Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAJ3_LEIDO

TriTrypDb:

LdBPK_361370.1 , LdCL_360018800 , LDHU3_36.1720

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	383	387	PF00656	0.545
CLV_MEL_PAP_1	133	139	PF00089	0.521
CLV_NRD_NRD_1	146	148	PF00675	0.488
CLV_NRD_NRD_1	151	153	PF00675	0.489
CLV_NRD_NRD_1	17	19	PF00675	0.738
CLV_NRD_NRD_1	206	208	PF00675	0.604
CLV_NRD_NRD_1	233	235	PF00675	0.615
CLV_NRD_NRD_1	342	344	PF00675	0.643
CLV_NRD_NRD_1	80	82	PF00675	0.625
CLV_PCSK_KEX2_1	145	147	PF00082	0.497
CLV_PCSK_KEX2_1	17	19	PF00082	0.738
CLV_PCSK_KEX2_1	206	208	PF00082	0.580
CLV_PCSK_KEX2_1	233	235	PF00082	0.570
CLV_PCSK_KEX2_1	342	344	PF00082	0.625
CLV_PCSK_KEX2_1	80	82	PF00082	0.767
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.625
CLV_PCSK_SKI1_1	185	189	PF00082	0.441
DEG_SPOP_SBC_1	295	299	PF00917	0.635
DEG_SPOP_SBC_1	306	310	PF00917	0.529
DOC_CKS1_1	86	91	PF01111	0.636
DOC_CKS1_1	92	97	PF01111	0.564
DOC_MAPK_gen_1	152	160	PF00069	0.454
DOC_MAPK_gen_1	17	27	PF00069	0.689
DOC_MAPK_MEF2A_6	153	162	PF00069	0.366
DOC_MAPK_RevD_3	133	146	PF00069	0.445
DOC_PP1_RVXF_1	191	197	PF00149	0.407
DOC_USP7_MATH_1	295	299	PF00917	0.684
DOC_USP7_MATH_1	38	42	PF00917	0.627
DOC_USP7_MATH_1	397	401	PF00917	0.620
DOC_USP7_MATH_1	55	59	PF00917	0.597
DOC_USP7_MATH_1	8	12	PF00917	0.592
DOC_USP7_UBL2_3	36	40	PF12436	0.651
DOC_WW_Pin1_4	100	105	PF00397	0.649
DOC_WW_Pin1_4	205	210	PF00397	0.512
DOC_WW_Pin1_4	248	253	PF00397	0.460
DOC_WW_Pin1_4	332	337	PF00397	0.623
DOC_WW_Pin1_4	356	361	PF00397	0.684
DOC_WW_Pin1_4	56	61	PF00397	0.718
DOC_WW_Pin1_4	85	90	PF00397	0.654
DOC_WW_Pin1_4	91	96	PF00397	0.561
LIG_14-3-3_CanoR_1	136	142	PF00244	0.587
LIG_14-3-3_CanoR_1	17	27	PF00244	0.717
LIG_14-3-3_CanoR_1	185	191	PF00244	0.439
LIG_14-3-3_CanoR_1	218	224	PF00244	0.486
LIG_14-3-3_CanoR_1	233	241	PF00244	0.403
LIG_14-3-3_CanoR_1	259	268	PF00244	0.524
LIG_14-3-3_CanoR_1	30	38	PF00244	0.629
LIG_14-3-3_CanoR_1	305	314	PF00244	0.704
LIG_14-3-3_CanoR_1	343	349	PF00244	0.707
LIG_14-3-3_CanoR_1	61	65	PF00244	0.630
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_BIR_III_2	285	289	PF00653	0.630
LIG_FHA_1	261	267	PF00498	0.423
LIG_FHA_1	307	313	PF00498	0.629
LIG_FHA_1	66	72	PF00498	0.639
LIG_FHA_2	235	241	PF00498	0.551
LIG_FHA_2	365	371	PF00498	0.715
LIG_FHA_2	381	387	PF00498	0.489
LIG_FHA_2	46	52	PF00498	0.732
LIG_FHA_2	86	92	PF00498	0.604
LIG_LIR_Gen_1	245	255	PF02991	0.548
LIG_LIR_Gen_1	45	55	PF02991	0.571
LIG_LIR_Gen_1	5	12	PF02991	0.559
LIG_LIR_Gen_1	59	69	PF02991	0.485
LIG_LIR_Nem_3	231	235	PF02991	0.472
LIG_LIR_Nem_3	243	247	PF02991	0.482
LIG_LIR_Nem_3	45	50	PF02991	0.586
LIG_LIR_Nem_3	5	9	PF02991	0.667
LIG_LIR_Nem_3	59	65	PF02991	0.640
LIG_PDZ_Class_2	417	422	PF00595	0.483
LIG_SH2_NCK_1	406	410	PF00017	0.433
LIG_SH2_NCK_1	47	51	PF00017	0.605
LIG_SH2_SRC	406	409	PF00017	0.436
LIG_SH2_STAP1	23	27	PF00017	0.760
LIG_SH2_STAP1	406	410	PF00017	0.452
LIG_SH2_STAT5	47	50	PF00017	0.607
LIG_SH3_3	287	293	PF00018	0.667
LIG_SH3_3	68	74	PF00018	0.668
LIG_SH3_5	19	23	PF00018	0.601
LIG_TRAF2_1	163	166	PF00917	0.357
MOD_CDK_SPK_2	100	105	PF00069	0.625
MOD_CDK_SPK_2	56	61	PF00069	0.615
MOD_CDK_SPK_2	85	90	PF00069	0.625
MOD_CDK_SPxxK_3	356	363	PF00069	0.571
MOD_CK1_1	103	109	PF00069	0.529
MOD_CK1_1	2	8	PF00069	0.632
MOD_CK1_1	21	27	PF00069	0.579
MOD_CK1_1	236	242	PF00069	0.505
MOD_CK1_1	260	266	PF00069	0.427
MOD_CK1_1	308	314	PF00069	0.626
MOD_CK1_1	395	401	PF00069	0.548
MOD_CK1_1	411	417	PF00069	0.440
MOD_CK1_1	43	49	PF00069	0.723
MOD_CK2_1	234	240	PF00069	0.641
MOD_CK2_1	356	362	PF00069	0.689
MOD_CK2_1	364	370	PF00069	0.650
MOD_CK2_1	401	407	PF00069	0.612
MOD_CK2_1	45	51	PF00069	0.692
MOD_GlcNHglycan	123	126	PF01048	0.548
MOD_GlcNHglycan	214	217	PF01048	0.561
MOD_GlcNHglycan	219	222	PF01048	0.466
MOD_GlcNHglycan	244	247	PF01048	0.553
MOD_GlcNHglycan	302	305	PF01048	0.680
MOD_GlcNHglycan	318	321	PF01048	0.508
MOD_GlcNHglycan	396	400	PF01048	0.515
MOD_GlcNHglycan	42	45	PF01048	0.652
MOD_GSK3_1	108	115	PF00069	0.586
MOD_GSK3_1	121	128	PF00069	0.476
MOD_GSK3_1	236	243	PF00069	0.547
MOD_GSK3_1	296	303	PF00069	0.653
MOD_GSK3_1	304	311	PF00069	0.691
MOD_GSK3_1	38	45	PF00069	0.671
MOD_GSK3_1	397	404	PF00069	0.622
MOD_GSK3_1	56	63	PF00069	0.681
MOD_GSK3_1	99	106	PF00069	0.702
MOD_N-GLC_1	280	285	PF02516	0.539
MOD_N-GLC_1	316	321	PF02516	0.666
MOD_N-GLC_1	356	361	PF02516	0.653
MOD_NEK2_1	186	191	PF00069	0.384
MOD_NEK2_1	300	305	PF00069	0.649
MOD_NEK2_1	316	321	PF00069	0.513
MOD_NEK2_2	296	301	PF00069	0.570
MOD_PIKK_1	260	266	PF00454	0.427
MOD_PK_1	344	350	PF00069	0.549
MOD_PKA_1	233	239	PF00069	0.534
MOD_PKA_1	344	350	PF00069	0.626
MOD_PKA_2	135	141	PF00069	0.578
MOD_PKA_2	217	223	PF00069	0.483
MOD_PKA_2	233	239	PF00069	0.451
MOD_PKA_2	300	306	PF00069	0.665
MOD_PKA_2	60	66	PF00069	0.614
MOD_Plk_1	181	187	PF00069	0.553
MOD_Plk_1	21	27	PF00069	0.548
MOD_Plk_4	308	314	PF00069	0.689
MOD_Plk_4	344	350	PF00069	0.628
MOD_Plk_4	401	407	PF00069	0.544
MOD_Plk_4	408	414	PF00069	0.449
MOD_ProDKin_1	100	106	PF00069	0.646
MOD_ProDKin_1	205	211	PF00069	0.512
MOD_ProDKin_1	248	254	PF00069	0.469
MOD_ProDKin_1	332	338	PF00069	0.621
MOD_ProDKin_1	356	362	PF00069	0.689
MOD_ProDKin_1	56	62	PF00069	0.719
MOD_ProDKin_1	85	91	PF00069	0.653
MOD_ProDKin_1	93	99	PF00069	0.685
MOD_SUMO_rev_2	28	38	PF00179	0.530
TRG_DiLeu_BaEn_1	182	187	PF01217	0.472
TRG_DiLeu_LyEn_5	182	187	PF01217	0.446
TRG_ENDOCYTIC_2	47	50	PF00928	0.579
TRG_ENDOCYTIC_2	6	9	PF00928	0.674
TRG_ER_diArg_1	145	147	PF00400	0.632
TRG_ER_diArg_1	16	18	PF00400	0.697
TRG_ER_diArg_1	232	234	PF00400	0.563
TRG_ER_diArg_1	416	419	PF00400	0.458
TRG_NLS_MonoExtN_4	342	347	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ64	Leptomonas seymouri	33%	100%
A4HNY9	Leishmania braziliensis	58%	100%
A4ICK4	Leishmania infantum	99%	100%
E9ASQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q1U4	Leishmania major	84%	100%