Adenylate kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenylate kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAL6_LEIDO

TriTrypDb:

LdBPK_361410.1 , LdCL_360019600 , LDHU3_36.1790

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A0A3S7XAL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAL6

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	1
GO:0009117	nucleotide metabolic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004017	adenylate kinase activity	6	12
GO:0004127	cytidylate kinase activity	6	1
GO:0004550	nucleoside diphosphate kinase activity	5	1
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.232
CLV_NRD_NRD_1	164	166	PF00675	0.248
CLV_PCSK_KEX2_1	126	128	PF00082	0.232
CLV_PCSK_KEX2_1	164	166	PF00082	0.241
CLV_PCSK_KEX2_1	206	208	PF00082	0.540
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.540
CLV_PCSK_PC7_1	122	128	PF00082	0.230
CLV_PCSK_SKI1_1	102	106	PF00082	0.346
CLV_Separin_Metazoa	97	101	PF03568	0.415
DOC_MAPK_gen_1	102	112	PF00069	0.528

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V0	Leptomonas seymouri	72%	100%
A0A0N0P5M7	Leptomonas seymouri	40%	76%
A0A0N0P6I5	Leptomonas seymouri	29%	92%
A0A0N1I6F5	Leptomonas seymouri	35%	100%
A0A0N1I7A0	Leptomonas seymouri	25%	100%
A0A0N1PD90	Leptomonas seymouri	32%	94%
A0A0S4IL27	Bodo saltans	29%	82%
A0A0S4IL79	Bodo saltans	35%	100%
A0A0S4J1F5	Bodo saltans	27%	91%
A0A0S4JF47	Bodo saltans	50%	100%

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