Endonuclease/exonuclease/phosphatase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease/exonuclease/phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XAJ4_LEIDO

TriTrypDb:

LdCL_360017200 , LDHU3_36.1550

Length:

928

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAJ4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019637	organophosphate metabolic process	3	7
GO:0030258	lipid modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0046839	phospholipid dephosphorylation	5	7
GO:0046856	phosphatidylinositol dephosphorylation	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0005975	carbohydrate metabolic process	3	1
GO:0006066	alcohol metabolic process	3	1
GO:0009056	catabolic process	2	1
GO:0019751	polyol metabolic process	4	1
GO:0043647	inositol phosphate metabolic process	4	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046164	alcohol catabolic process	4	1
GO:0046174	polyol catabolic process	5	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	1
GO:0046855	obsolete inositol phosphate dephosphorylation	5	1
GO:0071545	inositol phosphate catabolic process	5	1
GO:1901575	organic substance catabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901616	organic hydroxy compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004527	exonuclease activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	8	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	7	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	7	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.712
CLV_C14_Caspase3-7	230	234	PF00656	0.714
CLV_C14_Caspase3-7	326	330	PF00656	0.729
CLV_C14_Caspase3-7	598	602	PF00656	0.819
CLV_C14_Caspase3-7	640	644	PF00656	0.718
CLV_C14_Caspase3-7	662	666	PF00656	0.604
CLV_NRD_NRD_1	140	142	PF00675	0.643
CLV_NRD_NRD_1	206	208	PF00675	0.752
CLV_NRD_NRD_1	217	219	PF00675	0.715
CLV_NRD_NRD_1	268	270	PF00675	0.681
CLV_NRD_NRD_1	425	427	PF00675	0.625
CLV_NRD_NRD_1	459	461	PF00675	0.481
CLV_NRD_NRD_1	718	720	PF00675	0.468
CLV_NRD_NRD_1	722	724	PF00675	0.507
CLV_NRD_NRD_1	731	733	PF00675	0.599
CLV_NRD_NRD_1	777	779	PF00675	0.678
CLV_NRD_NRD_1	781	783	PF00675	0.503
CLV_NRD_NRD_1	804	806	PF00675	0.518
CLV_NRD_NRD_1	894	896	PF00675	0.492
CLV_PCSK_FUR_1	266	270	PF00082	0.682
CLV_PCSK_KEX2_1	206	208	PF00082	0.734
CLV_PCSK_KEX2_1	217	219	PF00082	0.675
CLV_PCSK_KEX2_1	268	270	PF00082	0.681
CLV_PCSK_KEX2_1	425	427	PF00082	0.521
CLV_PCSK_KEX2_1	458	460	PF00082	0.470
CLV_PCSK_KEX2_1	536	538	PF00082	0.627
CLV_PCSK_KEX2_1	718	720	PF00082	0.476
CLV_PCSK_KEX2_1	777	779	PF00082	0.677
CLV_PCSK_KEX2_1	781	783	PF00082	0.513
CLV_PCSK_KEX2_1	887	889	PF00082	0.549
CLV_PCSK_KEX2_1	894	896	PF00082	0.481
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.627
CLV_PCSK_PC1ET2_1	777	779	PF00082	0.676
CLV_PCSK_PC1ET2_1	887	889	PF00082	0.617
CLV_PCSK_SKI1_1	247	251	PF00082	0.585
CLV_PCSK_SKI1_1	537	541	PF00082	0.700
CLV_PCSK_SKI1_1	723	727	PF00082	0.508
CLV_PCSK_SKI1_1	733	737	PF00082	0.652
CLV_PCSK_SKI1_1	782	786	PF00082	0.489
CLV_PCSK_SKI1_1	819	823	PF00082	0.508
DEG_Kelch_Keap1_1	173	178	PF01344	0.588
DEG_SCF_FBW7_1	16	23	PF00400	0.588
DOC_CKS1_1	118	123	PF01111	0.711
DOC_CKS1_1	369	374	PF01111	0.374
DOC_CYCLIN_RxL_1	100	112	PF00134	0.524
DOC_MAPK_gen_1	723	730	PF00069	0.439
DOC_MAPK_gen_1	894	900	PF00069	0.482
DOC_MAPK_MEF2A_6	486	495	PF00069	0.458
DOC_MAPK_RevD_3	764	778	PF00069	0.637
DOC_PP1_RVXF_1	245	252	PF00149	0.517
DOC_PP2B_LxvP_1	766	769	PF13499	0.690
DOC_PP4_FxxP_1	352	355	PF00568	0.554
DOC_USP7_MATH_1	143	147	PF00917	0.813
DOC_USP7_MATH_1	184	188	PF00917	0.749
DOC_USP7_MATH_1	227	231	PF00917	0.817
DOC_USP7_MATH_1	304	308	PF00917	0.707
DOC_USP7_MATH_1	34	38	PF00917	0.729
DOC_USP7_MATH_1	469	473	PF00917	0.499
DOC_USP7_MATH_1	513	517	PF00917	0.776
DOC_USP7_MATH_1	522	526	PF00917	0.696
DOC_USP7_MATH_1	575	579	PF00917	0.656
DOC_USP7_MATH_1	644	648	PF00917	0.713
DOC_USP7_MATH_1	769	773	PF00917	0.655
DOC_USP7_MATH_1	89	93	PF00917	0.755
DOC_USP7_MATH_2	625	631	PF00917	0.696
DOC_WW_Pin1_4	117	122	PF00397	0.704
DOC_WW_Pin1_4	16	21	PF00397	0.719
DOC_WW_Pin1_4	189	194	PF00397	0.584
DOC_WW_Pin1_4	219	224	PF00397	0.778
DOC_WW_Pin1_4	260	265	PF00397	0.720
DOC_WW_Pin1_4	368	373	PF00397	0.534
DOC_WW_Pin1_4	495	500	PF00397	0.535
DOC_WW_Pin1_4	530	535	PF00397	0.727
DOC_WW_Pin1_4	538	543	PF00397	0.796
DOC_WW_Pin1_4	621	626	PF00397	0.632
DOC_WW_Pin1_4	677	682	PF00397	0.749
LIG_14-3-3_CanoR_1	104	109	PF00244	0.813
LIG_14-3-3_CanoR_1	110	114	PF00244	0.768
LIG_14-3-3_CanoR_1	185	193	PF00244	0.739
LIG_14-3-3_CanoR_1	207	213	PF00244	0.670
LIG_14-3-3_CanoR_1	278	283	PF00244	0.610
LIG_14-3-3_CanoR_1	468	478	PF00244	0.482
LIG_14-3-3_CanoR_1	537	542	PF00244	0.731
LIG_14-3-3_CanoR_1	631	637	PF00244	0.794
LIG_14-3-3_CanoR_1	888	896	PF00244	0.563
LIG_14-3-3_CanoR_1	899	907	PF00244	0.417
LIG_14-3-3_CanoR_1	908	916	PF00244	0.239
LIG_14-3-3_CanoR_1	94	102	PF00244	0.636
LIG_14-3-3_CterR_2	924	928	PF00244	0.666
LIG_APCC_ABBA_1	898	903	PF00400	0.484
LIG_BIR_III_2	168	172	PF00653	0.699
LIG_BIR_III_2	501	505	PF00653	0.672
LIG_BIR_III_4	585	589	PF00653	0.570
LIG_BRCT_BRCA1_1	555	559	PF00533	0.706
LIG_CSL_BTD_1	369	372	PF09270	0.480
LIG_eIF4E_1	401	407	PF01652	0.474
LIG_FHA_1	220	226	PF00498	0.784
LIG_FHA_1	277	283	PF00498	0.638
LIG_FHA_1	292	298	PF00498	0.784
LIG_FHA_1	349	355	PF00498	0.604
LIG_FHA_1	36	42	PF00498	0.603
LIG_FHA_1	390	396	PF00498	0.494
LIG_FHA_1	426	432	PF00498	0.505
LIG_FHA_1	474	480	PF00498	0.633
LIG_FHA_1	603	609	PF00498	0.667
LIG_FHA_1	688	694	PF00498	0.465
LIG_FHA_2	233	239	PF00498	0.702
LIG_FHA_2	496	502	PF00498	0.671
LIG_FHA_2	613	619	PF00498	0.715
LIG_FHA_2	631	637	PF00498	0.529
LIG_FHA_2	64	70	PF00498	0.583
LIG_FHA_2	861	867	PF00498	0.594
LIG_FHA_2	94	100	PF00498	0.735
LIG_GBD_Chelix_1	489	497	PF00786	0.468
LIG_HP1_1	914	918	PF01393	0.455
LIG_IBAR_NPY_1	579	581	PF08397	0.684
LIG_Integrin_RGD_1	364	366	PF01839	0.655
LIG_Integrin_RGD_1	663	665	PF01839	0.607
LIG_LIR_Apic_2	350	355	PF02991	0.554
LIG_LIR_Gen_1	248	258	PF02991	0.648
LIG_LIR_Gen_1	680	691	PF02991	0.502
LIG_LIR_Nem_3	248	254	PF02991	0.482
LIG_LIR_Nem_3	587	593	PF02991	0.752
LIG_LIR_Nem_3	680	686	PF02991	0.532
LIG_LIR_Nem_3	706	710	PF02991	0.488
LIG_MYND_1	117	121	PF01753	0.702
LIG_PTAP_UEV_1	120	125	PF05743	0.603
LIG_Rb_pABgroove_1	913	921	PF01858	0.456
LIG_REV1ctd_RIR_1	723	731	PF16727	0.489
LIG_SH2_CRK	590	594	PF00017	0.696
LIG_SH2_CRK	683	687	PF00017	0.483
LIG_SH2_CRK	707	711	PF00017	0.500
LIG_SH2_GRB2like	199	202	PF00017	0.689
LIG_SH2_NCK_1	901	905	PF00017	0.474
LIG_SH2_STAP1	854	858	PF00017	0.629
LIG_SH2_STAT3	199	202	PF00017	0.689
LIG_SH2_STAT3	712	715	PF00017	0.519
LIG_SH2_STAT3	810	813	PF00017	0.474
LIG_SH2_STAT5	380	383	PF00017	0.448
LIG_SH2_STAT5	417	420	PF00017	0.669
LIG_SH2_STAT5	465	468	PF00017	0.497
LIG_SH2_STAT5	810	813	PF00017	0.500
LIG_SH2_STAT5	879	882	PF00017	0.447
LIG_SH2_STAT5	901	904	PF00017	0.466
LIG_SH3_2	372	377	PF14604	0.492
LIG_SH3_3	108	114	PF00018	0.761
LIG_SH3_3	115	121	PF00018	0.712
LIG_SH3_3	137	143	PF00018	0.797
LIG_SH3_3	147	153	PF00018	0.703
LIG_SH3_3	369	375	PF00018	0.514
LIG_SH3_3	515	521	PF00018	0.599
LIG_SH3_3	567	573	PF00018	0.612
LIG_SH3_3	619	625	PF00018	0.768
LIG_SH3_5	195	199	PF00018	0.639
LIG_SUMO_SIM_anti_2	235	241	PF11976	0.605
LIG_SUMO_SIM_par_1	278	284	PF11976	0.567
LIG_SUMO_SIM_par_1	405	411	PF11976	0.448
LIG_SUMO_SIM_par_1	493	498	PF11976	0.492
LIG_SUMO_SIM_par_1	914	920	PF11976	0.455
LIG_UBA3_1	478	486	PF00899	0.563
MOD_CDC14_SPxK_1	263	266	PF00782	0.667
MOD_CDK_SPK_2	219	224	PF00069	0.607
MOD_CDK_SPK_2	495	500	PF00069	0.535
MOD_CDK_SPxK_1	260	266	PF00069	0.661
MOD_CDK_SPxK_1	368	374	PF00069	0.387
MOD_CDK_SPxK_1	530	536	PF00069	0.779
MOD_CDK_SPxxK_3	530	537	PF00069	0.581
MOD_CK1_1	15	21	PF00069	0.812
MOD_CK1_1	160	166	PF00069	0.665
MOD_CK1_1	173	179	PF00069	0.794
MOD_CK1_1	232	238	PF00069	0.700
MOD_CK1_1	281	287	PF00069	0.691
MOD_CK1_1	307	313	PF00069	0.789
MOD_CK1_1	525	531	PF00069	0.635
MOD_CK1_1	538	544	PF00069	0.643
MOD_CK1_1	562	568	PF00069	0.633
MOD_CK1_1	630	636	PF00069	0.777
MOD_CK1_1	92	98	PF00069	0.731
MOD_CK2_1	160	166	PF00069	0.582
MOD_CK2_1	172	178	PF00069	0.537
MOD_CK2_1	256	262	PF00069	0.640
MOD_CK2_1	344	350	PF00069	0.647
MOD_CK2_1	612	618	PF00069	0.720
MOD_CK2_1	621	627	PF00069	0.667
MOD_CK2_1	630	636	PF00069	0.691
MOD_CK2_1	769	775	PF00069	0.634
MOD_CK2_1	860	866	PF00069	0.590
MOD_Cter_Amidation	716	719	PF01082	0.472
MOD_Cter_Amidation	730	733	PF01082	0.589
MOD_DYRK1A_RPxSP_1	189	193	PF00069	0.582
MOD_GlcNHglycan	131	134	PF01048	0.765
MOD_GlcNHglycan	157	160	PF01048	0.621
MOD_GlcNHglycan	258	261	PF01048	0.641
MOD_GlcNHglycan	285	288	PF01048	0.744
MOD_GlcNHglycan	316	319	PF01048	0.673
MOD_GlcNHglycan	394	398	PF01048	0.494
MOD_GlcNHglycan	515	518	PF01048	0.685
MOD_GlcNHglycan	527	530	PF01048	0.713
MOD_GlcNHglycan	53	56	PF01048	0.667
MOD_GlcNHglycan	537	540	PF01048	0.587
MOD_GlcNHglycan	554	558	PF01048	0.597
MOD_GlcNHglycan	564	567	PF01048	0.759
MOD_GlcNHglycan	71	75	PF01048	0.634
MOD_GlcNHglycan	855	859	PF01048	0.655
MOD_GlcNHglycan	890	893	PF01048	0.494
MOD_GSK3_1	100	107	PF00069	0.730
MOD_GSK3_1	119	126	PF00069	0.683
MOD_GSK3_1	12	19	PF00069	0.841
MOD_GSK3_1	189	196	PF00069	0.749
MOD_GSK3_1	245	252	PF00069	0.683
MOD_GSK3_1	256	263	PF00069	0.639
MOD_GSK3_1	272	279	PF00069	0.632
MOD_GSK3_1	283	290	PF00069	0.690
MOD_GSK3_1	30	37	PF00069	0.708
MOD_GSK3_1	300	307	PF00069	0.741
MOD_GSK3_1	325	332	PF00069	0.692
MOD_GSK3_1	344	351	PF00069	0.542
MOD_GSK3_1	389	396	PF00069	0.527
MOD_GSK3_1	425	432	PF00069	0.514
MOD_GSK3_1	469	476	PF00069	0.484
MOD_GSK3_1	51	58	PF00069	0.752
MOD_GSK3_1	59	66	PF00069	0.779
MOD_GSK3_1	627	634	PF00069	0.714
MOD_GSK3_1	644	651	PF00069	0.785
MOD_GSK3_1	687	694	PF00069	0.482
MOD_GSK3_1	813	820	PF00069	0.569
MOD_GSK3_1	84	91	PF00069	0.716
MOD_GSK3_1	920	927	PF00069	0.603
MOD_LATS_1	423	429	PF00433	0.422
MOD_N-GLC_1	329	334	PF02516	0.629
MOD_N-GLC_1	59	64	PF02516	0.818
MOD_N-GLC_1	602	607	PF02516	0.820
MOD_N-GLC_1	631	636	PF02516	0.691
MOD_N-GLC_1	677	682	PF02516	0.727
MOD_N-GLC_1	78	83	PF02516	0.506
MOD_N-GLC_1	801	806	PF02516	0.499
MOD_N-GLC_1	867	872	PF02516	0.551
MOD_NEK2_1	250	255	PF00069	0.714
MOD_NEK2_1	272	277	PF00069	0.572
MOD_NEK2_1	300	305	PF00069	0.757
MOD_NEK2_1	493	498	PF00069	0.534
MOD_NEK2_1	51	56	PF00069	0.599
MOD_NEK2_1	545	550	PF00069	0.657
MOD_NEK2_1	559	564	PF00069	0.749
MOD_NEK2_1	687	692	PF00069	0.461
MOD_NEK2_1	7	12	PF00069	0.584
MOD_NEK2_1	788	793	PF00069	0.443
MOD_NEK2_1	84	89	PF00069	0.662
MOD_NEK2_1	93	98	PF00069	0.752
MOD_NEK2_2	89	94	PF00069	0.581
MOD_PIKK_1	170	176	PF00454	0.657
MOD_PIKK_1	184	190	PF00454	0.763
MOD_PIKK_1	20	26	PF00454	0.578
MOD_PIKK_1	305	311	PF00454	0.615
MOD_PIKK_1	408	414	PF00454	0.431
MOD_PIKK_1	429	435	PF00454	0.480
MOD_PIKK_1	648	654	PF00454	0.767
MOD_PK_1	278	284	PF00069	0.720
MOD_PKA_1	425	431	PF00069	0.518
MOD_PKA_1	887	893	PF00069	0.604
MOD_PKA_2	109	115	PF00069	0.674
MOD_PKA_2	184	190	PF00069	0.787
MOD_PKA_2	25	31	PF00069	0.743
MOD_PKA_2	348	354	PF00069	0.565
MOD_PKA_2	425	431	PF00069	0.518
MOD_PKA_2	630	636	PF00069	0.742
MOD_PKA_2	648	654	PF00069	0.654
MOD_PKA_2	848	854	PF00069	0.545
MOD_PKA_2	887	893	PF00069	0.604
MOD_PKA_2	907	913	PF00069	0.244
MOD_PKA_2	93	99	PF00069	0.637
MOD_Plk_1	545	551	PF00069	0.694
MOD_Plk_1	788	794	PF00069	0.442
MOD_Plk_2-3	612	618	PF00069	0.661
MOD_Plk_2-3	742	748	PF00069	0.777
MOD_Plk_2-3	826	832	PF00069	0.464
MOD_Plk_4	104	110	PF00069	0.617
MOD_Plk_4	545	551	PF00069	0.723
MOD_Plk_4	612	618	PF00069	0.769
MOD_Plk_4	682	688	PF00069	0.435
MOD_Plk_4	788	794	PF00069	0.442
MOD_ProDKin_1	117	123	PF00069	0.704
MOD_ProDKin_1	16	22	PF00069	0.721
MOD_ProDKin_1	189	195	PF00069	0.578
MOD_ProDKin_1	219	225	PF00069	0.777
MOD_ProDKin_1	260	266	PF00069	0.724
MOD_ProDKin_1	368	374	PF00069	0.532
MOD_ProDKin_1	495	501	PF00069	0.552
MOD_ProDKin_1	530	536	PF00069	0.728
MOD_ProDKin_1	538	544	PF00069	0.797
MOD_ProDKin_1	621	627	PF00069	0.632
MOD_ProDKin_1	677	683	PF00069	0.734
MOD_SUMO_rev_2	360	369	PF00179	0.612
TRG_DiLeu_BaEn_1	589	594	PF01217	0.726
TRG_ENDOCYTIC_2	4	7	PF00928	0.514
TRG_ENDOCYTIC_2	440	443	PF00928	0.465
TRG_ENDOCYTIC_2	590	593	PF00928	0.736
TRG_ENDOCYTIC_2	683	686	PF00928	0.488
TRG_ENDOCYTIC_2	707	710	PF00928	0.492
TRG_ENDOCYTIC_2	722	725	PF00928	0.514
TRG_ENDOCYTIC_2	901	904	PF00928	0.466
TRG_ER_diArg_1	206	208	PF00400	0.648
TRG_ER_diArg_1	216	218	PF00400	0.701
TRG_ER_diArg_1	266	269	PF00400	0.683
TRG_ER_diArg_1	425	427	PF00400	0.614
TRG_ER_diArg_1	458	460	PF00400	0.592
TRG_ER_diArg_1	780	782	PF00400	0.633
TRG_ER_diArg_1	894	896	PF00400	0.492
TRG_NLS_Bipartite_1	718	736	PF00514	0.511
TRG_NLS_Bipartite_1	872	890	PF00514	0.588
TRG_NLS_MonoExtC_3	731	737	PF00514	0.643
TRG_NLS_MonoExtC_3	776	781	PF00514	0.744
TRG_NLS_MonoExtN_4	777	782	PF00514	0.710

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEB1	Leptomonas seymouri	57%	100%
A4HNX5	Leishmania braziliensis	54%	99%
A4ICL9	Leishmania infantum	99%	100%
E9ASN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q1W1	Leishmania major	85%	100%