Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAL7_LEIDO

TriTrypDb:

LdBPK_361230.1 , LdCL_360017400 , LDHU3_36.1570

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7XAL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAL7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0015693	magnesium ion transport	7	2
GO:0030001	metal ion transport	6	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	3
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	3
GO:0022857	transmembrane transporter activity	2	3
GO:0022890	inorganic cation transmembrane transporter activity	4	3
GO:0046873	metal ion transmembrane transporter activity	5	3
GO:0015095	magnesium ion transmembrane transporter activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.591
CLV_C14_Caspase3-7	242	246	PF00656	0.564
CLV_NRD_NRD_1	418	420	PF00675	0.357
CLV_NRD_NRD_1	459	461	PF00675	0.437
CLV_NRD_NRD_1	475	477	PF00675	0.274
CLV_NRD_NRD_1	487	489	PF00675	0.309
CLV_NRD_NRD_1	5	7	PF00675	0.492
CLV_NRD_NRD_1	512	514	PF00675	0.391
CLV_NRD_NRD_1	553	555	PF00675	0.430
CLV_NRD_NRD_1	627	629	PF00675	0.424
CLV_PCSK_KEX2_1	294	296	PF00082	0.525
CLV_PCSK_KEX2_1	314	316	PF00082	0.397
CLV_PCSK_KEX2_1	324	326	PF00082	0.589
CLV_PCSK_KEX2_1	418	420	PF00082	0.401
CLV_PCSK_KEX2_1	461	463	PF00082	0.393
CLV_PCSK_KEX2_1	475	477	PF00082	0.298
CLV_PCSK_KEX2_1	487	489	PF00082	0.323
CLV_PCSK_KEX2_1	5	7	PF00082	0.492
CLV_PCSK_KEX2_1	512	514	PF00082	0.374
CLV_PCSK_KEX2_1	553	555	PF00082	0.426
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.525
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.397
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.520
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.426
CLV_PCSK_SKI1_1	294	298	PF00082	0.554
CLV_PCSK_SKI1_1	315	319	PF00082	0.480
CLV_PCSK_SKI1_1	418	422	PF00082	0.401
CLV_PCSK_SKI1_1	469	473	PF00082	0.364
CLV_PCSK_SKI1_1	488	492	PF00082	0.350
CLV_PCSK_SKI1_1	560	564	PF00082	0.304
CLV_PCSK_SKI1_1	6	10	PF00082	0.462
CLV_PCSK_SKI1_1	623	627	PF00082	0.405
DEG_Nend_UBRbox_1	1	4	PF02207	0.721
DEG_ODPH_VHL_1	601	613	PF01847	0.448
DEG_SCF_FBW7_2	269	276	PF00400	0.625
DOC_ANK_TNKS_1	58	65	PF00023	0.771
DOC_CKS1_1	270	275	PF01111	0.534
DOC_CYCLIN_yCln2_LP_2	495	501	PF00134	0.610
DOC_MAPK_DCC_7	356	365	PF00069	0.599
DOC_MAPK_gen_1	553	564	PF00069	0.585
DOC_MAPK_HePTP_8	550	565	PF00069	0.661
DOC_MAPK_MEF2A_6	557	565	PF00069	0.520
DOC_PP1_RVXF_1	486	493	PF00149	0.627
DOC_PP2B_LxvP_1	158	161	PF13499	0.652
DOC_PP4_FxxP_1	420	423	PF00568	0.585
DOC_SPAK_OSR1_1	503	507	PF12202	0.631
DOC_USP7_MATH_1	100	104	PF00917	0.765
DOC_USP7_MATH_1	328	332	PF00917	0.797
DOC_USP7_MATH_1	338	342	PF00917	0.597
DOC_USP7_MATH_1	355	359	PF00917	0.580
DOC_USP7_MATH_1	72	76	PF00917	0.741
DOC_USP7_UBL2_3	314	318	PF12436	0.763
DOC_WW_Pin1_4	14	19	PF00397	0.702
DOC_WW_Pin1_4	269	274	PF00397	0.524
DOC_WW_Pin1_4	410	415	PF00397	0.666
LIG_14-3-3_CanoR_1	164	170	PF00244	0.677
LIG_14-3-3_CanoR_1	356	360	PF00244	0.637
LIG_14-3-3_CanoR_1	418	423	PF00244	0.553
LIG_14-3-3_CanoR_1	5	11	PF00244	0.726
LIG_14-3-3_CanoR_1	51	56	PF00244	0.733
LIG_14-3-3_CanoR_1	628	632	PF00244	0.645
LIG_14-3-3_CanoR_1	86	90	PF00244	0.767
LIG_Actin_WH2_2	544	562	PF00022	0.628
LIG_AP2alpha_1	500	504	PF02296	0.640
LIG_APCC_ABBA_1	27	32	PF00400	0.628
LIG_APCC_ABBA_1	367	372	PF00400	0.506
LIG_BIR_III_4	448	452	PF00653	0.571
LIG_Clathr_ClatBox_1	116	120	PF01394	0.688
LIG_deltaCOP1_diTrp_1	124	128	PF00928	0.590
LIG_deltaCOP1_diTrp_1	372	375	PF00928	0.568
LIG_EH1_1	423	431	PF00400	0.578
LIG_eIF4E_1	264	270	PF01652	0.489
LIG_FHA_1	194	200	PF00498	0.733
LIG_FHA_1	201	207	PF00498	0.618
LIG_FHA_1	252	258	PF00498	0.710
LIG_FHA_1	270	276	PF00498	0.461
LIG_FHA_1	32	38	PF00498	0.661
LIG_FHA_1	337	343	PF00498	0.606
LIG_FHA_1	401	407	PF00498	0.693
LIG_FHA_1	533	539	PF00498	0.544
LIG_FHA_1	631	637	PF00498	0.629
LIG_FHA_2	251	257	PF00498	0.734
LIG_FHA_2	258	264	PF00498	0.661
LIG_FHA_2	287	293	PF00498	0.775
LIG_FHA_2	374	380	PF00498	0.516
LIG_FHA_2	64	70	PF00498	0.719
LIG_FHA_2	7	13	PF00498	0.655
LIG_FHA_2	86	92	PF00498	0.778
LIG_IRF3_LxIS_1	224	231	PF10401	0.626
LIG_LIR_Gen_1	136	146	PF02991	0.634
LIG_LIR_Gen_1	20	29	PF02991	0.617
LIG_LIR_Gen_1	203	210	PF02991	0.568
LIG_LIR_Gen_1	262	270	PF02991	0.582
LIG_LIR_Gen_1	344	355	PF02991	0.628
LIG_LIR_Gen_1	379	389	PF02991	0.520
LIG_LIR_Gen_1	489	500	PF02991	0.619
LIG_LIR_Gen_1	75	81	PF02991	0.658
LIG_LIR_Nem_3	136	142	PF02991	0.583
LIG_LIR_Nem_3	20	24	PF02991	0.625
LIG_LIR_Nem_3	203	208	PF02991	0.566
LIG_LIR_Nem_3	262	267	PF02991	0.572
LIG_LIR_Nem_3	344	350	PF02991	0.610
LIG_LIR_Nem_3	38	42	PF02991	0.622
LIG_LIR_Nem_3	489	495	PF02991	0.611
LIG_LIR_Nem_3	75	79	PF02991	0.638
LIG_PCNA_PIPBox_1	431	440	PF02747	0.600
LIG_PDZ_Class_2	632	637	PF00595	0.716
LIG_Pex14_2	420	424	PF04695	0.546
LIG_Pex14_2	500	504	PF04695	0.640
LIG_PTB_Apo_2	55	62	PF02174	0.682
LIG_SH2_CRK	139	143	PF00017	0.636
LIG_SH2_CRK	21	25	PF00017	0.694
LIG_SH2_CRK	614	618	PF00017	0.431
LIG_SH2_PTP2	264	267	PF00017	0.553
LIG_SH2_SRC	28	31	PF00017	0.669
LIG_SH2_STAP1	139	143	PF00017	0.638
LIG_SH2_STAP1	408	412	PF00017	0.706
LIG_SH2_STAP1	582	586	PF00017	0.382
LIG_SH2_STAT3	152	155	PF00017	0.632
LIG_SH2_STAT5	152	155	PF00017	0.613
LIG_SH2_STAT5	21	24	PF00017	0.672
LIG_SH2_STAT5	240	243	PF00017	0.575
LIG_SH2_STAT5	264	267	PF00017	0.498
LIG_SH2_STAT5	28	31	PF00017	0.646
LIG_SH2_STAT5	614	617	PF00017	0.382
LIG_SH2_STAT5	76	79	PF00017	0.639
LIG_SH3_3	10	16	PF00018	0.714
LIG_SH3_3	356	362	PF00018	0.623
LIG_SH3_3	503	509	PF00018	0.621
LIG_SH3_3	583	589	PF00018	0.381
LIG_Sin3_3	364	371	PF02671	0.594
LIG_SUMO_SIM_anti_2	248	256	PF11976	0.643
LIG_SUMO_SIM_par_1	534	539	PF11976	0.535
LIG_SUMO_SIM_par_1	574	580	PF11976	0.408
LIG_TRAF2_1	9	12	PF00917	0.724
LIG_TYR_ITIM	612	617	PF00017	0.358
LIG_UBA3_1	199	204	PF00899	0.568
LIG_UBA3_1	374	380	PF00899	0.563
LIG_WRC_WIRS_1	52	57	PF05994	0.707
LIG_WW_3	104	108	PF00397	0.774
MOD_CK1_1	165	171	PF00069	0.749
MOD_CK1_1	188	194	PF00069	0.758
MOD_CK1_1	231	237	PF00069	0.542
MOD_CK1_1	250	256	PF00069	0.619
MOD_CK1_1	259	265	PF00069	0.630
MOD_CK1_1	31	37	PF00069	0.663
MOD_CK1_1	319	325	PF00069	0.797
MOD_CK1_1	332	338	PF00069	0.645
MOD_CK1_1	399	405	PF00069	0.618
MOD_CK1_1	630	636	PF00069	0.718
MOD_CK2_1	148	154	PF00069	0.587
MOD_CK2_1	338	344	PF00069	0.638
MOD_CK2_1	355	361	PF00069	0.593
MOD_CK2_1	373	379	PF00069	0.447
MOD_CK2_1	6	12	PF00069	0.757
MOD_CK2_1	63	69	PF00069	0.724
MOD_GlcNHglycan	102	105	PF01048	0.597
MOD_GlcNHglycan	109	112	PF01048	0.583
MOD_GlcNHglycan	120	124	PF01048	0.365
MOD_GlcNHglycan	216	219	PF01048	0.386
MOD_GlcNHglycan	318	321	PF01048	0.567
MOD_GlcNHglycan	325	328	PF01048	0.546
MOD_GlcNHglycan	336	339	PF01048	0.370
MOD_GlcNHglycan	38	42	PF01048	0.462
MOD_GSK3_1	107	114	PF00069	0.728
MOD_GSK3_1	165	172	PF00069	0.673
MOD_GSK3_1	186	193	PF00069	0.777
MOD_GSK3_1	210	217	PF00069	0.587
MOD_GSK3_1	239	246	PF00069	0.621
MOD_GSK3_1	247	254	PF00069	0.665
MOD_GSK3_1	255	262	PF00069	0.666
MOD_GSK3_1	282	289	PF00069	0.747
MOD_GSK3_1	319	326	PF00069	0.761
MOD_GSK3_1	328	335	PF00069	0.733
MOD_GSK3_1	396	403	PF00069	0.607
MOD_GSK3_1	532	539	PF00069	0.533
MOD_GSK3_1	85	92	PF00069	0.777
MOD_LATS_1	4	10	PF00433	0.665
MOD_N-GLC_1	57	62	PF02516	0.479
MOD_NEK2_1	19	24	PF00069	0.655
MOD_NEK2_1	239	244	PF00069	0.592
MOD_NEK2_1	305	310	PF00069	0.759
MOD_NEK2_1	336	341	PF00069	0.694
MOD_NEK2_1	424	429	PF00069	0.513
MOD_NEK2_1	491	496	PF00069	0.539
MOD_NEK2_2	373	378	PF00069	0.481
MOD_PIKK_1	228	234	PF00454	0.614
MOD_PIKK_1	319	325	PF00454	0.691
MOD_PIKK_1	329	335	PF00454	0.682
MOD_PKA_1	313	319	PF00069	0.770
MOD_PKA_1	418	424	PF00069	0.587
MOD_PKA_2	355	361	PF00069	0.643
MOD_PKA_2	418	424	PF00069	0.584
MOD_PKA_2	532	538	PF00069	0.560
MOD_PKA_2	627	633	PF00069	0.619
MOD_PKA_2	85	91	PF00069	0.780
MOD_PKB_1	49	57	PF00069	0.681
MOD_Plk_1	19	25	PF00069	0.676
MOD_Plk_1	247	253	PF00069	0.639
MOD_Plk_1	57	63	PF00069	0.683
MOD_Plk_1	84	90	PF00069	0.615
MOD_Plk_2-3	148	154	PF00069	0.584
MOD_Plk_2-3	85	91	PF00069	0.715
MOD_Plk_4	148	154	PF00069	0.605
MOD_Plk_4	19	25	PF00069	0.666
MOD_Plk_4	195	201	PF00069	0.702
MOD_Plk_4	424	430	PF00069	0.492
MOD_Plk_4	491	497	PF00069	0.510
MOD_Plk_4	51	57	PF00069	0.719
MOD_Plk_4	577	583	PF00069	0.537
MOD_Plk_4	72	78	PF00069	0.676
MOD_ProDKin_1	14	20	PF00069	0.699
MOD_ProDKin_1	269	275	PF00069	0.531
MOD_ProDKin_1	410	416	PF00069	0.658
MOD_SUMO_rev_2	231	237	PF00179	0.639
MOD_SUMO_rev_2	291	296	PF00179	0.719
TRG_DiLeu_BaEn_2	123	129	PF01217	0.599
TRG_DiLeu_BaLyEn_6	631	636	PF01217	0.659
TRG_ENDOCYTIC_2	139	142	PF00928	0.638
TRG_ENDOCYTIC_2	21	24	PF00928	0.622
TRG_ENDOCYTIC_2	264	267	PF00928	0.514
TRG_ENDOCYTIC_2	614	617	PF00928	0.374
TRG_ENDOCYTIC_2	76	79	PF00928	0.631
TRG_ER_diArg_1	418	420	PF00400	0.588
TRG_ER_diArg_1	474	476	PF00400	0.536
TRG_ER_diArg_1	49	52	PF00400	0.732
TRG_ER_diArg_1	511	513	PF00400	0.584
TRG_ER_diArg_1	552	554	PF00400	0.654
TRG_NLS_MonoExtN_4	312	317	PF00514	0.758
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWZ8	Leptomonas seymouri	58%	96%
A0A0S4J7H4	Bodo saltans	21%	87%
A0A1X0NDD2	Trypanosomatidae	34%	100%
A0A3R7L723	Trypanosoma rangeli	32%	100%
A4HNX7	Leishmania braziliensis	72%	99%
A4ICL7	Leishmania infantum	100%	100%
B6DT97	Bodo saltans	22%	76%
D0A2U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ASN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q1V9	Leishmania major	94%	100%
V5B9T6	Trypanosoma cruzi	33%	100%