Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XAI6_LEIDO

TriTrypDb:

LdBPK_360510.1 , LdCL_360010000 , LDHU3_36.0670

Length:

225

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), COX 5b Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005751	mitochondrial respiratory chain complex IV	4	11
GO:0032991	protein-containing complex	1	11
GO:0045277	respiratory chain complex IV	4	11
GO:0070069	cytochrome complex	3	11
GO:0098796	membrane protein complex	2	11
GO:0098798	mitochondrial protein-containing complex	2	11
GO:0098800	inner mitochondrial membrane protein complex	3	11
GO:0098803	respiratory chain complex	3	11
GO:1902494	catalytic complex	2	11
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XAI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XAI6

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	11
GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	7	11
GO:0008152	metabolic process	1	11
GO:0009060	aerobic respiration	6	11
GO:0009987	cellular process	1	11
GO:0015980	energy derivation by oxidation of organic compounds	4	11
GO:0019646	aerobic electron transport chain	6	11
GO:0022900	electron transport chain	4	11
GO:0022904	respiratory electron transport chain	5	11
GO:0044237	cellular metabolic process	2	11
GO:0045333	cellular respiration	5	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.530
CLV_NRD_NRD_1	50	52	PF00675	0.517
DEG_Nend_Nbox_1	1	3	PF02207	0.528
DOC_MAPK_gen_1	3	9	PF00069	0.575
DOC_PP1_RVXF_1	74	80	PF00149	0.464
DOC_USP7_MATH_1	120	124	PF00917	0.470
DOC_USP7_MATH_1	15	19	PF00917	0.551
DOC_USP7_MATH_1	54	58	PF00917	0.519
DOC_USP7_UBL2_3	162	166	PF12436	0.392
DOC_WW_Pin1_4	50	55	PF00397	0.507
LIG_APCC_ABBA_1	184	189	PF00400	0.505
LIG_APCC_ABBA_1	64	69	PF00400	0.515
LIG_FHA_1	92	98	PF00498	0.531
LIG_FHA_2	201	207	PF00498	0.523
LIG_LIR_Gen_1	107	117	PF02991	0.548
LIG_LIR_Gen_1	155	164	PF02991	0.403
LIG_LIR_Gen_1	203	211	PF02991	0.501
LIG_LIR_Gen_1	212	222	PF02991	0.483
LIG_LIR_Nem_3	107	113	PF02991	0.538
LIG_LIR_Nem_3	203	207	PF02991	0.514
LIG_LIR_Nem_3	212	218	PF02991	0.482
LIG_Pex14_2	211	215	PF04695	0.481
LIG_SH2_GRB2like	221	224	PF00017	0.495
LIG_SH2_PTP2	110	113	PF00017	0.504
LIG_SH2_SRC	117	120	PF00017	0.521
LIG_SH2_SRC	221	224	PF00017	0.495
LIG_SH2_SRC	67	70	PF00017	0.490
LIG_SH2_STAP1	67	71	PF00017	0.481
LIG_SH2_STAT3	33	36	PF00017	0.517
LIG_SH2_STAT5	110	113	PF00017	0.504
LIG_SH2_STAT5	177	180	PF00017	0.388
LIG_SH2_STAT5	202	205	PF00017	0.525
LIG_SH2_STAT5	221	224	PF00017	0.495
LIG_SH3_1	31	37	PF00018	0.533
LIG_SH3_3	147	153	PF00018	0.557
LIG_SH3_3	182	188	PF00018	0.504
LIG_SH3_3	31	37	PF00018	0.541
LIG_SUMO_SIM_par_1	92	99	PF11976	0.531
MOD_CK1_1	18	24	PF00069	0.609
MOD_CK2_1	200	206	PF00069	0.532
MOD_GlcNHglycan	17	20	PF01048	0.565
MOD_GSK3_1	15	22	PF00069	0.592
MOD_GSK3_1	46	53	PF00069	0.536
MOD_NEK2_1	10	15	PF00069	0.498
MOD_NEK2_1	2	7	PF00069	0.515
MOD_NEK2_1	60	65	PF00069	0.571
MOD_PKA_2	2	8	PF00069	0.536
MOD_Plk_1	29	35	PF00069	0.673
MOD_Plk_1	60	66	PF00069	0.547
MOD_Plk_1	91	97	PF00069	0.527
MOD_Plk_4	91	97	PF00069	0.527
MOD_ProDKin_1	50	56	PF00069	0.506
TRG_ENDOCYTIC_2	110	113	PF00928	0.530
TRG_ENDOCYTIC_2	157	160	PF00928	0.407
TRG_ENDOCYTIC_2	67	70	PF00928	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILG0	Leptomonas seymouri	95%	100%
A0A0S4JMS0	Bodo saltans	77%	100%
A0A1X0P8B6	Trypanosomatidae	88%	100%
A0A422P2A1	Trypanosoma rangeli	88%	100%
A4HNQ6	Leishmania braziliensis	98%	100%
A4ICT9	Leishmania infantum	100%	100%
D0A2L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	88%	100%
E9ASG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q230	Leishmania major	100%	100%
V5BA06	Trypanosoma cruzi	86%	76%