Zn-finger in Ran binding protein and others, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in Ran binding protein and others, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAK2_LEIDO

TriTrypDb:

LdBPK_361480.1 , LdCL_360020300 , LDHU3_36.1890

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAK2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.571
CLV_NRD_NRD_1	175	177	PF00675	0.599
CLV_NRD_NRD_1	257	259	PF00675	0.619
CLV_NRD_NRD_1	407	409	PF00675	0.475
CLV_NRD_NRD_1	542	544	PF00675	0.392
CLV_NRD_NRD_1	555	557	PF00675	0.553
CLV_NRD_NRD_1	89	91	PF00675	0.599
CLV_PCSK_KEX2_1	175	177	PF00082	0.599
CLV_PCSK_KEX2_1	257	259	PF00082	0.674
CLV_PCSK_KEX2_1	407	409	PF00082	0.466
CLV_PCSK_SKI1_1	175	179	PF00082	0.545
CLV_PCSK_SKI1_1	231	235	PF00082	0.598
CLV_PCSK_SKI1_1	544	548	PF00082	0.607
CLV_PCSK_SKI1_1	557	561	PF00082	0.582
CLV_Separin_Metazoa	172	176	PF03568	0.596
DOC_CKS1_1	21	26	PF01111	0.672
DOC_CYCLIN_RxL_1	228	236	PF00134	0.500
DOC_PP4_FxxP_1	203	206	PF00568	0.668
DOC_USP7_MATH_1	549	553	PF00917	0.722
DOC_USP7_MATH_1	78	82	PF00917	0.571
DOC_USP7_UBL2_3	525	529	PF12436	0.363
DOC_WW_Pin1_4	20	25	PF00397	0.680
DOC_WW_Pin1_4	249	254	PF00397	0.659
DOC_WW_Pin1_4	305	310	PF00397	0.549
DOC_WW_Pin1_4	413	418	PF00397	0.475
DOC_WW_Pin1_4	437	442	PF00397	0.652
DOC_WW_Pin1_4	487	492	PF00397	0.677
LIG_14-3-3_CanoR_1	175	184	PF00244	0.543
LIG_14-3-3_CanoR_1	27	31	PF00244	0.682
LIG_14-3-3_CanoR_1	285	294	PF00244	0.569
LIG_14-3-3_CanoR_1	476	484	PF00244	0.644
LIG_14-3-3_CanoR_1	54	60	PF00244	0.673
LIG_14-3-3_CanoR_1	551	556	PF00244	0.675
LIG_14-3-3_CanoR_1	64	68	PF00244	0.551
LIG_AP2alpha_2	428	430	PF02296	0.566
LIG_BRCT_BRCA1_1	131	135	PF00533	0.426
LIG_BRCT_BRCA1_1	325	329	PF00533	0.480
LIG_BRCT_BRCA1_1	35	39	PF00533	0.678
LIG_BRCT_BRCA1_1	527	531	PF00533	0.348
LIG_CSL_BTD_1	21	24	PF09270	0.615
LIG_FHA_1	179	185	PF00498	0.500
LIG_FHA_1	227	233	PF00498	0.705
LIG_FHA_1	345	351	PF00498	0.564
LIG_FHA_1	58	64	PF00498	0.590
LIG_FHA_1	7	13	PF00498	0.657
LIG_FHA_2	195	201	PF00498	0.636
LIG_FHA_2	264	270	PF00498	0.687
LIG_FHA_2	306	312	PF00498	0.515
LIG_FHA_2	367	373	PF00498	0.688
LIG_FHA_2	465	471	PF00498	0.587
LIG_HOMEOBOX	280	283	PF00046	0.486
LIG_LIR_Apic_2	200	206	PF02991	0.654
LIG_LIR_Apic_2	310	315	PF02991	0.566
LIG_LIR_Gen_1	189	199	PF02991	0.488
LIG_LIR_Nem_3	113	119	PF02991	0.465
LIG_LIR_Nem_3	189	194	PF02991	0.478
LIG_PDZ_Class_2	556	561	PF00595	0.610
LIG_Pex14_1	455	459	PF04695	0.606
LIG_SH2_CRK	116	120	PF00017	0.482
LIG_SH2_CRK	56	60	PF00017	0.733
LIG_SH2_NCK_1	161	165	PF00017	0.386
LIG_SH2_NCK_1	196	200	PF00017	0.626
LIG_SH2_STAP1	527	531	PF00017	0.449
LIG_SH2_STAT3	384	387	PF00017	0.746
LIG_SH2_STAT5	196	199	PF00017	0.568
LIG_SH2_STAT5	330	333	PF00017	0.510
LIG_SH2_STAT5	384	387	PF00017	0.755
LIG_SH2_STAT5	396	399	PF00017	0.344
LIG_SH2_STAT5	459	462	PF00017	0.604
LIG_SH2_STAT5	56	59	PF00017	0.694
LIG_SH3_3	15	21	PF00018	0.679
LIG_SH3_3	271	277	PF00018	0.627
LIG_SH3_3	416	422	PF00018	0.453
LIG_SH3_3	423	429	PF00018	0.719
LIG_SH3_3	443	449	PF00018	0.728
LIG_SH3_3	552	558	PF00018	0.617
LIG_SH3_CIN85_PxpxPR_1	363	368	PF14604	0.622
LIG_TRAF2_1	169	172	PF00917	0.538
LIG_TYR_ITIM	114	119	PF00017	0.459
MOD_CDK_SPK_2	413	418	PF00069	0.475
MOD_CDK_SPxxK_3	20	27	PF00069	0.628
MOD_CK1_1	33	39	PF00069	0.629
MOD_CK1_1	406	412	PF00069	0.362
MOD_CK1_1	514	520	PF00069	0.475
MOD_CK1_1	66	72	PF00069	0.622
MOD_CK1_1	95	101	PF00069	0.500
MOD_CK2_1	164	170	PF00069	0.453
MOD_CK2_1	192	198	PF00069	0.516
MOD_CK2_1	263	269	PF00069	0.702
MOD_CK2_1	305	311	PF00069	0.529
MOD_CK2_1	366	372	PF00069	0.697
MOD_GlcNHglycan	235	238	PF01048	0.480
MOD_GlcNHglycan	341	344	PF01048	0.479
MOD_GlcNHglycan	430	433	PF01048	0.727
MOD_GlcNHglycan	46	49	PF01048	0.708
MOD_GlcNHglycan	505	508	PF01048	0.707
MOD_GlcNHglycan	51	54	PF01048	0.709
MOD_GlcNHglycan	516	519	PF01048	0.253
MOD_GSK3_1	190	197	PF00069	0.559
MOD_GSK3_1	26	33	PF00069	0.672
MOD_GSK3_1	460	467	PF00069	0.466
MOD_GSK3_1	483	490	PF00069	0.617
MOD_GSK3_1	547	554	PF00069	0.697
MOD_GSK3_1	55	62	PF00069	0.646
MOD_N-GLC_1	285	290	PF02516	0.613
MOD_N-GLC_1	403	408	PF02516	0.425
MOD_N-GLC_1	511	516	PF02516	0.628
MOD_NEK2_1	233	238	PF00069	0.485
MOD_NEK2_1	30	35	PF00069	0.680
MOD_NEK2_1	316	321	PF00069	0.486
MOD_NEK2_1	323	328	PF00069	0.452
MOD_NEK2_1	403	408	PF00069	0.449
MOD_NEK2_1	412	417	PF00069	0.449
MOD_NEK2_1	511	516	PF00069	0.628
MOD_NEK2_1	59	64	PF00069	0.615
MOD_NEK2_2	346	351	PF00069	0.435
MOD_NEK2_2	78	83	PF00069	0.567
MOD_OFUCOSY	284	289	PF10250	0.498
MOD_OFUCOSY	77	82	PF10250	0.559
MOD_PIKK_1	483	489	PF00454	0.635
MOD_PIKK_1	6	12	PF00454	0.614
MOD_PK_1	551	557	PF00069	0.675
MOD_PKA_1	175	181	PF00069	0.547
MOD_PKA_2	175	181	PF00069	0.564
MOD_PKA_2	26	32	PF00069	0.716
MOD_PKA_2	284	290	PF00069	0.585
MOD_PKA_2	406	412	PF00069	0.388
MOD_PKA_2	475	481	PF00069	0.551
MOD_PKA_2	550	556	PF00069	0.712
MOD_PKA_2	63	69	PF00069	0.621
MOD_Plk_1	178	184	PF00069	0.503
MOD_Plk_1	296	302	PF00069	0.556
MOD_Plk_1	511	517	PF00069	0.621
MOD_Plk_2-3	192	198	PF00069	0.610
MOD_Plk_2-3	366	372	PF00069	0.663
MOD_Plk_4	178	184	PF00069	0.627
MOD_Plk_4	26	32	PF00069	0.680
MOD_Plk_4	263	269	PF00069	0.709
MOD_Plk_4	346	352	PF00069	0.480
MOD_ProDKin_1	20	26	PF00069	0.682
MOD_ProDKin_1	249	255	PF00069	0.662
MOD_ProDKin_1	305	311	PF00069	0.551
MOD_ProDKin_1	413	419	PF00069	0.475
MOD_ProDKin_1	437	443	PF00069	0.655
MOD_ProDKin_1	487	493	PF00069	0.680
TRG_DiLeu_BaEn_1	99	104	PF01217	0.583
TRG_ENDOCYTIC_2	116	119	PF00928	0.480
TRG_ENDOCYTIC_2	56	59	PF00928	0.711
TRG_ER_diArg_1	174	176	PF00400	0.597
TRG_ER_diArg_1	465	468	PF00400	0.487
TRG_ER_diArg_1	531	534	PF00400	0.482
TRG_NLS_MonoExtC_3	119	124	PF00514	0.563
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3U7	Leptomonas seymouri	53%	98%
A0A0S4JG42	Bodo saltans	38%	100%
A0A1X0P892	Trypanosomatidae	46%	100%
A0A3R7KC50	Trypanosoma rangeli	46%	100%
A4HP02	Leishmania braziliensis	75%	100%
A4ICJ4	Leishmania infantum	99%	100%
D0A2X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ASR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1T4	Leishmania major	94%	100%
V5BJY2	Trypanosoma cruzi	46%	100%