Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAL8_LEIDO

TriTrypDb:

LdBPK_361300.1 , LdCL_360018100 , LDHU3_36.1640

Length:

773

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	723	727	PF00656	0.436
CLV_NRD_NRD_1	318	320	PF00675	0.386
CLV_PCSK_KEX2_1	318	320	PF00082	0.386
CLV_PCSK_SKI1_1	145	149	PF00082	0.513
CLV_PCSK_SKI1_1	166	170	PF00082	0.416
CLV_PCSK_SKI1_1	24	28	PF00082	0.613
CLV_PCSK_SKI1_1	268	272	PF00082	0.513
CLV_PCSK_SKI1_1	378	382	PF00082	0.411
CLV_PCSK_SKI1_1	403	407	PF00082	0.513
CLV_PCSK_SKI1_1	451	455	PF00082	0.411
CLV_PCSK_SKI1_1	481	485	PF00082	0.500
CLV_PCSK_SKI1_1	711	715	PF00082	0.448
CLV_PCSK_SKI1_1	742	746	PF00082	0.513
DEG_APCC_DBOX_1	23	31	PF00400	0.719
DEG_APCC_DBOX_1	317	325	PF00400	0.411
DEG_APCC_KENBOX_2	666	670	PF00400	0.397
DEG_Nend_UBRbox_1	1	4	PF02207	0.764
DEG_SPOP_SBC_1	123	127	PF00917	0.411
DEG_SPOP_SBC_1	237	241	PF00917	0.299
DEG_SPOP_SBC_1	656	660	PF00917	0.299
DOC_CKS1_1	263	268	PF01111	0.436
DOC_CYCLIN_RxL_1	163	173	PF00134	0.416
DOC_CYCLIN_RxL_1	21	31	PF00134	0.601
DOC_CYCLIN_RxL_1	375	383	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	617	623	PF00134	0.513
DOC_MAPK_gen_1	21	29	PF00069	0.646
DOC_MAPK_gen_1	318	326	PF00069	0.402
DOC_MAPK_gen_1	698	706	PF00069	0.411
DOC_MAPK_MEF2A_6	318	325	PF00069	0.513
DOC_MAPK_RevD_3	304	319	PF00069	0.404
DOC_PP2B_LxvP_1	438	441	PF13499	0.513
DOC_PP2B_LxvP_1	80	83	PF13499	0.822
DOC_PP2B_LxvP_1	99	102	PF13499	0.463
DOC_PP4_FxxP_1	688	691	PF00568	0.513
DOC_USP7_MATH_1	123	127	PF00917	0.411
DOC_USP7_MATH_1	15	19	PF00917	0.689
DOC_USP7_MATH_1	174	178	PF00917	0.381
DOC_USP7_MATH_1	287	291	PF00917	0.424
DOC_USP7_MATH_1	299	303	PF00917	0.468
DOC_USP7_MATH_1	350	354	PF00917	0.392
DOC_USP7_MATH_1	576	580	PF00917	0.378
DOC_USP7_MATH_1	674	678	PF00917	0.366
DOC_USP7_MATH_2	441	447	PF00917	0.436
DOC_WW_Pin1_4	198	203	PF00397	0.390
DOC_WW_Pin1_4	204	209	PF00397	0.208
DOC_WW_Pin1_4	214	219	PF00397	0.428
DOC_WW_Pin1_4	262	267	PF00397	0.513
DOC_WW_Pin1_4	4	9	PF00397	0.810
DOC_WW_Pin1_4	411	416	PF00397	0.373
DOC_WW_Pin1_4	432	437	PF00397	0.433
DOC_WW_Pin1_4	565	570	PF00397	0.357
DOC_WW_Pin1_4	71	76	PF00397	0.698
DOC_WW_Pin1_4	736	741	PF00397	0.471
LIG_14-3-3_CanoR_1	132	137	PF00244	0.436
LIG_14-3-3_CanoR_1	2	8	PF00244	0.757
LIG_14-3-3_CanoR_1	222	228	PF00244	0.474
LIG_14-3-3_CanoR_1	281	291	PF00244	0.299
LIG_14-3-3_CanoR_1	318	322	PF00244	0.400
LIG_14-3-3_CanoR_1	352	360	PF00244	0.353
LIG_14-3-3_CanoR_1	394	400	PF00244	0.436
LIG_14-3-3_CanoR_1	444	448	PF00244	0.436
LIG_14-3-3_CanoR_1	464	474	PF00244	0.183
LIG_14-3-3_CanoR_1	492	501	PF00244	0.513
LIG_14-3-3_CanoR_1	636	640	PF00244	0.513
LIG_14-3-3_CanoR_1	690	699	PF00244	0.513
LIG_14-3-3_CanoR_1	742	751	PF00244	0.389
LIG_Actin_WH2_2	321	336	PF00022	0.474
LIG_ActinCP_TwfCPI_2	688	698	PF01115	0.513
LIG_AP2alpha_1	155	159	PF02296	0.299
LIG_APCC_ABBA_1	152	157	PF00400	0.513
LIG_APCC_ABBA_1	420	425	PF00400	0.436
LIG_BIR_III_2	592	596	PF00653	0.513
LIG_BIR_III_4	430	434	PF00653	0.436
LIG_BIR_III_4	452	456	PF00653	0.443
LIG_BRCT_BRCA1_1	102	106	PF00533	0.513
LIG_BRCT_BRCA1_1	578	582	PF00533	0.299
LIG_deltaCOP1_diTrp_1	443	447	PF00928	0.411
LIG_EVH1_1	412	416	PF00568	0.436
LIG_EVH1_2	416	420	PF00568	0.436
LIG_FHA_1	205	211	PF00498	0.514
LIG_FHA_1	374	380	PF00498	0.374
LIG_FHA_1	400	406	PF00498	0.353
LIG_FHA_1	433	439	PF00498	0.371
LIG_FHA_1	549	555	PF00498	0.504
LIG_FHA_1	612	618	PF00498	0.453
LIG_FHA_1	620	626	PF00498	0.390
LIG_FHA_1	9	15	PF00498	0.809
LIG_FHA_2	165	171	PF00498	0.436
LIG_FHA_2	275	281	PF00498	0.510
LIG_FHA_2	721	727	PF00498	0.436
LIG_FHA_2	76	82	PF00498	0.743
LIG_GSK3_LRP6_1	415	420	PF00069	0.338
LIG_LIR_Gen_1	146	156	PF02991	0.411
LIG_LIR_Gen_1	418	427	PF02991	0.383
LIG_LIR_Gen_1	435	442	PF02991	0.399
LIG_LIR_Nem_3	116	121	PF02991	0.411
LIG_LIR_Nem_3	146	151	PF02991	0.411
LIG_LIR_Nem_3	335	341	PF02991	0.411
LIG_LIR_Nem_3	418	423	PF02991	0.383
LIG_LIR_Nem_3	435	440	PF02991	0.399
LIG_LIR_Nem_3	495	500	PF02991	0.513
LIG_NRBOX	149	155	PF00104	0.411
LIG_NRBOX	310	316	PF00104	0.513
LIG_NRBOX	461	467	PF00104	0.411
LIG_NRBOX	537	543	PF00104	0.513
LIG_Pex14_1	391	395	PF04695	0.436
LIG_Pex14_2	155	159	PF04695	0.513
LIG_Pex14_2	598	602	PF04695	0.389
LIG_Pex14_2	688	692	PF04695	0.513
LIG_RPA_C_Fungi	314	326	PF08784	0.402
LIG_SH2_CRK	23	27	PF00017	0.622
LIG_SH2_CRK	458	462	PF00017	0.389
LIG_SH2_STAP1	458	462	PF00017	0.389
LIG_SH2_STAT3	32	35	PF00017	0.719
LIG_SH2_STAT5	479	482	PF00017	0.513
LIG_SH2_STAT5	699	702	PF00017	0.357
LIG_SH3_3	188	194	PF00018	0.408
LIG_SH3_3	197	203	PF00018	0.318
LIG_SH3_3	206	212	PF00018	0.385
LIG_SH3_3	260	266	PF00018	0.436
LIG_SH3_3	410	416	PF00018	0.414
LIG_SH3_3	49	55	PF00018	0.573
LIG_SH3_3	523	529	PF00018	0.424
LIG_SH3_3	541	547	PF00018	0.333
LIG_Sin3_3	745	752	PF02671	0.513
LIG_SUMO_SIM_anti_2	149	155	PF11976	0.411
LIG_SUMO_SIM_anti_2	307	312	PF11976	0.513
LIG_SUMO_SIM_anti_2	320	325	PF11976	0.298
LIG_SUMO_SIM_anti_2	622	628	PF11976	0.377
LIG_SUMO_SIM_par_1	304	309	PF11976	0.418
LIG_SUMO_SIM_par_1	322	327	PF11976	0.208
LIG_TRAF2_1	90	93	PF00917	0.784
LIG_TYR_ITIM	336	341	PF00017	0.411
LIG_UBA3_1	744	750	PF00899	0.513
LIG_UBA3_1	96	105	PF00899	0.561
LIG_WRC_WIRS_1	118	123	PF05994	0.436
MOD_CDC14_SPxK_1	739	742	PF00782	0.436
MOD_CDK_SPxK_1	262	268	PF00069	0.513
MOD_CDK_SPxK_1	736	742	PF00069	0.436
MOD_CK1_1	131	137	PF00069	0.513
MOD_CK1_1	195	201	PF00069	0.482
MOD_CK1_1	285	291	PF00069	0.490
MOD_CK1_1	317	323	PF00069	0.424
MOD_CK1_1	344	350	PF00069	0.348
MOD_CK1_1	383	389	PF00069	0.411
MOD_CK1_1	4	10	PF00069	0.718
MOD_CK1_1	482	488	PF00069	0.383
MOD_CK1_1	515	521	PF00069	0.474
MOD_CK1_1	580	586	PF00069	0.507
MOD_CK1_1	657	663	PF00069	0.363
MOD_CK1_1	736	742	PF00069	0.424
MOD_CK1_1	85	91	PF00069	0.660
MOD_CK2_1	164	170	PF00069	0.436
MOD_CK2_1	174	180	PF00069	0.309
MOD_CK2_1	223	229	PF00069	0.403
MOD_CK2_1	274	280	PF00069	0.515
MOD_CK2_1	31	37	PF00069	0.593
MOD_CK2_1	603	609	PF00069	0.411
MOD_CK2_1	86	92	PF00069	0.699
MOD_GlcNHglycan	218	221	PF01048	0.443
MOD_GlcNHglycan	285	288	PF01048	0.388
MOD_GlcNHglycan	301	304	PF01048	0.402
MOD_GlcNHglycan	346	349	PF01048	0.299
MOD_GlcNHglycan	369	372	PF01048	0.513
MOD_GlcNHglycan	385	388	PF01048	0.465
MOD_GlcNHglycan	481	484	PF01048	0.407
MOD_GlcNHglycan	494	497	PF01048	0.362
MOD_GlcNHglycan	522	525	PF01048	0.521
MOD_GlcNHglycan	579	582	PF01048	0.454
MOD_GlcNHglycan	589	592	PF01048	0.353
MOD_GlcNHglycan	692	695	PF01048	0.513
MOD_GlcNHglycan	745	748	PF01048	0.413
MOD_GlcNHglycan	84	87	PF01048	0.805
MOD_GSK3_1	10	17	PF00069	0.674
MOD_GSK3_1	124	131	PF00069	0.411
MOD_GSK3_1	160	167	PF00069	0.436
MOD_GSK3_1	174	181	PF00069	0.384
MOD_GSK3_1	198	205	PF00069	0.513
MOD_GSK3_1	2	9	PF00069	0.768
MOD_GSK3_1	236	243	PF00069	0.487
MOD_GSK3_1	283	290	PF00069	0.513
MOD_GSK3_1	344	351	PF00069	0.366
MOD_GSK3_1	395	402	PF00069	0.299
MOD_GSK3_1	411	418	PF00069	0.323
MOD_GSK3_1	432	439	PF00069	0.498
MOD_GSK3_1	479	486	PF00069	0.429
MOD_GSK3_1	563	570	PF00069	0.384
MOD_GSK3_1	576	583	PF00069	0.288
MOD_GSK3_1	600	607	PF00069	0.416
MOD_GSK3_1	645	652	PF00069	0.459
MOD_GSK3_1	655	662	PF00069	0.336
MOD_GSK3_1	71	78	PF00069	0.640
MOD_GSK3_1	82	89	PF00069	0.802
MOD_NEK2_1	1	6	PF00069	0.722
MOD_NEK2_1	106	111	PF00069	0.513
MOD_NEK2_1	257	262	PF00069	0.402
MOD_NEK2_1	282	287	PF00069	0.411
MOD_NEK2_1	314	319	PF00069	0.465
MOD_NEK2_1	341	346	PF00069	0.397
MOD_NEK2_1	380	385	PF00069	0.443
MOD_NEK2_1	399	404	PF00069	0.299
MOD_NEK2_1	522	527	PF00069	0.448
MOD_NEK2_1	56	61	PF00069	0.670
MOD_NEK2_1	563	568	PF00069	0.447
MOD_NEK2_1	649	654	PF00069	0.420
MOD_NEK2_1	655	660	PF00069	0.362
MOD_PIKK_1	178	184	PF00454	0.362
MOD_PIKK_1	31	37	PF00454	0.593
MOD_PIKK_1	657	663	PF00454	0.464
MOD_PKA_2	1	7	PF00069	0.755
MOD_PKA_2	131	137	PF00069	0.436
MOD_PKA_2	15	21	PF00069	0.633
MOD_PKA_2	317	323	PF00069	0.411
MOD_PKA_2	351	357	PF00069	0.424
MOD_PKA_2	393	399	PF00069	0.513
MOD_PKA_2	443	449	PF00069	0.436
MOD_PKA_2	503	509	PF00069	0.342
MOD_PKA_2	520	526	PF00069	0.446
MOD_PKA_2	600	606	PF00069	0.416
MOD_PKA_2	635	641	PF00069	0.411
MOD_Plk_1	245	251	PF00069	0.402
MOD_Plk_1	512	518	PF00069	0.410
MOD_Plk_1	649	655	PF00069	0.513
MOD_Plk_4	109	115	PF00069	0.356
MOD_Plk_4	324	330	PF00069	0.429
MOD_Plk_4	380	386	PF00069	0.513
MOD_Plk_4	621	627	PF00069	0.454
MOD_Plk_4	635	641	PF00069	0.388
MOD_Plk_4	650	656	PF00069	0.411
MOD_ProDKin_1	198	204	PF00069	0.390
MOD_ProDKin_1	214	220	PF00069	0.452
MOD_ProDKin_1	262	268	PF00069	0.513
MOD_ProDKin_1	4	10	PF00069	0.809
MOD_ProDKin_1	411	417	PF00069	0.373
MOD_ProDKin_1	432	438	PF00069	0.433
MOD_ProDKin_1	565	571	PF00069	0.357
MOD_ProDKin_1	71	77	PF00069	0.701
MOD_ProDKin_1	736	742	PF00069	0.471
TRG_DiLeu_BaEn_1	537	542	PF01217	0.411
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.429
TRG_ENDOCYTIC_2	23	26	PF00928	0.623
TRG_ENDOCYTIC_2	338	341	PF00928	0.411
TRG_ENDOCYTIC_2	458	461	PF00928	0.389
TRG_ER_diArg_1	212	215	PF00400	0.397
TRG_ER_diArg_1	391	394	PF00400	0.411
TRG_ER_diArg_1	598	601	PF00400	0.360
TRG_ER_diArg_1	642	645	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	707	712	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYL2	Leptomonas seymouri	43%	100%
A4HNY4	Leishmania braziliensis	75%	100%
A4ICL0	Leishmania infantum	99%	100%
E9ASP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1V2	Leishmania major	92%	100%