LeishMANIAdb
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Serine/threonine protein kinase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine protein kinase, putative
Gene product:
protein kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7XAL3_LEIDO
TriTrypDb:
LdBPK_361590.1 * , LdCL_360021300 , LDHU3_36.2040
Length:
496

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 21
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 65
NetGPI no yes: 0, no: 65
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAL3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAL3

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 66
GO:0006793 phosphorus metabolic process 3 66
GO:0006796 phosphate-containing compound metabolic process 4 66
GO:0006807 nitrogen compound metabolic process 2 66
GO:0008152 metabolic process 1 66
GO:0009987 cellular process 1 66
GO:0016310 phosphorylation 5 66
GO:0019538 protein metabolic process 3 66
GO:0036211 protein modification process 4 66
GO:0043170 macromolecule metabolic process 3 66
GO:0043412 macromolecule modification 4 66
GO:0044237 cellular metabolic process 2 66
GO:0044238 primary metabolic process 2 66
GO:0071704 organic substance metabolic process 2 66
GO:1901564 organonitrogen compound metabolic process 3 66
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 66
GO:0003824 catalytic activity 1 66
GO:0004672 protein kinase activity 3 66
GO:0004674 protein serine/threonine kinase activity 4 47
GO:0005488 binding 1 66
GO:0005524 ATP binding 5 66
GO:0016301 kinase activity 4 66
GO:0016740 transferase activity 2 66
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 66
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 66
GO:0017076 purine nucleotide binding 4 66
GO:0030554 adenyl nucleotide binding 5 66
GO:0032553 ribonucleotide binding 3 66
GO:0032555 purine ribonucleotide binding 4 66
GO:0032559 adenyl ribonucleotide binding 5 66
GO:0035639 purine ribonucleoside triphosphate binding 4 66
GO:0036094 small molecule binding 2 66
GO:0043167 ion binding 2 66
GO:0043168 anion binding 3 66
GO:0097159 organic cyclic compound binding 2 66
GO:0097367 carbohydrate derivative binding 2 66
GO:0140096 catalytic activity, acting on a protein 2 66
GO:1901265 nucleoside phosphate binding 3 66
GO:1901363 heterocyclic compound binding 2 66

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 450 454 PF00656 0.406
CLV_NRD_NRD_1 220 222 PF00675 0.268
CLV_NRD_NRD_1 345 347 PF00675 0.519
CLV_NRD_NRD_1 390 392 PF00675 0.300
CLV_NRD_NRD_1 466 468 PF00675 0.362
CLV_PCSK_KEX2_1 104 106 PF00082 0.399
CLV_PCSK_KEX2_1 220 222 PF00082 0.279
CLV_PCSK_KEX2_1 244 246 PF00082 0.295
CLV_PCSK_KEX2_1 289 291 PF00082 0.370
CLV_PCSK_KEX2_1 344 346 PF00082 0.469
CLV_PCSK_KEX2_1 389 391 PF00082 0.319
CLV_PCSK_KEX2_1 466 468 PF00082 0.329
CLV_PCSK_KEX2_1 54 56 PF00082 0.340
CLV_PCSK_PC1ET2_1 104 106 PF00082 0.168
CLV_PCSK_PC1ET2_1 244 246 PF00082 0.259
CLV_PCSK_PC1ET2_1 289 291 PF00082 0.359
CLV_PCSK_PC1ET2_1 389 391 PF00082 0.324
CLV_PCSK_PC1ET2_1 54 56 PF00082 0.305
CLV_PCSK_SKI1_1 169 173 PF00082 0.292
CLV_PCSK_SKI1_1 294 298 PF00082 0.316
CLV_PCSK_SKI1_1 331 335 PF00082 0.434
CLV_PCSK_SKI1_1 378 382 PF00082 0.392
CLV_PCSK_SKI1_1 466 470 PF00082 0.265
DOC_CKS1_1 297 302 PF01111 0.295
DOC_CKS1_1 432 437 PF01111 0.330
DOC_MAPK_gen_1 169 178 PF00069 0.294
DOC_MAPK_gen_1 334 342 PF00069 0.521
DOC_MAPK_gen_1 389 395 PF00069 0.283
DOC_MAPK_MEF2A_6 344 351 PF00069 0.634
DOC_MAPK_MEF2A_6 356 363 PF00069 0.560
DOC_MAPK_RevD_3 231 245 PF00069 0.315
DOC_PP1_RVXF_1 367 373 PF00149 0.494
DOC_PP1_RVXF_1 464 471 PF00149 0.290
DOC_WW_Pin1_4 207 212 PF00397 0.296
DOC_WW_Pin1_4 296 301 PF00397 0.258
DOC_WW_Pin1_4 363 368 PF00397 0.514
DOC_WW_Pin1_4 431 436 PF00397 0.340
LIG_14-3-3_CanoR_1 137 143 PF00244 0.332
LIG_14-3-3_CanoR_1 346 352 PF00244 0.539
LIG_14-3-3_CanoR_1 356 360 PF00244 0.491
LIG_14-3-3_CanoR_1 483 489 PF00244 0.376
LIG_14-3-3_CanoR_1 55 62 PF00244 0.302
LIG_AP2alpha_1 18 22 PF02296 0.352
LIG_APCC_ABBA_1 393 398 PF00400 0.171
LIG_APCC_ABBAyCdc20_2 164 170 PF00400 0.311
LIG_BIR_II_1 1 5 PF00653 0.626
LIG_BRCT_BRCA1_1 432 436 PF00533 0.454
LIG_CaM_IQ_9 416 432 PF13499 0.403
LIG_Clathr_ClatBox_1 413 417 PF01394 0.171
LIG_deltaCOP1_diTrp_1 479 488 PF00928 0.374
LIG_FHA_1 299 305 PF00498 0.434
LIG_FHA_1 328 334 PF00498 0.526
LIG_FHA_1 356 362 PF00498 0.517
LIG_FHA_1 404 410 PF00498 0.368
LIG_FHA_1 45 51 PF00498 0.318
LIG_FHA_2 139 145 PF00498 0.391
LIG_FHA_2 196 202 PF00498 0.340
LIG_FHA_2 26 32 PF00498 0.404
LIG_FHA_2 334 340 PF00498 0.461
LIG_FHA_2 448 454 PF00498 0.403
LIG_Integrin_isoDGR_2 464 466 PF01839 0.171
LIG_IRF3_LxIS_1 300 307 PF10401 0.222
LIG_LIR_Apic_2 210 216 PF02991 0.291
LIG_LIR_Gen_1 188 199 PF02991 0.270
LIG_LIR_Gen_1 433 444 PF02991 0.310
LIG_LIR_Gen_1 91 100 PF02991 0.311
LIG_LIR_Nem_3 433 439 PF02991 0.310
LIG_LIR_Nem_3 440 446 PF02991 0.291
LIG_LIR_Nem_3 487 491 PF02991 0.257
LIG_LIR_Nem_3 91 96 PF02991 0.297
LIG_NRBOX 151 157 PF00104 0.168
LIG_NRBOX 232 238 PF00104 0.266
LIG_PCNA_PIPBox_1 482 491 PF02747 0.171
LIG_PCNA_yPIPBox_3 104 116 PF02747 0.271
LIG_PCNA_yPIPBox_3 273 283 PF02747 0.170
LIG_PCNA_yPIPBox_3 77 88 PF02747 0.255
LIG_Pex14_1 388 392 PF04695 0.295
LIG_Pex14_2 18 22 PF04695 0.395
LIG_Pex14_2 458 462 PF04695 0.324
LIG_PTB_Apo_2 86 93 PF02174 0.289
LIG_SH2_GRB2like 122 125 PF00017 0.338
LIG_SH2_GRB2like 195 198 PF00017 0.430
LIG_SH2_NCK_1 122 126 PF00017 0.327
LIG_SH2_PTP2 213 216 PF00017 0.301
LIG_SH2_PTP2 305 308 PF00017 0.223
LIG_SH2_PTP2 392 395 PF00017 0.171
LIG_SH2_SRC 122 125 PF00017 0.309
LIG_SH2_STAP1 195 199 PF00017 0.297
LIG_SH2_STAP1 224 228 PF00017 0.315
LIG_SH2_STAT5 213 216 PF00017 0.291
LIG_SH2_STAT5 305 308 PF00017 0.365
LIG_SH2_STAT5 392 395 PF00017 0.292
LIG_SH2_STAT5 449 452 PF00017 0.293
LIG_SH3_3 356 362 PF00018 0.510
LIG_SUMO_SIM_anti_2 415 420 PF11976 0.354
LIG_SUMO_SIM_par_1 411 417 PF11976 0.171
LIG_TRAF2_1 336 339 PF00917 0.549
LIG_TYR_ITIM 236 241 PF00017 0.306
LIG_UBA3_1 236 244 PF00899 0.299
LIG_WRC_WIRS_1 485 490 PF05994 0.171
MOD_CDC14_SPxK_1 366 369 PF00782 0.530
MOD_CDK_SPxK_1 363 369 PF00069 0.517
MOD_CDK_SPxxK_3 296 303 PF00069 0.403
MOD_CK1_1 292 298 PF00069 0.454
MOD_CK1_1 319 325 PF00069 0.519
MOD_CK1_1 384 390 PF00069 0.361
MOD_CK1_1 423 429 PF00069 0.305
MOD_CK1_1 44 50 PF00069 0.304
MOD_CK1_1 447 453 PF00069 0.302
MOD_CK1_1 484 490 PF00069 0.439
MOD_CK2_1 138 144 PF00069 0.363
MOD_CK2_1 25 31 PF00069 0.415
MOD_CK2_1 333 339 PF00069 0.431
MOD_CK2_1 434 440 PF00069 0.340
MOD_CK2_1 54 60 PF00069 0.244
MOD_Cter_Amidation 464 467 PF01082 0.315
MOD_GlcNHglycan 1 4 PF01048 0.709
MOD_GlcNHglycan 172 175 PF01048 0.333
MOD_GlcNHglycan 279 282 PF01048 0.345
MOD_GlcNHglycan 314 317 PF01048 0.458
MOD_GlcNHglycan 43 46 PF01048 0.320
MOD_GSK3_1 131 138 PF00069 0.381
MOD_GSK3_1 203 210 PF00069 0.294
MOD_GSK3_1 292 299 PF00069 0.393
MOD_GSK3_1 312 319 PF00069 0.486
MOD_GSK3_1 380 387 PF00069 0.354
MOD_GSK3_1 408 415 PF00069 0.365
MOD_GSK3_1 430 437 PF00069 0.433
MOD_NEK2_1 177 182 PF00069 0.287
MOD_NEK2_1 189 194 PF00069 0.282
MOD_NEK2_1 256 261 PF00069 0.312
MOD_NEK2_1 304 309 PF00069 0.337
MOD_NEK2_1 355 360 PF00069 0.482
MOD_PKA_1 289 295 PF00069 0.342
MOD_PKA_1 54 60 PF00069 0.282
MOD_PKA_2 289 295 PF00069 0.307
MOD_PKA_2 355 361 PF00069 0.496
MOD_PKA_2 423 429 PF00069 0.175
MOD_PKA_2 54 60 PF00069 0.294
MOD_Plk_1 319 325 PF00069 0.537
MOD_Plk_1 384 390 PF00069 0.331
MOD_Plk_2-3 70 76 PF00069 0.325
MOD_Plk_4 274 280 PF00069 0.277
MOD_Plk_4 292 298 PF00069 0.372
MOD_Plk_4 46 52 PF00069 0.306
MOD_Plk_4 484 490 PF00069 0.376
MOD_ProDKin_1 207 213 PF00069 0.296
MOD_ProDKin_1 296 302 PF00069 0.258
MOD_ProDKin_1 363 369 PF00069 0.509
MOD_ProDKin_1 431 437 PF00069 0.340
MOD_SUMO_for_1 23 26 PF00179 0.397
MOD_SUMO_rev_2 127 134 PF00179 0.295
TRG_DiLeu_BaEn_1 83 88 PF01217 0.315
TRG_ENDOCYTIC_2 238 241 PF00928 0.293
TRG_ENDOCYTIC_2 305 308 PF00928 0.393
TRG_ENDOCYTIC_2 392 395 PF00928 0.332
TRG_ENDOCYTIC_2 396 399 PF00928 0.298
TRG_ER_diArg_1 219 221 PF00400 0.272
TRG_ER_diArg_1 344 346 PF00400 0.506
TRG_ER_diArg_1 390 392 PF00400 0.313
TRG_ER_diArg_1 466 468 PF00400 0.368
TRG_NES_CRM1_1 111 121 PF08389 0.168
TRG_NLS_MonoExtN_4 287 292 PF00514 0.171
TRG_Pf-PMV_PEXEL_1 310 314 PF00026 0.454
TRG_Pf-PMV_PEXEL_1 331 335 PF00026 0.463
TRG_Pf-PMV_PEXEL_1 467 471 PF00026 0.275

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3N5 Leptomonas seymouri 35% 100%
A0A0N0P953 Leptomonas seymouri 34% 100%
A0A0N1I9A0 Leptomonas seymouri 30% 76%
A0A0N1PD05 Leptomonas seymouri 34% 100%
A0A0S4IMB7 Bodo saltans 39% 100%
A0A0S4IQ75 Bodo saltans 33% 98%
A0A0S4IRZ7 Bodo saltans 33% 100%
A0A0S4IVW1 Bodo saltans 26% 79%
A0A0S4IX86 Bodo saltans 34% 100%
A0A0S4J7K4 Bodo saltans 27% 100%
A0A0S4J804 Bodo saltans 38% 95%
A0A0S4JIJ6 Bodo saltans 30% 88%
A0A0S4JPZ1 Bodo saltans 33% 100%
A0A0S4JQN5 Bodo saltans 29% 71%
A0A1X0NFW4 Trypanosomatidae 27% 100%
A0A1X0NIA0 Trypanosomatidae 35% 100%
A0A1X0NIX2 Trypanosomatidae 32% 100%
A0A1X0NTL6 Trypanosomatidae 33% 100%
A0A1X0NUB2 Trypanosomatidae 31% 85%
A0A1X0P527 Trypanosomatidae 34% 100%
A0A1X0P549 Trypanosomatidae 36% 100%
A0A1X0P863 Trypanosomatidae 65% 100%
A0A1X0P994 Trypanosomatidae 65% 99%
A0A3Q8IAQ1 Leishmania donovani 42% 100%
A0A3Q8IFK8 Leishmania donovani 38% 100%
A0A3Q8IFW0 Leishmania donovani 35% 93%
A0A3Q8IIG1 Leishmania donovani 29% 100%
A0A3Q8IJM9 Leishmania donovani 36% 98%
A0A3R7KCZ4 Trypanosoma rangeli 35% 100%
A0A3R7MKG5 Trypanosoma rangeli 32% 100%
A0A3R7RIN5 Trypanosoma rangeli 34% 99%
A0A3S5H528 Leishmania donovani 26% 100%
A0A3S7X5M4 Leishmania donovani 31% 100%
A0A3S7X9R4 Leishmania donovani 29% 100%
A0A3S7X9S2 Leishmania donovani 29% 100%
A0A3S7XAT9 Leishmania donovani 85% 99%
A0A422NCP0 Trypanosoma rangeli 65% 100%
A0A422NH41 Trypanosoma rangeli 29% 86%
A0A422NT89 Trypanosoma rangeli 26% 75%
A4HCE6 Leishmania braziliensis 40% 100%
A4HJT5 Leishmania braziliensis 32% 96%
A4HJW2 Leishmania braziliensis 34% 92%
A4HKG9 Leishmania braziliensis 30% 100%
A4HLR0 Leishmania braziliensis 37% 100%
A4HN71 Leishmania braziliensis 29% 100%
A4HNI1 Leishmania braziliensis 36% 100%
A4HP12 Leishmania braziliensis 71% 100%
A4HP13 Leishmania braziliensis 79% 100%
A4HRT2 Leishmania infantum 26% 100%
A4HZW8 Leishmania infantum 42% 100%
A4I435 Leishmania infantum 29% 100%
A4I7A1 Leishmania infantum 38% 100%
A4I7C4 Leishmania infantum 35% 93%
A4I7Z6 Leishmania infantum 31% 100%
A4IBT4 Leishmania infantum 28% 100%
A4IBT9 Leishmania infantum 29% 100%
A4IC37 Leishmania infantum 36% 99%
A4IDC1 Leishmania infantum 73% 100%
A4IDC2 Leishmania infantum 85% 100%
C9ZUU2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 75%
C9ZWI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 100%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 87%
E9ACG8 Leishmania major 26% 100%
E9AFM1 Leishmania major 30% 100%
E9AFZ2 Leishmania major 35% 97%
E9AII8 Leishmania braziliensis 25% 100%
E9ALF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 100%
E9ASS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
E9AUS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 96%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 93%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 99%
O13839 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 69%
O35942 Mus musculus 30% 100%
O74426 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 30% 100%
P10665 Xenopus laevis 26% 68%
P18653 Mus musculus 25% 69%
Q03428 Trypanosoma brucei brucei 35% 100%
Q08942 Trypanosoma brucei brucei 35% 100%
Q15418 Homo sapiens 25% 67%
Q4Q1S3 Leishmania major 83% 100%
Q4Q1S4 Leishmania major 72% 100%
Q4Q598 Leishmania major 31% 100%
Q4Q5T9 Leishmania major 35% 93%
Q4Q5W2 Leishmania major 38% 100%
Q4Q7W2 Leishmania major 29% 100%
Q4Q9K2 Leishmania major 30% 100%
Q4QBQ2 Leishmania major 41% 100%
Q5KQF5 Oryza sativa subsp. japonica 28% 100%
Q63531 Rattus norvegicus 25% 67%
Q9GNR4 Leishmania major 30% 100%
V5BHW8 Trypanosoma cruzi 25% 78%
V5BPJ0 Trypanosoma cruzi 66% 100%
V5C224 Trypanosoma cruzi 35% 99%
V5D579 Trypanosoma cruzi 35% 100%
V5DFW9 Trypanosoma cruzi 30% 85%
V5DKY9 Trypanosoma cruzi 34% 80%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS