LeishMANIAdb
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Heat shock protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Heat shock protein, putative
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7XAJ1_LEIDO
TriTrypDb:
LdBPK_361380.1 * , LdCL_360018900 , LDHU3_36.1730
Length:
452

Annotations

LeishMANIAdb annotations

Apparently a chaperone for some membrane-associated process unique to Kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A0A3S7XAJ1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAJ1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 389 393 PF00656 0.681
CLV_NRD_NRD_1 141 143 PF00675 0.502
CLV_NRD_NRD_1 251 253 PF00675 0.455
CLV_NRD_NRD_1 277 279 PF00675 0.358
CLV_NRD_NRD_1 434 436 PF00675 0.406
CLV_NRD_NRD_1 95 97 PF00675 0.561
CLV_PCSK_FUR_1 192 196 PF00082 0.408
CLV_PCSK_KEX2_1 141 143 PF00082 0.502
CLV_PCSK_KEX2_1 194 196 PF00082 0.382
CLV_PCSK_KEX2_1 251 253 PF00082 0.479
CLV_PCSK_KEX2_1 276 278 PF00082 0.362
CLV_PCSK_KEX2_1 95 97 PF00082 0.561
CLV_PCSK_PC1ET2_1 194 196 PF00082 0.415
CLV_PCSK_SKI1_1 115 119 PF00082 0.639
CLV_PCSK_SKI1_1 167 171 PF00082 0.394
CLV_PCSK_SKI1_1 409 413 PF00082 0.399
CLV_PCSK_SKI1_1 436 440 PF00082 0.434
DEG_MDM2_SWIB_1 19 26 PF02201 0.186
DOC_CYCLIN_RxL_1 109 122 PF00134 0.406
DOC_CYCLIN_yCln2_LP_2 416 422 PF00134 0.584
DOC_MAPK_gen_1 276 283 PF00069 0.557
DOC_MAPK_MEF2A_6 376 385 PF00069 0.586
DOC_PP1_RVXF_1 177 183 PF00149 0.524
DOC_PP2B_LxvP_1 416 419 PF13499 0.623
DOC_PP4_FxxP_1 414 417 PF00568 0.612
DOC_USP7_MATH_1 206 210 PF00917 0.726
DOC_USP7_MATH_1 231 235 PF00917 0.493
DOC_USP7_MATH_1 339 343 PF00917 0.487
DOC_WW_Pin1_4 143 148 PF00397 0.700
DOC_WW_Pin1_4 55 60 PF00397 0.352
DOC_WW_Pin1_4 76 81 PF00397 0.332
LIG_14-3-3_CanoR_1 119 125 PF00244 0.361
LIG_14-3-3_CanoR_1 258 265 PF00244 0.614
LIG_14-3-3_CanoR_1 276 284 PF00244 0.635
LIG_14-3-3_CanoR_1 400 406 PF00244 0.648
LIG_14-3-3_CanoR_1 442 449 PF00244 0.618
LIG_14-3-3_CanoR_1 84 90 PF00244 0.408
LIG_14-3-3_CterR_2 447 452 PF00244 0.594
LIG_Actin_WH2_2 60 78 PF00022 0.341
LIG_BRCT_BRCA1_1 11 15 PF00533 0.186
LIG_BRCT_BRCA1_1 172 176 PF00533 0.595
LIG_BRCT_BRCA1_1 256 260 PF00533 0.668
LIG_CtBP_PxDLS_1 419 423 PF00389 0.521
LIG_FHA_1 120 126 PF00498 0.249
LIG_FHA_1 23 29 PF00498 0.171
LIG_FHA_1 39 45 PF00498 0.306
LIG_FHA_1 413 419 PF00498 0.564
LIG_FHA_1 59 65 PF00498 0.345
LIG_FHA_1 69 75 PF00498 0.415
LIG_FHA_1 77 83 PF00498 0.340
LIG_FHA_2 185 191 PF00498 0.611
LIG_FHA_2 348 354 PF00498 0.660
LIG_FHA_2 387 393 PF00498 0.699
LIG_LIR_Apic_2 412 417 PF02991 0.616
LIG_LIR_Gen_1 12 19 PF02991 0.176
LIG_LIR_Gen_1 20 31 PF02991 0.181
LIG_LIR_Gen_1 229 239 PF02991 0.534
LIG_LIR_Gen_1 41 49 PF02991 0.317
LIG_LIR_LC3C_4 41 46 PF02991 0.321
LIG_LIR_Nem_3 12 18 PF02991 0.186
LIG_LIR_Nem_3 20 26 PF02991 0.171
LIG_LIR_Nem_3 229 235 PF02991 0.543
LIG_LIR_Nem_3 237 242 PF02991 0.498
LIG_LIR_Nem_3 295 301 PF02991 0.322
LIG_LIR_Nem_3 41 46 PF02991 0.320
LIG_LIR_Nem_3 88 93 PF02991 0.357
LIG_MAD2 198 206 PF02301 0.547
LIG_Pex14_1 23 27 PF04695 0.186
LIG_Pex14_2 15 19 PF04695 0.181
LIG_Pex14_2 265 269 PF04695 0.660
LIG_Pex14_2 328 332 PF04695 0.391
LIG_PTB_Apo_2 37 44 PF02174 0.314
LIG_SH2_CRK 197 201 PF00017 0.535
LIG_SH2_CRK 239 243 PF00017 0.602
LIG_SH2_CRK 8 12 PF00017 0.358
LIG_SH2_NCK_1 239 243 PF00017 0.539
LIG_SH2_STAT5 27 30 PF00017 0.367
LIG_SH2_STAT5 31 34 PF00017 0.321
LIG_SH2_STAT5 314 317 PF00017 0.368
LIG_SUMO_SIM_par_1 133 139 PF11976 0.315
LIG_SUMO_SIM_par_1 436 441 PF11976 0.640
LIG_TRAF2_1 350 353 PF00917 0.575
LIG_TYR_ITIM 6 11 PF00017 0.382
MOD_CK1_1 123 129 PF00069 0.419
MOD_CK1_1 154 160 PF00069 0.695
MOD_CK1_1 209 215 PF00069 0.686
MOD_CK1_1 403 409 PF00069 0.449
MOD_CK1_1 58 64 PF00069 0.644
MOD_CK2_1 156 162 PF00069 0.631
MOD_CK2_1 171 177 PF00069 0.521
MOD_CK2_1 184 190 PF00069 0.492
MOD_CK2_1 231 237 PF00069 0.349
MOD_CK2_1 347 353 PF00069 0.451
MOD_Cter_Amidation 249 252 PF01082 0.549
MOD_GlcNHglycan 11 14 PF01048 0.171
MOD_GlcNHglycan 125 128 PF01048 0.361
MOD_GlcNHglycan 138 141 PF01048 0.620
MOD_GlcNHglycan 154 157 PF01048 0.681
MOD_GlcNHglycan 207 211 PF01048 0.564
MOD_GlcNHglycan 223 227 PF01048 0.516
MOD_GlcNHglycan 260 263 PF01048 0.638
MOD_GlcNHglycan 3 6 PF01048 0.428
MOD_GlcNHglycan 444 447 PF01048 0.575
MOD_GSK3_1 119 126 PF00069 0.390
MOD_GSK3_1 152 159 PF00069 0.728
MOD_GSK3_1 17 24 PF00069 0.184
MOD_GSK3_1 205 212 PF00069 0.620
MOD_GSK3_1 254 261 PF00069 0.634
MOD_GSK3_1 26 33 PF00069 0.359
MOD_GSK3_1 301 308 PF00069 0.501
MOD_GSK3_1 399 406 PF00069 0.496
MOD_GSK3_1 58 65 PF00069 0.563
MOD_N-GLC_1 254 259 PF02516 0.712
MOD_N-GLC_1 305 310 PF02516 0.584
MOD_N-GLC_1 420 425 PF02516 0.459
MOD_N-GLC_1 50 55 PF02516 0.436
MOD_N-GLC_2 366 368 PF02516 0.348
MOD_NEK2_1 1 6 PF00069 0.424
MOD_NEK2_1 117 122 PF00069 0.707
MOD_NEK2_1 136 141 PF00069 0.472
MOD_NEK2_1 19 24 PF00069 0.153
MOD_NEK2_1 38 43 PF00069 0.519
MOD_NEK2_1 74 79 PF00069 0.478
MOD_NEK2_1 83 88 PF00069 0.477
MOD_NEK2_2 231 236 PF00069 0.396
MOD_NEK2_2 339 344 PF00069 0.509
MOD_NEK2_2 63 68 PF00069 0.455
MOD_PIKK_1 154 160 PF00454 0.589
MOD_PIKK_1 276 282 PF00454 0.563
MOD_PKA_1 276 282 PF00069 0.553
MOD_PKA_2 120 126 PF00069 0.440
MOD_PKA_2 276 282 PF00069 0.496
MOD_PKA_2 399 405 PF00069 0.498
MOD_PKA_2 83 89 PF00069 0.455
MOD_Plk_1 305 311 PF00069 0.567
MOD_Plk_1 420 426 PF00069 0.490
MOD_Plk_1 440 446 PF00069 0.395
MOD_Plk_1 50 56 PF00069 0.437
MOD_Plk_2-3 186 192 PF00069 0.500
MOD_Plk_2-3 347 353 PF00069 0.586
MOD_Plk_4 11 17 PF00069 0.186
MOD_Plk_4 120 126 PF00069 0.294
MOD_Plk_4 22 28 PF00069 0.166
MOD_Plk_4 38 44 PF00069 0.372
MOD_Plk_4 85 91 PF00069 0.480
MOD_ProDKin_1 143 149 PF00069 0.640
MOD_ProDKin_1 55 61 PF00069 0.432
MOD_ProDKin_1 76 82 PF00069 0.407
TRG_DiLeu_BaLyEn_6 279 284 PF01217 0.564
TRG_DiLeu_BaLyEn_6 70 75 PF01217 0.430
TRG_ENDOCYTIC_2 197 200 PF00928 0.543
TRG_ENDOCYTIC_2 239 242 PF00928 0.378
TRG_ENDOCYTIC_2 8 11 PF00928 0.161
TRG_ER_diArg_1 106 109 PF00400 0.720
TRG_ER_diArg_1 118 121 PF00400 0.518
TRG_ER_diArg_1 141 143 PF00400 0.698
TRG_ER_diArg_1 276 278 PF00400 0.528
TRG_Pf-PMV_PEXEL_1 282 286 PF00026 0.279

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P358 Leptomonas seymouri 52% 100%
A0A1X0P876 Trypanosomatidae 43% 100%
A0A3R7N2F8 Trypanosoma rangeli 40% 100%
A4HNZ0 Leishmania braziliensis 73% 100%
A4ICK3 Leishmania infantum 100% 100%
D0A2V8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9ASQ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q1U3 Leishmania major 95% 100%
V5BUV1 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS