PF00786	0.490
LIG_Integrin_RGD_1	438	440	PF01839	0.549
LIG_LIR_Apic_2	17	23	PF02991	0.447
LIG_LIR_Apic_2	283	287	PF02991	0.657
LIG_LIR_Apic_2	288	294	PF02991	0.651
LIG_LIR_Gen_1	109	119	PF02991	0.469
LIG_LIR_Gen_1	44	52	PF02991	0.468
LIG_LIR_LC3C_4	80	84	PF02991	0.407
LIG_LIR_Nem_3	109	114	PF02991	0.478
LIG_LIR_Nem_3	44	48	PF02991	0.497
LIG_PCNA_PIPBox_1	398	407	PF02747	0.523
LIG_PCNA_yPIPBox_3	392	405	PF02747	0.506
LIG_PTAP_UEV_1	347	352	PF05743	0.624
LIG_SH2_CRK	45	49	PF00017	0.498
LIG_SH2_STAT5	45	48	PF00017	0.514
LIG_SH3_1	345	351	PF00018	0.628
LIG_SH3_3	284	290	PF00018	0.673
LIG_SH3_3	310	316	PF00018	0.605
LIG_SH3_3	317	323	PF00018	0.655
LIG_SH3_3	330	336	PF00018	0.597
LIG_SH3_3	345	351	PF00018	0.607
LIG_SUMO_SIM_anti_2	124	129	PF11976	0.568
LIG_TRAF2_1	147	150	PF00917	0.574
LIG_TRAF2_1	371	374	PF00917	0.559
LIG_TRAF2_1	396	399	PF00917	0.540
LIG_TYR_ITIM	43	48	PF00017	0.511
LIG_WRC_WIRS_1	401	406	PF05994	0.519
MOD_CK1_1	286	292	PF00069	0.792
MOD_CK1_1	337	343	PF00069	0.671
MOD_CK1_1	344	350	PF00069	0.671
MOD_CK1_1	36	42	PF00069	0.535
MOD_CK1_1	409	415	PF00069	0.567
MOD_CK1_1	58	64	PF00069	0.583
MOD_CK1_1	70	76	PF00069	0.452
MOD_CK1_1	85	91	PF00069	0.381
MOD_CK2_1	144	150	PF00069	0.584
MOD_CK2_1	234	240	PF00069	0.527
MOD_CK2_1	368	374	PF00069	0.575
MOD_CK2_1	393	399	PF00069	0.541
MOD_CK2_1	70	76	PF00069	0.501
MOD_GlcNHglycan	14	17	PF01048	0.304
MOD_GlcNHglycan	146	149	PF01048	0.557
MOD_GlcNHglycan	309	312	PF01048	0.662
MOD_GlcNHglycan	348	351	PF01048	0.695
MOD_GlcNHglycan	360	363	PF01048	0.642
MOD_GlcNHglycan	416	419	PF01048	0.638
MOD_GlcNHglycan	84	87	PF01048	0.207
MOD_GSK3_1	1	8	PF00069	0.471
MOD_GSK3_1	109	116	PF00069	0.552
MOD_GSK3_1	335	342	PF00069	0.701
MOD_GSK3_1	407	414	PF00069	0.603
MOD_GSK3_1	78	85	PF00069	0.517
MOD_GSK3_1	86	93	PF00069	0.405
MOD_N-GLC_1	109	114	PF02516	0.312
MOD_N-GLC_1	36	41	PF02516	0.350
MOD_N-GLC_1	406	411	PF02516	0.614
MOD_N-GLC_2	31	33	PF02516	0.330
MOD_NEK2_1	1	6	PF00069	0.463
MOD_NEK2_1	420	425	PF00069	0.653
MOD_NEK2_1	43	48	PF00069	0.497
MOD_NEK2_1	55	60	PF00069	0.495
MOD_NEK2_1	78	83	PF00069	0.601
MOD_PIKK_1	227	233	PF00454	0.511
MOD_PIKK_1	253	259	PF00454	0.530
MOD_PKA_2	393	399	PF00069	0.545
MOD_Plk_1	109	115	PF00069	0.513
MOD_Plk_1	181	187	PF00069	0.501
MOD_Plk_1	43	49	PF00069	0.466
MOD_Plk_4	113	119	PF00069	0.536
MOD_Plk_4	400	406	PF00069	0.520
MOD_Plk_4	43	49	PF00069	0.512
MOD_Plk_4	55	61	PF00069	0.510
MOD_Plk_4	78	84	PF00069	0.526
MOD_ProDKin_1	14	20	PF00069	0.447
MOD_ProDKin_1	152	158	PF00069	0.644
MOD_ProDKin_1	283	289	PF00069	0.804
MOD_ProDKin_1	344	350	PF00069	0.645
MOD_ProDKin_1	360	366	PF00069	0.702
TRG_ENDOCYTIC_2	45	48	PF00928	0.498
TRG_ER_diArg_1	177	179	PF00400	0.561
TRG_ER_diArg_1	435	438	PF00400	0.423
TRG_NES_CRM1_1	57	72	PF08389	0.449
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.290
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F6	Leptomonas seymouri	48%	100%
A0A0S4JFM0	Bodo saltans	31%	100%
A0A3R7MMF8	Trypanosoma rangeli	32%	100%
A4HP00	Leishmania braziliensis	68%	100%
A4ICJ6	Leishmania infantum	100%	100%
E9ASR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%
Q4Q1T6	Leishmania major	87%	98%
V5DL00	Trypanosoma cruzi	34%	100%