LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7XAI8_LEIDO
TriTrypDb:
LdBPK_361240.1 , LdCL_360017500 , LDHU3_36.1580
Length:
335

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XAI8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAI8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 247 251 PF00656 0.495
CLV_NRD_NRD_1 267 269 PF00675 0.528
CLV_PCSK_KEX2_1 267 269 PF00082 0.447
CLV_PCSK_SKI1_1 268 272 PF00082 0.531
CLV_PCSK_SKI1_1 308 312 PF00082 0.481
DEG_Nend_Nbox_1 1 3 PF02207 0.622
DEG_SCF_FBW7_1 172 179 PF00400 0.690
DOC_CYCLIN_RxL_1 149 157 PF00134 0.529
DOC_CYCLIN_RxL_1 305 314 PF00134 0.474
DOC_MAPK_gen_1 267 275 PF00069 0.446
DOC_MAPK_gen_1 70 78 PF00069 0.485
DOC_MAPK_HePTP_8 265 277 PF00069 0.447
DOC_MAPK_MEF2A_6 142 151 PF00069 0.556
DOC_MAPK_MEF2A_6 268 277 PF00069 0.438
DOC_MAPK_MEF2A_6 70 78 PF00069 0.409
DOC_PP4_FxxP_1 79 82 PF00568 0.545
DOC_USP7_MATH_1 216 220 PF00917 0.479
DOC_USP7_MATH_1 237 241 PF00917 0.569
DOC_USP7_MATH_1 326 330 PF00917 0.680
DOC_USP7_MATH_1 82 86 PF00917 0.514
DOC_WW_Pin1_4 143 148 PF00397 0.550
DOC_WW_Pin1_4 154 159 PF00397 0.470
DOC_WW_Pin1_4 172 177 PF00397 0.688
DOC_WW_Pin1_4 28 33 PF00397 0.460
LIG_14-3-3_CanoR_1 51 55 PF00244 0.513
LIG_14-3-3_CanoR_1 6 10 PF00244 0.626
LIG_Actin_WH2_2 35 53 PF00022 0.449
LIG_APCC_ABBA_1 275 280 PF00400 0.532
LIG_BRCT_BRCA1_1 230 234 PF00533 0.553
LIG_Clathr_ClatBox_1 310 314 PF01394 0.474
LIG_FHA_1 100 106 PF00498 0.540
LIG_FHA_1 123 129 PF00498 0.431
LIG_FHA_1 144 150 PF00498 0.533
LIG_FHA_1 177 183 PF00498 0.724
LIG_FHA_1 39 45 PF00498 0.511
LIG_FHA_2 317 323 PF00498 0.631
LIG_LIR_Gen_1 219 229 PF02991 0.563
LIG_LIR_Gen_1 266 277 PF02991 0.412
LIG_LIR_Gen_1 37 45 PF02991 0.532
LIG_LIR_LC3C_4 125 129 PF02991 0.545
LIG_LIR_Nem_3 201 206 PF02991 0.527
LIG_LIR_Nem_3 219 224 PF02991 0.206
LIG_LIR_Nem_3 266 272 PF02991 0.411
LIG_LIR_Nem_3 37 42 PF02991 0.528
LIG_PCNA_yPIPBox_3 61 75 PF02747 0.500
LIG_REV1ctd_RIR_1 14 24 PF16727 0.598
LIG_RPA_C_Fungi 188 200 PF08784 0.392
LIG_SH2_SRC 75 78 PF00017 0.490
LIG_SH2_STAP1 101 105 PF00017 0.579
LIG_SH2_STAT5 101 104 PF00017 0.442
LIG_SH2_STAT5 75 78 PF00017 0.490
LIG_SH3_2 147 152 PF14604 0.601
LIG_SH3_3 144 150 PF00018 0.540
LIG_SH3_3 39 45 PF00018 0.574
LIG_SH3_3 71 77 PF00018 0.403
LIG_SUMO_SIM_anti_2 125 131 PF11976 0.486
LIG_SUMO_SIM_anti_2 60 66 PF11976 0.506
LIG_SUMO_SIM_par_1 125 131 PF11976 0.555
LIG_SUMO_SIM_par_1 309 314 PF11976 0.427
LIG_SUMO_SIM_par_1 60 66 PF11976 0.460
LIG_TRFH_1 28 32 PF08558 0.569
LIG_WRC_WIRS_1 138 143 PF05994 0.512
LIG_WRC_WIRS_1 36 41 PF05994 0.577
MOD_CDK_SPxK_1 172 178 PF00069 0.690
MOD_CK1_1 230 236 PF00069 0.534
MOD_CK1_1 5 11 PF00069 0.598
MOD_CK1_1 85 91 PF00069 0.585
MOD_GlcNHglycan 179 182 PF01048 0.710
MOD_GlcNHglycan 303 306 PF01048 0.548
MOD_GlcNHglycan 54 57 PF01048 0.621
MOD_GSK3_1 118 125 PF00069 0.655
MOD_GSK3_1 162 169 PF00069 0.739
MOD_GSK3_1 172 179 PF00069 0.647
MOD_GSK3_1 233 240 PF00069 0.513
MOD_GSK3_1 297 304 PF00069 0.502
MOD_GSK3_1 326 333 PF00069 0.738
MOD_GSK3_1 5 12 PF00069 0.677
MOD_N-GLC_1 189 194 PF02516 0.604
MOD_N-GLC_1 227 232 PF02516 0.545
MOD_N-GLC_1 28 33 PF02516 0.495
MOD_N-GLC_1 297 302 PF02516 0.501
MOD_N-GLC_1 88 93 PF02516 0.582
MOD_N-GLC_2 207 209 PF02516 0.547
MOD_NEK2_1 177 182 PF00069 0.671
MOD_NEK2_1 189 194 PF00069 0.484
MOD_NEK2_1 2 7 PF00069 0.641
MOD_NEK2_1 50 55 PF00069 0.520
MOD_NEK2_1 9 14 PF00069 0.480
MOD_NEK2_2 107 112 PF00069 0.449
MOD_NEK2_2 137 142 PF00069 0.507
MOD_PIKK_1 162 168 PF00454 0.740
MOD_PKA_2 177 183 PF00069 0.773
MOD_PKA_2 5 11 PF00069 0.616
MOD_PKA_2 50 56 PF00069 0.504
MOD_Plk_1 227 233 PF00069 0.529
MOD_Plk_4 122 128 PF00069 0.454
MOD_Plk_4 181 187 PF00069 0.762
MOD_Plk_4 217 223 PF00069 0.412
MOD_Plk_4 38 44 PF00069 0.444
MOD_ProDKin_1 143 149 PF00069 0.546
MOD_ProDKin_1 154 160 PF00069 0.468
MOD_ProDKin_1 172 178 PF00069 0.690
MOD_ProDKin_1 28 34 PF00069 0.460
TRG_DiLeu_BaLyEn_6 184 189 PF01217 0.760
TRG_DiLeu_BaLyEn_6 45 50 PF01217 0.444
TRG_ENDOCYTIC_2 138 141 PF00928 0.502
TRG_ENDOCYTIC_2 203 206 PF00928 0.541
TRG_ENDOCYTIC_2 36 39 PF00928 0.510
TRG_ENDOCYTIC_2 75 78 PF00928 0.408
TRG_ER_diArg_1 267 269 PF00400 0.528
TRG_NES_CRM1_1 33 47 PF08389 0.458
TRG_Pf-PMV_PEXEL_1 204 208 PF00026 0.483
TRG_Pf-PMV_PEXEL_1 48 52 PF00026 0.454
TRG_Pf-PMV_PEXEL_1 61 66 PF00026 0.419

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC55 Leptomonas seymouri 41% 100%
A0A422NTW5 Trypanosoma rangeli 31% 100%
A4HNX8 Leishmania braziliensis 75% 100%
A4ICL6 Leishmania infantum 100% 100%
D0A2U4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9ASN8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q1V8 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS